Vinicius Mendes Vidal

@ufrj.br

Laboratorio Multidisciplinar de Pesquisa, Faculdade de Medicina, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro
Universidade Federal do Rio de Janeiro

Vinicius Mendes Vidal


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https://researchid.co/viniciusmendesvidal

RESEARCH, TEACHING, or OTHER INTERESTS

Immunology
6

Scopus Publications

Scopus Publications

  • The different meanings of tolerating the gut microbiome
    Vinicius Mendes Vidal, Elena Montes-Cobos, Fábio B. Canto, Marcelo Torres Bozza
    Mbio, 2026
    Multicellular life arose in a world dominated by microorganisms, a reality that has imposed a constant and pervasive selective pressure on all subsequent complex organisms. The immune system has been historically defined by its role in pathogen clearance through resistance mechanisms. However, a complementary and equally critical strategy is to enable the peaceful and inevitable coexistence with microorganisms, allowing each host species to shelter a unique associated microbiome. The term tolerance holds multiple meanings in immunology, yet all underlie a balanced and cooperative host-microorganism relationship. Each represents a different aspect of how the immune system limits tissue damage while maintaining functionality in the presence of microbial or inflammatory stimuli. Using the intestinal mucosa as a paradigm, we explore how epithelial barrier integrity, toxin neutralization, tissue repair, and stress response underpin disease tolerance; how microbial exposure calibrates innate immunity via epigenetic and metabolic reprogramming (LPS tolerance); and how the gut microenvironment fosters the generation of tolerogenic antigen-presenting cells and microbe-specific regulatory T cells to enforce immunological tolerance. We further explore how the microbiota itself is a potent inducer of these tolerogenic pathways and highlight IL-10 as a major hub, connecting different tolerogenic circuits. Finally, we examine the hygiene hypothesis, arguing that lifestyle changes during the Anthropocene disrupt these finely tuned tolerance mechanisms, thereby contributing to the rising incidence of immune-mediated diseases. We posit that these tolerance programs are fundamental prerequisites for engendering host-microbiota symbiosis, a relationship forged over millennia of co-evolution and endangered in the contemporary world.
  • A global survey of taxa-metabolic associations across mouse microbiome communities
    Bahtiyar Yilmaz, Isabel Baertschi, Karin H.U. Meier, Constance Le Gac, Sebastian B.U. Jordi, et al.
    Cell Host and Microbe, 2025
  • Bactericidal and anti-inflammatory effects of Moquilea tomentosa Benth. flavonoid-rich leaf extract
    Mariana Freire Campos, Leopoldo Clemente Baratto, Vinícius Mendes Vidal, Ivana Ventura Nascimento, Brendo Araujo Gomes, et al.
    BMC Complementary Medicine and Therapies, 2023
    Background Natural products are an important source of bioproducts with pharmacological properties. Here we investigate the components of leaves from M. tomentosa Benth. (Fritsch) (Chrysobalanaceae) and its effects on bacterial cell growth, biofilm production and macrophage activity. Methods The effect of the different leaf extracts against bacterial cell growth was performed using the microdilution method. The most active extract was analyzed by mass spectrometry, and its effect on bacterial biofilm production was evaluated on polystyrene plates. The extract effect on macrophage activity was tested in the RAW264.7 cell line, which was stimulated with different concentrations of the extract in the presence or absence of LPS. Results We show that the ethyl acetate (EtOAc) extract was the most effective against bacterial cell growth. EtOAc extract DI-ESI (-)MSn analysis showed the presence of a glycosylated flavonoid tentatively assigned as myricetin 3-O-xylosyl-rhamnoside (MW 596). Also, the EtOAc extract increased biofilm formation by S. aureus and inhibited cytokine and NO production induced by LPS in RAW macrophages. Conclusion M. tomentosa flavonoid-enriched EtOAc extract presented a bactericidal and anti-inflammatory pharmacological potential.
  • Oligosymptomatic long-term carriers of SARS-CoV-2 display impaired innate resistance but increased high-affinity anti-spike antibodies
    Elena Montes-Cobos, Victoria C. Bastos, Clarice Monteiro, João C.R. de Freitas, Heiny D.P. Fernandes, et al.
    Iscience, 2023
  • MIF is essential to the establishment of house dust mite-induced airway inflammation and tissue remodeling in mice
    Leticia Lintomen, Luciana M. Kluppel, Jamil Z. Kitoko, Elena Montes‐Cobos, Vinícius M. Vidal, et al.
    European Journal of Immunology, 2023
    Macrophage migration inhibitory factor (MIF) is present in high amounts in the BALF and serum of asthmatic patients, contributing to the pathogenesis of experimental asthma induced by OVA in mice. Whether MIF contributes to the physiopathology on a more complex and relevant asthma model has not been characterized. Mif‐deficient (Mif−/−) or WT mice treated with anti‐MIF antibody were challenged multiple times using house dust mite (HDM) extract by the intranasal route. HDM‐challenged Mif−/− mice presented decreased airway hyperresponsiveness, lung infiltration of eosinophils, mucus hypersecretion, and subepithelial fibrosis compared to HDM‐challenged WT mice. Amounts of IL‐4, IL‐5, and IL‐13 were decreased in the lungs of Mif−/− mice upon HDM challenges, but the increase of CCL11 was preserved, compared to HDM‐challenged WT mice. We also observed increased numbers of group 2 innate lymphoid cells and Th2 cells in the BALF and mediastinal LNs (mLN)‐induced challenged by HDM of WT mice, but not in HDM‐challenged Mif−/− mice. Anti‐MIF treatment abrogated the airway infiltration of eosinophils, mucus hypersecretion, and subepithelial fibrosis in the lungs of HDM‐challenged mice. In conclusion, MIF ablation prevents the pathologic hallmarks of asthma in HDM‐challenged mice, reinforcing the promising target of MIF for asthma therapy.
  • The re-emergency and persistence of vaccine preventable diseases
    RODRIGO C.N. BORBA, VINÍCIUS M. VIDAL, LILIAN O. MOREIRA
    Anais Da Academia Brasileira De Ciencias, 2015
    The introduction of vaccination worldwide dramatically reduced the incidence of pathogenic bacterial and viral diseases. Despite the highly successful vaccination strategies, the number of cases among vaccine preventable diseases has increased in the last decade and several of those diseases are still endemic in different countries. Here we discuss some epidemiological aspects and possible arguments that may explain why ancient diseases such as, measles, polio, pertussis, diphtheria and tuberculosis are still with us.