Adriana Ribeiro SIlva

Scopus Publications

Role of α7 Nicotinic Acetylcholine Receptor and Protein Kinase C in Rat Retinal Ganglion Cell Survival In Vitro
Renan Lyra Miranda, Larissa Costa Santos, Cassiano Felippe Gonçalves‐de‐Albuquerque, Adriana Ribeiro Silva, Hugo Caire Castro‐Faria‐Neto, et al.
European Journal of Neuroscience, 2026
Retinal ganglion cell (RGC) death profoundly impacts vision because RGC axons form the optic nerve, which transmits information to central visual areas. The α7 nicotinic acetylcholine receptor (α7nAChR) participates in the cholinergic anti‐inflammatory pathway and plays a neuroprotective role in the central nervous system. Previously, we showed that protein kinase C activation by phorbol 12‐myristate 13‐acetate (PMA) treatment for 48 h increases the survival of neonatal rat RGCs by modulating muscarinic receptor levels. Herein, we aimed to investigate the effects of the selective α7nAChR agonist PNU‐282987 in rat retinal cell cultures and analyse whether the activation of this receptor is involved in PMA‐mediated RGC survival. Our results showed that α7nAChR inhibition using methyllycaconitine (MLA) abolished the effects of selected cholinergic agonists on RGC survival. We also observed that PNU‐282987 regulates TNF‐α and IL‐1β levels and release. Moreover, PNU‐282987 promoted RGC survival, and its neuroprotection was partially mediated by the induction of TNF‐α and IL‐1β during the initial stages of culture. MLA blocked the effect of PMA (50 ng/mL) on RGC, whereas PMA slightly increased the α7 subunit levels at 48 h. Further, PMA treatment decreased intracellular TNF‐α and p‐NF‐κB p50 levels through α7nAChR activation. In conclusion, we provide evidence that α7nAChR activation leads to the modulation of pro‐inflammatory cytokines in rat retinal cell cultures, thereby increasing RGC survival. Furthermore, activated α7nAChR enhances PKC activation and increases RGC survival after axotomy, corroborating the role of this receptor in neuroprotection.
Glial Cells as Central Players in Neuroinflammation and Neuronal Damage Caused by Bacterial Pneumonia
Aléxia M. S. Ferreira, Léo Victor G. Castro, Marina Ferreira-Costa, Cassiano F. Gonçalves-de-Albuquerque, Adriana R. Silva
Neuroimmunomodulation, 2026
Background: Pneumonia is an infection that affects the alveolar spaces of the lungs, associated with high global mortality, and remains a significant public health challenge worldwide. In a compromised immune system, the infection can progress, leading to the establishment of pneumonia. During this process, an intense inflammatory response is triggered in the lungs through the activation of resident immune cells, especially alveolar macrophages. This activation promotes the recruitment of neutrophils and the release of pro-inflammatory cytokines, ultimately resulting in the formation of exudative infiltrates within the alveoli. Pneumonia is a leading cause of sepsis, particularly among hospitalized patients and in intensive care units. Sepsis represents one of the most severe complications of pneumonia and is characterized by a dysregulated systemic inflammatory response to lung infection. Another critical challenge to treating clinical infectious conditions, which can lead to life-threatening sepsis, septic shock, and multiorgan dysfunction, is the continuous growth of antimicrobial resistance in bacteria. Summary: Among the organ dysfunctions associated with sepsis, sepsis-associated encephalopathy (SAE) is the most frequent and constitutes a primary contributor to the neurological alterations observed in critically ill patients. Although SAE is often classified as a fully reversible pathophysiological process, increasing evidence suggests an association between sepsis, structural brain injury, and long-term neurological sequelae. The central nervous system (CNS) is one of the first regions exposed to peripheral inflammation during sepsis, allowing inflammatory mediators and immune cells to infiltrate the brain. This process activates microglia, the resident immune cells of the CNS, exposing neurons to an oxidative stress-rich environment that leads to neuronal dysfunction and apoptosis. A dysregulated pro-inflammatory microglial response plays a significant role in SAE, as microglia-derived cytokines are strongly associated with neuronal damage. Furthermore, activated microglia stimulate astrocytes to adopt a reactive inflammatory phenotype, thereby amplifying neuroinflammation. Key Messages: Recent studies have demonstrated that regulating microglial and astrocytic hyperactivation can attenuate the inflammatory response. Therefore, targeting glial cells during SAE holds significant therapeutic potential, offering a promising avenue for the development of new strategies aimed at reversing the exacerbated CNS inflammatory response, mitigating neuronal damage, and ultimately reducing the long-term neurological sequelae observed in post-septic patients.
A Lipid Road to Neuroimmunology: Fatty Acids Linking Immune and Nervous Systems
Isabelle Moraes-de-Souza, Bianca Portugal Tavares de Moraes, Renan Muniz-Santos, Gabrielle Lacerda de Souza Gomes-Reis, Francisco da Silva dos Santos, et al.
Neuroimmunomodulation, 2026
Background: Neuroimmunology focuses on the two-way communication between the nervous and immune systems, a crucial relationship that maintains the body’s internal balance. Disruptions in this neural-immune axis are associated with several disorders. Summary: Fatty acids, as bioactive molecules, can modulate both neural and immune functions. Saturated fatty acids (SFAs) and polyunsaturated fatty acids (PUFAs) have opposite effects: SFAs promote inflammation and are associated with neurodegenerative diseases and cognitive impairment, whereas PUFAs exhibit anti-inflammatory and neuroprotective properties. The balance between SFAs and PUFAs is key in regulating neuroimmune interactions. Key Messages: Fatty acid receptors act as essential molecular sensors, connecting lipid signaling to both immune and neural outcomes, and their activation or inhibition influences cytokine production and neuron survival. Due to their role in these pathways, targeting fatty acid interactions to control inflammation and promote neural repair represents a promising strategy for neurological disease therapies. This review examines how fatty acids influence neuroimmune cells and may pave the way for the development of new therapeutic approaches.
Correction: Omega 3 fatty acid docosahexaenoic acid (DHA) mitigates inflammatory responses in experimental sepsis (Frontiers in Pharmacology, (2025), 16, (1708348), 10.3389/fphar.2025.1708348)
Bianca Portugal Tavares de Moraes, Isabelle Moraes-de-Souza, Gabrielle Lacerda de Souza Gomes-Reis, Marina Ferreira-Costa, Carolina Medina Coeli da Cunha, et al.
Frontiers in Pharmacology, 2026
Bosutinib mitigates inflammation in experimental sepsis
C. M. C. Cunha, V. H. P. Abreu, V. Estato, G. M. V. Soares, B. P. T. Moraes, et al.
European Journal of Clinical Investigation, 2025
BackgroundSepsis, a leading cause of death globally, lacks targeted and effective treatment. Its pathophysiology involves unbalanced inflammation, marked by a high release of inflammatory mediators, leukocyte recruitment, vascular changes and dysfunction of the nervous and respiratory systems. Src family tyrosine kinases (SFK) play a critical role in immune responses, and their inhibition can modulate excessive inflammation. This study investigates the potential of bosutinib, an SFK inhibitor, as a treatment for sepsis.MethodsClinical signs, survival rates, systemic and neuronal inflammatory responses, cell recruitment, lung function and cerebral microcirculation were analysed in mice treated with bosutinib (3 mg/kg) or DMSO/saline followed by cecal ligation and puncture (CLP)‐induced sepsis.ResultsBosutinib treatment reduced the severity of sepsis, improved survival rates and reduced the levels of pro‐inflammatory cytokines and chemokines in peritoneal lavage, plasma and brain tissue. It also reduced cellular infiltration and bacterial growth at the infection site and protected lung function by reducing diffuse alveolar damage. Using intravital microscopy and laser speckle techniques, bosutinib improved capillary density and blood perfusion and reduced leukocyte recruitment and adhesion in the cerebral microcirculation of septic animals.ConclusionsBosutinib pretreatment attenuated dysregulated inflammatory responses and neurovascular changes in experimental sepsis.
Corrigendum to “Luteolin: A novel approach to fight bacterial infection” [Microb. Pathog. 204 (2025) 107519] (Microbial Pathogenesis (2025) 204, (S088240102500244X), (10.1016/j.micpath.2025.107519))
Maria do Socorro dos Santos Chagas, Carla Junqueira Moragas Tellis, Adriana R. Silva, Maria Alice dos Santos Mascarenhas Brito, Anderson Junger Teodoro, et al.
Microbial Pathogenesis, 2025
Luteolin: A novel approach to fight bacterial infection
Maria do Socorro dos Santos Chagas, Carla Junqueira Moragas Tellis, Adriana R. Silva, Maria Alice dos Santos Mascarenhas Brito, Anderson Junger Teodoro, et al.
Microbial Pathogenesis, 2025
Bioactive Properties of Murici (Byrsonima crassifolia) and Bacuri (Platonia insignis) and Their Antioxidant and Anti-Inflammatory Effects in Rats
Raquel Martins Martinez, Audrey Cristina Cintra, Carolina de Oliveira Ramos Petra de Almeida, Thuane Passos Barbosa Lima, Isabelle Moraes de Souza, et al.
Journal of Medicinal Food, 2025
Status of Sepsis Care in European Hospitals Results from an International Cross-Sectional Survey
Christian S. Scheer, Evangelos J. Giamarellos-Bourboulis, Ricard Ferrer, Evgeny A. Idelevich, Djillali Annane, et al.
American Journal of Respiratory and Critical Care Medicine, 2025
Rationale Early detection, standardized therapy, adequate infrastructure, and strategies for quality improvement should constitute essential components of every hospital’s sepsis plan. Objectives To investigate the extent to which recommendations from the sepsis guidelines are implemented and the availability of infrastructure for the care of patients with sepsis in acute-care hospitals. Methods A multidisciplinary cross-sectional questionnaire was used to investigate sepsis care in hospitals. This included the use of sepsis definitions, the implementation of sepsis guideline recommendations, diagnostic and therapeutic infrastructure, antibiotic stewardship, and quality improvement initiatives (QIIs) in hospitals. Measurements and Main Results A total of 1,023 hospitals in 69 countries were included. Most of them, 835 (81.6%), were in Europe. Sepsis screening was used in 54.2% of emergency departments (EDs), 47.9% of wards, and 61.7% of ICUs. Sepsis management was standardized in 57.3% of EDs, 45.2% of wards, and 70.7% of ICUs. The implementation of comprehensive QIIs was associated with increased screening (EDs, +33.3%; wards, +44.4%; ICUs, +23.8% absolute difference) and increased standardized sepsis management (EDs, +33.6%; wards, +40.0%; ICUs, +17.7% absolute difference) compared with hospitals without QIIs. A total of 9.8% of hospitals had implemented ongoing QIIs, and 4.6% had invested in sepsis programs. Conclusions The findings indicate that there is considerable room for improvement in a large number of mainly European hospitals, particularly with regard to early identification and standardized management of sepsis, the availability of guidelines, diagnostic and therapeutic infrastructure, and the implementation of QIIs. Further efforts are required to implement a more comprehensive and appropriate quality of care.
Omega 3 fatty acid docosahexaenoic acid (DHA) mitigates inflammatory responses in experimental sepsis
Bianca Portugal Tavares de Moraes, Isabelle Moraes-de-Souza, Gabrielle Lacerda de Souza Gomes-Reis, Marina Ferreira-Costa, Carolina Medina Coeli da Cunha, et al.
Frontiers in Pharmacology, 2025
Background Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection. Sepsis induces systemic inflammation and increases adhesion molecule expression and activation, promoting leukocyte adhesion to the endothelium. In addition, sepsis leads to the disruption of vascular integrity with fluid leakage and migration of leukocytes across the compromised endothelial barrier, leading to organ damage. Bioactive food compounds such as DHA, an essential omega 3 polyunsaturated fatty acid (PUFA) in the Mediterranean Diet (MedDiet), are known for their anti-inflammatory and pro-resolving properties. Thus, the supplementation of DHA may affect sepsis development, protecting the host. Methods To investigate the role of DHA in neutrophil function, we conducted flow chamber assays using isolated neutrophils from mice and humans treated with DHA. To assess whether similar effects occur in vivo , we performed intravital microscopy of the TNF-stimulated cremaster muscle. Finally, we employed the cecal ligation and puncture (CLP) model to evaluate the therapeutic potential of DHA in experimental sepsis, and we applied intravital microscopy to assess cerebral vascular perfusion and the cerebral microcirculation in septic mice. Results We found a significant reduction in neutrophil rolling and adhesion in DHA-treated neutrophils compared to controls in flow chamber assays, which can be mechanistically explained by a substantial reduction in adhesion markers, such as PSGL-1, CD11a, and CXCR4. Next, we employed intravital microscopy in the mouse cremaster muscle, stimulating it with tumor necrosis factor, and found a significant reduction in leukocyte rolling and adhesion in DHA-treated mice, confirming the in vitro flow chamber results. We also used a CLP model of sepsis. We found that DHA treatment ameliorated CLP-related sepsis parameters, including mortality, clinical score, total leukocyte and neutrophil transmigration, cytokine levels in peritoneal exudate, plasma, and brain tissue, and lactate levels. DHA treatment also improved cerebral microcirculatory perfusion and exhibited anti-inflammatory and pro-resolving effects, reflected by increased plasma and brain tissue resolving D1 and D2 levels. Conclusion Together, we identify DHA as a promising anti-inflammatory therapeutic agent that mitigates sepsis-related vascular dysfunction and prevents organ failure.
Accumulation of lipid droplets induced by Listeria monocytogenes in macrophages: implications for survival and evasion of innate immunity
Filipe S Pereira-Dutra, Ellen K Souza, Tamyris S Souza, Taynná C Goltara-Gomes, Felipe Ferraro-Moreira, et al.
Journal of Leukocyte Biology, 2024
Effects of nanocapsules containing lumefantrine and artemether in an experimental model of cerebral malaria
Bianca Portugal Tavares de Moraes, Karoline Paiva da Silva, Karina Paese, Adilson Paulo Sinhorin, Silvia S. Guterres, et al.
Discover Nano, 2024
Tiny Green Army: Fighting Malaria with Plants and Nanotechnology
Isabelle Moraes-de-Souza, Bianca P. T. de Moraes, Adriana R. Silva, Stela R. Ferrarini, Cassiano F. Gonçalves-de-Albuquerque
Pharmaceutics, 2024
Pro-resolving role of glucagon in lipopolysaccharide-induced mice lung neutrophilia
Daniella Bianchi Reis Insuela, Maximiliano Ruben Ferrero, Amanda da Silva Chaves, Diego de Sá Coutinho, Nathalia dos Santos Magalhães, et al.
Journal of Endocrinology, 2023
Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis
Renan Muniz-Santos, Giovanna Lucieri-Costa, Matheus Augusto P. de Almeida, Isabelle Moraes-de-Souza, Maria Alice Dos Santos Mascarenhas Brito, et al.
Frontiers in Immunology, 2023
The Na/K-ATPase role as a signal transducer in lung inflammation
Adriana Ribeiro Silva, Kauê Franscisco Correa de Souza e Souza, Thamires Bandeira De Souza, Mauricio Younes-Ibrahim, Patrícia Burth, et al.
Frontiers in Immunology, 2023
Murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.)) and Tapereba (Spondias mombin) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet Rats
Vanessa Rosse de Souza, Thuane Passos Barbosa Lima, Teresa Palmiciano Bedê, Sabrina Baptista Alves Faria, Renata Alves, et al.
Foods, 2023
Potential of nanoformulations in malaria treatment
Janaina Braga Chaves, Bianca Portugal Tavares de Moraes, Stela Regina Ferrarini, Francisco Noé da Fonseca, Adriana Ribeiro Silva, et al.
Frontiers in Pharmacology, 2022
Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome
Sarah de Oliveira Rodrigues, Matheus Augusto Patricio de Almeida, Hugo Caire Castro-Faria-Neto, Adriana Ribeiro Silva, Cassiano Felippe Gonçalves-de-Albuquerque
Journal of Visualized Experiments Jove, 2022
Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome
Sarah de Oliveira Rodrigues, Matheus Augusto Patricio de Almeida, Hugo Caire Castro-Faria-Neto, Adriana Ribeiro Silva, Cassiano Felippe Gonçalves-de-Albuquerque
Journal of Visualized Experiments, 2022
Polarization of Microglia and Its Therapeutic Potential in Sepsis
Léo Victor G. Castro, Cassiano F. Gonçalves-de-Albuquerque, Adriana R. Silva
International Journal of Molecular Sciences, 2022
Isolation of Microvesicles from Plasma Samples Avoiding Lipoprotein Contamination
Laura B. Merij, Fernanda B. Andrade, Adriana R. Silva, Eugenio D. Hottz
Methods in Molecular Biology, 2022
Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds
Maria do Socorro S. Chagas, Maria D. Behrens, Carla J. Moragas-Tellis, Gabriela X. M. Penedo, Adriana R. Silva, et al.
Oxidative Medicine and Cellular Longevity, 2022
Inflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life
Marcelo Gomes Granja, Letícia Pires Alves, Marina Leardini-Tristão, Michelle Edelman Saul, Letícia Coelho Bortoni, et al.
Journal of Neuroinflammation, 2021
Mechanisms, pathophysiology and currently proposed treatments of chronic obstructive pulmonary disease
Sarah de Oliveira Rodrigues, Carolina Medina Coeli da Cunha, Giovanna Martins Valladão Soares, Pedro Leme Silva, Adriana Ribeiro Silva, et al.
Pharmaceuticals, 2021
Glucagon Reduces Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice
Daniella Bianchi Reis Insuela, Maximiliano Ruben Ferrero, Cassiano Felippe Gonçalves-de-Albuquerque, Amanda da Silva Chaves, Adriano Yagho Oliveira da Silva, et al.
Frontiers in Immunology, 2021
Na+/K+-ATPase as a Target of Cardiac Glycosides for the Treatment of SARS-CoV-2 Infection
Kauê Francisco Corrêa Souza e Souza, Bianca Portugal Tavares Moraes, Izabel Christina Nunes de Palmer Paixão, Patrícia Burth, Adriana Ribeiro Silva, et al.
Frontiers in Pharmacology, 2021
Impact of positive biphasic pressure during low and high inspiratory efforts in Pseudomonas aeruginosa-induced pneumonia
Daniela G. da Cruz, Raquel F. de Magalhães, Gisele A. Padilha, Mariana C. da Silva, Cassia L. Braga, et al.
Plos One, 2021
PPAR gamma: From definition to molecular targets and therapy of lung diseases
Márcia V. de Carvalho, Cassiano F. Gonçalves-de-Albuquerque, Adriana R. Silva
International Journal of Molecular Sciences, 2021
Time-Controlled Adaptive Ventilation Versus Volume-Controlled Ventilation in Experimental Pneumonia
Raquel F. de Magalhães, Daniela G. Cruz, Mariana A. Antunes, Marcos V. de S. Fernandes, Milena V. Oliveira, et al.
Critical Care Medicine, 2021
Mediterranean diet: Lipids, inflammation, and malaria infection
Adriana R. Silva, Bianca P. T. Moraes, Cassiano F. Gonçalves-de-Albuquerque
International Journal of Molecular Sciences, 2020
Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis
Flora Magno de Jesus Oliveira, Cassiano Felippe Gonçalves-de-Albuquerque, Isabel Matos Medeiros de Moraes, Patrícia Alves Reis, Vinicius Novaes Rocha, et al.
Mediators of Inflammation, 2020
Lycopene and Tomato Sauce Improve Hepatic and Cardiac Cell Biomarkers in Rats
Vanessa Azevedo de Jesuz, Monique de Barros Elias Campos, Vanessa Rosse de Souza, Teresa Palmiciano Bede, Bianca Portugal Tavares de Moraes, et al.
Journal of Medicinal Food, 2019
IGF-1 and IGF-1R modulate the effects of IL-4 on retinal ganglion cells survival: The involvement of M1 muscarinic receptor
Marcelo Gomes Granja, Luis Eduardo Gomes Braga, Raphael Monteiro de Oliveira, Eliezer de Mello Silva, Cassiano Felippe Gonçalves-de-Albuquerque, et al.
Biochemical and Biophysical Research Communications, 2019
Serum albumin saturation test based on non-esterified fatty acids imbalance for clinical employment
Cassiano Felippe Gonçalves-de-Albuquerque, Marcos Roberto Colombo Barnese, Mariana Alves Soares, Mauro Velho Castro-Faria, Adriana Ribeiro Silva, et al.
Clinica Chimica Acta, 2019
Immune-endocrine interactions related to a high risk of infections in chronic metabolic diseases: The role of PPAR gamma
Adriana Ribeiro Silva, Cassiano Felippe Gonçalves-de-Albuquerque, Ana Rosa Pérez, Vinicius de Frias Carvalho
European Journal of Pharmacology, 2019
High-fat diet-induced kidney alterations in rats with metabolic syndrome: Endothelial dysfunction and decreased antioxidant defense
Raquel Rangel Silvares, Evelyn Nunes Goulart da Silva Pereira, Edgar Eduardo Ilaquita Flores, Karine Lino Rodrigues, Adriana Ribeiro Silva, et al.
Diabetes Metabolic Syndrome and Obesity, 2019
Serum albumin-fatty acid saturation test
Cassiano Felippe Gonçalves-de-Albuquerque, Marcos Roberto Colombo Barnese, Mariana Alves Soares, Mauro Velho Castro Faria, Adriana Ribeiro Silva, et al.
Methodsx, 2019
The Yin and Yang of tyrosine kinase inhibition during experimental polymicrobial sepsis
Cassiano Felippe Gonçalves-de-Albuquerque, Ina Rohwedder, Adriana Ribeiro Silva, Alessandra Silveira Ferreira, Angela R. M. Kurz, et al.
Frontiers in Immunology, 2018
Omega-9 oleic acid, the main compound of olive oil, mitigates inflammation during experimental sepsis
Isabel Matos Medeiros-de-Moraes, Cassiano Felippe Gonçalves-de-Albuquerque, Angela R. M. Kurz, Flora Magno de Jesus Oliveira, Victor Hugo Pereira de Abreu, et al.
Oxidative Medicine and Cellular Longevity, 2018
Na/K pump and beyond: Na/K-ATPase as a modulator of apoptosis and autophagy
Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Camila Ignácio da Silva, Hugo Caire Castro-Faria-Neto, Patrícia Burth
Molecules, 2017
Variable ventilation improves pulmonary function and reduces lung damage without increasing bacterial translocation in a rat model of experimental pneumonia
Raquel F. de Magalhães, Cynthia S. Samary, Raquel S. Santos, Milena V. de Oliveira, Nazareth N. Rocha, et al.
Respiratory Research, 2016
Escherichia coli Braun Lipoprotein (BLP) exhibits endotoxemia - Like pathology in Swiss albino mice
Chikkamenahalli Lakshminarayana Lakshmikanth, Shancy Petsel Jacob, Avinash Kundadka Kudva, Calivarathan Latchoumycandane, Puttaraju Srikanta Murthy Yashaswini, et al.
Scientific Reports, 2016
Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
Cassiano Felippe Gonçalves-de-Albuquerque, Isabel Matos Medeiros-de-Moraes, Flora Magno de Jesus Oliveira, Patrícia Burth, Patrícia Torres Bozza, et al.
Plos One, 2016
A PPARγ agonist enhances bacterial clearance through neutrophil extracellular trap formation and improves survival in sepsis
Cláudia V. Araújo, Clarissa Campbell, Cassiano F. Gonçalves-de-Albuquerque, Raphael Molinaro, Mark J. Cody, et al.
Shock, 2016
Oleic acid and lung injury
Cassiano F. Gonçalves-de-Albuquerque, Adriana R. Silva, Patrícia Burth, Mauro V. Castro-Faria, Hugo C. Castro-Faria-Neto
Handbook of Lipids in Human Function Fatty Acids, 2016
Possible mechanisms of Pseudomonas aeruginosa-associated lung disease
Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Patrícia Burth, Patricia Rieken Macêdo Rocco, Mauro Velho Castro-Faria, et al.
International Journal of Medical Microbiology, 2016
Acute respiratory distress syndrome: Role of oleic acid-triggered lung injury and inflammation
Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Patrícia Burth, Mauro Velho Castro-Faria, Hugo Caire Castro-Faria-Neto
Mediators of Inflammation, 2015
Glucagon induces airway smooth muscle relaxation by nitric oxide and prostaglandin E2
Daniella B R Insuela, Julio B Daleprane, Luciana P Coelho, Adriana R Silva, Patrícia M R e Silva, et al.
Journal of Endocrinology, 2015
Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor
Cassiano Felippe Gonçalves-de-Albuquerque, Patrícia Burth, Adriana Ribeiro Silva, Isabel Matos Medeiros de Moraes, Flora Magno de Jesus Oliveira, et al.
Respiratory Research, 2014
Na/K-ATPase assay in the intact mice lung subjected to perfusion
Cassiano Felippe Gonçalves-de-Albuquerque, Patrícia Burth, Adriana Ribeiro Silva, IsabelMatos Medeiros de Moraes, FloraMagno Jesus de Oliveira, et al.
BMC Research Notes, 2014
Oleic acid inhibits lung Na/K-ATPase in mice and induces injury with lipid body formation in leukocytes and eicosanoid production
Cassiano Gonçalves-de-Albuquerque, Patrícia Burth, Adriana Silva, Isabel Matos de Moraes, Flora de Jesus Oliveira, et al.
Journal of Inflammation United Kingdom, 2013
Oleic acid induces lung injury in mice through activation of the ERK pathway
Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Patrícia Burth, Isabel Matos Medeiros de Moraes, Flora Magno de Jesus Oliveira, et al.
Mediators of Inflammation, 2012
Leptospira and inflammation
C. F. Gonçalves-de-Albuquerque, P. Burth, A. R. Silva, M. Younes-Ibrahim, H. C. Castro-Faria-Neto, et al.
Mediators of Inflammation, 2012
Activation of PPARγ by restores mast cell numbers and reactivity in alloxan-diabetic rats by reducing the systemic glucocorticoid levels
Rafael C. Torres, Marcelo M. Batista, Andrea H. Pons, Adriana R. Silva, Renato S.B. Cordeiro, et al.
European Journal of Pharmacology, 2012
PPAR gamma activation protects the brain against microvascular dysfunction in sepsis
C.V. Araújo, V. Estato, E. Tibiriçá, P.T. Bozza, H.C. Castro-Faria-Neto, et al.
Microvascular Research, 2012
PPARγ expression and function in mycobacterial infection: Roles in lipid metabolism, immunity, and bacterial killing
Patricia E. Almeida, Alan Brito Carneiro, Adriana R. Silva, Patricia T. Bozza
Ppar Research, 2012
Host cell lipid bodies triggered by Trypanosoma cruzi infection and enhanced by the uptake of apoptotic cells are associated with prostaglandin E2 generation and increased parasite growth
Heloisa D’Avila, Célio G. Freire-de-Lima, Natalia R. Roque, Livia Teixeira, Christina Barja-Fidalgo, et al.
Journal of Infectious Diseases, 2011
Lipid bodies in oxidized LDL-induced foam cells are leukotriene-synthesizing organelles: a MCP-1/CCL2 regulated phenomenon
Adriana R. Silva, Patricia Pacheco, Adriana Vieira-de-Abreu, Clarissa M. Maya-Monteiro, Barbara D'Alegria, et al.
Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 2009
Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor γ expression and activation: Functions in inflammation, lipid metabolism, and pathogenesis
Patrícia E Almeida, Adriana R Silva, Clarissa M Maya-Monteiro, Dániel Töröcsik, Heloisa D′Ávila, et al.
Journal of Immunology, 2009
Monocyte chemoattractant protein-1/CC chemokine ligand 2 controls microtubule-driven biogenesis and leukotriene B4-synthesizing function of macrophage lipid bodies elicited by innate immune response
Patricia Pacheco, Adriana Vieira-de-Abreu, Rachel N Gomes, Giselle Barbosa-Lima, Leticia B Wermelinger, et al.
Journal of Immunology, 2007
Lung production of platelet-activating factor acetylhydrolase in oleic acid-induced acute lung injury
Jorge I. Salluh, Alexandre V. Pino, Adriana R. Silva, Rachel N. Gomes, Heitor S. Souza, et al.
Prostaglandins Leukotrienes and Essential Fatty Acids, 2007
Impairment of endothelium-dependent aorta relaxation by phospholipid components of oxidized low-density lipoprotein
Eunice Vasques, Andressa L. F. Almeida, Vivian Noya, Bárbara D'Alegria, Gopal Marathe, et al.
Endothelium Journal of Endothelial Cell Research, 2006
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor γ agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
Edson F de Assis, Adriana R Silva, Lara F C Caiado, Gopal K Marathe, Guy A Zimmerman, et al.
Journal of Immunology, 2003
Erratum: Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist (Proceedings of the National Academy of Sciences of the United States of America (January 7, 2003) 100:1 (131-136))
Proceedings of the National Academy of Sciences of the United States of America, 2003
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist
Thomas M. McIntyre, Aaron V. Pontsler, Adriana R. Silva, Andy St. Hilaire, Yong Xu, et al.
Proceedings of the National Academy of Sciences of the United States of America, 2003
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein
Adriana R Silva, Edson F de Assis, Lara F C Caiado, Gopal K Marathe, Marcelo T Bozza, et al.
Journal of Immunology, 2002
Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids
Gopal K. Marathe, Adriana Ribeiro Silva, Hugo Caire de Castro Faria Neto, Larry W. Tjoelker, Stephen M. Prescott, et al.
Journal of Lipid Research, 2001
Mechanisms of allergen- and LPS-induced bone marrow eosinophil mobilization and eosinophil accumulation into the pleural cavity: A role for CD11b/CD18 complex
A. P. Larangeira, A. R. Silva, R. N. Gomes, C. Penido, M. G. M. O. Henriques, et al.
Inflammation Research, 2001
Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines
Gopal K. Marathe, Sean S. Davies, Kathleen A. Harrison, Adriana R. Silva, Robert C. Murphy, et al.
Journal of Biological Chemistry, 1999
Bradykinin down-regulates LPS-induced eosinophil accumulation in the pleural cavity of mice through type 2-kinin receptor activation: A role for prostaglandins
A R Silva, A P Larangeira, P Pacheco, J B Calixto, M G M O Henriques, et al.
British Journal of Pharmacology, 1999
A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS
Hugo C Castro-Faria-Neto, Carmen M Penido, Andréa P Larangeira, Adriana R Silva, Patrícia T Bozza
Memorias do Instituto Oswaldo Cruz, 1997
LPS-induced blood neutrophilia is inhibited by α1-adrenoceptor antagonists: A role for catecholamines
Sonia P Altenburg, Marco A Martins, Adriana R Silva, Renato S B Cordeiro, Hugo C Castro-Faria-Neto
Journal of Leukocyte Biology, 1997
Lipopolysaccharide-induced pleural neutrophil accumulation depends on marrow neutrophils and platelet-activating factor
Patricia T. Bozza, Hugo C. Castro-Faria-Neto, Adriana R. Silva, Andréa P. Larangeira, Patrícia M.R. Silva, et al.
European Journal of Pharmacology Environmental Toxicology and, 1994
Interference of azelastine with anaphylaxis induced by ovalbumin challenge in actively sensitized rats
Hugo C. Castro-Faria-Neto, Patrícia T. Bozza, Adriana R. Silva, Patrícia M.R. Silva, Márcia C.R. Lima, et al.
European Journal of Pharmacology, 1992

Adriana Ribeiro SIlva

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