Materials Chemistry, Organic Chemistry, Polymers and Plastics, Biomaterials
8
Scopus Publications
115
Scholar Citations
5
Scholar h-index
2
Scholar i10-index
Scopus Publications
Radical and Environmentally Friendly Route to Poly(fullerene)s Incorporating C60, C70, and PCBM Eleftheria Batagianni, Olivier Doat, Nicolas Elissalt, Douvotsu Elisa Moungadji Bouassa, Jessyka Carolina Bittencourt, Gabriel Cardoso Goncalves, Vitor Fernandes Moreno, João Victor Morais Lima, Gabriel Leonardo Nogueira, Lucas Jorge Affonço, João Vitor Paulin, Silvia Leticia Fernandes, Renato Ferranti, Abdel Khoukh, Luiz Carlos da Silva Filho, Deuber Lincon da Silva Agostini, Clarissa de Almeida Olivati, Patricia Targon Campana, Carlos F. O. Graeff, Didier Bégué, Roger C. Hiorns Macromolecules, 2025 For the first time, this article shows how it is possible to make well-soluble poly(fullerene xylene)s using potassium iodide and in low amounts of solvents. This new method makes it possible to use low-cost, environmentally friendly starting materials, nonchlorinated solvents, and main-chain C60, PCBM, and for the first time, C70, polymers. The reaction can even be performed in the presence of water, further increasing its environmental friendliness. Specifically, a dibromomethylated comonomer, such as 2,5-bis(bromomethyl)-1,4-bis(oxidodecyl)benzene, is reacted with potassium iodide, 18-crown-6, and fullerene in refluxing toluene to yield highly modular alternating copolymers. Model reactions show that polymerization works by the transformation of methylene bromides into methylene iodides, which then disintegrate to make methylene radicals that react with the fullerenes. The radical nature of this new iodine-mediated polymerization (IMP) is confirmed by its sensitivity to the radical trap (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO). The comonomers add in pairs to the fullerene to yield linear chains. NMR and UV–visible spectroscopy along with quantum calculations suggest that most bonds to the fullerene are in 1,4-positions on the same hexagonal ring, however, a minority of C60-methylene bonds are situated several bonds apart on the fullerene, suggesting that iodine “walks” across the fullerene surface. This new polymerization of fullerene, without its reliance on copper and chlorinated solvents and ability to work in the presence of water, makes it of wide use for materials for optoelectronics and medicine where even trace impurities can impact heavily on material properties.
Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2,4-Diaryl-quinoline Derivatives in Water Lucas Michelão Martins, Vitor Fernandes Moreno, Ilana Sganzerla Rosário, Carlos Frederico de Oliveira Graeff, Luiz Carlos Silva Filho Orbital, 2022 Quinolines are an important class of natural and synthetic products, with several biological activity and applications in medicine and electronics. In this work we present a greener method of synthesis of 2,4-diaryl-quinoline derivatives by an easy one-pot multicomponent reaction between aniline derivatives, aldehyde derivatives and phenylacetylene in water, with hydrochloric acid as promoter. With this method we could synthesize several compounds with good yield and reaction time, including new alkylamino-containing 2,4-diaryl-quinoline derivatives that could not be synthesized with niobium pentachloride catalyst in similar conditions. DOI: http://dx.doi.org/10.17807/orbital.v14i1.1689
Heterocyclic compounds as antiviral drugs: Synthesis, structure–activity relationship and traditional applications Giovanny Carvalho dos Santos, Lucas Michelão Martins, Bruna Andressa Bregadiolli, Vitor Fernandes Moreno, Luiz Carlos da Silva‐Filho, Bruno Henrique Sacoman Torquato da Silva Journal of Heterocyclic Chemistry, 2021 A virus outbreak challenges the economic, medical, and public health infrastructure worldwide. More than one virus capable of triggering diseases have been identified per year since 1972, which requires the development of new ways of treatment and prevention, however, such processes are not rapid and easy. With the pandemic scenario experienced since early 2020, several drugs with well‐known purposes have gained prominence, due to speculation of their use in the treatment against the new coronavirus. Among the main drugs studied, the vast majority contain a heterocyclic structure. In this review, we presented the traditional and efficient synthesis of 15 drugs that have been studied for the COVID‐19 treatment, containing in their structure heterocycles like indole, quinoline, pyrimidone, tetrahydrofuran, pyrrolidine, triazole, pyridazine, pyrazole, pyrrolopyrimidine, azetidine, pyrrolotriazine, pyrazine, tetrahydropyran, benzofuran, spiroketal, and thiazole. Furthermore, we have shown the original applications, as well as their structure–activity relationship and what is their situation as a drug candidate against COVID‐19. Thus, the objective was to consolidate the main synthetic and pharmacological aspects involving clinically developed heterocycles that at some point were presented as promising against SARS‐CoV‐2.
NbCl5 Promoted the Efficient Synthesis of Phthalein Derivatives: Optical Characterization and Solvatochromic Effect Vitor Fernandes Moreno, Giovanny Carvalho dos Santos, Gyordanna Mayara Gaspar da Costa, Marcelo Henrique Ayala Gomes, Luiz Carlos da Silva‐Filho Journal of Heterocyclic Chemistry, 2019 Organic dyes derived from phthaleins have a large number of industrial applications and can be synthesized using a Lewis acid by Friedel–Crafts acylation, followed by an addition reaction to the carbonyl compound. This work aims to investigate the use of NbCl5 as a catalyst for the acylation reaction. The behavior of the phthalein derivatives in several solvents and when subjected to different pH conditions was studied. These compounds showed a color‐changing effect depending on the pH and solvent, making them useful for applications as indicators. The phthaleins change their conformations depending on the condition of the medium. Photophysical studies of these compounds were carried out through their UV–Vis absorption spectra. Here, we show the umbrella‐like conformation change of phthalein derivatives that depend on the solvent and the pH of the medium.
Heterocyclic anthrazoline derivatives: A critical review Giovanny Carvalho dos Santos, Vitor Fernandes Moreno, Bruno Henrique Sacoman Torquato da Silva, Luiz Carlos da Silva-Filho New Journal of Chemistry, 2019 The anthrazolinic core is an important building block for several applications, especially those depending on the effect of light.
Radical and Environmentally Friendly Route to Poly(fullerene)s Incorporating C60, C70, and PCBM Macromolecules, https://doi.org/10.1021/acs.macromol.4c0 , 2025 2025.0 Citations: 2
New quinoline-based photoinitiators for polymerization applied to dental resins VF Moreno, LC da Silva Filho, AY Furuse 18° Brazilian Polymer Conference, 1604 , 2025 2025.0
Aplicação de derivados quinolínicos na síntese de polímeros VF Moreno Universidade Estadual Paulista (Unesp) , 2024 2024.0
Novel quinoline photoinitiators for dimethacrylate monomer photopolymerization under UV and blue light VF Moreno, BH Barboza, LM Martins, C Gaglieri, G Bannach, ... European Polymer Journal 218, 113331 , 2024 2024.0 Citations: 9
Compostos de nióbio: uma importante ferramenta na síntese de compostos heterocíclicos LCSF Vitor Fernandes Moreno, Giovanny Carvalho dos Santos Química orgânica sintética: Brasil 2022 3, 417-427 , 2022 2022.0
Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2, 4-Diaryl-quinoline Derivatives in Water LM Martins, VF Moreno, IS Rosário, CF de Oliveira Graeff, ... Orbital: The Electronic Journal of Chemistry, 1-9 , 2022 2022.0 Citations: 5
Heterocyclic compounds as antiviral drugs: Synthesis, structure–activity relationship and traditional applications GC dos Santos, LM Martins, BA Bregadiolli, VF Moreno, LC da Silva‐Filho, ... Journal of Heterocyclic Chemistry 58 (12), 2226-2260 , 2021 2021.0 Citations: 61
Heterocyclic compounds as antiviral drugs: synthesis, structure-activity relationship and traditional applications GC Santos, LM Martins, BA Bregadiolli, VF Moreno, LC Silva-Filho, ... Wiley , 2021 2021.0 Citations: 2
Environmental effects in nitroquinoline derivatives solutions: Solvatochromism, acid-base effect and ion-sensor investigation GC dos Santos, JL Rodrigues, VF Moreno, LC da Silva-Filho Journal of Molecular Structure 1235, 130260 , 2021 2021.0 Citations: 3
Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2, 4-Diaryl-quinoline Derivatives in Water LM Martins, VF Moreno, IS Rosario, CF de Oliveira Graeff, LC Silva Filho ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY 14 (1), 9 , 2021 2021.0 Citations: 2
LC daSilva-Filho GC dos Santos, JL Rodrigues, VF Moreno J. Mol. Struct 1235, 130260 , 2021 2021.0 Citations: 5
NbCl 5 Promoted the Efficient Synthesis of Phthalein Derivatives: Optical Characterization and Solvatochromic Effect VF Moreno, GC dos Santos, GMG da Costa, MHA Gomes, LC Silva‐Filho Journal of Heterocyclic Chemistry 56 (10), 2811-2821 , 2019 2019.0 Citations: 4
Síntese e aplicação de derivados quinolínicos como inibidores de corrosão em aço inoxidável AISI 430 VF Moreno Universidade Estadual Paulista (Unesp) , 2019 2019.0 Citations: 1
rsc. li/njc GC dos Santos, VF Moreno, BHST da Silva, LC da Silva-Filho, N Juneja, ... New J. Chem 43, 18433 , 2019 2019.0
Heterocyclic anthrazoline derivatives: a critical review GC Dos Santos, VF Moreno, BHST Da Silva, LC da Silva-Filho New Journal of Chemistry 43 (47), 18415-18432 , 2019 2019.0 Citations: 8
NbCl5 a multifunctional reagent for the synthesis of new halogenated aminoquinoline compounds through innovative one-pot reaction and the acidochromism effect GC dos Santos, VF Moreno, PB Oshiro, LC da Silva-Filho Tetrahedron 74 (42), 6144-6149 , 2018 2018.0 Citations: 13
Estudos sobre o uso do pentacloreto de Nióbio, como ácido de Lewis, na síntese de corantes orgânicos derivados de ftaleínas VF Moreno Universidade Estadual Paulista (Unesp) , 2017 2017.0
Positional isomerism in nitro-quinoline photoinitiators: exploring the effects of hydroxyl and methacrylate substituents on the photopolymerization of advanced composite resins VF Moreno, LC Silva-Filho, AY Furuse Available at SSRN 6561760 , 0
Heterocyclic compounds as antiviral drugs: synthesis, structure-activity GC dos Santos, LM Martins, BA Bregadiolli, VF Moreno, LC da Silva-Filho, ...
Synthesis and photopolymerization of quinoline derivatives containing methacrylate group with potential application in biomaterials IS Rosário, VF Moreno, LC da Silva Filho
MOST CITED SCHOLAR PUBLICATIONS
Heterocyclic compounds as antiviral drugs: Synthesis, structure–activity relationship and traditional applications GC dos Santos, LM Martins, BA Bregadiolli, VF Moreno, LC da Silva‐Filho, ... Journal of Heterocyclic Chemistry 58 (12), 2226-2260 , 2021 2021.0 Citations: 61
NbCl5 a multifunctional reagent for the synthesis of new halogenated aminoquinoline compounds through innovative one-pot reaction and the acidochromism effect GC dos Santos, VF Moreno, PB Oshiro, LC da Silva-Filho Tetrahedron 74 (42), 6144-6149 , 2018 2018.0 Citations: 13
Novel quinoline photoinitiators for dimethacrylate monomer photopolymerization under UV and blue light VF Moreno, BH Barboza, LM Martins, C Gaglieri, G Bannach, ... European Polymer Journal 218, 113331 , 2024 2024.0 Citations: 9
Heterocyclic anthrazoline derivatives: a critical review GC Dos Santos, VF Moreno, BHST Da Silva, LC da Silva-Filho New Journal of Chemistry 43 (47), 18415-18432 , 2019 2019.0 Citations: 8
Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2, 4-Diaryl-quinoline Derivatives in Water LM Martins, VF Moreno, IS Rosário, CF de Oliveira Graeff, ... Orbital: The Electronic Journal of Chemistry, 1-9 , 2022 2022.0 Citations: 5
LC daSilva-Filho GC dos Santos, JL Rodrigues, VF Moreno J. Mol. Struct 1235, 130260 , 2021 2021.0 Citations: 5
NbCl 5 Promoted the Efficient Synthesis of Phthalein Derivatives: Optical Characterization and Solvatochromic Effect VF Moreno, GC dos Santos, GMG da Costa, MHA Gomes, LC Silva‐Filho Journal of Heterocyclic Chemistry 56 (10), 2811-2821 , 2019 2019.0 Citations: 4
Environmental effects in nitroquinoline derivatives solutions: Solvatochromism, acid-base effect and ion-sensor investigation GC dos Santos, JL Rodrigues, VF Moreno, LC da Silva-Filho Journal of Molecular Structure 1235, 130260 , 2021 2021.0 Citations: 3
Radical and Environmentally Friendly Route to Poly(fullerene)s Incorporating C60, C70, and PCBM Macromolecules, https://doi.org/10.1021/acs.macromol.4c0 , 2025 2025.0 Citations: 2
Heterocyclic compounds as antiviral drugs: synthesis, structure-activity relationship and traditional applications GC Santos, LM Martins, BA Bregadiolli, VF Moreno, LC Silva-Filho, ... Wiley , 2021 2021.0 Citations: 2
Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2, 4-Diaryl-quinoline Derivatives in Water LM Martins, VF Moreno, IS Rosario, CF de Oliveira Graeff, LC Silva Filho ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY 14 (1), 9 , 2021 2021.0 Citations: 2
Síntese e aplicação de derivados quinolínicos como inibidores de corrosão em aço inoxidável AISI 430 VF Moreno Universidade Estadual Paulista (Unesp) , 2019 2019.0 Citations: 1
New quinoline-based photoinitiators for polymerization applied to dental resins VF Moreno, LC da Silva Filho, AY Furuse 18° Brazilian Polymer Conference, 1604 , 2025 2025.0
Aplicação de derivados quinolínicos na síntese de polímeros VF Moreno Universidade Estadual Paulista (Unesp) , 2024 2024.0
Compostos de nióbio: uma importante ferramenta na síntese de compostos heterocíclicos LCSF Vitor Fernandes Moreno, Giovanny Carvalho dos Santos Química orgânica sintética: Brasil 2022 3, 417-427 , 2022 2022.0
rsc. li/njc GC dos Santos, VF Moreno, BHST da Silva, LC da Silva-Filho, N Juneja, ... New J. Chem 43, 18433 , 2019 2019.0
Estudos sobre o uso do pentacloreto de Nióbio, como ácido de Lewis, na síntese de corantes orgânicos derivados de ftaleínas VF Moreno Universidade Estadual Paulista (Unesp) , 2017 2017.0
Positional isomerism in nitro-quinoline photoinitiators: exploring the effects of hydroxyl and methacrylate substituents on the photopolymerization of advanced composite resins VF Moreno, LC Silva-Filho, AY Furuse Available at SSRN 6561760 , 0
Heterocyclic compounds as antiviral drugs: synthesis, structure-activity GC dos Santos, LM Martins, BA Bregadiolli, VF Moreno, LC da Silva-Filho, ...
Synthesis and photopolymerization of quinoline derivatives containing methacrylate group with potential application in biomaterials IS Rosário, VF Moreno, LC da Silva Filho
GRANT DETAILS
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO (FAPESP), Brazil
Grant number: 2024/14443-6
Industry, Institute, or Organisation Collaboration
Universidade de São Paulo (USP), Brazil; Universidade Estadual Paulista (UNESP), Brazil and Université de Pau et des Pays de l'Adour (UPPA), France.