Clelia Akiko Hiruma-Lima

@.unesp.br

Department of General and Applied Biology
Universidade Estadual Paulista Julio de Mesquita Filho

Clelia Akiko Hiruma-Lima


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https://researchid.co/clelia.hiruma
Clelia Akiko Hiruma-Lima is a full professor at the Department of Structural and Functional Biology (Physiology) at the Bioscience Institute of the São Paulo State University - UNESP (Botucatu, São Paulo, Brazil). Her work has been mainly focused on understanding the action of natural products (flavonoids and essential oil) in the treatment of gastrointestinal diseases (gastroesophageal reflux, peptic ulcers, intestinal inflammation and obesity). The morphofunctional, biochemical, and molecular aspects of gastrointestinal disorders are analyzed in rodents (mice and rats). The focus of the studies also involves the ethnopharmacological evaluation of Brazilian medicinal plants and all their therapeutic potential.

EDUCATION

Clelia Akiko Hiruma-Lima is a biologist from the State University of São Paulo (UNESP), holds a Master's degree in Pharmacology and Chemistry of Natural Products from UFPB, and a PhD in Physiology from Unicamp.

RESEARCH, TEACHING, or OTHER INTERESTS

Drug Discovery, Physiology, Structural Biology, Pharmacology (medical)
134

Scopus Publications

9152

Scholar Citations

56

Scholar h-index

126

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Citral exerts a more pronounced antinociceptive effect in obese adult male C57BL/6J mice mediated through the CB2 receptor
    FL Dario, MLA Aquino, MT Emílio-Silva, FL Fagundes, LVF de Oliveira, ...
    European Journal of Pharmacology, 178894 , 2026
    2026
  • Citral impairs intestinal changes caused by ulcerative colitis through modulation of antioxidant, anti-inflammatory and healing activities
    MT Emílio-Silva, VP Rodrigues, AJ Ruiz-Malagon, IG Guidolin, FL Dario, ...
    Inflammopharmacology 34 (1), 655-669 , 2026
    2026
  • Myrcene suppressed fever by downregulating systemic TNF-α levels in acute LPS-induced systemic inflammation in rats
    MT Emilio-Silva, VP Rodrigues, MM Fioravanti, LGS Branco, ...
    Advances in Traditional Medicine, 1-10 , 2025
    2025
  • The Anthocyanidins Malvidin and Cyanidin Alleviate Irinotecan-Triggered Intestinal Mucositis by Modulating Oxidative Stress and Cytokine Release
    GF Machado, QC Pereira, FL Fagundes, MT Emílio-Silva, VP Rodrigues, ...
    International Journal of Molecular Sciences 26 (21), 10747 , 2025
    2025
    Citations: 1
  • Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation
    MT Emílio-Silva, VP Rodrigues, MM Fioravanti, AJ Ruiz-Malagon, ...
    Frontiers in Pharmacology 16, 1567217 , 2025
    2025
    Citations: 7
  • A high-fat diet changes the interaction of the extracellular matrix, cytokines, and growth factors in gastric ulcer repair
    R Ohara, FL Dario, MT Emílio-Silva, R Assunção, VP Rodrigues, G Bueno, ...
    Biochemical and Biophysical Research Communications 755, 151565 , 2025
    2025
    Citations: 1
  • Melatonin enhances cell death and suppresses the metastatic capacity of ovarian cancer cells by attenuating the signaling of multiple kinases
    MS Cucielo, PP Freire, MT Emílio-Silva, GG Romagnoli, RF Carvalho, ...
    Pathology-Research and Practice 248, 154637 , 2023
    2023
    Citations: 24
  • Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats
    BM Santos, WS Santos, IG Solon, FS Garcia, MT Emilio-Silva, AA Jesus, ...
    Archives of Oral Biology 152, 105734 , 2023
    2023
    Citations: 9
  • Citral modulates MMP-2 and MMP-9 activities on healing of gastric ulcers associated with high-fat diet-induced obesity
    R Ohara, FL Dario, MT Emílio-Silva, R Assunção, VP Rodrigues, G Bueno, ...
    International Journal of Molecular Sciences 24 (5), 4888 , 2023
    2023
    Citations: 21
  • Role of the antioxidant pathway in the healing of peptic ulcers induced by ischemia–reperfusion in male and female rats treated with Eugenia punicifolia
    L Lucena Périco, R de Cássia dos Santos, V Peixoto Rodrigues, ...
    Inflammopharmacology 30 (4), 1383-1394 , 2022
    2022
    Citations: 8
  • Effect of Baccharis trimera Less (DC) essential oil in obese mice on a high-fat diet, part 1. adipose tissues evaluation.
    G Bueno, VP Rodrigues, R Ohara, MTE Silva, R Assunção, V Gomes, ...
    MDPI , 2021
    2021
  • Antipyretic effect of myrcene (MCN) as a potential therapeutic alternative for the treatment of systemic inflammation response (SI) in euthermic rats model
    MT Emílio-Silva, ML Zarricueta, VP Rodrigues, PR Raimundo, ...
    MDPI , 2021
    2021
  • Citral, a valuable aid against metabolic inflammation?
    VP Rodrigues, MT Emílio-Silvaa, R Oharaa, G Buenoa, PR Raimundoa, ...
    MDPI , 2021
    2021
  • Is citrals anti-inflammatory action capable of changing the hypothalamic inflammation in obese mice?
    PR Raimundoa, VP Rodrigues, MT Emílio-Silvaa, G Buenoa, VG Gomesa, ...
    MDPI , 2021
    2021
    Citations: 1
  • Modulation of matrix metalloproteinases exerted by Citral in the healing of gastric ulcers in eutrophic and obese mice
    R Ohara, F Dario, G Bueno, V Rodrigues, M Silva, R Assunção, ...
    MDPI , 2021
    2021
  • Evaluation of protective effect of citral on gastroesophageal reflux disease in eutrophic and obese mice
    A Fioretto, R Ohara, MTE Silva, VP Rodrigues, G Bueno, R Assunçao, ...
    MDPI , 2021
    2021
  • Phytomedicinal study on Brazilian medicinal plants for their potential in chronic diseases treatment
    MJD Silva, LL Périco, MA da Silva, D Rinaldo, A Gambero, LC dos Santos, ...
    Phytochemicals in Food and Health, 151-196 , 2021
    2021
    Citations: 7
  • Genotoxicity induced by nerol, an essential oil present in citric plants using human peripheral blood mononuclear cells (PBMC) and HepG2/C3A cells as a model
    BO Silva, JB Orlando, CL Pires, CA Hiruma-Lima, ...
    Journal of Toxicology and Environmental Health, Part A 84 (12), 518-528 , 2021
    2021
    Citations: 17
  • The essential oil from Baccharis trimera (Less.) DC improves gastric ulcer healing in rats through modulation of VEGF and MMP-2 activity
    G Bueno, SLC Rico, LL Perico, R Ohara, VP Rodrigues, MT Emilio-Silva, ...
    Journal of ethnopharmacology 271, 113832 , 2021
    2021
    Citations: 29
  • Increased oxidative stress and cancer biomarkers in the ventral prostate of older rats submitted to maternal malnutrition
    LMF Portela, SAA Santos, FB Constantino, ACL Camargo, KT Colombelli, ...
    Molecular and cellular endocrinology 523, 111148 , 2021
    2021
    Citations: 28

MOST CITED SCHOLAR PUBLICATIONS

  • Flavonoids with gastroprotective activity
    KS de Lira Mota, GEN Dias, MEF Pinto, Â Luiz-Ferreira, ...
    Molecules 14 (3), 979-1012 , 2009
    2009
    Citations: 593
  • Plantas medicinais na Amazônia e na Mata Atlântica
    LC Di Stasi, CA Hiruma-Lima
    Editora Unesp , 2002
    2002
    Citations: 574
  • Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretion
    TM Moraes, H Kushima, FC Moleiro, RC Santos, LRM Rocha, ...
    Chemico-Biological Interactions 180 (3), 499-505 , 2009
    2009
    Citations: 276
  • Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts
    M Sannomiya, VB Fonseca, MA Da Silva, LRM Rocha, LC Dos Santos, ...
    Journal of Ethnopharmacology 97 (1), 1-6 , 2005
    2005
    Citations: 233
  • Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: Involvement of heat-shock protein-70, vasoactive …
    AL Rozza, T de Mello Moraes, H Kushima, A Tanimoto, MOM Marques, ...
    Chemico-biological interactions 189 (1-2), 82-89 , 2011
    2011
    Citations: 210
  • Evaluation of the analgesic and antiedematogenic activities of Quassia amara bark extract
    W Toma, JS Gracioso, CA Hiruma-Lima, FDP Andrade, W Vilegas, ...
    Journal of Ethnopharmacology 85 (1), 19-23 , 2003
    2003
    Citations: 207
  • The juice of fresh leaves of Boerhaavia diffusa L.(Nyctaginaceae) markedly reduces pain in mice
    CA Hiruma-Lima, JS Gracioso, EJB Bighetti, LG Robineou, ARMS Brito
    Journal of ethnopharmacology 71 (1-2), 267-274 , 2000
    2000
    Citations: 194
  • A review of the role of flavonoids in peptic ulcer (2010–2020)
    C Serafim, ME Araruna, EA Júnior, M Diniz, C Hiruma-Lima, L Batista
    Molecules 25 (22), 5431 , 2020
    2020
    Citations: 190
  • Plantas medicinais na Amazônia
    D Stasi
    Plantas medicinais na Amazônia, 194-194 , 1989
    1989
    Citations: 176
  • Antiulcerogenic activity of Alchornea castaneaefolia: effects on somatostatin, gastrin and prostaglandin
    CA Hiruma-Lima, TR Calvo, CM Rodrigues, FDP Andrade, W Vilegas, ...
    Journal of Ethnopharmacology 104 (1-2), 215-224 , 2006
    2006
    Citations: 173
  • The effect of a minor constituent of essential oil from Citrus aurantium: The role of β-myrcene in preventing peptic ulcer disease
    F Bonamin, TM Moraes, RC Dos Santos, H Kushima, FM Faria, MA Silva, ...
    Chemico-biological interactions 212, 11-19 , 2014
    2014
    Citations: 163
  • Medicinal plants popularly used in Brazilian Amazon.
    LC Stasi, CA Hiruma, EM Guimarães, CM Santos
    1994
    Citations: 140
  • Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves ( Mangifera indica L.)
    JA Severi, ZP Lima, H Kushima, AR Monteiro Souza Brito, ...
    Molecules 14 (3), 1098-1110 , 2009
    2009
    Citations: 137
  • Preliminary studies of Mammea americana L.(Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice
    W Toma, CA Hiruma-Lima, RO Guerrero, ARMS Brito
    Phytomedicine 12 (5), 345-350 , 2005
    2005
    Citations: 130
  • Hancornia speciosa: Indications of gastroprotective, healing and anti-Helicobacter pylori actions
    T de Mello Moraes, CM Rodrigues, H Kushima, TM Bauab, W Villegas, ...
    Journal of Ethnopharmacology 120 (2), 161-168 , 2008
    2008
    Citations: 127
  • Can the aqueous decoction of mango flowers be used as an antiulcer agent?
    ZP Lima, JA Severi, CH Pellizzon, A Brito, PN Solis, A Cáceres, LM Girón, ...
    Journal of Ethnopharmacology 106 (1), 29-37 , 2006
    2006
    Citations: 127
  • Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara
    ARMS Brito, JA Rodriguez, CA Hiruma-Lima, M Haun, DS Nunes
    Planta Medica 64 (02), 126-129 , 1998
    1998
    Citations: 118
  • Antimicrobial activity of some medicinal plants of the Cerrado, Brazil
    ES Costa, CA Hiruma‐Lima, EO Lima, GC Sucupira, AO Bertolin, SF Lolis, ...
    Phytotherapy Research: An International Journal Devoted to Pharmacological … , 2008
    2008
    Citations: 115
  • Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection
    MA Andreo, KVR Ballesteros, CA Hiruma-Lima, LRM da Rocha, ...
    Journal of Ethnopharmacology 107 (3), 431-441 , 2006
    2006
    Citations: 115
  • Anti-inflammatory and Antinociceptive Effects in Rodents of the Essential Oil of Croton cajucara Benth
    EJB Bighetti, CA Hiruma-Lima, JS Gracioso, ARMS Brito
    Journal of Pharmacy and Pharmacology 51 (12), 1447-1453 , 1999
    1999
    Citations: 109