Gisela Tunes da Silva

@ime.usp.br

Associate professor/ Statistics department/ University of São Paulo
Universidade de São Paulo

Gisela Tunes da Silva


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https://researchid.co/giselatunes

RESEARCH, TEACHING, or OTHER INTERESTS

Statistics and Probability, Statistics and Probability
20

Scopus Publications

1070

Scholar Citations

12

Scholar h-index

13

Scholar i10-index

Scopus Publications

  • Physical Activity and Survival After an Acute Coronary Syndrome: Data From the ERICO Study
    Carlos Alberto Treff, Gisela Tunes da Silva, Alessandra Carvalho Goulart, Alexandre Costa Pereira, Paulo Andrade Lotufo, Isabela Martins Bensenor, Itamar de Souza Santos
    Journal of Physical Activity and Health, 2025
    Background: Due to enhancements in health care, the number of individuals who survive an acute coronary syndrome (ACS) event is rising. In this population, the impact of physical activity on long-term survival is still a matter of debate. We aimed to analyze the association between the level of physical activity during the first 4 years of follow-up and survival. Methods: We analyzed data from 692 patients admitted due to an ACS event in a community hospital in Brazil. Physical activity was assessed using the long version of the International Physical Activity Questionnaire at 30 days, 180 days, and yearly after the first event. Mortality data were obtained using phone contacts, medical records, and official death documents. We built time-dependent Cox proportional hazard models to analyze whether physical activity levels during follow-up were associated with survival. Results: Our main sample had 280 (40.5%) women and a mean age of 62.6 (12.5) years. In all assessments, 50.8% to 74.9% of study participants had physical activity levels below recommendations for healthy individuals. Physical inactivity increased the risk of death (hazard ratio [HR], 1.82; 95% confidence interval, 1.13–2.92). There was no statistically significant survival difference between insufficiently active and active participants. Conclusions: Many individuals who survive an ACS event have poor physical activity levels. Physical inactivity after an ACS event significantly increases the risk of death. Our findings provide additional support to reinforce, in clinical practice, the benefits of physical activity in individuals who survive an ACS event.
  • The utility of an artificial intelligence model based on decision tree and evolution algorithm to evaluate steatotic liver disease in a primary care setting
    A.C. Goulart, A.P. Alencar, G. Tunes, L.L.T. Bianchi, M.H. Miname, C.M. Padilha, J.M.S. Pescuma, A.L.C.C. Rodrigues, B.B. Henares, M.S. de Almeida, T.A.O. Machado, D.H. Syllos, Y.P. Wang, M. Rienzo
    Brazilian Journal of Medical and Biological Research, 2025
    Many ways of classifying steatotic liver disease (SLD) with metabolic conditions have been proposed. Thus, SLD-related variables were verified using a decision tree. We tested if the suggested components of the actual classification (metabolic dysfunction-associated steatotic liver disease, MASLD) are also present in young and middle-aged adults. In a cross-sectional study involving 6,839 adults (median age: 46 years, 69.5% men) in a primary care setting, a decision tree was created to determine potential clinical and laboratory variables related to SLD. The odds ratio (OR) with a respective 95% confidence interval (95%CI) was calculated for both sexes. SLD frequency was 26.6% (23% in men). More variables and with higher ORs for the association with SLD were identified in women: category 1 (body mass index (BMI) ≥29 kg/m2, age <51 years, high-sensitivity C-reactive protein (hs-CRP) ≥0.195 mg/dL): OR=10.9, 95%CI: 4.40-26.6; category 2 (BMI <9 kg/m2, metabolic syndrome (MS), age ≥50 years, neck circumference (NC) ≥36 cm): OR=8.1, 95%CI: 2.2-29.9; and category 3 (BMI ≥29 kg/m2, age <51 y-old, dyslipidemia, high-density lipoprotein cholesterol (HDL-c) <42 mg/dL): OR=4.7, 95%CI: 2.20-10.7. For men: category 1 (waist circumference (WC) ≥101 cm, alanine aminotransferase (ALT) <28 mg/dL, glycated hemoglobin (HbA1c) ≥5.7%): OR=4.7, 95%CI: 2.8-7.9; and category 2 (WC ≥101 cm, ALT ≥28 mg/dL): OR=3.2, 95%CI: 2.5-4.0). The decision tree identified more variables related to SLD, particularly in women, such as age of more than 50 years, elevated hs-CRP, and NC≥36 cm than variables related to MASLD.
  • Bayesian mixed model for survival data with semicompeting risks based on the Clayton copula
    Elizabeth González Patiño, Gisela Tunes, Nelson Ithiro Tanaka
    Brazilian Journal of Probability and Statistics, 2024
    Motivated by a chronic kidney disease dataset, we propose a Bayesian model for clustered semicompeting risks data based on Archimedean copulas, allowing for treatment switching. We consider the modeling of both independent and clustered observations. For clustered data, random effects are included to consider the dependence among observations in the same group. For the Clayton copula, we provide theoretical results for the posterior distribution when improper priors are used. A simulation study was conducted to evaluate the performance of the proposed model. Finally, the results of the analysis of chronic kidney disease data are discussed.
  • Predictive value of functional disability scales among stroke survivors: A long-term mortality evaluation in a Brazilian stroke cohort
    Ana Cristina G de Goes, Karla A S Souza, Gisela Tunes, Airlane P Alencar, Ana C. Varella, Tiffany E Gooden, Neil G Thomas, Gregoy YH Lip, Itamar S Santos, Paulo A Lotufo, Isabela M Benseñor, Alessandra C Goulart
    Journal of Stroke and Cerebrovascular Diseases, 2024
  • Long-term survival, quality of life, and quality-adjusted survival in critically ill patients with cancer
    Karina Normilio-Silva, Adelaide Cristina de Figueiredo, Antonio Carlos Pedroso-de-Lima, Gisela Tunes-da-Silva, Adriana Nunes da Silva, Andresa Delgado Dias Levites, Ana Tereza de-Simone, Patrícia Lopes Safra, Roberta Zancani, Paula Camilla Tonini, Ulysses Vasconcelos de Andrade e Silva, Thiago Buosi Silva, Juliana Martins Giorgi, José Eluf-Neto, Anderson Costa, Ludhmila Abrahão Hajjar, Alexandre Biasi Cavalcanti
    Critical Care Medicine, 2016
    Objectives: To assess the long-term survival, health-related quality of life, and quality-adjusted life years of cancer patients admitted to ICUs. Design: Prospective cohort. Setting: Two cancer specialized ICUs in Brazil. Patients: A total of 792 participants. Interventions: None. Measurements and Main Results: The health-related quality of life before ICU admission; at 15 days; and at 3, 6, 12, and 18 months was assessed with the EQ-5D-3L. In addition, the vital status was assessed at 24 months. The mean age of the subjects was 61.6 ± 14.3 years, 42.5% were female subjects and half were admitted after elective surgery. The mean Simplified Acute Physiology Score 3 was 47.4 ± 15.6. Survival at 12 and 18 months was 42.4% and 38.1%, respectively. The mean EQ-5D-3L utility measure before admission to the ICU was 0.47 ± 0.43, at 15 days it was 0.41 ± 0.44, at 90 days 0.56 ± 0.42, at 6 months 0.60 ± 0.41, at 12 months 0.67 ± 0.35, and at 18 months 0.67 ± 0.35. The probabilities for attaining 12 and 18 months of quality-adjusted survival were 30.1% and 19.1%, respectively. There were statistically significant differences in survival time and quality-adjusted life years according to all assessed baseline characteristics (ICU admission after elective surgery, emergency surgery, or medical admission; Simplified Acute Physiology Score 3; cancer extension; cancer status; previous surgery; previous chemotherapy; previous radiotherapy; performance status; and previous health-related quality of life). Only the previous health-related quality of life and performance status were associated with the health-related quality of life during the 18-month follow-up. Conclusions: Long-term survival, health-related quality of life, and quality-adjusted life year expectancy of cancer patients admitted to the ICU are limited. Nevertheless, these clinical outcomes exhibit wide variability among patients and are associated with simple characteristics present at the time of ICU admission, which may help healthcare professionals estimate patients’ prognoses.
  • A provenance model based on declarative specifications for intensive data analyses in hemotherapy information systems
    Fernanda Nascimento Almeida, Gisela Tunes, Julio Cezar Brettas da Costa, Ester Cerdeira Sabino, Alfredo Mendrone-Júnior, João Eduardo Ferreira
    Future Generation Computer Systems, 2016
  • A provenance model based on declarative specifications for intensive data analyses in hemotherapy information systems
    Fernanda Nascimento Almeida, Gisela Tunes, Ester Cerdeira Sabino, Alfredo Mendrone-Junior, Joao Eduardo Ferreira
    Proceedings 2014 IEEE 10th International Conference on Escience Escience 2014, 2014
    In the donation process, blood donors are screened for the level of hemoglobin or hematocrit in order to protect them from developing anemia. Nevertheless, there is no standard procedure to predict anemia development after blood donation. The São Paulo Blood Center is responsible for maintaining a database with information on each donation. However, this database doesn't have a good quality and consequently it is difficult to establish systematic analysis using the donation database without previous data validations. In order to provide a better quality of donation data, this paper presents a provenance description based on a classification criteria defined by specialists. More concretely, this paper answers the follow main question: is there a connection between blood donation and decrease in hematocrit level in order to prevent undesirable outcomes to blood donors? In this paper we show that it is possible to provide detailed investigations in order to answer this main question using the data description without the need to impose changes in the current database system structures that is sponsored by São Paulo Blood Center.
  • Predictors of low haematocrit among repeat donors in São Paulo, Brazil: Eleven year longitudinal analysis
    Fernanda N. Almeida, Ester C. Sabino, Gisela Tunes, George B. Schreiber, Pedro Paulo S.B. da Silva, Anna Barbara F. Carneiro-Proietti, João Eduardo Ferreira, Alfredo Mendrone-Junior
    Transfusion and Apheresis Science, 2013
  • High-sensitivity C-reactive protein levels and treadmill exercise test responses in men and women without overt heart disease
    Experimental and Clinical Cardiology, 2013
  • Effect of acute and chronic GVHD on relapse and survival after reduced-intensity conditioning allogeneic transplantation for myeloma
    O Ringdén, S Shrestha, G T da Silva, M-J Zhang, A Dispenzieri, M Remberger, R Kamble, C O Freytes, R P Gale, J Gibson, V Gupta, L Holmberg, H Lazarus, P McCarthy, K Meehan, H Schouten, G A Milone, S Lonial, P N Hari
    Bone Marrow Transplantation, 2012
  • Quality of Life Perspectives in Chronic Disease and Disorder Studies
    Gisela Tunes-da-Silva, Antonio Carlos Pedroso-de-Lima, Pranab Kumar Sen
    Handbook of Statistics, 2012
  • Cutpoint selection for discretizing a continuous covariate for generalized estimating equations
    Gisela Tunes-da-Silva, John P. Klein
    Computational Statistics and Data Analysis, 2011
  • Effect of age on outcome of reduced-intensity hematopoietic cell transplantation for older patients with acute myeloid leukemia in first complete remission or with myelodysplastic syndrome
    Brian L. McClune, Daniel J. Weisdorf, Tanya L. Pedersen, Gisela Tunes da Silva, Martin S. Tallman, Jorge Sierra, John DiPersio, Armand Keating, Robert P. Gale, Biju George, Vikas Gupta, Theresa Hahn, Luis Isola, Madan Jagasia, Hillard Lazarus, David Marks, Richard Maziarz, Edmund K. Waller, Chris Bredeson, Sergio Giralt
    Journal of Clinical Oncology, 2010
  • Influence of demographic and metabolic variables on forearm blood flow and vascular conductance in individuals without overt heart disease
    Vascular Health and Risk Management, 2010
  • A semi-markov multistate model for estimation of the mean quality-adjusted survival for non-progressive processes
    Gisela Tunes-da-Silva, Antonio C. Pedroso-de-Lima, Pranab K. Sen
    Lifetime Data Analysis, 2009
  • Regression analysis of mean quality-adjusted survival time based on pseudo-observations
    G. Tunes‐da‐Silva, J. P. Klein
    Statistics in Medicine, 2009
  • Methods for Equivalence and Noninferiority Testing
    Gisela Tunes da Silva, Brent R. Logan, John P. Klein
    Biology of Blood and Marrow Transplantation, 2009
  • Estimation of the mean quality-adjusted survival using a multistate model for the sojourn times
    Gisela Tunes-da-Silva, Pranab K. Sen, Antonio Carlos Pedroso-de-Lima
    Journal of Statistical Planning and Inference, 2008
  • Direct regression models for survival parameters based on pseudo-values
    JOHN P. KLEIN, GISELA TUNES-DA-SILVA
    Frontiers of Applied and Computational Mathematics New Jersey Institute of Technology Usa 19 21 May 2008, 2008
  • Left ventricular mass in patients with heart failure.
    Arquivos Brasileiros De Cardiologia, 2004

RECENT SCHOLAR PUBLICATIONS

  • Physical Activity and Survival After an Acute Coronary Syndrome: Data From the ERICO Study
    SIS Treff CA, Tunes da Silva G, Goulart AC, Pereira AC, Lotufo PA, Bensenor IM
    J Phys Act Health 13, 1-7 , 2025
    2025
    Citations: 1
  • The impact of atrial fibrillation and long-term oral anticoagulant use on all-cause and cardiovascular mortality: A 12-year evaluation of the prospective Brazilian Study of …
    AC Goulart, RD Olmos, IS Santos, G Tunes, AP Alencar, N Thomas, ...
    International Journal of Stroke, 1747493021995592 , 2021
    2021
    Citations: 34
  • Machine learning to predict 30-day quality-adjusted survival in critically ill patients with cancer
    HG dos Santos, FG Zampieri, K Normilio-Silva, GT da Silva, ACP de Lima, ...
    Journal of critical care , 2019
    2019
    Citations: 24
  • Modeling Data With Semicompeting Risks: An Application to Chronic Kidney Disease in Colombia.
    E GONZÁLEZ PATIÑO, G Tunes, MI Munera
    Colombian Journal of Statistics/Revista Colombiana de Estadística 42 (1) , 2019
    2019
  • Premature atrial and ventricular complexes in outpatients referred from a primary care facility
    WN Ribeiro, AT Yamada, CJ Grupi, GT da Silva, AJ Mansur
    PloS one 13 (9), e0204246 , 2018
    2018
    Citations: 16
  • The influence of cell concentration at cryopreservation on neutrophil engraftment after autologous peripheral blood stem cell transplantation
    OMWO Félix, G Tunes, VC Ginani, PC Simões, DP Barros, E Delbuono, ...
    Hematology, transfusion and cell therapy 40, 233-239 , 2018
    2018
    Citations: 26
  • Hematology, TransfusionandCellTherapy
    OMW de Oliveira Félix, G Tunes, VC Ginani, PC Simões, DP Barros, ...
    2018
  • Long-term survival, quality of life, and quality-adjusted survival in critically ill patients with cancer
    K Normilio-Silva, AC de Figueiredo, AC Pedroso-de-Lima, ...
    Critical care medicine 44 (7), 1327-1337 , 2016
    2016
    Citations: 63
  • Non-alcoholic fatty liver disease (NAFLD) and low bone mineral density among obese and sedentary adolescents in Sao Paulo city: T3: S17: 33
    MB Fernandes, G Tunes, UF Neto
    Obesity Reviews 17, 44-45 , 2016
    2016
  • A Provenance Model Based on Declarative Specifications for Intensive Data Analyses in Hemotherapy Information Systems
    F Nascimento Almeida, G Tunes, E Cerdeira Sabino, A Mendrone-Junior, ...
    e-Science (e-Science), 2014 IEEE 10th International Conference on 1, 92-99 , 2014
    2014
    Citations: 4
  • Predictors of low haematocrit among repeat donors in São Paulo, Brazil: Eleven year longitudinal analysis
    FN Almeida, EC Sabino, G Tunes, GB Schreiber, PPSB da Silva, ...
    Transfusion and Apheresis Science 49 (3), 553-559 , 2013
    2013
    Citations: 12
  • High-sensitivity C-reactive protein levels and treadmill exercise test responses in men and women without overt heart disease
    RAB Nunes, F Araujo, GF Correia, GT da Silva, AJ Mansur
    Experimental & Clinical Cardiology 18 (2), 124 , 2013
    2013
    Citations: 13
  • Effect of acute and chronic GVHD on relapse and survival after reduced-intensity conditioning allogeneic transplantation for myeloma
    O Ringdén, S Shrestha, GT Da Silva, MJ Zhang, A Dispenzieri, ...
    Bone marrow transplantation 47 (6), 831-837 , 2012
    2012
    Citations: 46
  • Quality of Life Perspectives in Chronic Disease and Disorder Studies
    G Tunes-da-Silva, AC Pedroso-de-Lima, PK Sen
    Handbook of Statistics 28, 401-431 , 2012
    2012
  • Cutpoint selection for discretizing a continuous covariate for generalized estimating equations
    G Tunes-da-Silva, JP Klein
    Computational Statistics & Data Analysis 55 (1), 226-235 , 2011
    2011
    Citations: 35
  • Effect of age on outcome of reduced-intensity hematopoietic cell transplantation for older patients with acute myeloid leukemia in first complete remission or with …
    BL McClune, DJ Weisdorf, TL Pedersen, GT da Silva, MS Tallman, ...
    Journal of Clinical Oncology 28 (11), 1878-1887 , 2010
    2010
    Citations: 584
  • A semi-Markov multistate model for estimation of the mean quality-adjusted survival for non-progressive processes
    G Tunes-da-Silva, AC Pedroso-de-Lima, PK Sen
    Lifetime data analysis 15 (2), 216-240 , 2009
    2009
    Citations: 7
  • Regression analysis of mean quality‐adjusted survival time based on pseudo‐observations
    G Tunes‐da‐Silva, JP Klein
    Statistics in medicine 28 (7), 1054-1066 , 2009
    2009
    Citations: 9
  • Survival Following Allogeneic Stem Cell Transplantation for Congenital Immunodeficiency and Metabolic Disorders
    ME Horwitz, GT da Silva, M Eapen, EM Horwitz
    Biology of Blood and Marrow Transplantation 15 (2), 78 , 2009
    2009
    Citations: 1
  • Methods for equivalence and noninferiority testing
    GT da Silva, BR Logan, JP Klein
    Biology of Blood and Marrow Transplantation 15 (1), 120-127 , 2009
    2009
    Citations: 150

MOST CITED SCHOLAR PUBLICATIONS

  • Effect of age on outcome of reduced-intensity hematopoietic cell transplantation for older patients with acute myeloid leukemia in first complete remission or with …
    BL McClune, DJ Weisdorf, TL Pedersen, GT da Silva, MS Tallman, ...
    Journal of Clinical Oncology 28 (11), 1878-1887 , 2010
    2010
    Citations: 584
  • Methods for equivalence and noninferiority testing
    GT da Silva, BR Logan, JP Klein
    Biology of Blood and Marrow Transplantation 15 (1), 120-127 , 2009
    2009
    Citations: 150
  • Long-term survival, quality of life, and quality-adjusted survival in critically ill patients with cancer
    K Normilio-Silva, AC de Figueiredo, AC Pedroso-de-Lima, ...
    Critical care medicine 44 (7), 1327-1337 , 2016
    2016
    Citations: 63
  • Effect of acute and chronic GVHD on relapse and survival after reduced-intensity conditioning allogeneic transplantation for myeloma
    O Ringdén, S Shrestha, GT Da Silva, MJ Zhang, A Dispenzieri, ...
    Bone marrow transplantation 47 (6), 831-837 , 2012
    2012
    Citations: 46
  • Cutpoint selection for discretizing a continuous covariate for generalized estimating equations
    G Tunes-da-Silva, JP Klein
    Computational Statistics & Data Analysis 55 (1), 226-235 , 2011
    2011
    Citations: 35
  • The impact of atrial fibrillation and long-term oral anticoagulant use on all-cause and cardiovascular mortality: A 12-year evaluation of the prospective Brazilian Study of …
    AC Goulart, RD Olmos, IS Santos, G Tunes, AP Alencar, N Thomas, ...
    International Journal of Stroke, 1747493021995592 , 2021
    2021
    Citations: 34
  • Non-myeloablative hematopoietic stem cell transplantation in older patients with AML and MDS: results from the Center for International Blood and Marrow Transplant Research …
    B McClune, DJ Weisdorf, JF DiPersio, A Keating, TL Pedersen, ...
    Blood 112 (11), 346-346 , 2008
    2008
    Citations: 27
  • The influence of cell concentration at cryopreservation on neutrophil engraftment after autologous peripheral blood stem cell transplantation
    OMWO Félix, G Tunes, VC Ginani, PC Simões, DP Barros, E Delbuono, ...
    Hematology, transfusion and cell therapy 40, 233-239 , 2018
    2018
    Citations: 26
  • Machine learning to predict 30-day quality-adjusted survival in critically ill patients with cancer
    HG dos Santos, FG Zampieri, K Normilio-Silva, GT da Silva, ACP de Lima, ...
    Journal of critical care , 2019
    2019
    Citations: 24
  • Premature atrial and ventricular complexes in outpatients referred from a primary care facility
    WN Ribeiro, AT Yamada, CJ Grupi, GT da Silva, AJ Mansur
    PloS one 13 (9), e0204246 , 2018
    2018
    Citations: 16
  • High-sensitivity C-reactive protein levels and treadmill exercise test responses in men and women without overt heart disease
    RAB Nunes, F Araujo, GF Correia, GT da Silva, AJ Mansur
    Experimental & Clinical Cardiology 18 (2), 124 , 2013
    2013
    Citations: 13
  • Predictors of low haematocrit among repeat donors in São Paulo, Brazil: Eleven year longitudinal analysis
    FN Almeida, EC Sabino, G Tunes, GB Schreiber, PPSB da Silva, ...
    Transfusion and Apheresis Science 49 (3), 553-559 , 2013
    2013
    Citations: 12
  • Left ventricular mass in patients with heart failure
    MRP Markus, HFG Freitas, PR Chizzola, GT Silva, ACP Lima, AJ Mansur
    Arquivos brasileiros de cardiologia 83 (3), 227-231 , 2004
    2004
    Citations: 11
  • Regression analysis of mean quality‐adjusted survival time based on pseudo‐observations
    G Tunes‐da‐Silva, JP Klein
    Statistics in medicine 28 (7), 1054-1066 , 2009
    2009
    Citations: 9
  • A semi-Markov multistate model for estimation of the mean quality-adjusted survival for non-progressive processes
    G Tunes-da-Silva, AC Pedroso-de-Lima, PK Sen
    Lifetime data analysis 15 (2), 216-240 , 2009
    2009
    Citations: 7
  • A Provenance Model Based on Declarative Specifications for Intensive Data Analyses in Hemotherapy Information Systems
    F Nascimento Almeida, G Tunes, E Cerdeira Sabino, A Mendrone-Junior, ...
    e-Science (e-Science), 2014 IEEE 10th International Conference on 1, 92-99 , 2014
    2014
    Citations: 4
  • Estimation of the mean quality-adjusted survival using a multistate model for the sojourn times
    G Tunes-da-Silva, PK Sen, AC Pedroso-de-Lima
    Journal of Statistical Planning and Inference 138 (8), 2267-2282 , 2008
    2008
    Citations: 3
  • Similar 5-year survival after peripheral blood autotransplants (AutoPB) versus HLA matched sibling myeloablative transplants (AlloBMT) for acute myeloid leukemia (AML) in first …
    A Keating, M Kukreja, GT da Silva, V Gupta, C Cutler, MS Tallman, ...
    ASH Annual Meeting Abstracts 112 (11) , 2008
    2008
    Citations: 2
  • Using SAS software for Multilevel Models in Survival Analysis
    GT Da Silva, ACP de Lima
    PharmaSUG SAS Users Group Conference, Miami, Florida , 2003
    2003
    Citations: 2
  • Physical Activity and Survival After an Acute Coronary Syndrome: Data From the ERICO Study
    SIS Treff CA, Tunes da Silva G, Goulart AC, Pereira AC, Lotufo PA, Bensenor IM
    J Phys Act Health 13, 1-7 , 2025
    2025
    Citations: 1