Delly Ramadon is a lecturer and researcer from the Pharmaceutics and Pharmaceutical Technology Laboratory at the Faculty of Pharmacy, Universitas Indonesia. He obtained his PhD degree from the School of Pharmacy, Queen’s University Belfast, UK, in 2020. His research is focused on transdermal/intradermal drug delivery system using various kinds of enhancement strategies, including permeation enhancers, nanoparticles, nanovesicles, and polymeric microneedles. His research has been supported by research grants from Universitas Indonesia; the Ministry of Higher Education, Science, and Technology, Republic of Indonesia; the National Research and Innovation Agency (BRIN) of Indonesia; and overseas pharmaceutical companies. In 2022, he has served as a Postdoctoral Research Fellow at Daewoong Pharmaceuticals, South Korea. He was also invited as a Visiting Scholar in the Global Excellence in Pharmacy program at Ulster University in 2024.
Ultrasonic-assisted extraction (UAE) of Javanese turmeric rhizomes using natural deep eutectic solvents (NADES): Screening, optimization, and in vitro cytotoxicity evaluation Donna Maretta Ariestanti, Abdul Mun’im, Pietradewi Hartrianti, Basmah Nadia, Erika Chriscensia, Shereen Angelina Rattu, Redhalfi Fadhila, Anastacia Harianto, Adelina Simamora, Delly Ramadon, Richard Johari James, Fadlina Chany Saputri, Mitsuyasu Kato, Meidi Utami Puteri Ultrasonics Sonochemistry, 2025 Javanese turmeric (Curcuma xanthorrhiza Roxb.) is known for its diverse pharmacological activities due to its rich phytoconstituents, including curcuminoids and xanthorrhizol. Typically, these compounds are extracted using organic solvents, which pose health and environmental risks. Therefore, safer and more environmentally friendly green extraction methods are being developed. This study investigated the effect of ultrasound-assisted extraction (UAE) combined with natural deep eutectic solvents (NADES) based on choline chloride and organic acids (lactic, malic, and citric acid) to find the best combination for extracting curcuminoids and xanthorrhizol from Javanese turmeric. Results showed that UAE using choline chloride and malic acid (1:1) (ChCl-MA) yielded the best results. The Box-Behnken Design optimized water addition, solvent-to-powder ratio, and extraction time, with optimal conditions being 25 % water addition, a 20 mL/g ratio, and a 15-minute extraction time. This method yielded 4.58 mg/g of curcuminoids and 12.93 mg/g of xanthorrhizol. Furthermore, the ChCl-MA NADES with UAE extraction showed more cytoselective activity towards the HeLa cancer cell line compared to the non-cancer HaCaT cell line. In contrast, traditional ethanol extraction was non-selective, as indicated by similar cell viability reductions in both HeLa and HaCaT cells at 6.25 ppm. Collectively, this study is the first to report the optimal NADES combination with UAE, based on salts and organic acids, for the extraction of Javanese turmeric rhizomes with selective cytotoxic effects against cancer cells. These findings may contribute to the development of novel, naturally derived anticancer agents using green extraction techniques.
Considerations in excipient selection for colon-targeted dosage forms Maxius Gunawan, Delly Ramadon, Kurnia Sari Setio Putri, Raditya Iswandana Journal of Applied Pharmaceutical Science, 2025 The colon is a potential organ for drug delivery systems because it has several advantages, such as long transit time and neutral pH conditions. Moreover, colon targeting can avoid enzymatic reactions in the stomach and small intestine which increase the bioavailability of the drug. A colon-targeted drug delivery system (CDDS) requires excipients that have distinctive characteristics to prevent drug release in the upper gastrointestinal tract and enhance drug release in the colon. Polysaccharides are suitable in CDDS due to the degradation mechanism by colonic microflora enzymes. Furthermore, polysaccharides can swell when hydrated so that drugs can be released from the matrix system by diffusion and/or relaxation. Polysaccharides can swell when hydrated, which will form a gel-like matrix that enables drug release through diffusion, where the drug diffuses through the swollen matrix. Additionally, drug release can occur through a relaxation mechanism, where the polymer chains gradually unwind and erode, further facilitating the drug release. This degradation and swelling mechanism can lead to the release of the drug at the colon site. Some polysaccharides that can be utilized for CDDS are alginate, amylose, arabinoxylan, dextran, guar gum, inulin, carrageenan, chitosan, chondroitin sulfate, lactulose, locust bean gum, pectin, and cyclodextrin. Moreover, polymers can also be employed as excipients in CDDS due to conformation changes in different pH of the gastrointestinal tract. These pH-dependent properties can ensure that the drug is protected during transit through the stomach and small intestine and is only released when the dosage form reaches the colon. Some polymers that are potential for CDDS are cellulose derivatives, poly (acrylic acid) (PAA), poly (metha-acrylic acid) (PMAA), Eudragit®, poly (lactic-co-glycolic acid) (PLGA), Kollicoat®, and Shellac®. The combination and/or modification of these excipients can increase the effectiveness of CDDS and prevent the early release of drugs in the upper gastrointestinal tract which can lead to the drug release being more precisely controlled in the colonic site.
Formulation and evaluation of gel and emulgel of chili extract (Capsicum frutescens L.) as topical dosage forms International Journal of Pharmacy and Pharmaceutical Sciences, 2014
RECENT SCHOLAR PUBLICATIONS
Preserving Cytoprotective Function in Freeze-Dried Umbilical Cord Mesenchymal Stem Cells Secretome: Influence of Pre-Freezing Duration and Primary Drying Temperature P Hartrianti, E Chriscensia, D Ramadon, K Kho, ABN Putra, A Kurniawan, ... Journal of Pharmaceutical Innovation 21 (3), 296 , 2026 2026
Development of poly (vinyl alcohol)/poly (N-vinyl caprolactam)-based hydrogel-forming microneedle for transdermal delivery of captopril: fabrication, characterization and in … S Fatriyah, NM Nizardo, FC Saputri, H Jung, A Lee, CA Mulyadi, ... Drug Delivery and Translational Research, 1-18 , 2026 2026
Teaching for turbulence: global evidence on pharmacists’ crisis contributions and implications for education. A scoping review FHR Mohammad, A Abuelhana, W Ammari, D Ramadon, AD Permana, ... International Journal of Pharmacy Practice 34 (Supplement_1), i12-i12 , 2026 2026
Spectra Characterization, Antioxidant, and Antityrosinase Activities of Nonpolar to Polar Fractions from Averrhoa bilimbi L. Leaf Extract. SI Khudeja, B Elya, RC Forestrania, D Ramadon Tropical Journal of Natural Product Research 10 (2), 7605 , 2026 2026
Recent advances of micro/nanoneedles for cosmetic delivery CF Goh, D Ramadon, KW Ng, GF Punu, JY Lee Nanotechnology in Cosmeceuticals: Advances, Challenges and Future Perspectives , 2026 2026
Recent developments of micro/nanoneedles for cosmetic delivery CF Goh, D Ramadon, KW Ng, GF Punu, JY Lee Nanotechnology in Cosmeceuticals, 433-456 , 2026 2026 Citations: 1
Enhancing capsaicin solubility in lidocaine-based therapeutic deep eutectic solvents (THEDES): a COSMO-RS predictive study:. N Asma, RS Alwi, D Ramadon, A Mun'im JURNAL ILMU KEFARMASIAN INDONESIA 23 (2), 336-347 , 2025 2025
Revolutionizing colon-targeted drug delivery: The pivotal role of lipid nano-carriers and their transformative modifications YBA Wilie, M Gunawan, Y Hadad, D Ramadon, FC Saputri, P Jansook, ... Journal of Drug Delivery Science and Technology, 107319 , 2025 2025 Citations: 9
Combination of lipid-based nanoparticles with microneedles as a promising strategy for enhanced transdermal delivery systems: A comprehensive review M Gunawan, AN Bestari, D Ramadon, A Efendi, V Boonkanokwong Journal of Drug Delivery Science and Technology 107, 106807 , 2025 2025 Citations: 9
Ultrasonic-assisted extraction (UAE) of Javanese turmeric rhizomes using natural deep eutectic solvents (NADES): Screening, optimization, and in vitro cytotoxicity evaluation DM Ariestanti, A Mun’im, P Hartrianti, B Nadia, E Chriscensia, SA Rattu, ... Ultrasonics Sonochemistry 114, 107271 , 2025 2025 Citations: 13
Considerations in excipient selection for colon-targeted dosage forms M Gunawan, D Ramadon, KSS Putri, R Iswandana Journal of Applied Pharmaceutical Science 15 (3), 063-085 , 2025 2025 Citations: 6
Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation QK Anjani, N Moreno-Castellanos, M Adhami, D Ramadon, J Jangga, ... Drug Delivery and Translational Research 15 (1), 355-371 , 2025 2025 Citations: 21
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test S Fatriyah, NM Nizardo, D Ramadon DARU Journal of Pharmaceutical Sciences 33 (1), 8 , 2024 2024 Citations: 2
Double-layer dissolving microneedles for delivery of mesenchymal stem cell Secretome: Formulation, characterisation and skin irritation study ADC Nainggolan, P Hartrianti, QK Anjani, RF Donnelly, ABN Putra, K Kho, ... European Journal of Pharmaceutics and Biopharmaceutics 204, 114495 , 2024 2024 Citations: 2
Development of ropivacaine hydrochloride-loaded dissolving microneedles as a local anesthetic agent: A proof-of-concept D Ramadon, PR Karn, QK Anjani, MH Kim, DY Cho, H Hwang, DH Kim, ... International Journal of Pharmaceutics 660, 124347 , 2024 2024 Citations: 12
Transdermal delivery of captopril using poly (vinyl pyrrolidone)/poly (vinyl alcohol)-based dissolving and hydrogel-forming microneedles: A proof of concept D Ramadon, F Muliawardani, NA Nisrina, OT Hamda, R Iswandana, ... European Polymer Journal 208, 112860 , 2024 2024 Citations: 12
Transdermal delivery of ketoprofen for osteoarthritis treatment and management: a literature review on current progression DA Ramadhani, Y Harahap, E Sagita, KCDP Sari, RK Andranilla, J Trisina, ... Pharmaceutical Sciences and Research 11 (1), 18-26 , 2024 2024 Citations: 2
Microneedle-mediated transdermal delivery of genetic materials, stem cells, and secretome: an update and progression ADC Nainggolan, QK Anjani, P Hartrianti, RF Donnelly, A Kurniawan, ... Pharmaceutics 15 (12), 2767 , 2023 2023 Citations: 12
Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs: polymer materials and solvent casting micromoulding method RK Andranilla, QK Anjani, P Hartrianti, RF Donnelly, D Ramadon Pharmaceutical Development and Technology 28 (10), 1016-1031 , 2023 2023 Citations: 29
Development and validation of simultaneous analysis method of brazilin and 6-gingerol in the combined extracts of sappan wood (Caesalpinia sappan) and ginger rhizome (Zingiber … DE Gondokusumo, A Mun'im, D Ramadon, FA Saputri, R Soraya, H Silfian 2023
MOST CITED SCHOLAR PUBLICATIONS
Enhancement strategies for transdermal drug delivery systems: current trends and applications D Ramadon, MTC McCrudden, AJ Courtenay, RF Donnelly Drug delivery and translational research 12 (4), 758-791 , 2022 2022 Citations: 779
Natural deep eutectic solvents (NADES): Phytochemical extraction performance enhancer for pharmaceutical and nutraceutical product development NPE Hikmawanti, D Ramadon, I Jantan, A Mun’im Plants 10 (10), 2091 , 2021 2021 Citations: 377
Versatility of hydrogel-forming microneedles in in vitro transdermal delivery of tuberculosis drugs QK Anjani, AD Permana, Á Cárcamo-Martínez, J Domínguez-Robles, ... European Journal of Pharmaceutics and Biopharmaceutics 158, 294-312 , 2021 2021 Citations: 159
Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal … K Peng, LK Vora, IA Tekko, AD Permana, J Domínguez-Robles, ... Journal of Controlled Release 339, 361-380 , 2021 2021 Citations: 132
Cosmetic Serum Containing Grape (Vitis vinifera L.) Seed Extract Phytosome: Formulation and In Vitro Penetration Study S Surini, H Mubarak, D Ramadon Journal of Young Pharmacists 10 (2s), s51-s55 , 2018 2018 Citations: 76
Pemanfaatan nanoteknologi dalam sistem penghantaran obat baru untuk produk bahan alam D Ramadon, A MUN Jurnal ilmu kefarmasian Indonesia 14 (2), 118-127 , 2016 2016 Citations: 75
Development, evaluation, and pharmacokinetic assessment of polymeric microarray patches for transdermal delivery of vancomycin hydrochloride D Ramadon, AD Permana, AJ Courtenay, MTC McCrudden, IA Tekko, ... Molecular Pharmaceutics 17 (9), 3353-3368 , 2020 2020 Citations: 60
Novel transdermal ethosomal gel containing green tea (Camellia sinensis L. Kuntze) leaves extract: formulation and in vitro penetration study D Ramadon, AW Goldie, E Anwar Journal of young pharmacists 9 (3), 336 , 2017 2017 Citations: 54
Formulation and Evaluation of Gel and Emulgel of Chili Extract (Capsicum frutescens L.) as Topical Dosage Forms E Anwar, D Ramadon, Harmita International Journal of Pharmacy and Pharmaceutical Sciences 6 (Supplement … , 2014 2014 Citations: 49
Formulation and evaluation of gel and emulgel of chili extract (Capsicum frutescens L.) as topical dosage forms E Anwar, D Ramadon, Harmita Int J Pharm Pharm Sci 6, 13-6 , 2014 2014 Citations: 49
Enhancing intradermal delivery of lidocaine by dissolving microneedles: comparison between hyaluronic acid and poly (vinyl pyrrolidone) backbone polymers D Ramadon, LFP Sutrisna, Y Harahap, KSS Putri, F Ulayya, P Hartrianti, ... Pharmaceutics 15 (1), 289 , 2023 2023 Citations: 48
Combination of dissolving microneedles with nanosuspension and co-grinding for transdermal delivery of ketoprofen D Ramadon, F Ulayya, AS Qur’ani, I Iskandarsyah, Y Harahap, QK Anjani, ... Pharmaceuticals 16 (3), 378 , 2023 2023 Citations: 41
A sensitive HPLC-UV method for quantifying vancomycin in biological matrices: Application to pharmacokinetic and biodistribution studies in rat plasma, skin and lymph nodes D Ramadon, AJ Courtenay, AD Permana, IA Tekko, E McAlister, ... Journal of Pharmaceutical and Biomedical Analysis 189, 113429 , 2020 2020 Citations: 36
In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel. D Ramadon, E Anwar, Y Harahap Indian journal of pharmaceutical sciences 79 (6) , 2017 2017 Citations: 30
Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs: polymer materials and solvent casting micromoulding method RK Andranilla, QK Anjani, P Hartrianti, RF Donnelly, D Ramadon Pharmaceutical Development and Technology 28 (10), 1016-1031 , 2023 2023 Citations: 29
Solid lipid nanoparticles (SLN): formulation and fabrication GF Punu, Y Harahap, QK Anjani, P Hartrianti, RF Donnelly, D Ramadon Pharm. Sci. Res.(PSR) 10, 55-66 , 2023 2023 Citations: 26
Gel formulation containing microcapsules of grape seed oil (Vitis vinifera L.) for skin moisturizer S Surini, K Nursatyani, D Ramadon Journal of Young Pharmacists 10 (1), 41 , 2018 2018 Citations: 24
Novel transethosome containing green tea (Camellia sinensis L. Kuntze) leaf extract for enhanced skin delivery of epigallocatechin gallate: Formulation and in vitro penetration … E Anwar, D Ramadon, GD Ardi Int J Appl Pharm 10 (1), 1-4 , 2018 2018 Citations: 23
Formulation, stability test and in vitro penetration study of transethosomal gel containing green tea (Camellia sinensis L. Kuntze) leaves extract D Ramadon, SS Pramesti, E Anwar Int J Appl Pharm 9 (5), 91-6 , 2017 2017 Citations: 23
Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation QK Anjani, N Moreno-Castellanos, M Adhami, D Ramadon, J Jangga, ... Drug Delivery and Translational Research 15 (1), 355-371 , 2025 2025 Citations: 21
