SMC5/6-mediated plasmid silencing is directed by SIMC1–SLF2 and antagonized by the SV40 large T antigen M Oravcová, M Nie, T Otomo, MN Boddy eLife 14, RP106815 , 2025 2025 Citations: 1
Structural Insights into the GABARAP–ATG3 Backside Interaction and Apo ATG3 Conformation K Ohashi, GJ Kroon, T Otomo Biochemistry 64 (15), 3178-3189 , 2025 2025
Structural Analyses of a GABARAP~ ATG3 Conjugate Uncover a Novel Non-covalent Ubl-E2 Backside Interaction K Ohashi, T Otomo bioRxiv , 2024 2024
Structural basis for RNA slicing by a plant Argonaute Y Xiao, S Maeda, T Otomo, IJ MacRae Nature structural & molecular biology 30 (6), 778-784 , 2023 2023 Citations: 32
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers M Oravcová, M Nie, N Zilio, S Maeda, Y Jami-Alahmadi, ... Elife 11, e79676 , 2022 2022 Citations: 31
Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein S Fan, L Yue, W Wan, Y Zhang, B Zhang, C Otomo, Q Li, T Lin, J Hu, P Xu, ... Angewandte Chemie International Edition 60 (50), 26105-26114 , 2021 2021 Citations: 100
Selenomethionine as an expressible handle for bioconjugations DT Flood, JCJ Hintzen, KW Knouse, DE Hill, C Lu, PA Cistrone, JS Chen, ... Proceedings of the National Academy of Sciences 118 (8), e2005164118 , 2021 2021 Citations: 8
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A S Maeda, H Yamamoto, LN Kinch, CM Garza, S Takahashi, C Otomo, ... Nature structural & molecular biology 27 (12), 1194-1201 , 2020 2020 Citations: 347
ATG2A transfers lipids between membranes in vitro T Otomo, S Maeda Autophagy 15 (11), 2031-2032 , 2019 2019 Citations: 24
The autophagic membrane tether ATG2A transfers lipids between membranes S Maeda, C Otomo, T Otomo elife 8, e45777 , 2019 2019 Citations: 386
Author response: The autophagic membrane tether ATG2A transfers lipids between membranes S Maeda, C Otomo, T Otomo (No Title) , 2019 2019
Structural studies of mammalian autophagy lipidation complex K Ohashi, C Otomo, Z Metlagel, T Otomo Autophagy: Methods and Protocols, 57-75 , 2019 2019 Citations: 2
Structural Studies of Mammalian Autophagy Lipidation Complex C Otomo, T Otomo, K Ohashi, Z Metlagel (No Title) , 2019 2019
Structural and biochemical analyses of the autophagic ATG2A-WIPI4 complex. S Chowdhury, C Otomo, A Leitner, K Ohashi, A Rudolf, GC Lander, ... MOLECULAR BIOLOGY OF THE CELL 29 (26) , 2018 2018
The rod-shaped ATG2A-WIPI4 complex tethers membranes in vitro T Otomo, S Chowdhury, GC Lander Contact 1, 2515256418819936 , 2018 2018 Citations: 27
Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex S Chowdhury, C Otomo, A Leitner, K Ohashi, R Aebersold, GC Lander, ... Proceedings of the National Academy of Sciences 115 (42), E9792-E9801 , 2018 2018 Citations: 257
Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes K Ohashi, T Otomo Biochemical and biophysical research communications 463 (3), 447-452 , 2015 2015 Citations: 13
Structural insights into E2–E3 interaction for LC3 lipidation Z Metlagel, C Otomo, K Ohashi, G Takaesu, T Otomo Autophagy 10 (3), 522-523 , 2014 2014 Citations: 44
Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12 Z Metlagel, C Otomo, G Takaesu, T Otomo Proceedings of the National Academy of Sciences 110 (47), 18844-18849 , 2013 2013 Citations: 117
Structure of the human ATG12~ ATG5 conjugate required for LC3 lipidation in autophagy C Otomo, Z Metlagel, G Takaesu, T Otomo Nature structural & molecular biology 20 (1), 59-66 , 2013 2013 Citations: 516
MOST CITED SCHOLAR PUBLICATIONS
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain T Otomo, DR Tomchick, C Otomo, SC Panchal, M Machius, MK Rosen Nature 433 (7025), 488-494 , 2005 2005 Citations: 522
Structure of the human ATG12~ ATG5 conjugate required for LC3 lipidation in autophagy C Otomo, Z Metlagel, G Takaesu, T Otomo Nature structural & molecular biology 20 (1), 59-66 , 2013 2013 Citations: 516
The autophagic membrane tether ATG2A transfers lipids between membranes S Maeda, C Otomo, T Otomo elife 8, e45777 , 2019 2019 Citations: 386
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A S Maeda, H Yamamoto, LN Kinch, CM Garza, S Takahashi, C Otomo, ... Nature structural & molecular biology 27 (12), 1194-1201 , 2020 2020 Citations: 347
Structural basis of Rho GTPase-mediated activation of the formin mDia1 T Otomo, C Otomo, DR Tomchick, M Machius, MK Rosen Molecular cell 18 (3), 273-281 , 2005 2005 Citations: 325
Segmental isotope labeling for protein NMR using peptide splicing T Yamazaki, T Otomo, N Oda, Y Kyogoku, K Uegaki, N Ito, Y Ishino, ... Journal of the American Chemical Society 120 (22), 5591-5592 , 1998 1998 Citations: 289
Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex S Chowdhury, C Otomo, A Leitner, K Ohashi, R Aebersold, GC Lander, ... Proceedings of the National Academy of Sciences 115 (42), E9792-E9801 , 2018 2018 Citations: 257
NMR observation of selected segments in a larger protein: central-segment isotope labeling through intein-mediated ligation T Otomo, N Ito, Y Kyogoku, T Yamazaki Biochemistry 38 (49), 16040-16044 , 1999 1999 Citations: 166
Improved segmental isotope labeling of proteins and application to a larger protein T Otomo, K Teruya, K Uegaki, T Yamazaki, Y Kyogoku Journal of biomolecular NMR 14 (2), 105-114 , 1999 1999 Citations: 130
Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12 Z Metlagel, C Otomo, G Takaesu, T Otomo Proceedings of the National Academy of Sciences 110 (47), 18844-18849 , 2013 2013 Citations: 117
Flexible linker in the RNA polymerase alpha subunit facilitates the independent motion of the C-terminal activator contact domain YH Jeon, T Yamazaki, T Otomo, A Ishihama, Y Kyogoku Journal of molecular biology 267 (4), 953-962 , 1997 1997 Citations: 116
Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein S Fan, L Yue, W Wan, Y Zhang, B Zhang, C Otomo, Q Li, T Lin, J Hu, P Xu, ... Angewandte Chemie International Edition 60 (50), 26105-26114 , 2021 2021 Citations: 100
Structure of the heterodimeric complex between CAD domains of CAD and ICAD T Otomo, H Sakahira, K Uegaki, S Nagata, T Yamazaki Nature structural biology 7 (8), 658-662 , 2000 2000 Citations: 78
Crystal structure of the Formin mDia1 in autoinhibited conformation T Otomo, DR Tomchick, C Otomo, M Machius, MK Rosen PLoS One 5 (9), e12896 , 2010 2010 Citations: 73
A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox T Shemesh, T Otomo, MK Rosen, AD Bershadsky, MM Kozlov The Journal of cell biology 170 (6), 889-893 , 2005 2005 Citations: 73
Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling A Seth, T Otomo, HL Yin, MK Rosen Biochemistry 42 (14), 3997-4008 , 2003 2003 Citations: 69
Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor K Uegaki, T Otomo, H Sakahira, M Shimizu, N Yumoto, Y Kyogoku, ... Journal of molecular biology 297 (5), 1121-1128 , 2000 2000 Citations: 50
Structural insights into E2–E3 interaction for LC3 lipidation Z Metlagel, C Otomo, K Ohashi, G Takaesu, T Otomo Autophagy 10 (3), 522-523 , 2014 2014 Citations: 44
Structural basis for RNA slicing by a plant Argonaute Y Xiao, S Maeda, T Otomo, IJ MacRae Nature structural & molecular biology 30 (6), 778-784 , 2023 2023 Citations: 32
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers M Oravcová, M Nie, N Zilio, S Maeda, Y Jami-Alahmadi, ... Elife 11, e79676 , 2022 2022 Citations: 31
