Rosely Oliveira Godinho

Scopus Publications

Extracellular cAMP elicits contraction of rat vas deferens: Involvement of ecto-5′-nucleotidase and adenosine A1 receptors
Enio Setsuo Arakaki Pacini, Raíssa de Paula Moro, Rosely Oliveira Godinho
Toxicology and Applied Pharmacology, 2024
Impact of the cAMP efflux and extracellular cAMP-adenosine pathway on airway smooth muscle relaxation induced by formoterol and phosphodiesterase inhibitors
Naiara Ayako Satori, Enio Setsuo Arakaki Pacini, Rosely Oliveira Godinho
Chemico Biological Interactions, 2023
Effects of inhibition of 5-lipoxygenase and 12-lipoxygenase pathways on skeletal muscle fiber regeneration
Marcio Vinícius Damico, Cristiane Damas Gil, Rosely Oliveira Godinho, Enio Setsuo Arakaki Pacini, Consuelo Latorre Fortes-Dias, et al.
Chemico Biological Interactions, 2023
The early inhibition of the COX-2 pathway in viperid phospholipase A2-induced skeletal muscle myotoxicity accelerates the tissue regeneration
Ana Carolina Siqueira Zuntini, Marcio Vinícius Damico, Cristiane Damas Gil, Rosely Oliveira Godinho, Enio Setsuo Arakaki Pacini, et al.
Toxicology and Applied Pharmacology, 2023
Extracellular cAMP-Adenosine Pathway Signaling: A Potential Therapeutic Target in Chronic Inflammatory Airway Diseases
Enio Setsuo Arakaki Pacini, Naiara Ayako Satori, Edwin Kerry Jackson, Rosely Oliveira Godinho
Frontiers in Immunology, 2022
Adenosine is a purine nucleoside that,viaactivation of distinct G protein-coupled receptors, modulates inflammation and immune responses. Under pathological conditions and in response to inflammatory stimuli, extracellular ATP is released from damaged cells and is metabolized to extracellular adenosine. However, studies over the past 30 years provide strong evidence for another source of extracellular adenosine, namely the “cAMP-adenosine pathway.” The cAMP-adenosine pathway is a biochemical mechanism mediated by ATP-binding cassette transporters that facilitate cAMP efflux and by specific ectoenzymes that convert cAMP to AMP (ecto-PDEs) and AMP to adenosine (ecto-nucleotidases such as CD73). Importantly, the cAMP-adenosine pathway is operative in many cell types, including those of the airways. In airways, β2-adrenoceptor agonists, which are used as bronchodilators for treatment of asthma and chronic respiratory diseases, stimulate cAMP efflux and thus trigger the extracellular cAMP-adenosine pathway leading to increased concentrations of extracellular adenosine in airways. In the airways, extracellular adenosine exerts pro-inflammatory effects and induces bronchoconstriction in patients with asthma and chronic obstructive pulmonary diseases. These considerations lead to the hypothesis that the cAMP-adenosine pathway attenuates the efficacy of β2-adrenoceptor agonists. Indeed, our recent findings support this view. In this mini-review, we will highlight the potential role of the extracellular cAMP-adenosine pathway in chronic respiratory inflammatory disorders, and we will explore how extracellular cAMP could interfere with the regulatory effects of intracellular cAMP on airway smooth muscle and innate immune cell function. Finally, we will discuss therapeutic possibilities targeting the extracellular cAMP-adenosine pathway for treatment of these respiratory diseases.
Extracellular metabolism of 3′,5′-cyclic AMP as a source of interstitial adenosine in the rat airways
Enio Setsuo Arakaki Pacini, Edwin Kerry Jackson, Rosely Oliveira Godinho
Biochemical Pharmacology, 2021
The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines
Helena Pereira da Silva Zamith, Rosely Oliveira Godinho, Valter Luiz da Costa Junior, Alexandre Pinto Corrado
Toxicology in Vitro, 2021
Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine
Lucas de Carvalho Porta, Valmir Fadel, Joana D’Arc Campeiro, Eduardo Brandt Oliveira, Rosely Oliveira Godinho, et al.
Journal of Molecular Medicine, 2020
In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine
Lucas C. Porta, Joana D. Campeiro, Giovanna B. Papa, Eduardo B. Oliveira, Rosely O. Godinho, et al.
Toxicon, 2020
Identification of potential target genes associated with the reversion of androgen-dependent skeletal muscle atrophy
Priscila de O. Coelho, Flavia A. Guarnier, Leonardo Bruno Figueiredo, Livia S. Zaramela, Enio S.A. Pacini, et al.
Archives of Biochemistry and Biophysics, 2019
Intrinsic Adaptation of SHR Right Atrium Reduces Heart Rate
Juliano Quintella Dantas Rodrigues, Henrique Camara, Edilson Dantas da Silva Junior, Rosely Oliveira Godinho, Aron Jurkiewicz
Journal of Cardiovascular Pharmacology, 2019
Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles
Sunamita de Carvalho Lima, Lucas de Carvalho Porta, Álvaro da Costa Lima, Joana D’Arc Campeiro, Ywlliane Meurer, et al.
Plos Neglected Tropical Diseases, 2018
The extracellular cAMP-adenosine pathway in airway smooth muscle
Enio S.A. Pacini, Sarah Sanders-Silveira, Rosely O. Godinho
Journal of Pharmacology and Experimental Therapeutics, 2018
Increased Gi protein signaling potentiates the negative chronotropic effect of adenosine in the SHR right atrium
Juliano Q.D. Rodrigues, Henrique Camara, Aron Jurkiewicz, Rosely O. Godinho
Naunyn Schmiedeberg S Archives of Pharmacology, 2018
Erratum: Integrated analysis of the involvement of nitric oxide synthesis in mitochondrial proliferation, mitochondrial deficiency and apoptosis in skeletal muscle fibres (Scientific Reports (2016) 6 (20780) DOI:10.1038/srep20780)
Gabriela Silva Rodrigues, Rosely Oliveira Godinho, Beatriz Hitomi Kiyomoto, Juliana Gamba, Acary Souza Bulle Oliveira, et al.
Scientific Reports, 2016
Integrated analysis of the involvement of nitric oxide synthesis in mitochondrial proliferation, mitochondrial deficiency and apoptosis in skeletal muscle fibres
Gabriela Silva Rodrigues, Rosely Oliveira Godinho, Beatriz Hitomi Kiyomoto, Juliana Gamba, Acary Souza Bulle Oliveira, et al.
Scientific Reports, 2016
New perspectives in signaling mediated by receptors coupled to stimulatory G protein: The emerging significance of cAMP effux and extracellular cAMP-adenosine pathway
Rosely O. Godinho, Thiago Duarte, Enio S. A. Pacini
Frontiers in Pharmacology, 2015
Activating cAMP/PKA signaling in skeletal muscle suppresses the ubiquitin-proteasome-dependent proteolysis: Implications for sympathetic regulation
W. A. Silveira, D. A. Gonçalves, F. A. Graça, A. L. Andrade-Lopes, L. B. Bergantin, et al.
Journal of Applied Physiology, 2014
The kinin B1 receptor regulates muscle-specific E3 ligases expression and is involved in skeletal muscle mass control
Lucas T. Parreiras-e-Silva, Rosana I. Reis, Geisa A. Santos, Marcelo Pires-Oliveira, João B. Pesquero, et al.
Clinical Science, 2014
Calcium influx through L-type channels attenuates skeletal muscle contraction via inhibition of adenylyl cyclases
Francisco Sandro Menezes-Rodrigues, Marcelo Pires-Oliveira, Thiago Duarte, Edgar Julian Paredes-Gamero, Tiago Chiavegatti, et al.
European Journal of Pharmacology, 2013
Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure
Renata M. Lataro, Carlos A. A. Silva, Rubens Fazan, Marcos A. Rossi, Cibele M. Prado, et al.
American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2013
Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β 2-adrenoceptors to G s and G i proteins in mouse skeletal muscle
Thiago Duarte, Francisco Sandro Menezes-Rodrigues, Rosely Oliveira Godinho
Journal of Pharmacology and Experimental Therapeutics, 2012
Nitric oxide in skeletal muscle: Role on mitochondrial biogenesis and function
Celia Tengan, Gabriela Rodrigues, Rosely Godinho
International Journal of Molecular Sciences, 2012
The lumbrical muscle: A novel in situ system to evaluate adult skeletal muscle proteolysis and anticatabolic drugs for therapeutic purposes
Leandro Bueno Bergantin, Leonardo Bruno Figueiredo, Rosely Oliveira Godinho
Journal of Applied Physiology, 2011
Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity
Janaína Drawanz Pereira, Afonso Caricati-Neto, Regiane Miranda-Ferreira, Soraya Shoubi Smaili, Rosely Oliveira Godinho, et al.
European Journal of Pharmacology, 2011
Functional characterization of heterotrimeric G-proteins in rat diaphragm muscle
Ana Luiza Andrade-Lopes, Marcelo Pires-Oliveira, Francisco Sandro Menezes-Rodrigues, Rosely Oliveira Godinho
Respiratory Physiology and Neurobiology, 2011
Heparin induces rat aorta relaxation via integrin-dependent activation of muscarinic M3 receptors
Edgar J. Paredes-Gamero, Valquíria P. Medeiros, Eduardo H.C. Farias, Giselle Z. Justo, Edvaldo S. Trindade, et al.
Hypertension, 2010
Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: Effects of sex hormone withdrawal
Gracielle Alves-Amaral, Marcelo Pires-Oliveira, Ana Luiza Andrade-Lopes, Tiago Chiavegatti, Rosely Oliveira Godinho
Chemico Biological Interactions, 2010
Effects of 17β-estradiol replacement on the apoptotic effects caused by ovariectomy in the rat hippocampus
Sayuri Sales, Rodrigo Portes Ureshino, Renato Tavares dos Santos Pereira, Milene Schmidt Amaral Luna, Marcelo Pires de Oliveira, et al.
Life Sciences, 2010
Testosterone represses ubiquitin ligases atrogin-1 and Murf-1 expression in an androgen-sensitive rat skeletal muscle in vivo
Marcelo Pires-Oliveira, Ana Leticia G. C. Maragno, Lucas T. Parreiras-e-Silva, Tiago Chiavegatti, Marcelo D. Gomes, et al.
Journal of Applied Physiology, 2010
The special issue "Cell Receptors and Signaling"
Rosely Oliveira Godinho, Maria Christina W. Avellar
Annual Review of Biomedical Sciences, 2009
Increased expression of acetylcholine receptors in the diaphragm muscle of mdx mice
Paulo C. Ghedini, Tânia A. Viel, Luciana Honda, Maria Christina W. Avellar, Rosely O. Godinho, et al.
Muscle and Nerve, 2008
Effects of short-term zidovudine exposure on mitochondrial DNA content and succinate dehydrogenase activity of rat skeletal muscle cells
Beatriz H. Kiyomoto, Celia H. Tengan, Rosely O. Godinho
Journal of the Neurological Sciences, 2008
Effects of estrogen on intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors and on acetylcholinesterase activity in rat hippocampus
Renato Tavares dos Santos Pereira, Catarina Segreti Porto, Rosely Oliveira Godinho, Fernando Maurício Francis Abdalla
Biochemical Pharmacology, 2008
Skeletal muscle expresses the extracellular cyclic AMP-adenosine pathway
T Chiavegatti, V L Costa, M S Araújo, R O Godinho
British Journal of Pharmacology, 2008
The role of nitric oxide in muscle fibers with oxidative phosphorylation defects
Célia H. Tengan, Beatriz H. Kiyomoto, Rosely O. Godinho, Juliana Gamba, Afonso C. Neves, et al.
Biochemical and Biophysical Research Communications, 2007
Melatonin modulates rat myotube-acetylcholine receptors by inhibiting calmodulin
Lidiana Duarte de Almeida-Paula, Leticia V. Costa-Lotufo, Zulma Silva Ferreira, Amanda Elisa G. Monteiro, Mauro Cesar Isoldi, et al.
European Journal of Pharmacology, 2005
Developing skeletal muscle cells express functional muscarinic acetylcholine receptors coupled to different intracellular signaling systems
Ingrid Furlan, Rosely Oliveira Godinho
British Journal of Pharmacology, 2005
Ectopic development of skeletal muscle induced by subcutaneous transplant of rat satellite cells
M.G. Fukushima, I. Furlan, T. Chiavegatti, B.H. Kiyomoto, R.O. Godinho
Brazilian Journal of Medical and Biological Research, 2005
Vitamin E prevents cell death induced by mild oxidative stress in chicken skeletal muscle cells
Viviane A. Nunes, Andrezza J. Gozzo, Ilana Cruz-Silva, Maria A. Juliano, Tania A. Viel, et al.
Comparative Biochemistry and Physiology C Toxicology and Pharmacology, 2005
Effect of invertebrate serine proteinase inhibitors on carrageenan-induced pleural exudation and bradykinin release
Kelly C Malavazi-Piza, Mariana S Araújo, Rosely O Godinho, Aparecida S Tanaka
International Immunopharmacology, 2004
Regulation of intracellular cyclic AMP in skeletal muscle cells involves the efflux of cyclic nucleotide to the extracellular compartment
Rosely Oliveira Godinho, Valter Luiz Costa‐Jr
British Journal of Pharmacology, 2003
Comparison of the efficacy of biodegradable and non-biodegradable scintillation liquids on the counting of tritium- and [14C]-labeled compounds
R.B. Medeiros, R.O. Godinho, M.F.S.S. Mattos
Brazilian Journal of Medical and Biological Research, 2003
Segment-specific decrease of both catecholamine concentration and acetylcholinesterase activity are accompanied by nerve refinement in the rat cauda epididymis during sexual maturation
Journal of Andrology, 2002
Short- and long-term influences of calcitonin gene-related peptide on the synthesis of acetylcholinesterase in mammalian myotubes
Valter Luiz Da Costa, Antonio José Lapa, Rosely O Godinho
British Journal of Pharmacology, 2001
Evidence for activation of the tissue kallikrein-kinin system in nociceptive transmission and inflammatory responses of mice using a specific enzyme inhibitor
José A da S Emim, Caden Souccar, Maria S de A Castro, Rosely O Godinho, Maria H S Cezari, et al.
British Journal of Pharmacology, 2000
Testosterone control of endplate and non-endplate acetylcholinesterase in the rat levator ani muscle
Rosely Oliveira Godinho, Caden Souccar, Antonio Jos� Lapa
Neurochemical Research, 1994
Globular and asymmetric forms of acetylcholinesterase in the rat levator ani muscle.
Brazilian Journal of Medical and Biological Research Revista Brasileira De Pesquisas Medicas E Biologicas Sociedade Brasileira De Biofisica Et Al, 1991
Pharmacological screening of Ageratum conyzoides L. (Mentrasto).
Lucia A. Yamamoto, Janete C. Soldera, José A. S. Emim, Rosely O. Godinho, Caden Souccar, et al.
Memorias do Instituto Oswaldo Cruz, 1991
Early and late influences of testosterone on acetylcholinesterase activity of skeletal muscles from developing rats.
Brazilian Journal of Medical and Biological Research Revista Brasileira De Pesquisas Medicas E Biologicas Sociedade Brasileira De Biofisica Et Al, 1988
Trophic control of cholinesterase activity in a testosterone-dependent muscle of the rat. II. Effects of testosterone administration
Rosely Oliveira Godinho, Maria Teresa Lima-Landman, Caden Souccar, Antonio José Lapa
Experimental Neurology, 1987
Trophic control of cholinesterase activity in a testosterone-dependent muscle of the rat: Effects of castration and denervation
Rosely Oliveira Godinho, Maria Teresa Lima-Landman, Caden Souccar, Antonio José Lapa
Experimental Neurology, 1987

Rosely Oliveira Godinho

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Scopus Publications