Seaweed in the Diet as a Source of Bioactive Metabolites and a Potential Natural Immunity Booster: A Comprehensive Review Amiya Kumar Mandal, Sudhamayee Parida, Akshaya Kumar Behera, Siba Prasad Adhikary, Andrey A. Lukatkin, Alexander S. Lukatkin, Mrutyunjay Jena Pharmaceuticals, 2025 Seaweed plays an essential role in the survival of marine life, provides habitats and helps in nutrient recycling. It is rich in valuable nutritious compounds such as pigments, proteins, polysaccharides, minerals, vitamins, omega-rich oils, secondary metabolites, fibers and sterols. Pigments like fucoxanthin and astaxanthin and polysaccharides like laminarin, fucoidan, galactan and ulvan possess immune-modulatory and immune-enhancing properties. Moreover, they show antioxidative, antidiabetic, anticancer, anti-inflammatory, antiproliferative, anti-obesity, antimicrobial, anticoagulation and anti-aging properties and can prevent diseases such as Alzheimer’s and Parkinson’s and cardiovascular diseases. Though seaweed is frequently consumed by Eastern Asian countries like China, Japan, and Korea and has gained the attention of Western countries in recent years due to its nutritional properties, its consumption on a global scale is very limited because of a lack of awareness. Thus, to incorporate seaweed into the global diet and to make it familiar as a functional food, issues such as large-scale cultivation, processing, consumer acceptance and the development of seaweed-based food products need to be addressed. This review is intended to give a brief overview of the present status of seaweed, its nutritional value and its bioactive metabolites as functional foods for human health and diseases owing to its immunity-boosting potential. Further, seaweed as a source of sustainable food and its prospects along with its issues are discussed in this review.
A Novel Phytocolorant, Neoxanthin, as a Potent Chemopreventive: Current Progress and Future Prospects Sudhamayee Parida, Mrutyunjay Jena, Akshaya Kumar Behera, Amiya Kumar Mandal, Rabindra Nayak, Srimanta Patra Current Medicinal Chemistry, 2024 : Cancer is a general term for a group of similar diseases. It is a combined process that results from an accumulation of abnormalities at different biological levels, which involves changes at both genetic and biochemical levels in the cells. Several modifiable risk factors for each type of cancer include heredity, age, and institutional screening guidelines, including colonoscopy, mammograms, prostate-specific antigen testing, etc., which an individual cannot modify. Although a wide range of resources is available for cancer drugs and developmental studies, the cases are supposed to increase by about 70% in the next two decades due to environmental factors commonly driven by the way of living. The drugs used in cancer prevention are not entirely safe, have potential side effects and are generally unsuitable owing to substantial monetary costs. Interventions during the initiation and progression of cancer can prevent, diminish, or stop the transformation of healthy cells on the way to malignancy. Diet modifications are one of the most promising lifestyle changes that can decrease the threat of cancer development by nearly 40%. Neoxanthin is a xanthophyll pigment found in many microalgae and macroalgae, having significant anti-cancer, antioxidant and chemo-preventive activity. In this review, we have focused on the anti-cancer activity of neoxanthin on different cell lines and its cancer-preventive activity concerning obesity and oxidative stress. In addition to this, the preclinical studies and future perspectives are also discussed in this review.
Zeaxanthin: A Novel Therapeutic Agent against Human Diseases Biswajita Pradhan, Sneha Nayak, Srimanta Patra, Rabindra Nayak, Amiya Kumar Mandal, Sudhamayee Parida, Yubaraj Satapathy, Prajna Paramita Bhuyan, Mrutyunjay Jena Algal Biotechnology Applications for Industrial Development and Human Welfare, 2024 Carotenoids are isoprenoid pigments that have significance effect on human health and reduce several disorders owing to their antioxidative properties. The carotenoids are comprised of carotenes, β-α-carotene, lutein, lycopene, zeaxanthin, fucoxanthin, β-cryptoxanthin, astaxanthin and canthaxanthin, which have potent anticancer activity in several cancer subtypes both in vitro and in vivo. Among all the carotenoids, zeaxanthin, a crucial carotenoid found in nature can exhibit anticancer property both in vitro and in vivo. Zeaxanthin-mediated chemoprevention is one of the most imperative approaches for cancer prevention. Apart from cancer, it can also be used as a therapeutic agent against cardiovascular, skin and eye disease. More importantly, zeaxanthin can also be used as a dietary supplement or food adjuvant. In this present chapter, the mode of cancer prevention and therapeutic approaches against other age-associated diseases using zeaxanthin are described with special notation to their molecular mechanisms.
Phyco-fabrication of iron oxide nanoparticles using Chlorella vulgaris: Antibacterial potential and antioxidant activity AK Mandal, S Parida, AK Behera, SG Mandal, A Nito, A Quarta, A Ragusa, ... Journal of Applied Phycology, 1-12 , 2026 2026
Cyanobacterial scytonemin, a potential photoprotective natural pigment: biomedical, industrial and environmental applications AK Behera, S Parida, AK Mandal, S Patra, M Jena Archives of Microbiology 207 (11), 265 , 2025 2025 Citations: 3
Seaweed in the diet as a source of bioactive metabolites and a potential natural immunity booster: a comprehensive review AK Mandal, S Parida, AK Behera, SP Adhikary, AA Lukatkin, AS Lukatkin, ... Pharmaceuticals 18 (3), 367 , 2025 2025 Citations: 17
Microalgal nanofactory: green synthesis of zinc oxide nanoparticles and their antibacterial and antioxidant potentials AK Mandal, AK Behera, S Parida, R Nayak, P Hembram, C Behera, ... BioNanoScience 15 (1), 119 , 2025 2025 Citations: 13
A comprehensive review on phycoremediation of azo dye to combat industrial wastewater pollution S Parida, AK Mandal, AK Behera, S Patra, R Nayak, C Behera, M Jena Journal of Water Process Engineering 70, 107088 , 2025 2025 Citations: 32
Impact of Microplastics on Marine Ecosystem , Human Health and its solution through Phycoremediation S Parida, AK Mandal, AK Behera, R Nayak, M Jena Proceedings of Odisha Environment Congress 2024 15 (1), 281-296 , 2024 2024
Bioremediation of Textile Dye Fiery Magenta by Unicellular Green Algae Chlamydomonas reinhardtii S Parida, HS Dharua, AK Behera, AK Mandal, SP Nayak, M Jena Research Journal of Berhampur University 8, 8-12 , 2024 2024
A novel phytocolorant, neoxanthin, as a potent chemopreventive: Current progress and future prospects S Parida, M Jena, AK Behera, AK Mandal, R Nayak, S Patra Current medicinal chemistry 31 (32), 5149-5164 , 2024 2024 Citations: 9
Zeaxanthin: A novel therapeutic agent against human diseases B Pradhan, S Nayak, S Patra, R Nayak, AK Mandal, S Parida, Y Satapathy, ... Algal Biotechnology, 307-319 , 2024 2024 Citations: 1
Algal-derived nanoparticles and their antibacterial potential: Current evidence and future prospectives AK Mandal, R Nayak, B Pradhan, C Behera, AK Behera, S Parida, S Patra, ... Journal of Microbiological Methods 211, 106790 , 2023 2023 Citations: 15
Microalgal biofilm and their prospective application for wastewater treatment and biofuel production R Nayak, B Pradhan, S Patra, PP Bhuyan, C Behera, S Parida, AK Behera, ... Understanding microbial biofilms, 147-164 , 2023 2023 Citations: 2
A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections B Pradhan, R Nayak, S Patra, PP Bhuyan, PK Behera, AK Mandal, ... Carbohydrate Polymers 291, 119551 , 2022 2022 Citations: 126
In vitro antidiabetic, anti-inflammatory and antibacterial activity of marine alga Enteromorpha compressa collected from Chilika lagoon, Odisha, India B Pradhan, S Patra, SR Dash, Y Satapathy, S Nayak, AK Mandal, M Jena Vegetos 35 (3), 614-621 , 2022 2022 Citations: 26
Ethno medicinal study in North West Ganjam, Odisha A Leelaveni, S Dash, SK Behera, S Das, AK Mandal Int. J. Innov. Sci. Res 7, 1167-1174 , 2018 2018 Citations: 8
MOST CITED SCHOLAR PUBLICATIONS
A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections B Pradhan, R Nayak, S Patra, PP Bhuyan, PK Behera, AK Mandal, ... Carbohydrate Polymers 291, 119551 , 2022 2022 Citations: 126
A comprehensive review on phycoremediation of azo dye to combat industrial wastewater pollution S Parida, AK Mandal, AK Behera, S Patra, R Nayak, C Behera, M Jena Journal of Water Process Engineering 70, 107088 , 2025 2025 Citations: 32
In vitro antidiabetic, anti-inflammatory and antibacterial activity of marine alga Enteromorpha compressa collected from Chilika lagoon, Odisha, India B Pradhan, S Patra, SR Dash, Y Satapathy, S Nayak, AK Mandal, M Jena Vegetos 35 (3), 614-621 , 2022 2022 Citations: 26
Seaweed in the diet as a source of bioactive metabolites and a potential natural immunity booster: a comprehensive review AK Mandal, S Parida, AK Behera, SP Adhikary, AA Lukatkin, AS Lukatkin, ... Pharmaceuticals 18 (3), 367 , 2025 2025 Citations: 17
Algal-derived nanoparticles and their antibacterial potential: Current evidence and future prospectives AK Mandal, R Nayak, B Pradhan, C Behera, AK Behera, S Parida, S Patra, ... Journal of Microbiological Methods 211, 106790 , 2023 2023 Citations: 15
Microalgal nanofactory: green synthesis of zinc oxide nanoparticles and their antibacterial and antioxidant potentials AK Mandal, AK Behera, S Parida, R Nayak, P Hembram, C Behera, ... BioNanoScience 15 (1), 119 , 2025 2025 Citations: 13
A novel phytocolorant, neoxanthin, as a potent chemopreventive: Current progress and future prospects S Parida, M Jena, AK Behera, AK Mandal, R Nayak, S Patra Current medicinal chemistry 31 (32), 5149-5164 , 2024 2024 Citations: 9
Ethno medicinal study in North West Ganjam, Odisha A Leelaveni, S Dash, SK Behera, S Das, AK Mandal Int. J. Innov. Sci. Res 7, 1167-1174 , 2018 2018 Citations: 8
Cyanobacterial scytonemin, a potential photoprotective natural pigment: biomedical, industrial and environmental applications AK Behera, S Parida, AK Mandal, S Patra, M Jena Archives of Microbiology 207 (11), 265 , 2025 2025 Citations: 3
Microalgal biofilm and their prospective application for wastewater treatment and biofuel production R Nayak, B Pradhan, S Patra, PP Bhuyan, C Behera, S Parida, AK Behera, ... Understanding microbial biofilms, 147-164 , 2023 2023 Citations: 2
Zeaxanthin: A novel therapeutic agent against human diseases B Pradhan, S Nayak, S Patra, R Nayak, AK Mandal, S Parida, Y Satapathy, ... Algal Biotechnology, 307-319 , 2024 2024 Citations: 1
Phyco-fabrication of iron oxide nanoparticles using Chlorella vulgaris: Antibacterial potential and antioxidant activity AK Mandal, S Parida, AK Behera, SG Mandal, A Nito, A Quarta, A Ragusa, ... Journal of Applied Phycology, 1-12 , 2026 2026
Impact of Microplastics on Marine Ecosystem , Human Health and its solution through Phycoremediation S Parida, AK Mandal, AK Behera, R Nayak, M Jena Proceedings of Odisha Environment Congress 2024 15 (1), 281-296 , 2024 2024
Bioremediation of Textile Dye Fiery Magenta by Unicellular Green Algae Chlamydomonas reinhardtii S Parida, HS Dharua, AK Behera, AK Mandal, SP Nayak, M Jena Research Journal of Berhampur University 8, 8-12 , 2024 2024
