Dorlene Maria Cardoso de Aquino

@portalpadrao.ufma.br

Professora titular do Departamento de Enfermagem
Universidade Federal do Maranhão

Dorlene Maria Cardoso de Aquino


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https://researchid.co/dorleneaqn

RESEARCH, TEACHING, or OTHER INTERESTS

Infectious Diseases, Research and Theory
8

Scopus Publications

Scopus Publications

  • Leprosy cases diagnosed by contacts examination in a hyperendemic capital city of northeastern Brazil
    Aruse Maria Marques Soares, Rita da Graça Carvalhal Frazão Corrêa, Kezia Cristina Batista dos Santos, Ivan Abreu Figueiredo, Maria de Fátima Lires Paiva, et al.
    Anais Brasileiros De Dermatologia, 2021
  • Presence of Mycobacterium leprae DNA and PGL-1 antigen in household contacts of leprosy patients from a hyperendemic area in Brazil
    J.D. Pinho, P.M.S. Rivas, M.B.P. Mendes, R.E.P. Soares, G.C. Costa, et al.
    Genetics and Molecular Research, 2015
  • Immunodominant antigens of leishmania chagasi associated with protection against human visceral leishmaniasis
    Daniel R. Abánades, Leonardo V. Arruda, Elaine S. Arruda, José Roberto A. S. Pinto, Mario S. Palma, et al.
    Plos Neglected Tropical Diseases, 2012
  • TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
    Amanda Farage Frade, Lea Campos de Oliveira, Dorcas Lamounier Costa, Carlos Henrique Nery Costa, Dorlene Aquino, et al.
    Infection Genetics and Evolution, 2011
  • Short report: Epidemiological study of the association between anti-Lutzomyia longipalpis saliva antibodies and development of delayed-type hypersensitivity to Leishmania antigen
    Dorlene M. C. Aquino, Arlene J. M. Caldas, José Carlos Miranda, Antonio A. M. Silva, Manoel Barral-Netto, et al.
    American Journal of Tropical Medicine and Hygiene, 2010
    Recent reports from animal models and from cross-sectional studies have suggested that host responses to anti-Lutzomyia longipalpis saliva antibodies may be related to delayed-type hypersensitivity to Leishmania antigen. In a prospective cohort study, we evaluated 1,080 children from two endemic areas for visceral leishmaniasis (VL) by means of Kaplan-Meier analysis. The incidence rate of delayed-type hypersensitivity to Leishmania antigen, measured at the 24th follow-up month, was higher among those reactive to Lu. longipalpis saliva antibodies at the beginning of the study (0.0217 cases per person-month) than among those previously negative (0.0131 cases per person-month) (P value for the log-rank test = 0.0006). It seems that mounting an anti-saliva immune response helps the development of a cell-mediated anti-Leishmania response.
  • Using recombinant proteins from Lutzomyia longipalpis saliva to estimate human vector exposure in visceral leishmaniasis endemic areas
    Ana Paula Souza, Bruno Bezerril Andrade, Dorlene Aquino, Petter Entringer, José Carlos Miranda, et al.
    Plos Neglected Tropical Diseases, 2010
  • Are there differences in clinical and laboratory parameters between children and adults with American visceral leishmaniasis?
    Arlene J.M. Caldas, Jackson Costa, Dorlene Aquino, Antônio Augusto M. Silva, Manoel Barral-Netto, et al.
    Acta Tropica, 2006
  • Balance of IL-10 and interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis
    Arlene Caldas, Cecília Favali, Dorlene Aquino, Vera Vinhas, Johan van Weyenbergh, et al.
    BMC Infectious Diseases, 2005
    BackgroundLeishmaniasis remains a serious public health problem in several parts of the developing world. Effective prophylactic measurements are hampered by imprecise comprehension of different aspects of the disease, including its immunoregulation. A better comprehension of immunoregulation in human VL may be useful both for designing and evaluating immunoprophylaxis.MethodsTo explore immunoregulatory mechanisms, 20 visceral leishmaniasis (VL) patients were evaluated during active disease and at different periods up to one year after treatment determining their plasma cytokine levels, clinical parameters (palpable spleen and liver) and antibody levels.ResultsElevated plasma levels of IFN-γ and of IL-12 p40 were observed during active disease, significantly decreasing after treatment whereas in vitro Leishmania antigen-stimulated IFN-γ production by PBMC exhibited an inverse pattern being low during disease and increasing steadily thereafter. Absence of IFN-γ activity is a hallmark of VL. The main candidate for blunting IFN-γ activity is IL-10, a cytokine highly elevated in plasma with sharp decrease after treatment. Activity of IL-10 is inferred by high levels of anti-Leishmania specific IgG1 and IgG3. TGF-β had elevated total, but not of active, levels lessening the likelihood of being the IFN-γ counterpart. Spleen or liver size presented a steady decrease but return to normal values at only 120 days after treatment. Anti-Leishmania IgG (total and subclasses) levels and DTH or Leishmania-stimulated lymphocyte proliferation conversion to positive also present a slow decrease after treatment. IL-6 plasma levels were elevated in only a few patients.ConclusionTaken together our results suggest that IFN-γ and IL-10 are the molecules most likely involved in determining fate of disease. After treatment, there is a long delay before the immune profile returns to normal what precludes using plasma cytokine levels as criteria of cure as simpler clinical evaluations, as a palpable spleen or liver, can be used.