Ali Kalantari-Hesari

Scopus Publications

A novel copper-based nanosystem for augmented breast cancer photothermal and chemodynamic therapy
Mohammad Seyedhamzeh, Farzaneh Falahi, Ali Kalantari-Hesari, Kimia Esmaeilzadeh, Laleh Salarilak, Hadi Bagheri, Shayesteh Bochani, Satar Yousefiasl, Helia Behrouzfar, Mohammad Esmaeil Akbari, Aziz Maleki
Rsc Advances, 2026
This work develops and characterizes copper-cysteine nanoparticles as a multifunctional nanoplatform combining photothermal therapy and chemodynamic therapy to ablates primary tumors and inhibit metastatic breast cancer cells in tumor-bearing mice.
Protective role of fucoidan against cognitive deficits and redox imbalance in a scopolamine-induced Alzheimer’s disease model in rats
Maryam Salmani, Mahdieh Anoush, Ali Kalantari-Hesari, Armin Jahani-Maleki, Fatemeh Nouri, Mir-Jamal Hosseini, Mojdeh Mohammadi
Scientific Reports, 2025
This study examined the neuroprotective impacts of fucoidan on behavioral performance and oxidative damage in an animal model with scopolamine-induced cognitive deficits. Male Wistar rats, aged 8 weeks, were administered scopolamine (2 mg/kg) for 10 days. Fucoidan (15–60 mg/kg) or donepezil (1 mg/kg) was administered prior to behavioral tests over three consecutive weeks. To assess memory and learning, all rats underwent the Morris water maze (MWM) task and the Novel Object Recognition (NOR) test. Following the tests, the hippocampi and prefrontal cortex (PFC) of the rats were collected to evaluate oxidative stress parameters across all treatment groups. A significant decrease in the mean Q 2 time was observed during the probe trial in the water maze task after scopolamine injection on the test day. Administration of fucoidan (15–60 mg/kg) or donepezil (1 mg/kg) notably improved cognitive dysfunction (p < 0.001) . Biochemical analysis demonstrated a decline in protein carbonyl and malondialdehyde levels, along with an elevation in reduced glutathione and total antioxidant capacity in the fucoidan-treated rats (15–60 mg/kg). It is supposed that cholinergic dysfunction and oxidative stress are key contributors to cognitive deficits, and fucoidan may protect the hippocampus and prefrontal cortex by mitigating oxidative damage biomarkers.
Application of edaravone-loaded nanogel in alleviating behavioral deficits and oxidative stress in schizophrenia rat model
Sina Montazeri, Soroush Bijani, Hamid Rashidzadeh, Ali Ramazani, Sina Andalib, Ali Kalantari-Hesari, Ghazale Cheraghi, Mir-Jamal Hosseini
Scientific Reports, 2025
Schizophrenia is considered as a main one of the public health issues, and imposes numerous burdens on patients and society. We previously reported, the pathophysiology of schizophrenia is influenced by inflammation and mitochondrial dysfunction. Edaravone (EDV) as a potent antioxidant with neuroprotective traits, has been approved for the treatment of amyotrophic lateral sclerosis (ALS), effecting through neutralizing soluble/insoluble peroxyl radicals. However, the main disadvantages of EDV are its low stability in aqueous media, poor water solubility, and un-optimized bioavailability. To effectively address these obstacles, nanogel was utilized as the drug vehicle. The decoration of nanogel surface with glutathione (GSH) was carried out to elevate edaravone's brain delivery. The probable improvement in drug delivery of edaravone loaded GSH-nanogel is the main hypothesis of this study. In order to mimic schizophrenia-like behaviors, we applied two month of post-weaning social isolation stress (PWSI) to rodent model. The choice of PWSI model was made due to the maturation and development of prefrontal cortex and hippocampus during adolescence. In addition to causing oxidative stress and upregulating genes linked to innate immunity in the prefrontal cortex (PFC), the data showed that PWSI triggered schizophrenia-like behaviors in rats. This study demonstrated that treatment with edaravone loaded GSH-nanogel decreased the impact of PWSI on behavioral dysfunctions and oxidative stress in the PFC of rats. Edaravone loaded GSH-nanogel (GSH-PMAA-EDV) down-regulated Toll-like receptor 4 (Tlr-4) and AMP-activated protein kinase (Ampk) gene expression which are involved in inflammation and cellular energy homeostasis, respectively. Increase immunoreactivity feedback and Brain-derived neurotrophic factor (Bdnf) as direct impact in neurogenesis and neural cell plasticity was observed in EDV loaded GSH-nanogel treated groups. edaravone loaded GSH-nanogel (100 µg/kg) in comparison to free form of edaravone (5 mg/kg) revealed more beneficial effects, which might be useful for future clinical use especially for the treatment of schizophrenia.
Visceral leishmaniosis in dogs from western Iran
Alireza Sazmand, Georgiana Deak, Ali Kalantari-Hesari, Pouria Rafiei, Navid Etemadi, Hesam Hajilou, Mina Malekmohammadi, Leili Moradi, Monireh Khordadmehr, Seyedmousa Motavallihaghi, Ali Fattahi-Bafghi, Mariaelisa Carbonara, Stephanie Oren, Domenico Otranto
Veterinary Parasitology Regional Studies and Reports, 2025
Comparison of the Cytotoxicity of Second- and Third-Generation Nanodendrimers on PC12 and Vero Cell Lines to Evaluate Their Safety in Drug Delivery Systems
Journal of Military Medicine, 2025
An intelligent ZIF-based nanoplatform for photothermal/chemodynamic-induced combination therapy with O2 evolution properties for improved infected wound regeneration
Rezvaneh Azizi, Mehraneh Kermanian, Vajihe Alinezhad, Ali Kalantari-Hesari, Satar Yousefiasl, Lidia Maeso, Gorka Orive, Abbas Mohammadi, Kimia Esmaeilzadeh, Mohammad Seyedhamzeh, Faezeh Almasi, Aziz Maleki
Journal of Materials Chemistry B, 2025
A multifunctional ZIF-based nanosystem incorporating Cu ions and a phytosterol showed excellent antibacterial and photothermal activities, making it a promising wound healing candidate.
Evaluation of Hydrolyzed Black Cumin Seed Protein as a Bioactive Peptide Source in Broiler Chicken Diets
Iranian Journal of Applied Animal Science, 2025
Neuroprotective effects of empagliflozin against scopolamine-induced memory impairment and oxidative stress in rats
Mahdieh Anoush, Neda Taghaddosi, Zahra Bokaei Hosseini, Fatemeh Rahmati, Soroush Bijani, Ali Kalantari-Hesari, Mir-Jamal Hosseini
Ibro Neuroscience Reports, 2025
Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders. The main medicinal theory for the management of AD belongs to the acetyl-cholinesterase-inhibition pathway and NMDA antagonism. Recent investigation proposed memory improvement by sodium-glucose co-transporter 2 (SGLT2) inhibitors which indicated to improve glycemic control in adults with type 2 diabetes mellitus. According to the lack of sufficient evidence about the efficacy of empagliflozin (EMPA) for memory improvement, in comparison with donepezil (DON), the present research was carried out in order to investigate this hypothesis towards scopolamine-induced neurotoxicity on experimental male Wistar rats. The animals divided into two sets, each included 4 groups: The first set of Healthy animals [Control, EMPA (4 or 10 mg/kg), DON (1 mg/kg)]. The second set of rat Alzheimer model, which received 2 mg/kg Scopolamine by intraperitoneal route for 10 days followed by other treatments [AD, AD+ EMPA (4 or 10 mg/kg) and AD+DON]. Normal rats and AD rats, with each group receiving different substances for 8 consecutive days and 24 h after the accomplishment of the drug administrations, the memory functions assessed through Morris water maze (MWM) paradigm. This task was followed by decapitation of rats in order to evaluate the biochemical oxidative stress parameters in brain tissue. Our data indicated that EMPA significantly improved animals' performance in the behavioral test with a significant decrease in oxidative stress and antioxidant imbalance. In addition, EMPA (4 mg/kg) significantly reduced both cellular malondialdehyde and protein carbonyl content while conversely increased the total reduced glutathione content. Besides, the levels of total as well as endogenous antioxidants in the ferric reducing antioxidant power assay reported to be augmented. It seems that EMPA significantly improved both cellular biochemical aspects and memory performance in animal models in accordance with histopathological assessments. Conclusively, 4 mg/kg EMPA demonstrated better results in all aspects that were evaluated during this research.
Synergistic photothermal and photodynamic therapy to promote bacteria-infected wound healing using ZnO@PDA/Ag-integrated waterborne polyurethane films
Negar Salehi, Abbas Mohammadi, Vajihe Alinezhad, Shayesteh Bochani, Ali Kalantari-Hesari, Fakhri Haghi, Francisco Javier Sierra Valdez, Tomás Jafed Buenfil-Chi, Aziz Maleki, Saeed Beigi-Boroujeni
Journal of Materials Chemistry B, 2025
Light-induced antibacterial effects aim to overcome the limitations of antibiotic-resistant bacteria and provide an effective solution for wound healing applications.
Evaluation of image analysis software competency in skeletal muscle percentage assessment in meat products
Journal of Food Science and Technology Iran, 2025
Impact of Enzymatically Hydrolyzed and Fermented Canola Meal on Broiler Performance, Intestinal Health, and Peptide Transporter Peptide Transporters Gene Expression
Rassoli Dabagh, R., Navidshad, B., Kalantari Hesari, A., Mirzaei Aghjehgheshlagh, F., Hosseinpoor, L.
Iranian Journal of Applied Animal Science, 2025
Thymoquinone mitigates diclofenac-induced hepatorenal toxicity in male Wistar rats by balancing the redox state and modulating Bax/Bcl-2/caspase-3 apoptotic pathways and NF-κB signaling
Amir Safi, Shakila Mohammadi, Mina Emami, Alireza Radaei, Ali Kalantari-Hesari, Ali Nouri, Mohammad Rahimi-Madiseh, Reza Ahmadi
Research in Pharmaceutical Sciences, 2025
Improvement of the immunological and antioxidant capacity of rainbow trout (Oncorhynchus mykiss) by using the paraprobiotic Bacillus subtilis subsp. spizizenii
Alireza Neissi, Marzieh Heidarieh, Gholamreza Shahhosseini, Hamed Majidi Zahed, Ali Kalantari-Hesari
Aquaculture Reports, 2024
Effects of Reduced Dietary Crude Protein and Amino Acids on the Performance, Carcass Characteristics and Intestinal Morphology of Broiler Chickens.
Bahman Navidshad, Neda Sadeghi, Tohid Mokarrami, Ali Kalantari Hesari, Farzad Mirzaei Aghjehgheshlagh
Poultry Science Journal, 2024
Copper-Cysteine Nanostructures for Synergetic Photothermal Therapy and Chemodynamic Therapy of Bacterial Skin Abscesses
Hadi Bagheri, Shayesteh Bochani, Mohammad Seyedhamzeh, Zahra Shokri, Ali Kalantari‐Hesari, Raymond J. Turner, Mahshid Kharaziha, Kimia Esmaeilzadeh, Mehdi Golami, Habib Zeighami, Aziz Maleki
Advanced Therapeutics, 2024
Chitosan conjugated-ordered mesoporous silica: a biocompatible dissolution enhancer for promoting the antidiabetic effect of a poorly water-soluble drug of repaglinide
Aziz Maleki, Shayesteh Bochani, Mehraneh Kermanian, Pooyan Makvandi, Mir-Jamal Hosseini, Mehrdad Hamidi, Ali Kalantari-Hesari, Hamid Reza Kheiri, Mohammad Reza Eskandari, Maryam Rosta, Virgilio Mattoli, Seyed Hojjat Hosseini
Journal of Nanostructure in Chemistry, 2024
A diet enriched with Pistacia atlantica fruits improves the female rats' reproductive system
Manijeh Dogani, Nayere Askari, Ali Kalantari Hesari
Journal of Traditional and Complementary Medicine, 2024
The role of gender differences in the outcome of juvenile social isolation: Emphasis on changes in behavioral, biochemical and expression of nitric oxide synthase genes alteration
Soroush Bijani, Fatemeh Sadat Kashfi, Sadaf Zahedi-Vanjani, Keivan Nedaei, Ali Sharafi, Ali Kalantari-Hesari, Mir-Jamal Hosseini
Heliyon, 2024
Antioxidant, hemostatic, and injectable hydrogels with photothermal antibacterial activity to accelerate full-thickness wound regeneration
Vajihe Alinezhad, Reza Ghodsi, Hadi Bagheri, Farzaneh Mahmoudi Beram, Habib Zeighami, Ali Kalantari-Hesari, Laleh Salarilak, Ebrahim Mostafavi, Zainab Ahmadian, Mohammad-Ali Shahbazi, Aziz Maleki
New Journal of Chemistry, 2024
Protective Effect of Low-Volume High-Intensity Interval Training on Aspirin-Induced Reproductive Impairments in Adult Male Wistar Rats
Mehdi Asadi, Mohammad Rahmani, Ali Samadi, Ali Kalantari Hesari
Reproductive Sciences, 2024
4-methylimidazole can promote oxidative stress, inflammation and histopathological assessment following sub-chronic exposure in rats: mechanistic approaches
Asma Ghasemi, Firouzeh Nazari, Ali Kalantari-Hesari, Mehran Mohseni, Mir-Jamal Hosseini
Toxin Reviews, 2024
Effect of salinity on the epidermal chloride cells of Periophthalmus waltoni: Immunohistochemistry characterization of Na+-K+ATPase pump and Na+-K+-2Cl- cotransporter
Iranian Journal of Fisheries Sciences, 2024
Examining the Stomach Structure and Function in Mudskipper (Periophthalmus waltoni) by Histological and Immunohistochemical Methods
Jonathan Mark Wilson, Mina Amiri Farahani, Kaveh Esfandiyari, Mohammad Babaei, Ali Kalantari-Hesari
Brazilian Archives of Biology and Technology, 2024
Estimating Proportion of Meat and Validating Results of Meat Products Using Histochemistry and Image Analysis in Meat Products of Hamadan City, Iran
Iranian Journal of Nutrition Sciences and Food Technology, 2023
A Case History of Gross and Radiological Observations of Agnathia: Otocephaly in a Mehraban Ewe-lamb
Mohammad Babaei, , Morteza Yavari, Seyed Masoud Zolhavarieh, Ali Kalantari Hesari, , , and
Iranian Journal of Veterinary Medicine, 2023
Injectable, antibacterial, and oxygen-releasing chitosan-based hydrogel for multimodal healing of bacteria-infected wounds
Shayesteh Bochani, Atefeh Zarepour, Ali Kalantari-Hesari, Fakhri Haghi, Mohammad-Ali Shahbazi, Ali Zarrabi, Sophia Taheri, Aziz Maleki
Journal of Materials Chemistry B, 2023
Engineering a platelet-rich plasma-based multifunctional injectable hydrogel with photothermal, antibacterial, and antioxidant properties for skin regeneration
Vajihe Alinezhad, Kimia Esmaeilzadeh, Hadi Bagheri, Habib Zeighami, Ali Kalantari-Hesari, Rahim Jafari, Pooyan Makvandi, Yi Xu, Hamidreza Mohammadi, Mohammad-Ali Shahbazi, Aziz Maleki
Biomaterials Science, 2023
The Antioxidant Properties of Bioactive Peptides Derived from Enzymatic Hydrolyzed or Fermented Canola Meal and Its Effects on Broiler Chickens
Leili Hosseinpoor, Bahman Navidshad, Mohammad Faseleh Jahromi, Sadegh Karimzadeh, Ali Kalantari Hesari, Farzad Mirzaei Aghjehgheshlagh, Houshang Lotfollahian, Ehsan Oskoueian, Amir Heydari
International Journal of Peptide Research and Therapeutics, 2023
Effects of Hydroalcoholic Extract of Malva Sylvestris L. on the Histological Structure of the Brain in a Mice Model of Parkinson’s Disease
Mohammad Babaei, Taher Elmi, Ali Kalantari-Hesari
Neuroscience Journal of Shefaye Khatam, 2023
An Evaluation of the Protective Effects of Coenzyme Q10 on Fertility Parameters of Male Mice Treated with Methotrexate
Journal of Babol University of Medical Sciences, 2023
Effect of Molybdenum Trioxide Nanoparticles on the Kidney in Rats
Journal of Gorgan University of Medical Sciences, 2023
Edaravone Improves Streptozotocin-Induced Memory Impairment via Alleviation of Behavioral Dysfunction, Oxidative Stress, Inflammation, and Histopathological Parameters
Mahdieh Anoush, Soroush Bijani, Fatemeh Moslemifar, Fatemeh Jahanpour, Ali Kalantari-Hesari, Mir-Jamal Hosseini
Behavioural Neurology, 2023
Edaravone Improved Behavioral Abnormalities, Alleviated Oxidative Stress Inflammation, and Metabolic Homeostasis Pathways in Depression
Sina Montazeri, Soroush Bijani, Mahdieh Anoush, Ali Sharafi, Ali Kalantari-Hesari, Mir-Jamal Hosseini
Depression and Anxiety, 2023
Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery
Faezeh Mozafari, Hamid Rashidzadeh, Soroush Bijani, Faezeh Zare-Molaei, Ziba Islambulchilar, Hossein Danafar, Ali Kalantari-Hesari, Ali Ramazani, Mir-Jamal Hosseini
Oxidative Medicine and Cellular Longevity, 2023
Effectiveness of Hydroalcoholic Seed Extract of Securigera securidaca on Pancreatic Local Renin-Angiotensin System and Its Alternative Pathway in Streptozotocin-Induced Diabetic Animal Model
Fatemeh Khomari, Bahar Kiani, Shahin Alizadeh-Fanalou, Mohammad Babaei, Ali Kalantari-Hesari, Iraj Alipourfard, Fatemeh Mirzaei, Sahar Yarahmadi, Elham Bahreini
Oxidative Medicine and Cellular Longevity, 2023
Protective role of ellagic acid and taurine against fluoxetine induced hepatotoxic effects on biochemical and oxidative stress parameters, histopathological changes, and gene expressions of IL-1β, NF-κB, and TNF-α in male Wistar rats
Tayebeh Beigi, Amir Safi, Mahdi Satvati, Ali Kalantari-Hesari, Reza Ahmadi, Mohammad-Hassan Meshkibaf
Life Sciences, 2022
In Vivo Anti-malarial Activity and Toxicity of Allium ursinum (Wild Garlic) Hydroalcoholic Extract
Journal of Applied Biotechnology Reports, 2022
The effects of P. atlantica as a libido booster and sexual enhancer on the reproductive system of male rats
Manijeh Dogani, Nayere Askari, Ali Kalantari-Hesari, Fatemeh Hosseini Rahbar
Journal of Traditional and Complementary Medicine, 2022
Acetylsalicylic acid-induced alterations in male reproductive parameters in Wistar rats and the effect of sprint interval training
Mehdi Asadi, Mohammad Rahmani, Ali Samadi, Ali Kalantari Hesari
Andrologia, 2022
Correction to: Antiplasmodial Effect of Nano Dendrimer G2 Loaded with Chloroquine in Mice Infected with Plasmodium berghei (Acta Parasitologica, (2022), 67, 1, (298-308), 10.1007/s11686-021-00459-4)
Taher Elmi, Mehdi Shafiee Ardestani, Manijeh Motevalian, Ali Kalantari Hesari, Mohammad Seyyed hamzeh, Zahra Zamani, Fatemeh Tabatabaie
Acta Parasitologica, 2022
Antiplasmodial Effect of Nano Dendrimer G2 Loaded with Chloroquine in Mice Infected with Plasmodium berghei
Taher Elmi, Mehdi Shafiee Ardestani, Manijeh Motevalian, Ali Kalantari Hesari, Mohammad Seyyed hamzeh, Zahra Zamani, Fatemeh Tabatabaie
Acta Parasitologica, 2022
Investigating the Fraud of Using Unauthorized Tissues in Sausages Produced in Hamadan Province
Journal of Veterinary Research, 2022
The Effect of Limiting the Time of Feed Access during the Growing Phase on the Performance of Broilers
Iranian Journal of Applied Animal Science, 2022
Localization of Na+-K+-ATPase and Na+-K+-2Clcotransporter, and Na+-H+ exchanger in the renal system of Walton's mudskipper (Periophthalmus waltoni) using immunohistochemistry and histology methods
Iranian Journal of Fisheries Sciences, 2022
The Effect of Hydroalcoholic Seed Extract of Securigera Securidaca on the Hepatic Renin-Angiotensin System in the Streptozotocin-Induced Diabetic Animal Model
Bahar Kiani, Shahin Alizadeh-Fanalou, Fatemeh Khomari, Mohammad Babaei, Iraj Alipourfard, Ali Kalantari Hesari, Mohammad Najafi, Ali-Mohammad Sharifi, Elham Bahreini
Clinical Diabetology, 2022
Injectable Antibacterial Gelatin-Based Hydrogel Incorporated with Two-Dimensional Nanosheets for Multimodal Healing of Bacteria-Infected Wounds
Shayesteh Bochani, Ali Kalantari-Hesari, Fakhri Haghi, Vajihe Alinezhad, Hadi Bagheri, Pooyan Makvandi, Mohammad-Ali Shahbazi, Abdollah Salimi, Ikue Hirata, Virgilio Mattoli, Aziz Maleki, Baolin Guo
ACS Applied Bio Materials, 2022
Effect of sodium cyanide-induced tissue hypoxia on reproductive capability of male mice and the protective effect of ethyl pyruvate
M. Nourani, A. Kalantari Hesari, R. Shahrooz, M. Asadi
Archives of Razi Institute, 2021
Hepatoprotective effects of Lactobacillus plantarum 299v supplemented via drinking water against aflatoxin-induced liver damage
Abdolamir Allameh, Maryam Khanian, Mohammad-Amir Karimi-Torshizi, Ali Kalantari-Hesari
Avian Pathology, 2021
Dietary garlic powder supplementation could ameliorate unfavorable effects of choline deficiency on the liver health and immune system of broiler chickens
Iranian Journal of Applied Animal Science, 2019
Effect of phenylhydrazine-induced hemolytic anemia on renal cortex in adult mice: Protective effect of crocin
مسعود ادیب مرادی, علی کلانتری حصاری, رسول شهروز, محمدرضا اسدی
Journal of Veterinary Research, 2018
Effects of fish oil replacement with vegetable oils in rainbow trout (Oncorhynchus mykiss) fingerlings diet on growth performance and foregut histology
Rasoul Shahrooz, Naser Agh, Nasim Jafari, Ali Kalantari, Reza Jalili, Ali Karimi
Turkish Journal of Fisheries and Aquatic Sciences, 2018
Evaluation of sperm quality in mice exposed to camphor and protective role of Vitamin E
Journal of Veterinary Research, 2016
Study of histomorphometric changes in adult rats skin following injection of PRP and PPP
Journal of Veterinary Research, 2016
Crocin prevention of anemia-induced changes in structural and functional parameters of mice testes
Ali Kalantari Hesari, Rasoul Shahrooz, Abbas Ahmadi, Hasan Malekinejad, Ehsan Saboory
Journal of Applied Biomedicine, 2015
Effect of prenatal stress on density of NMDA receptors in rat brain
Elham Tavassoli, Ehsan Saboory, Masood Teshfam, Yusef Rasmi, Shiva Roshan‐Milani, Behrooz Ilkhanizadeh, Ali Kalantari Hesari
International Journal of Developmental Neuroscience, 2013

Ali Kalantari-Hesari

EDUCATION

RESEARCH INTERESTS

Scopus Publications