Md Ikbal Husain

@ripsat.tripura.gov.in

Student (M.Pharm), Department of Pharmaceutics
Regional Institute of Pharmaceutical Science and Technology

Md Ikbal Husain


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https://researchid.co/ikbal_research-2025

RESEARCH, TEACHING, or OTHER INTERESTS

Multidisciplinary, Chemistry
1

Scopus Publications

11

Scholar Citations

2

Scholar h-index

Scopus Publications

  • Decoding breast cancer: insights into molecular pathways & therapeutic approaches
    Tanjima Tarique Laskar, Hasina Mehnaj Laskar, Jiaul Ahmed Mazumder, Rupajit Bhattacharjee, Md Ikbal Husain, Bandana Das, Panchami Das, Paromita Dutta Choudhury, Monica Arora, Sudarshana Borah, Debarupa Chakraborty, Prithviraj Chakraborty, Amlan Das
    Discover Oncology, 2025
    Breast cancer is a highly heterogeneous malignancy encompassing distinct molecular subtypes such as Luminal A & B, HER2 enriched and triple negative breast cancer, each characterized by unique genomic, transcriptomic and proteomic landscapes that dictate differential prognosis and therapeutic response. This review delineates the complex signalling pathways underlying breast cancer including estrogen receptor, progesterone receptor and HER2 pathways and their downstream effectors such as PI3K/AKT/mTOR, RAS/MAPK, Notch, Wnt/β-catenin and JAK/STAT cascades. The interconnectivity of these pathways not only governs tumor cell proliferation, survival and metastasis but also contributes to intrinsic and acquired resistance mechanisms against standard-of-care therapies including endocrine agents, HER2-targeted antibodies and chemotherapy. Emerging therapeutic strategies such as next-generation selective estrogen receptor degraders, proteolysis-targeting chimeras, antibody-drug conjugates, immune checkpoint inhibitors and pathway-specific small-molecule inhibitors highlights their mechanistic rationale, clinical evidence and biomarker-guided applicability. Resistance mechanisms involving ESR1 mutations, PTEN loss, p95HER2 expression, BRCA reversions and tumor microenvironment-mediated immunosuppression contributes to therapy resistance. The review explores molecular subtypes, oncogenic signalling pathways, treatment approaches, resistance mechanisms including acquired resistance & crosstalk, metabolic reprogramming, epigenetic modifications, immune modulations and tumor microenvironment, spatial transcriptomics insights into immune cell subsets & treatment response biomarkers and the role of artificial intelligence in breast cancer treatment. The integration of artificial intelligence-based predictive modelling and rational drug combinations offers a promising paradigm for overcoming resistance and tailoring precision oncology approaches. By comprehensively mapping these oncogenic factors and therapeutic intersections, this review provides a strategic framework for optimizing breast cancer management in the era of molecular medicine.

RECENT SCHOLAR PUBLICATIONS

  • Bilosomes as Novel Nanocarrier: A Review. Sch Acad J Pharm
    MI Husain, S Sarkar, D Nilimanka
    Scholars Academic Journal of Pharmacy 2, 32-41 , 2026
    2026.0
  • Machine Learning-Based Design of Lipid Nanoparticles for mRNA Delivery: A Review
    MDI HUSAIN, M JONGKEY, N CHAKMA, P DEBNATH, S ROUTH, ...
    2026.0
  • The First Step Into Death: Postulation on Identifying the Initial Irreversible Event That Ends Life
    MI Husain, B De
    Acta Scientific MEDICAL SCIENCES (ISSN: 2582-0931) 10 (1) , 2026
    2026.0
  • Decoding breast cancer: insights into molecular pathways & therapeutic approaches
    L Tanjima Tarique, Hasina ML, JA Mazumder, R Bhattacharjee, Md Ikbal Husain ...
    Discover Oncology 16 (1), 1-43 , 2025
    2025.0
    Citations: 9
  • Essential Oil-Based Microemulsions In Antimicrobial Applications: A Natural Approach
    ACMI Husain
    International Journal of Creative Research Thoughts 13 (11), 55-58 , 2025
    2025.0
  • Unveiling the Anticancer Potential of Curcuma Caesia Roxb. Against Ovarian Cancer: An Indigenous Plant of Assam
    K Barman, S Borah, B Das, TT Laskar, DD Chakraborty, P Chakraborty, ...
    Journal of Neonatal Surgery 14 (8s) , 2025
    2025.0
    Citations: 2
  • Targeting Breast Cancer Complexity: Molecular Signalling, Microenvironment and Next-Generation Therapeutic Strategies
    TT Laskar, M Arora, JA Mazumder, R Bhattacharjee, MI Husain, B Das, ...
    Studies in Science of Science| ISSN: 1003-2053 43 (8), 464-506 , 2025
    2025.0
  • SCREENING OF SEEDS AND LEAVES OF LEUCAENA LEUCOCEPHALA FOR TREATMENT OF DIABETES
    B De, K Choudhury, Y Sila, MI Husain, L Deb, MA Sharma, B Tiwari
    2025.0
  • Bioactive Metabolites: Unlocking Nature’s Therapeutic Potential through Advanced Extraction and Sustainable Innovation
    MIH Das, Jayita

MOST CITED SCHOLAR PUBLICATIONS

  • Decoding breast cancer: insights into molecular pathways & therapeutic approaches
    L Tanjima Tarique, Hasina ML, JA Mazumder, R Bhattacharjee, Md Ikbal Husain ...
    Discover Oncology 16 (1), 1-43 , 2025
    2025.0
    Citations: 9
  • Unveiling the Anticancer Potential of Curcuma Caesia Roxb. Against Ovarian Cancer: An Indigenous Plant of Assam
    K Barman, S Borah, B Das, TT Laskar, DD Chakraborty, P Chakraborty, ...
    Journal of Neonatal Surgery 14 (8s) , 2025
    2025.0
    Citations: 2
  • Bilosomes as Novel Nanocarrier: A Review. Sch Acad J Pharm
    MI Husain, S Sarkar, D Nilimanka
    Scholars Academic Journal of Pharmacy 2, 32-41 , 2026
    2026.0
  • Machine Learning-Based Design of Lipid Nanoparticles for mRNA Delivery: A Review
    MDI HUSAIN, M JONGKEY, N CHAKMA, P DEBNATH, S ROUTH, ...
    2026.0
  • The First Step Into Death: Postulation on Identifying the Initial Irreversible Event That Ends Life
    MI Husain, B De
    Acta Scientific MEDICAL SCIENCES (ISSN: 2582-0931) 10 (1) , 2026
    2026.0
  • Essential Oil-Based Microemulsions In Antimicrobial Applications: A Natural Approach
    ACMI Husain
    International Journal of Creative Research Thoughts 13 (11), 55-58 , 2025
    2025.0
  • Targeting Breast Cancer Complexity: Molecular Signalling, Microenvironment and Next-Generation Therapeutic Strategies
    TT Laskar, M Arora, JA Mazumder, R Bhattacharjee, MI Husain, B Das, ...
    Studies in Science of Science| ISSN: 1003-2053 43 (8), 464-506 , 2025
    2025.0
  • SCREENING OF SEEDS AND LEAVES OF LEUCAENA LEUCOCEPHALA FOR TREATMENT OF DIABETES
    B De, K Choudhury, Y Sila, MI Husain, L Deb, MA Sharma, B Tiwari
    2025.0
  • Bioactive Metabolites: Unlocking Nature’s Therapeutic Potential through Advanced Extraction and Sustainable Innovation
    MIH Das, Jayita