Talal Chatila

@childrenshospital.org

Department of Pediatrics/Division of Immunology
Boston Children's Hospital

Talal Chatila


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https://researchid.co/chatila

RESEARCH, TEACHING, or OTHER INTERESTS

Immunology, Immunology and Allergy, Immunology and Microbiology, Molecular Medicine
292

Scopus Publications

38345

Scholar Citations

98

Scholar h-index

244

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • CTLA-4 Variant Interpretation and Clinical Impact
    JP Silva, ACG de Oteyza, S Posadas-Cantera, M Krausz, E Sindram, ...
    Journal of Human Immunity 2 (CIS2026), eCIS2026abstract. 135 , 2026
    2026
  • Regulatory T Cells: The Past as a Prelude to the Future
    TA Chatila, CB Williams
    Journal of Allergy and Clinical Immunology , 2026
    2026
  • A Novel Phosphoglucomutase-3 Gene Variant Causing Milder Phenotype in Two Families
    B Gemici Karaaslan, M Benamar, S Ulas, S Aydemir, G Yesil, A Gezdirici, ...
    Journal of Clinical Immunology , 2026
    2026
  • Chemical and toxicological impacts of the 2025 Southern California wildfires on urban air quality in Los Angeles
    Y Aghaei, MM Badami, PSG Subramanian, V Verma, T Chatila, C Sioutas
    Atmospheric Environment, 121961 , 2026
    2026
  • Environmental exposure trains the immune system to dampen allergic responses
    TA Chatila
    Nature 650 (8103), 838-839 , 2026
    2026
  • DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells
    ER Siniscalco, C Fisher, MP Lu, JDS Grassmann, CD Mack, R Yaakoubi, ...
    Journal of Experimental Medicine 223 (3), e20241707 , 2026
    2026
    Citations: 1
  • Beyond the skin: immunological profiles and infectious complications in ALOX12B-associated autosomal recessive congenital ichthyosis
    AP Sefer, MC Catak, I An, N Keser Ozturk, L Baykal Selcuk, OS Dincer, ...
    Frontiers in Immunology 16, 1662858 , 2025
    2025
  • Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis
    M Benamar, P Contini, K Schmitz-Abe, O Lanzetta, F Getachew, ...
    Immunity 58 (11), 2753-2768. e6 , 2025
    2025
    Citations: 9
  • IL-4 variant and school mouse exposure increases asthma morbidity in urban schoolchildren
    HB Ruran, YS Jung, Q Chen, K Nadeau, W Phipatanakul, TA Chatila
    The Journal of allergy and clinical immunology, S0091-6749 (25) 01032-2 , 2025
    2025
  • Notch3+ regulatory T cells drive autoimmune neuroinflammation in multiple sclerosis 2040
    M Benamar, P Contini, K Schmitz-Abe, C Bachelin, O Lanzetta, ...
    The Journal of Immunology 214 (Supplement_1), vkaf283. 012 , 2025
    2025
  • Metabolomic and immunological signatures of asthma severity in children
    E Crestani, H Harb, M Benamar, R Kaddurah‐Daouk, W Phipatanakul, ...
    Pediatric Allergy and Immunology 36 (11), e70242 , 2025
    2025
  • Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
    M Di Gioia, V Poli, PJ Tan, R Spreafico, A Chu, AG Cuenca, Z Wu, ...
    Immunity 58 (9), 2190-2207. e13 , 2025
    2025
    Citations: 6
  • Prostaglandin I2 signaling restrains Treg ST2 expression by repressing β-catenin in allergic airway inflammation
    AE Norlander, M Abney, J Zhang, VV Polosukhin, CM Thomas, ...
    Journal of Allergy and Clinical Immunology , 2025
    2025
  • DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis
    E Janssen, M Das, J Butts, M Alasharee, S Mukherjee, GL Lozano, C Rao, ...
    Immunity 58 (7), 1794-1810. e5 , 2025
    2025
    Citations: 2
  • Inborn errors of regulatory T-cell differentiation and function
    FB Oktelik, Y Luo, M Benamar, TA Chatila
    Journal of Allergy and Clinical Immunology , 2025
    2025
    Citations: 6
  • Functional diversification of dietary plant small molecules by the gut microbiome
    GA Kuziel, GL Lozano, C Simian, L Li, J Manion, E Stephen-Victor, ...
    Cell 188 (7), 1967-1983. e22 , 2025
    2025
    Citations: 38
  • Progressively differentiated T FH 13 cells are stabilized by JunB to mediate allergen germinal center responses
    P Chandrakar, CS Nelson, MA Podestà, CB Cavazzoni, M Gempler, ...
    Nature immunology 26 (3), 473-483 , 2025
    2025
    Citations: 10
  • RELMβ sets the threshold for microbiome-dependent oral tolerance
    E Stephen-Victor, GA Kuziel, M Martinez-Blanco, BE Jugder, M Benamar, ...
    Nature 638 (8051), 760-768 , 2025
    2025
    Citations: 30
  • Gene by Environment Interaction Between IL-4 Variant and School Mouse Exposure: Health Disparity in the School Inner-City Asthma Study
    H Ruran, YS Jung, Q Chen, T Chatila, W Phipatanakul
    Journal of Allergy and Clinical Immunology 155 (2), AB182 , 2025
    2025
  • Notch4 regulatory T cells and SARS‐CoV‐2 viremia shape COVID19 survival outcome
    M Benamar, PS Lai, CY Huang, Q Chen, FB Oktelik, P Contini, M Wang, ...
    Allergy 80 (2), 557-569 , 2025
    2025
    Citations: 3

MOST CITED SCHOLAR PUBLICATIONS

  • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    JL Round, SM Lee, J Li, G Tran, B Jabri, TA Chatila, SK Mazmanian
    Science 332 (6032), 974-977 , 2011
    2011
    Citations: 1940
  • Human inborn errors of immunity: 2019 update on the classification from the International Union of Immunological Societies Expert Committee
    SG Tangye, W Al-Herz, A Bousfiha, T Chatila, C Cunningham-Rundles, ...
    Journal of clinical immunology 40 (1), 24-64 , 2020
    2020
    Citations: 1465
  • JM2 , encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome
    TA Chatila, F Blaeser, N Ho, HM Lederman, C Voulgaropoulos, C Helms, ...
    The Journal of clinical investigation 106 (12), R75-R81 , 2000
    2000
    Citations: 1228
  • The association of atopy with a gain-of-function mutation in the α subunit of the interleukin-4 receptor
    GKK Hershey, MF Friedrich, LA Esswein, ML Thomas, TA Chatila
    New England Journal of Medicine 337 (24), 1720-1725 , 1997
    1997
    Citations: 1064
  • International union of immunological societies: 2017 primary immunodeficiency diseases committee report on inborn errors of immunity
    C Picard, H Bobby Gaspar, W Al-Herz, A Bousfiha, JL Casanova, ...
    Journal of clinical immunology 38 (1), 96-128 , 2018
    2018
    Citations: 1046
  • Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015
    C Picard, W Al-Herz, A Bousfiha, JL Casanova, T Chatila, ME Conley, ...
    Journal of clinical immunology 35 (8), 696-726 , 2015
    2015
    Citations: 932
  • Human inborn errors of immunity: 2019 update of the IUIS phenotypical classification
    A Bousfiha, L Jeddane, C Picard, W Al-Herz, F Ailal, T Chatila, ...
    Journal of clinical immunology 40 (1), 66-81 , 2020
    2020
    Citations: 874
  • Corrigendum: Primary Immunodeficiency Diseases: An Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary …
    W Al-Herz, A Bousfiha, JL Casanova, T Chatila, ME Conley, ...
    Frontiers in Immunology 5, 460 , 2014
    2014
    Citations: 730
  • The 2017 IUIS phenotypic classification for primary immunodeficiencies
    A Bousfiha, L Jeddane, C Picard, F Ailal, H Bobby Gaspar, W Al-Herz, ...
    Journal of clinical immunology 38 (1), 129-143 , 2018
    2018
    Citations: 712
  • Regulatory T cell development in the absence of functional Foxp3
    W Lin, D Haribhai, LM Relland, N Truong, MR Carlson, CB Williams, ...
    Nature immunology 8 (4), 359-368 , 2007
    2007
    Citations: 652
  • Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
    KR Engelhardt, S McGhee, S Winkler, A Sassi, C Woellner, ...
    Journal of Allergy and Clinical Immunology 124 (6), 1289-1302. e4 , 2009
    2009
    Citations: 638
  • Mechanisms of dupilumab
    H Harb, TA Chatila
    Clinical & Experimental Allergy 50 (1), 5-14 , 2020
    2020
    Citations: 588
  • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
    D Haribhai, JB Williams, S Jia, D Nickerson, EG Schmitt, B Edwards, ...
    Immunity 35 (1), 109-122 , 2011
    2011
    Citations: 579
  • A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis
    MN Rivas, OT Burton, P Wise, Y Zhang, SA Hobson, MG Lloret, ...
    Journal of Allergy and Clinical Immunology 131 (1), 201-212 , 2013
    2013
    Citations: 572
  • CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like syndrome, and defective IL-10 expression from CD4 lymphocytes
    AA Caudy, ST Reddy, T Chatila, JP Atkinson, JW Verbsky
    Journal of Allergy and Clinical Immunology 119 (2), 482-487 , 2007
    2007
    Citations: 536
  • Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects
    C Schwab, A Gabrysch, P Olbrich, V Patiño, K Warnatz, D Wolff, ...
    Journal of Allergy and Clinical Immunology 142 (6), 1932-1946 , 2018
    2018
    Citations: 496
  • Regulatory T cells in allergic diseases
    MN Rivas, TA Chatila
    Journal of Allergy and Clinical Immunology 138 (3), 639-652 , 2016
    2016
    Citations: 489
  • Role of regulatory T cells in human diseases
    TA Chatila
    Journal of allergy and clinical immunology 116 (5), 949-959 , 2005
    2005
    Citations: 469
  • Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy
    MN Rivas, OT Burton, P Wise, LM Charbonnier, P Georgiev, HC Oettgen, ...
    Immunity 42 (3), 512-523 , 2015
    2015
    Citations: 441
  • Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy
    A Abdel-Gadir, E Stephen-Victor, GK Gerber, M Noval Rivas, S Wang, ...
    Nature medicine 25 (7), 1164-1174 , 2019
    2019
    Citations: 437