Veterinary, Veterinary, General Veterinary, Small Animals
96
Scopus Publications
1163
Scholar Citations
18
Scholar h-index
37
Scholar i10-index
Scopus Publications
Electrocardiographic parameters and heart rate variability in free-ranging Jaguars (Panthera onca) immobilized with tiletamine–zolazepam–dexmedetomidine Karina Resende Assoni, Joares Adenilson May Júnior, Amanda Sarita Cruz Aleixo, Miriam Harumi Tsunemi, Renee Laufer Amorim, et al. BMC Veterinary Research, 2026 Understanding the physiology and particularities of wild felids is important for improving the ability of veterinary medicine to contribute to the preservation of these species. Thus, the objective of this study was to describe the electrocardiographic parameters and heart rate variability (HRV) of wild jaguars ( Panthera onca ) captured in Brazil. The anaesthetic protocol used for chemical restraint of the animals involved the drug combination of tiletamine and zolazepam (7 mg/Kg) along with the α2 adrenergic (receptor) agonist dexmedetomidine (10 µg/Kg). The 42 electrocardiographic reports from 39 animals were categorized (sex, estimated age, and body weight) and statistically analysed; 25 females and 14 males between two and 21 years old with a mean weight of 80.96 ± 23 kg were analysed. During the examination, the mean heart rate maintained by the animals was 99 bpm, with a maximum heart rate during the examination of 122 bpm and a minimum heart rate of 93 bpm; the values were comparable with the reference values for large felids. Electrocardiographic parameters differed between the sexes ( p < 0,05) (P wave amplitude, QT interval and ST segment) and between the estimated ages (P wave amplitude) and the body weight (P wave amplitude and S amplitude) of the animals. The HRV determined by electrocardiogram did not differ (SDNN 52.89 ± 50.37, rMSSD 59.99 ± 59.79, ApEntropy 0.47 ± 0.36, CVI 3.03 ± 1.35, CSI 1.75 ± 0.82, alpha 1 DFA 0.821 ± 0.264, alpha 2 DFA 0.689 ± 0.385); however, the effect of tiletamine–zolazepam in combination with an anaesthetic agent such as dexmedetomidine (an α2 adrenergic receptor) has never been described. Since this anaesthetic protocol has currently been used effectively in wild felids, the description of electrocardiographic parameters and HRV in free-ranging jaguars seems to be particularly important for future studies of the autonomic tone in the sedation of this species.
Comparative Effects of Aminophylline, Caffeine, and Doxapram in Hypoxic Neonatal Dogs Born by Cesarean Section Júlia Cosenza Mendonça, Keylla Helena Nobre Pacífico Pereira, Gleice Mendes Xavier, Kárita da Mata Fuchs, Thaís Gomes Faustino, et al. Animals, 2025 Background: Perinatal hypoxia is a leading cause of early mortality in canine neonates and accounts for over 90% of early deaths in canine neonates. Respiratory depression may result from dystocia, prolonged labor, or anesthetic protocols used during cesarean delivery, requiring rapid pharmacological support. This study evaluated the effects of aminophylline, caffeine, and doxapram on clinical and biochemical viability parameters in hypoxic neonatal dogs. Methods: Forty-five puppies born via elective or emergency cesarean section were included, of which 35 exhibiting cardiorespiratory depression (heart rate ≤ 180 bpm, respiratory rate < 15 movements per minute, Apgar score < 7, and reflex score < 3) were randomly allocated into aminophylline group (AG; n = 12), caffeine group (CafG; n = 11), or doxapram group (DG; n = 12). Ten clinically healthy neonates constituted the physiological control group (CG). Apgar score, neonatal reflexes, lactate, blood glucose, oxygen saturation, blood gas parameters, and cardiac troponin I (cTnI) were evaluated immediately after birth (M1) and 10 min following treatment (M10). Results: No significant differences were observed in laboratory parameters among groups (p > 0.05). Although all evaluated drugs improved clinical status by increasing heart rate, respiratory rate, and reflex scores, caffeine produced the greatest enhancement in vitality. The Δ Apgar score showed a significant difference between CafG and DG (p = 0.0095), while no statistical differences were detected between AG and CafG (p = 0.08) or between AG and GD (p = 0.60). Conclusions: Aminophylline, caffeine, and doxapram supported postnatal resuscitation in hypoxic neonatal puppies; however, caffeine demonstrated superior improvement in Apgar recovery, suggesting its potential as a preferred pharmacological adjunct in neonatal canine resuscitation protocols.
Clinical Approach to Cleft Lip and Palate with or Without Surgical Correction in Ten Brachycephalic Puppies Gleice Mendes Xavier, Keylla Helena Nobre Pacífico Pereira, Kárita da Mata Fuchs, Júlia Conseza Mendonça, Rebeca Bastos Abibe, et al. Veterinary Sciences, 2025 Congenital defects are among the leading causes of neonatal mortality in small animals. Among them, cleft palate is one of the most commonly found malformations in dogs. Appropriate clinical management and surgical correction are determining factors for the survival of puppies affected by this alteration. Thus, the objective of this study is to describe 10 clinical cases of successful clinical management of cleft palate, highlighting the therapeutic strategies used, the results obtained, and the evolution of patients after treatment. Ten neonatal dogs of three breeds were treated by the Small Animal Reproduction Service of FMVZ, Unesp—Botucatu: French Bulldog (6), Pug (3), and American Bully (1) presented with cleft palate at birth or during the first week of age. Patients underwent clinical and nutritional management, in addition to immunological support. At four months of age, the patients underwent medially positioned flap repair. The animals were fed via an esophageal tube for 10 days after surgery. The clinical management proved to be effective since, throughout the follow-up, the animals showed good development and did not present complications arising from the cleft palate, and the surgical procedures were successful, restoring the quality of life of the animals.
Necropsy Technique and Histological Characterisation of Organs From Neonatal Puppies: What Do We Know? Victória Ghedin, Jéssica Cardia de Melo, Fernanda Barthelson Carvalho de Moura, Keylla Helena Nobre Pacífico Pereira, Carlos Mario Gonzalez Zambrano, et al. Veterinary Medicine and Science, 2025 Neonatal mortality in dogs is high, ranging from approximately 5% to 35%, yet investigations into its causes and risk factors remain scarce. Postmortem examination is a crucial tool for identifying the underlying causes of neonatal death and improving disease diagnosis. However, the anatomical, physiological and histological differences between neonates and adults present unique challenges for necropsy procedures. Establishing a standardised neonatal necropsy protocol is essential for accurately determining the causes of death and associated diseases. This pilot study aimed to standardise a necropsy technique for canine neonates. During the examination, the spleen, heart, lungs, tongue, stomach, intestines, liver, pancreas, kidneys, bladder, brain and bones were collected from nine neonatal canines. The method involved monoblock organ removal, followed by separation on the basis of the standard organisation used in adult necropsies. Histological staining and analysis revealed structural differences between neonatal and adult tissues. Neonatal hepatocytes presented a more basophilic cytoplasm, suggesting high metabolic activity, whereas gastric glands and parietal cells were less developed, indicating ongoing maturation. Additionally, the pancreas, lungs, kidneys and spleen displayed morphological characteristics consistent with those of the early development stages. Understanding these particularities may enhance veterinary diagnostic and clinical approaches, contribute to the development of preventive measures and ultimately reduce neonatal mortality in dogs. The standardisation of necropsy protocols facilitates the recognition of disease patterns, improves pathological documentation and supports further research on neonatal canine mortality.
Study of the Arrhythmogenic Profile in Dogs with Acute and Chronic Monocytic Ehrlichiosis Carolina Dragone Latini, Angélica Alfonso, Maurício Gianfrancesco Filippi, Mayra de Castro Ferreira Lima, Antônio Carlos Paes, et al. Life, 2025 Canine monocytic ehrlichiosis (CME) is a globally prevalent disease transmitted by the tick Rhipicephalus sanguineus and caused by the Gram-negative bacterium Ehrlichia spp. Following an incubation period, the infection is categorized based on the progression of the disease into acute, subclinical, and chronic stages. Besides hematological alterations, the cardiovascular system is significantly impacted by the hemodynamic effects of the disease, as persistent anemia can lead to myocardial hypoxia and the activation of inflammatory processes, potentially causing myocarditis. It is known that in dogs infected with Ehrlichia canis, there is a higher occurrence of arrhythmias and a predominance of sympathetic activity. This study assessed arrhythmogenic parameters, including P wave dispersion (Pd), QT dispersion (QTd), and QT instability, along with heart rate variability (HRV) analysis from 24 h Holter monitoring in naturally infected dogs during the acute phase (n = 10) and chronic phase (n = 10) compared to a control group (n = 10). The Pd and QTd values were higher in the infect group, confirming the arrhythmogenic character. Instability parameters (TI, LTI, and STI) were higher in sick animals, but no worsening was observed in the chronic phase. All HRV metrics in the time domain were higher in the control group, indicating a balanced sympathovagal activity throughout the day in healthy dogs. Additionally, parameters linked to parasympathetic activity (rMSSD and pNN50) were reduced in the sick groups, confirming the dominance of sympathetic activity. These findings indicate a decrease in HRV in sick individuals and reinforce this useful marker for assessing the influence of the autonomic nervous system on the cardiovascular system. In conclusion, CME exhibits arrhythmogenic activity characterized by the deterioration of predictive parameters for ventricular arrhythmias and increased activity of the sympathetic autonomic nervous system in the heart. This is likely secondary to myocarditis, myocardial hypoxia, and structural damage to cardiomyocytes.
Treatment of anasarca in neonatal American Bully dogs – case report T.M. Camargo, M.L.G. Lourenço, K.H.N.P. Pereira Arquivo Brasileiro De Medicina Veterinaria E Zootecnia, 2025 Fetal anasarca is a congenital disorder commonly described in brachycephalic breeds, characterized by generalized edema, which may be associated with cardiac, lymphatic, hepatic or renal malformations. As it is considered a defect with often lethal prognosis, it is a condition that is often neglected in clinical routine, since many animals do not receive adequate treatment. Thus, the objective of this report was to describe the treatment of anasarca in newborn American Bully dogs and discuss the possible cause of this defect in the litter. Four neonates presented generalized edema at birth, and treatment was initiated with furosemide, subcutaneously, every three hours. After six administrations of the drug, the neonates reached the ideal weight, with no generalized edema. In the complementary exams, renal alterations were followed by ultrasound, demonstrating altered cortico-medullary relationships, with a report describing a possible congenital nephropathy, suggestive of renal dysplasia. Urea and creatinine were within normal limits for age. Quarterly monitoring of renal changes was recommended. This report demonstrates that treatment of anasarca is possible, and the clinical response of the animal will depend on the underlying cause. Furosemide was effective in treating the generalized edema in this litter. Immediate identification and intervention are essential for the survival of these patients.
Vagal indigestion in mini-cattle1 Lucas V.O. Ferreira, Maria L.G. Lourenço, Regina K. Takahira, Juliana M. Alonso, José P. Oliveira-Filho, et al. Pesquisa Veterinaria Brasileira, 2023
Renal resistive index in obese and non-obese cats Fúlvia Bueno de Souza, Natália Volpi Gonçalves, Shayra Peruch Bonatelli, Alexandra Frey Belotta, Silvano Salgueiro Geraldes, et al. Veterinaria Italiana, 2022
Effect of obesity on ecocardiographic parameters and vertebral heart size (VHS) in cats Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Fúlvia Bueno de Souza, Danilo Velazquez Golino, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Shayra Peruch Bonatelli, et al. Semina Ciencias Agrarias, 2020
Primary hypoparathyroidism in a dog Mateus Do Amaral Freitas, Paulo César Jark, Mariana Isa Poci Palumbo, Maria Lucia Gomes Lourenço, Luiz Henrique De Araujo Machado Semina Ciencias Agrarias, 2014
Ecg of the month Maria C. F. Vailati, Denise S. Schwartz, Nilciene M. Galli, Jorge P. Conti, Maria L. G. Lourenço, et al. Journal of the American Veterinary Medical Association, 2011
Electrocardiographic evolution in cats from birth to 30 days of age Canadian Veterinary Journal, 2003
Dissecting aortic aneurysm in a cat Canadian Veterinary Journal, 2002
RECENT SCHOLAR PUBLICATIONS
Electrocardiographic parameters and heart rate variability in free-ranging Jaguars (Panthera onca) immobilized with tiletamine–zolazepam–dexmedetomidine KR Assoni, JA May Júnior, ASC Aleixo, MH Tsunemi, RL Amorim, ... BMC Veterinary Research 22 (1), 137 , 2026 2026
Efficacy of fresh frozen plasma immunotherapy as an adjuvant treatment of neonatal sepsis in puppies KHNP Pereira, K da Mata Fuchs, GM Xavier, JC Mendonça, DR Câmara, ... Research in Veterinary Science, 106085 , 2026 2026
Left atrial strain response to acute preload reduction in healthy dogs using a translational blood donation model RB Cepinho, AAL de Souza, CJL Reyes, R Francisco, MH Tsunemi, ... Scientific Reports , 2026 2026
An overview of feline atopic skin syndrome AG Stefaniszen, J Meira, LVO Ferreira, VG Mazziero, LMB Padilha, ... Vlaams Diergeneeskundig Tijdschrift 94 (6) , 2025 2025
Comparative Effects of Aminophylline, Caffeine, and Doxapram in Hypoxic Neonatal Dogs Born by Cesarean Section JC Mendonça, KHNP Pereira, GM Xavier, KM Fuchs, TG Faustino, ... Animals 15 (23), 3485 , 2025 2025
Treatment of anasarca in neonatal American Bully dogs-case report TM Camargo, MLG Lourenço, K Pereira Arquivo Brasileiro de Medicina Veterinária e Zootecnia 77 (5), e13423 , 2025 2025
Histological alterations in placentas of normal and anomalous pups: correlation with neonatal outcomes and fetal health LM Lovo, MV Estevam, S Beretta, A Marmol, LM Pasqui, ... Theriogenology 243, 117458 , 2025 2025 Citations: 2
Laboratorial parameters of septic neonate dogs after adjuvant treatment with fresh frozen plasma KH Pereira, K Fuchs, G Xavier, JC Mendonca, D Camara, LEC Correia, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Effects of aminophylline, caffeine and doxapram in hypoxic neonatal dogs born by caesarean section-Preliminary results JC Mendonca, KH Pereira, G Xavier, K Fuchs, M Apparicio, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Congenital aplasia cutis in a newborn Cavalier King Charles Spaniel dog-Case report JC Mendonca, KH Pereira, K Fuchs, G Xavier, M Apparicio, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Preliminary evaluation results of assessment of left ventricular systolic function by doppler echocardiography in neonate dogs R Francisco, MM Mantovani, KH Pereira, MLG Lourenco, AC Donato REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
CT and histopathological findings in canine fetal anasarcas FA Rodrigues-Silva, A Hataka, VMV Machado, FB Guimaraes, RO Barreto, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Dopplerflowmetry in fetal and its correlation with the probable date of delivery and neonatal viability in toy poodle dogs G Xavier, M Fernandes, K Fuchs, JC Mendonca, MV Loiola, Filho, AR, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Relationship of placental proteome and viability of canine neonates AL Campos-Martins, PB Guerra, K Fuchs, JZ de Moura, MG de Carvalho, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Evaluation of the safety and feasibility of extracorporeal therapy: therapeutic plasma exchange in dogs-report of five cases SR Maia, RS de Moraes, SS Geraldes, MGP de Azevedo, AG Stefaniszen, ... BMC Veterinary Research 21 (1), 348 , 2025 2025
Clinical Approach to Cleft Lip and Palate with or Without Surgical Correction in Ten Brachycephalic Puppies GM Xavier, KHNP Pereira, KM Fuchs, JC Mendonça, RB Abibe, ... Veterinary Sciences 12 (5), 474 , 2025 2025 Citations: 1
Efficacy of VG26 and K1 acupuncture points in cardiopulmonary resuscitation of neonatal puppies born by cesarean section MLG Lourenço, FC Knupp, KHNP Pereira, KM Fuchs, GM Xavier, ... Frontiers in Veterinary Science 12, 1579758 , 2025 2025
Study of the arrhythmogenic profile in dogs with acute and Chronic Monocytic Ehrlichiosis CD Latini, A Alfonso, MG Filippi, MCF Lima, AC Paes, JV Corrêa, ... Life 15 (3), 490 , 2025 2025 Citations: 1
Neonatal Sepsis in Dogs Caused by Beta-Hemolytic Streptococcus Sourced From Maternal Mastitis—Case Report KHNP Pereira, JC Mendonça, K da Mata Fuchs, GM Xavier, DR Câmara, ... Case Reports in Veterinary Medicine 2025 (1), 6551231 , 2025 2025
Tratamento da anasarca em cães neonatos da raça American Bully-relato de caso TM Camargo, MLG Lourenço, K Pereira Arquivo Brasileiro de Medicina Veterinária e Zootecnia 77, e13423 , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Topics in the routine assessment of newborn puppy viability FG Vassalo, CRB Simões, MJ Sudano, NC Prestes, MD Lopes, ... Topics in companion animal medicine 30 (1), 16-21 , 2015 2015 Citations: 96
Incidence of congenital malformations and impact on the mortality of neonatal canines KHNP Pereira, LEC dos Santos Correia, ELR Oliveira, RB Bernardo, ... Theriogenology 140, 52-57 , 2019 2019 Citations: 51
Características do período de transição fetal-neonatal e particularidades fisiológicas do neonato canino MLG Lourenço, LHA Machado 2013 Citations: 42
Neonatology: topics on puppies and kittens neonatal management to improve neonatal outcome KHNP Pereira, KM Fuchs, JV Corrêa, SB Chiacchio, MLG Lourenço Animals 12 (23), 3426 , 2022 2022 Citations: 38
Routine screening examinations in attendance of cats with obstructive lower urinary tract disease AM Neri, LH de Araújo Machado, PTCG Okamoto, MG Filippi, ... Topics in companion animal medicine 31 (4), 140-145 , 2016 2016 Citations: 34
Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs KHNP Pereira, VY Hibaru, K da Mata Fuchs, LEC dos Santos Correia, ... Theriogenology 180, 146-153 , 2022 2022 Citations: 33
Electrocardiographic evolution in cats from birth to 30 days of age MLG Lourenço, H Ferreira The Canadian Veterinary Journal 44 (11), 914 , 2003 2003 Citations: 32
Neonatal sepsis in dogs: Incidence, clinical aspects and mortality KHNP Pereira, K da Mata Fuchs, VY Hibaru, LEC dos Santos Correia, ... Theriogenology 177, 103-115 , 2022 2022 Citations: 31
Topics in the routine assessment of newborn kitten vitality: Apgar score, reflexes and complementary assessments VY Hibaru, KHNP Pereira, KM Fuchs, MD Lopes, A Alfonso, FF de Souza, ... Journal of Feline Medicine and Surgery 24 (6), e34-e42 , 2022 2022 Citations: 28
Scaling relationships among heart rate, electrocardiography parameters, and body weight ASC Aleixo, A Alfonso, E Oba, FF de Souza, RKS Cruz, MG Fillippi, ... Topics in companion animal medicine 32 (2), 66-71 , 2017 2017 Citations: 26
Cuidados com neonatos e filhotes MLG Lourenço Tratado de medicina interna de cães e gatos. Rio de Janeiro: Roca, 363-675 , 2015 2015 Citations: 25
The normal electrocardiograms in the conscious newborn lambs in neonatal period and its progression K Koether, CMV Ulian, MLG Lourenço, RS Gonçalves, MJ Sudano, ... BMC physiology 16 (1), 1 , 2015 2015 Citations: 24
Topics on maternal, fetal and neonatal immunology of dogs and cats KHNP Pereira, K da Mata Fuchs, JC Mendonça, GM Xavier, FC Knupp, ... Veterinary immunology and immunopathology 266, 110678 , 2023 2023 Citations: 23
Electrolyte, blood gas and electrocardiographic profile of neonatal foals in the first 48 hours of life. RKS Cruz, A Alfonso, MLG Lourenço, CMV Ulian, MJ Sudano, E Oba, ... 2015 Citations: 21
Diagnóstico ultrassonográfico de hidropisia fetal intrauterino–relato de caso TTM Da Silva, RDS Zakimi, PD Garcia, HE Thomé, MLG Lorenço, ... Revista de educação Continuada em Medicina Veterinária e Zootecnia do CRMV … , 2012 2012 Citations: 21
Necrotic skin lesion in a dog attributed to Loxosceles (brown spider) bite: a case report LHA Machado, M Antunes, AM Mazini, M Sakate, R Torres-Neto, ... Journal of Venomous Animals and Toxins Including Tropical Diseases 15, 572-581 , 2009 2009 Citations: 21
Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis M Gianfranchesco Filippi, M de Castro Ferreira Lima, AC Paes, ... PLoS One 14 (5), e0216552 , 2019 2019 Citations: 19
Feline gingivitis-stomatitis complex: a review/Complexo gengivite estomatite felina: revisao de literatura/Complejo gingivitis-estomatites felina: revision de la literatura KS Matilde, MLG Lourengo, FS Zahn, LH de Araújo Machado Veterinária e Zootecnia 20 (2), 160-171 , 2013 2013 Citations: 18
Escore de Apgar: história e importância na medicina veterinária FG Vassalo, LP Silva, MLG Lourenço, SB Chiacchio 2014 Citations: 17
Dissecting aortic aneurysm in a cat MLG Lourenço, MCF Vailati, AM Luis, JL Sequeira, JA Peres, ... The Canadian Veterinary Journal 43 (9), 720 , 2002 2002 Citations: 16