Bachelor of Chemistry, graduated with honors from the Federal University of Paraíba (UFPB). She actively participated in the Green Chemistry Laboratory at UFPB’s Campus II, where she worked on the development of starch-based biofilms derived from corn for fruit coating applications. In this project, Ionic Liquids (ILs) and Deep Eutectic Solvents (DESs) were employed as plasticizing agents. She later earned her Master’s degree in Chemistry from UFPB, Campus I, focusing her research on the investigation of bioactive isatin molecules and their derivatives, as well as on evaluating the role of Deep Eutectic Solvents (DESs) as co-catalysts in the Morita–Baylis–Hillman (MBH) reaction at the Paraíba Medicinal Organic Synthesis Laboratory (LASOM-PB). She is currently enrolled in the PhD program in Chemistry at the Fluminense Federal University (UFF), conducting her research in the Applied Organic Synthesis Laboratory (LABSOA) under the supervision of Dr. Fernando de Carvalho da Silva and Dr. L
Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva Chemistry and Biodiversity, 2025 Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years, aiming to address gaps in the discovery of potent new drugs. This review presents a comprehensive survey of the synthetic strategies employed to obtain isatin–thiazole derivatives, highlighting the key reactive sites of the isatin core. In addition, it summarizes the biological activities of isatin–thiazole compounds that exhibit promising anticancer, anticonvulsant, anti‐HIV, anti‐inflammatory, antidiabetic, and antioxidant properties. The goal of this review is to provide an updated and thorough overview of the synthesis and biological activities for potential applications of isatin–thiazole derivatives, based on studies published up to 2024.
Antifungal profile of menadione tethered to 1H-1,2,3-triazolyl-selenoester: synthesis, in vitro and in silico analyses Nathália R.C. Martins, Ruan C.B. Ribeiro, Mariana O.L. Desmarais, André Luiz Lourenço, Aldo R. da Silva, Thaís D.C. Almeida, Sarah Christina G. Gonçalves, Norman A. Ratcliffe, Isadora M.G. Andrade, Laís M. Marins, Sandy P. Valle, Luana da S.M. Forezi, Vitor F. Ferreira, Vanessa Nascimento, Helena Carla Castro, Fernando de C. da Silva Bioorganic and Medicinal Chemistry, 2025
Multicomponent synthesis of spiro 1,3,4-thiadiazolines with anticancer activity by using deep eutectic solvent under microwave irradiation Aleff Castro, Isadora Maria Gouveia Andrade, Maísa Cavalcanti Coelho, Daniel Pereira da Costa, Dayse das Neves Moreira, Rachel Azevedo Maia, Gesiane da Silva Lima, Gabriel Franco dos Santos, Boniek Gontijo Vaz, Gardênia Carmen Gadelha Militão, Paulo Bruno Norberto da Silva, Mário Luiz Araujo de Almeida Vasconcellos, Claudio Gabriel Lima‐Junior Journal of Heterocyclic Chemistry, 2023 Abstract This work describes a simple and efficient alternative method for obtaining 1,3,4‐thiadialzolinic spirocompounds, combining the use of deep eutectic solvents (DES) with microwave irradiation in a one‐pot process. A series of DES based on different acids was explored as a solvent in a three‐component reaction including isatin derivatives (monomeric and dimeric), thiosemicarbazide, and acetic anhydride. Choline chloride and oxalic acid (1:1) showed better results concerning the other solvents evaluated, reaching yields of up to 79% when applied to the other compounds of the proposed series. For most of the monomeric compounds, the yields were very close to or higher than those reported in the literature for two‐step synthesis. These results demonstrate the possibility of using one‐pot synthesis as a faster, cleaner, and more efficient alternative method for obtaining thiadiazolines with expressive cytotoxic activity.
