Lucia Mosna

EDUCATION

Comenius University Bratislava: Bratislava, Bratislava Region, SK
2023-09 to present | PhD (Animal physiology)

Comenius University Bratislava: Bratislava, Bratislava Region, SK
2021-09 to 2023-06 | Mgr. (Animal physiology and ethology)

Comenius University Bratislava: Bratislava, Bratislava Region, SK
2018-09 to 2021-06 | Bc. (Biology)

RESEARCH, TEACHING, or OTHER INTERESTS

Physiology, Neuroscience, Neurology (clinical)

Scopus Publications

Plasma irisin and the brain-derived neurotrophic factor levels in sedentary subjects: Effect of 8-weeks lifestyle intervention
Zofia Radikova, Lucia Mosna, Carmen Eckerstorfer, Boris Bajer, Andrea Havranova, Richard Imrich, Miroslav Vlcek, Adela Penesova
Endocrine Regulations, 2024
Objectives. Sedentary lifestyle increasingly observed in the population contributes to the incremental incidence of obesity, cardiovascular diseases, mental disorders, type 2 diabetes, hyper-tension, dyslipidemia, and others. Physical inactivity together with an imbalance in caloric intake and expenditure leads to a loss of muscle mass, reduced insulin sensitivity, and accumulation of the visceral fat. Organokines (adipokines, myokines, hepatokines, etc.) serve in the organism for inter-organ communication. However, human studies focused on the exercise-related changes in plasma levels of certain myokines have produced contradictory results. In the present study, we verified a hypothesis that myokine irisin, which is expected to increase in response to physical activity, induces brain-derived neurotrophic factor (BDNF) production and by this way mediates the beneficial effect of exercise on several brain functions. Subjects and Methods. Women (n=27) and men (n=10) aged 44.5±12.0 years, who were sedentary and overweight/obese (men ≥25%, women ≥28% body fat), participated in the study. The effect of an 8-week intensive lifestyle intervention (150 minutes of moderate physical activity per week, diet modification, and reduction of caloric intake) on the selected organokines (irisin, BDNF) in the context of an expected improvement in cardiometabolic status was examined. Results. The 8-week lifestyle intervention resulted in a significant (p<0.05) reduction in body mass index, body fat, blood pressure, insulin resistance, lipid and liver parameters, and irisin levels (p<0.001). However, BDNF increase in the whole group did not reach statistical significance. After the improvement of cardiometabolic parameters, a significant decrease in irisin and increase in BDNF levels were also observed in the subgroup with unsatisfactory (≤5%) body weight reduction. Neither relationship between irisin and BDNF levels, nor effect of age or sex on their levels was observed. Conclusions. We cannot confirm the hypothesis that exercise-induced irisin may increase the BDNF levels, whereas, the organokine levels in the periphery may not completely reflect the processes in the brain compartments. The observed decrease in irisin levels after 8-week intensive lifestyle intervention program, which was in contrary to its supposed mechanisms of action and dynamics, suggests the presence of several yet undiscovered impacts on the secretion of irisin.

Publications

MOSNÁ, Lucia** - BORBÉLYOVÁ, Veronika - CELEC, Peter - RENCZÉS, Emese. Neurozápal pri poruchách autistického spektra = Neuroinflammation in autism spectrum disorder. In Československá fyziologie : biomedicínsky časopis, 2024, roč. 72, č. 2, s. 51-55. ISSN 1210-6313.

Mosná L, Hardoňová M, Vlček M, Šiarnik P, Havranová A, Penesová A, Imrich R, Žitňanová I, Turčáni P, Kollár B, Rádiková Ž: Podávania agonistu receptora pre GLP-1 zlepšuje kardiovaskulárne a antioxidačné parametre u pacientov so sclerosis multiplex. 100. fyziologické dny Praha, s.119-119, február 2025.

Lucia Mosná; Miroslava Hardoňová, Miroslav Vlček, Pavol Šiarnik, Andrea Havranová; Adela Penesová, Richard Imrich, Ingrid Žitňanová, Peter Turčáni, Branislav Kollár, Žofia Rádiková: Adding GLP-1 Receptor Agonist to Standard Therapy in Patients with Multiple Sclerosis Improved Cardiovascular and Antioxidant Parameters. European pharmaceutical journal, (1): 107-107, 2024.

Rádiková Žofia, Bajer Boris, Havranová A, Penesová Adela: Irisín a BDNF u jedincov so sedavým spôsobom života po 8-týždňovej intervencii životného štýlu. 99. fyziologické dni, s.107-108, 2024.