A Review on Potential Footprints of Piper methysticum for Chronic Disease Management Nidhi Singh, Avijit Mazumder, Priyanka Bansal Journal of Natural Remedies, 2026 Background: For centuries, Kava (Piper methysticum) has been incorporated as medicine in the Pacific Islands, and modern studies now confirm its therapeutic value on several chronic diseases. Aim: This review aims to explore the modes of action of kavalactones and flavokavains in kava to treat neurological disorders, cancer and inflammation. Methods: A systematic review was conducted through PubMed, Scopus, Science Direct and Google Scholar databases on articles between 2010 and 2025 by investigating keywords that matched both kava and chronic diseases. Results: Kavalactones, including kavain and methysticin, control excessive neuron activity by interacting with GABA receptors and preventing sodium channel activity, which supports kava’s historical application for anxiety treatment and its new use in treating epilepsy and providing neuroprotection. Flavokavain A shows strong anti-inflammatory properties because it prevents NF-κB pathway destruction while it activates the protective Nrf2 antioxidant system. Flavokavains induce cancer cell death through various mechanisms, including disrupting the equilibrium between pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins and blocking the blood flow needed by tumours. The therapeutic potential of flavokavain B, which exists in organic solvent extracts, creates a serious risk because it causes damage to the liver. Conclusion: kava’s kavalactones and flavokavains offer compelling therapeutic benefits for neurological disorders, cancer, and inflammation — calming neural excitability, inducing cancer cell death, and activating antioxidant defences. Moving forward, rigorous clinical studies are needed to fully unlock this ancient botanical’s modern medicinal benefits. Major Findings: Kava’s bioactive components kavalactones and flavokavains show remarkable therapeutic potential like neuroprotection, anxiolysis, and anti-inflammatory effects through GABAergic and NF-κB/Nrf2 pathways, while demonstrating potent anticancer activity via apoptosis and angiogenesis inhibition.
Phytotherapeutic approaches to PCOS: Key plant species and their therapeutic potential Reshpal Kaur, Avijit Mazumder, Saumya Das, M.V.N.L Chaitanya Allelopathy Journal, 2026 Polycystic Ovary Syndrome (PCOS) is a very common multifactorial endocrine disorder that affects women of reproductive age, characterized by hormonal imbalance, insulin resistance, chronic anovulation together with polycystic ovaries. Although conventional pharmacological treatments are effective, but they have side effects and do not manage all features of syndrome. Hence, there is an emerging interest in plant-based therapies that are well recognized for their holistic action and safety profile. Historically, medicinal plants have been used in various traditional medicine systems to promote gynecologic health and are rich source of bioactive compounds (Flavonoids, alkaloids and phytoestrogens) which have hormone regulatory, insulin sensitizing, anti-inflammatory and antioxidant properties. This review determined the medicinal potential of plants based on their phytochemical composition and their beneficial effects on PCOS symptoms and review plant species efficacious against PCOS. Synthesizing scientifically validated research and finding the underexplored medicinal plant species, to integrate integrate them in modern therapeutic strategies to innovative, sustainable and multitarget treatments for PCOS.
Synthesis, Computational, and In Vitro Evaluation of Pyridine Analogs to Combat Lung Cancer Ashish Maurya, Rakhi Mishra, Rupa Mazumder, Avijit Mazumder, Shruti Varshney, Anjna Rani Russian Journal of General Chemistry, 2026 A novel series of pyridine-based urea derivatives was developed in this thesis as potential inhibitors of EGFR tyrosine kinase, utilizing rational drug design strategies. The study was conducted in four integrated phases, beginning with in silico prediction of ADME (absorption, distribution, metabolism, and excretion) and physicochemical properties. Synthetically, the pyridine core was constructed via a modified Hantzsch reaction, followed by hydrolysis, chlorination, and urea coupling to introduce diverse functionalities. The resulting compounds N,N-dicarbamoyl-4-(3-phenyl)-2,6-dimethyl-4H-1-pyridine-3,5-dicarboxamide derivatives were characterized using IR, NMR, and mass spectrometry, exhibiting melting points between 80 and 156°C and good yields (74–95%). Physicochemical profiling indicated moderate polarity, with hydrogen bond acceptors (4–8), donors (5–7), and molar refractivity (99.77–113.07). Drug-likeness scores ranged from 0.17 to 0.55, indicating some favorable features but underscoring the need for further optimization to enhance oral bioavailability. ADME predictions showed no blood-brain barrier penetration and poor gastrointestinal absorption, characteristics typical of systemic anticancer agents. The compounds were relatively hydrophilic (log P: –0.25 to 1.23), which could limit membrane permeability but reduce off-target effects. Molecular docking against the EGFR kinase domain (PDB: 1M17) using Cresset Flare revealed several compounds with strong binding affinities. Notably, compound N3,N5-dicarbamoyl-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide showed a binding strength close to crizotinib and superior to erlotinib. Biological evaluation via MTT assay on lung cancer cells demonstrated that compounds N3,N5-dicarbamoyl-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide, N3,N5-dicarbamoyl-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide, and especially N3,N5-bis(2-nitrobenzamido)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide exhibited significant cytotoxicity, with N3,N5-bis(2-nitrobenzamido)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide being the most potent (IC50 = 10 to 100 μM). At the same time, N3,N5-dicarbamoyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide and N3,N5-dicarbamoyl-4-(3,4-dihydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide were inactive.
CYFRA 21-1 as a circulating biomarker in non-small cell lung cancer Neelam Singla, Kavita Goyal, Pawan Goud, Vaishali Goel, Avijit Mazumder, K.P. Hemalatha, Vijayakumar Sachidananda, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, Brian Gregory George Oliver Clinica Chimica Acta, 2026
Fabrication and Testification of Tailored Liposomes for Targeted Drug Delivery of Celecoxib Avijit Mazumder, Anjali Mishra, Shalini Sharma International Journal of Pharmaceutical Sciences and Nanotechnology, 2026 Background of the Topic: One of the most popular NSAID celecoxib has vital applications in pharmaceutical field, however due to its undesirable side effects, its use has been restricted under extreme conditions. Purpose of the study: This project's primary goal was to eliminate any possible adverse effects in order to increase celecoxib's bioavailability. Research rationale: The main concern behind selecting and fabricating liposomes of celecoxib was to eradicate the obvious side effects of COX-2 enzyme inhibitors. General methods: The methodology applied here was thin film hydration technology, one of the most feasible and most practical technology to fabricate liposomes. Results: A total of six formulae were fabricated and it was depicted that around 47% of drug were entrapped in formula L1, making it highest among rest. The SEM analysis of formed lipid vesicles appeared to be rough thus paving a way for easy sliding of active pharmaceutical ingredients. Conclusions: This study corroborated that liposomal carriers of celecoxib have the potential to prevent serious hazards of celecoxib and enhances the permeation rates and also solves the issues relating to efficacy
Bioactive-Guided Isolation and Optimization of Luffa Acutangula Nanoemulsion for In vitro, In vivo, and In silico Cholinesterase Inhibition for Alzheimer's Disease Management Anmol Kanda, Avijit Mazumder, Saumya Das, Archna Singh, Vishnu Prabhakar Chemistry and Biodiversity, 2026 Alzheimer's disease (AD) progressively impairs memory and cognition. Luffa acutangula (LA), rich in triterpenoids, fatty acids, and iridoid glycosides, exerts anti‐Alzheimer's effects by inhibiting acetylcholinesterase (AChE). This study aims to isolate bioactive compounds from LA fruits, formulate and optimize a nanoemulsion to improve brain targeting, and assess its anti‐Alzheimer efficacy through in vitro, in vivo, and in silico approaches. LA was extracted using a 1:1 hydro‐ethanol mixture and subsequently underwent chromatographic isolation to yield four major constituents: oleanolic acid, stearic acid, cucurbitacin H, and acutoside C. A multiple nanoemulsion (containing a mixture of isolated constituents) was formulated using Box–Behnken design and characterized for particle size, viscosity, entrapment efficiency, and FTIR compatibility. In vivo studies were conducted in scopolamine‐induced memory‐impaired mice using Hebb–William's Maze (HWM) and Cook's pole climbing tests. AChE activity was biochemically assessed, followed by histopathological brain analysis. Molecular docking was used to predict ligand‐AChE binding affinities. The optimized L. acutangula loaded multiple nanoemulsion (LAMN) exhibited an average particle size of 142.1 nm, viscosity of 60 cP, and entrapment efficiency (EE) of 96.8 %. It decreased learning scores in the HWM and shortened latency time in Cook's pole‐climbing test in memory‐impaired mice. AChE levels were significantly reduced in LAMN‐treated groups, correlating with histological evidence of hippocampal protection. Molecular docking revealed strong AChE binding, particularly by oleanolic acid (−10.5 kcal/mol), comparable to donepezil (−10.7 kcal/mol). LAMN offers a promising phytopharmaceutical intervention for AD, with multitargeted neuroprotective effects mediated through AChE inhibition and improved drug delivery across the blood–brain barrier. The findings support further clinical development of LA‐based nanoformulations for AD management.
Discovery of Novel PTP1B Inhibitors by High-throughput Virtual Screening Abhijit Debnath, Anjna Rani, Rupa Mazumder, Avijit Mazumder, Rajesh Kumar Singh, Shalini Sharma, Shikha Srivastava, Hema Chaudhary, Rashmi Mishra, Navneet Khurana, Jahanvi Sanchitra, Sk Ashif Jan Current Computer Aided Drug Design, 2026
Unravelling the nutraceutical and therapeutic perspectives of corosolic acid: Journey so far and the road ahead Sachin Kumar Singh, Pavankumar Chintamaneni, Vinoth Kumarasamy, M V N L Chaitanya, Rashmi Saxena Pal, Saranya Punniyakotti, Sukriti Vishwas, Avijit Mazumder, Prathiba Pandey, Smriti Arora, Amandeep Singh, Navneet Khurana, Patrick Amoateng, Yogendra Pal, Vetriselvan Subramaniyan, Ling Shing Wong, Gaurav Gupta, Mohamed M. Abdel-Daim, Jon Adams, Kamal Dua Phytochemistry Reviews, 2026
Steroidal derivatives in the management of diabetes mellitus Natural Therapeutics for Diabetes Mellitus Medicinal Plants Phytochemicals and Bioactive Compounds, 2025
The medicinal chemistry of piperazines: A review Md Faizan, Rajnish Kumar, Avijit Mazumder, Salahuddin, Neelima Kukreti, Arvind Kumar, M. V. N. L. Chaitanya Chemical Biology and Drug Design, 2024
Steroidal derivatives in the management of diabetes mellitus Naturally Occurring Chemicals for the Treatment and Management of Diabetes Mellitus and Related Disorders, 2024
Synthesis, Anticonvulsant, and Molecular Docking Studies of 2-(2-Benzyl-1Hbenzo[ d]imidazol-1-yl)-1-(3,5-disubstituted phenyl)-4,5-dihydro-1H-pyrazol-1-yl) ethan-1-ones Indian Journal of Heterocyclic Chemistry, 2022
Isolation of Quercetin from Pomegranate Peel, its Conversion to 3-O-Octylquercetin, and their In-silico Analysis Indian Journal of Heterocyclic Chemistry, 2022
Synthesis and Pharmacological Evaluation of Some New (1H-Benzimidazol-2-yl)-substituted Methyl-1-(6-substituted-2-chloroquinolin-3-yl)Methanimines Indian Journal of Heterocyclic Chemistry, 2022
Design, Synthesis, In Vivo, and In Silico Studies of New Hydrazone Derivatives Bearing Benzothiazole Moiety as Antiepileptic Agents Indian Journal of Heterocyclic Chemistry, 2022
NOVEL APPROACHES IN OCULAR DRUG DELIVERY-A REVOLUTION AYUSHI KAUSHIK, RUPA MAZUMDER, SWARUPANJALI PADHI, AVIJIT MAZUMDER, RAJAT BUDHORI, MANORMA, SWARNALI DAS PAUL International Journal of Applied Pharmaceutics, 2022
Association between Glycemic Control and Drug Therapy Concordance in Individuals with Type 2 Diabetes Mellitus: A Cross-sectional Study Journal of Association of Physicians of India, 2022
Synthesis, Characterization, and Antidiabetic Evaluation of Substituted 5-(2-Chloro-Quinolin-3-Ylmethylene)-Thiazolidine-2,4-Dione Indian Journal of Heterocyclic Chemistry, 2021
Antidiabetic and antihyperlipidemic potential of abelmoschus esculentus against streptozotocin-induced diabetes: Biochemical and histopathological observation Latin American Journal of Pharmacy, 2021
Synthesis, antimicrobial, and molecular docking studies of 1,3-Thiazolidin-4-one analogs bearing benzothiazole Indian Journal of Heterocyclic Chemistry, 2020
Effectiveness of pregabalin compared to duloxetine in diabetic peripheral neuropathic pain: An observational study Journal of Association of Physicians of India, 2019
Synthesis and anticonvulsant activity of a combined pharmacophore of 2-oxo-1,2-dihydroquinoline containing 1,3,4-oxadiazole derivatives Indian Journal of Heterocyclic Chemistry, 2017
Pharmacognostical and antimicrobial studies of the stem of Tabernaemontana divaricata Linn International Journal of Pharmacy and Pharmaceutical Sciences, 2015
Protective effect of cedrus deodara and pinus roxburghii on experimentally induced gastric ulcers in rat International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Pharmacognostical evaluation and antibacterial activity of bark of Plumeria alba Linn. International Journal of Pharma and Bio Sciences, 2013
Evaluation of antidiabetic activity of methanolic leaf extract of Coriandrum sativum in alloxan induced diabetic rats Research Journal of Pharmaceutical Biological and Chemical Sciences, 2013
Wound healing potentiality of methanolic extract of Aerial Parts of Cleome viscose International Journal of Pharmtech Research, 2013
Evaluation of wound healing potentiality of methanolic extract of Wedelia chinensis whole plant Research Journal of Pharmaceutical Biological and Chemical Sciences, 2013
Lagerstroemia species: A current review International Journal of Pharmtech Research, 2013
Wedelia chinensis (Asteraceae)-an overview of a potent medicinal herb International Journal of Pharmtech Research, 2013
Synthesis and biological activity of hydrazide, thiocarbamate, thiadiazoleand oxadiazole of (E)-2-undecen-1,11-dioic acid obtained from aleuritic acid of shellac Journal of the Indian Chemical Society, 2013
Comparative antibacterial and antifungal activity of the methanolic extract of leaves of Plumeria alba Linn. (Apocynaceae) International Journal of Pharmacy and Pharmaceutical Sciences, 2011
Studies of the antifungal and antiviral activity of methanolic extract of leaves of Grewia asiatica Pharmacognosy Journal, 2009
Targeted drug identification and susceptibility testing of typical mycobacterium tuberculosis directly from versa trek mycobottles with trouble shooting approach of extracts & isolates from Wrightia tomentosa Pharmacologyonline, 2008
Stimuli responsive hydrogels as floating drug delivery system Pharma Times, 2008
Evaluation of anti-tubercular activity directly from Versa TREK myco bottles using Wrightia tomentosa alcoholic extracts Pharmacologyonline, 2008
In vitro antioxidant activity of alcoholic extracts of Wrightia tomentosa Pharmacologyonline, 2008
Antihyperlipidemic activity of Camellia sinensis leaves in Triton WR-1339 induced albino rats Pharmacognosy Magazine, 2008
Chemical composition and antimicrobial activity of the flower essential oil of Solanecio gigas (Vatke) C. Jeffrey International Journal of Essential Oil Therapeutics, 2007
Composition, antimicrobial and free-radical scavenging properties of the essential oil of Damakese (Ocimum lamiifolium): A popular home remedy in Ethiopia International Journal of Essential Oil Therapeutics, 2007
Comparative anti-allodynic effects and toxicity studies for the herbal Wrightia tomentosa leaf & bark in swiss albino mice Pharmacologyonline, 2007
