Roberto Carlos Campos Martins

@ippn.ufrj.br

Instituto de Pesquisa de Produtos Naturais Walter Mors (IPPN)
Universidade Federal do Rio de Janeiro

Roberto Carlos Campos Martins


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https://researchid.co/roberto.rcc

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Plant Science, Spectroscopy
28

Scopus Publications

Scopus Publications

  • Chemical Characterization and Bio-Screening of Neuroprotective Potential of Brazilian Brown Seaweed Canistrocarpus cervicornis in 6-OHDA-Induced Neurotoxicity Model
    Thalisia Cunha dos Santos, Johana Marcela Concha Obando, Joana Silva, Ana Luíza Vidal Pimentel Santos, Roberto Carlos Campos Martins, Diana Negrão Cavalcanti, Rui Pedrosa, Celso Alves
    Antioxidants, 2025
    Brazilian native seaweed Canistrocarpus cervicornis (Ochrophyta, Dictyotaceae) is recognized for its chemodiversity, particularly cyclic diterpenes and polysaccharides, yet its relevance to neurological disorders remains unexplored. This study evaluated the neuroprotective potential of a hydroethanolic extract (ECCH), its polar fraction (CCFPol), a dichloromethane extract (ECCD), and eight derived fractions (CCF1–2, CCF3, CCF4, CCF5–6, CCF7, CCF8–10, and CCF11–15). Cytotoxicity was evaluated in SH-SY5Y neuroblastoma cells, and neuroprotection was examined against 6-OHDA–induced toxicity. The mitochondrial membrane potential, ROS and H2O2 generation assays were conducted to explore the mechanisms underlying the observed effects. Among the key findings, the CCF3 fraction exhibited a high content (75.04%) of dolastane-type diterpenoids. Both CCFPol (100 µg/mL) and CCF3 (1 µg/mL) increased cell viability to 68.43 ± 4.60% and 60.61 ± 0.80%, respectively, compared with 6-OHDA–treated cells (50.70 ± 2.71%). Additionally, CCF3 and CCFPol reduced H2O2 levels (200.0 ± 18.19% and 195.5 ± 16.13%, respectively, vs. 6-OHDA-treated cells: 302.2 ± 17.07%) and lowered intracellular ROS (122.6 ± 22.7% and 129.6 ± 19.4%, respectively, vs. 6-OHDA-treated cells: 153.0 ± 32.7%). This is the first study to demonstrate the neuroprotective potential of the C. cervicornis in a 6-OHDA-induced neurotoxicity cellular model, contributing to the understanding of marine bioactive resources and their relevance for neurological research. Additional studies aimed at isolating the active constituents and clarifying their mechanisms of action will further strengthen and expand the biological relevance of this specie as source of neuroprotective agents.
  • Coupling countercurrent chromatography to mass spectrometry to resolve natural products complex mixtures
    Felipe Costa Cardoso, Roberto Carlos Campos Martins, Ricardo Moreira Borges, Fernanda das Neves Costa
    Journal of Chromatography A, 2025
  • Antinociceptive in vivo activity and chemical profiling by UHPLC-MS/MS of stem bark and leaves extracts of Ficus maxima Mill. (Moraceae)
    Felipe Costa Cardoso, Filipe Eloi Alves de Carvalho, Thamires Ferreira de Freitas, Bismarck Rezende, Marsen Garcia Pinto Coelho, Guilherme Carneiro Montes, Roberto Carlos Campos Martins
    Journal of Ethnopharmacology, 2025
  • Marine Bacillus pumilus substances exhibit antimicrobial effect on multidrug-resistant Staphylococcus aureus
    Jéssyca Freitas-Silva, Roberto Carlos Campos Martins, Carla Monteiro Leal, Simony Carvalho Mendonça, Jefferson Bomfim Silva Cypriano, Walter Martin Roland Oelemann, Fernanda de Avila Abreu, Ana Luisa Andrade-Oliveira, Marcia Giambiagi-deMarval, Marinella Silva Laport
    Journal of Applied Microbiology, 2024
    Aims This study aimed to assess the antimicrobial potential of Bp1-AdE, produced by Bacillus pumilus 64–1, and to investigate its mode of action against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Methods and results Bp-1AdE, derived from sponge-associated B. pumilus, exhibited bactericidal activity at 1 550 µg ml−1 against S. aureus ATCC29213 and MRSA strains. Light and fluorescence microscopy revealed drastic cell lysis of S. aureus treated with Bp-1AdE. Scanning and transmission electron microscopy suggested that Bp-1AdE disrupts the cytoplasmic membrane. Toxicity assays showed that Bp-1AdE was non-toxic to Tenebrio molitor larvae. Liquid chromatography-mass spectrometry and Global Natural Product Social spectral libraries identified four substances within Bp-1AdE, including aliphatic alcohols [3,4-dipentylhexane-2,5-diol and 1,1′-(4,5-dibutyl-3,6-dimethylcyclohexane-1,2-diyl)bis(ethan-1-one)] and terpenoids (cholic acid and canrenone). Conclusions Bp-1AdE demonstrated selective toxicity and bactericidal activity, highlighting its potential for controlling infections caused by multidrug-resistant S. aureus strains.
  • Approaches of marine compounds and relevant immune mediators in Autism Spectrum Disorder: Opportunities and challenges
    Thalisia Cunha dos Santos, Johana Marcela Concha Obando, Paulo Emílio Corrêa Leite, Mariana Rodrigues Pereira, Mônica de Freitas Leitão, Caio Abujadi, Lara de Freitas Leitão Pimenta, Roberto Carlos Campos Martins, Diana Negrão Cavalcanti
    European Journal of Medicinal Chemistry, 2024
  • Dermocosmetic properties of bioproducts from Sargassum macroalgae: chemical aspects, challenges, and opportunities
    Thalisia Cunha dos Santos, Levi Pompermayer Machado, Ana Luíza Vidal Pimentel Santos, Roberto Carlos Campos Martins, Diana Negrão Cavalcanti, Guilherme Wolff Bueno, Ana Letícia Madeira Sanches, Johana Marcela Concha Obando
    Frontiers in Marine Science, 2024
    The cosmetics industry is experiencing continuous growth and the search for dermoactive metabolites continues to increase, positioning natural marine products as an essential element in this market. The genus Sargassum, a cosmopolitan brown alga, stands out for its diversified arsenal of metabolites with biological properties of great interest for the cosmetic sector. This study presents an updated review of the dermocosmetic properties of 17 Sargassum species published between 2020 and 2024, emphasizing increasing interest in its antioxidant and photoprotective properties. Furthermore, the review highlights the crucial role of green extraction methodologies, such as ultrassom-assisted extraction (EAU), enzyme-assisted extraction (EAE) and microwave-assisted extraction (MAE). It is also provided a conceptual outline of the spectrometric analytical techniques used for characterization of extracts and identification of active composts, such as polysaccharides (alginate and fucoidane), phenolic composts (phlorotannins and phenylpropanóids) and terpenoids (diterpenoids, saponins and norisoprenóids). In addition to addressing bioprospecting and the potential of the biorefinery in the cosmetics sector, this review analyzes challenges related to quality control of raw materials, seasonal fluctuations of seaweed and regulations governing the collection and use of seaweed. To provide a detailed update on the dermocosmetic potential of these algae, the review aims to support future research and encourage bioprospection of this biomass as a sustainable and promising source for the development of new bioproducts.
  • Chemical Profile by UPLC-HRMS and Antifungal and Antioxidant Activity of Marine Macroalgae Dictyota menstrualis
    Thalisia C. dos Santos, Johanna M. C. Obando, Roberto C. C. Martins, Marina A. Alves, Roberto C. Villaça, Levi P. Machado, Maria Cândida de G. Gasparoto, Diana N. Cavalcanti
    Revista Virtual De Quimica, 2024
    The brown macroalgae Dictyota menstrualis constitutes an organism with a rich and diverse metabolism in terms of the chemistry of natural products. It is known to mainly produce diterpenes, in addition to sterols, vitamins and polysaccharides with antiviral, anti-inflammatory, anticoagulant and antioxidant properties. Despite its vast metabolic arsenal, most studies are directed to the identification of already known diterpenes, opening the field of investigation for new approaches and discoveries. Knowing this, this work aims to chemically characterize the macroalgae D. menstrualis through the technique of Ultra Efficiency Liquid Chromatography associated with High-Resolution Mass Spectrometry (UPLC-HRMS) and perform a biological screening of potential antioxidants and antifungals through bioautography. For this, specimens of D. menstrualis were collected in the São Pedro São Paulo Archipelago (PE, Brazil) and attended to ingestion with dichloromethane and fractionation by column chromatography with silica gel. The extract and fractions were then analyzed by UPLC-HRMS with ElectroSpray Ionization (ESI) in positive mode. In addition, bioautography assays were performed to evaluate the antioxidant potential with DPPH and the antifungal potential against the Cladosporium sphaerospermum . The UPLC-HRMS analyzes allowed identifying diterpenes, sterols, faty acids, glycerolipids, derivatives of photosynthetic pigments and carotenoids. Bioautography assays suggested antifungal and antioxidant potential of the organic extract and fractions. Thus, the results suggest that D. menstrualis has pharmacological potential to be explored and that studies on its chemical composition using modern techniques such as UPLC-HRMS can lead to the discovery of new structures and reinforcement of the knowledge of the chemistry of this algae.
  • Bioactive Metabolites and Biotechnological Applications of Macroalgae of the Genus Sargassum: A Review
    Thalisia C. dos Santos, Thiago M. Vale, Diana N. Cavalcanti, Levi P. Machado, Elisabete Barbarino, Roberto C. C. Martins, Johana M. C. Obando
    Revista Virtual De Quimica, 2023
    The genus Sargassum belongs to the group of tropical and subtropical brown macroalgae of shallow marine meadows.Macroalgae of this genus have often been associated with negative impacts on coastal environments due to their great capacity to produce biomass and the natural cliff events, in which this material accumulates on beaches.However, these algae are an opportunity for the bioeconomy as they are sources of value-added bioactive compounds such as phlorotannins, fatty acids, sterols, terpenoids, and polysaccharides.These molecules identified in Sargassum are applicable to the pharmaceutical industry, in anti-inflammatory, antioxidant, neuroprotective, antimicrobial, antitumor, and antiviral products, among others.In addition to the vast pharmacological potential, Sargassum products are relevant raw materials in different biotechnological sectors such as food, agriculture, bioenergetics, andcosmeticsc.This knowledge still lies in the investigative phase of development and spreads across different areas of knowledge.By knowing this, this review article aims to present and discuss information covered through 52 scientific articles, which explored 25 species of Sargassum, identifying the associated bioactive metabolites and classifying the industrial and biotechnological potential of the species.The data presented here provide the opportunity for future research with an evidence-based approach to promote the use of these organisms in product development for biotechnology sectors.
  • Current and promising applications of seaweed culture in laboratory conditions
    Johana Marcela Concha Obando, Thalisia Cunha dos Santos, Roberto Carlos Campos Martins, Valeria Laneuville Teixeira, Elisabete Barbarino, Diana Negrão Cavalcanti
    Aquaculture, 2022
  • Structural Elucidation of an Atropisomeric Entcassiflavan-(4β→8)-Epicatechin Isolated from Dalbergia monetaria L.f. Based on NMR and ECD Calculations in Comparison to Experimental Data
    Patrícia Homobono Brito de Moura, Wolfgang Brandt, Andrea Porzel, Roberto Carlos Campos Martins, Ivana Correa Ramos Leal, Ludger A. Wessjohann
    Molecules, 2022
    A rare dihydoxyflavan-epicatechin proanthocyanidin, entcassiflavan-(4β→8)-epicatechin, was isolated from Dalbergia monetaria, a plant widely used by traditional people from the Amazon to treat urinary tract infections. The constitution and relative configuration of the compound were elucidated by HR-MS and detailed 1D- and 2D-NMR measurements. By comparing the experimental electronic circular dichroism (ECD) spectrum with the calculated ECD spectra of all 16 possible isomers, the absolute configuration, the interflavan linkage, and the atropisomers could be determined.
  • Antiinflammatory activity of natural triterpenes—An overview from 2006 to 2021
    Rodrigo de Souza Miranda, Bárbara da Silva Mascarenhas de Jesus, Sandra Regina da Silva Luiz, Cristina Borges Viana, Camila Rodrigues Adão Malafaia, Fabiana de Souza Figueiredo, Tatiane dos Santos Conceição Carvalho, Matheus Lopes Silva, Vinicius Silva Londero, Thais Alves da Costa‐Silva, João Henrique Ghilardi Lago, Roberto Carlos Campos Martins
    Phytotherapy Research, 2022
  • Antioxidant capacity and fragmentation features of C-glycoside isoflavones by high-resolution electrospray ionization tandem mass spectrometry using collision-induced and high-energy collisional dissociation techniques
    Patricia Homobono Brito de Moura, Andrea Porzel, Rafaela Machado Nunes, Leopoldo Clemente Baratto, Ludger A. Wessjohann, Roberto Carlos Campos Martins, Ivana Correa Ramos Leal
    Journal of Mass Spectrometry, 2021
  • Exploring chemical diversity of phorbas sponges as a source of novel lead compounds in drug discovery
    Alessia Caso, Fernanda Barbosa da Silva, Germana Esposito, Roberta Teta, Gerardo Della Sala, Laura P. A. Nunes Cavalcanti, Alessandra Leda Valverde, Roberto Carlos C. Martins, Valeria Costantino
    Marine Drugs, 2021
  • Corrigendum to “Integrated analytical workflow for chromatographic profiling and metabolite annotation of a cytotoxic Phorbas amaranthus extract” (Journal of Chromatography B (2021) 1174, (122720), (S1570023221002002), (10.1016/j.jchromb.2021.122720))
    Bruno S. do Amaral, Fernanda B. da Silva, Gabriel Mazzi Leme, Letícia S.S. Schmitz, Paula C. Jimenez, Roberto Carlos Campos Martins, Quezia B. Cass, Alessandra L. Valverde
    Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2021
  • Integrated analytical workflow for chromatographic profiling and metabolite annotation of a cytotoxic Phorbas amaranthus extract
    Bruno S. do Amaral, Fernanda B. da Silva, Gabriel Mazzi Leme, Letícia S.S. Schmitz, Paula C. Jimenez, Roberto Carlos Campos Martins, Quezia B. Cass, Alessandra L. Valverde
    Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2021
  • I’m that Chemist”! An homage to Walter Mors on the centennial of his birth
    Alessandra Leda Valverde, Fernanda da Costa Neves, Roberto Carlos Campos Martins, Luiz Mors Cabral
    Revista Virtual De Quimica, 2021
  • Characterization of Antibacterial Proanthocyanidins of Dalbergia monetaria, an Amazonian Medicinal Plant, by UHPLC-HRMS/MS
    Patricia Homobono Brito de Moura, Amaryllis Almeida de Sousa, Andrea Porzel, Ludger A. Wessjohann, Ivana Correa Ramos Leal, Roberto Carlos Campos Martins
    Planta Medica, 2020
  • Antiparasitic activity and characterization of lignans from the ethanolic extract of zanthoxylum monogynum A. St-Hil. leaves
    Fernanda B. da Silva, Amanda L. Gomes, Marcelo Trovó, Ana M. Mazotto, Alane B. Vermelho, Roberto Carlos C. Martins
    Revista Virtual De Quimica, 2019
  • Metal content in medicinal teas used in the urubueua de fátima river community, Abaetetuba-Pará state, Brazil
    Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2019
  • Larvicidal activity of secondary plant metabolites in aedes aegypti control: An overview of the previous 6 years
    Aline Camargo Jesus de Souza Wuillda, Roberto Carlos Campos Martins, Fernanda das Neves Costa
    Natural Product Communications, 2019
  • Bioactive properties and phytochemical assessment of Bacupari-anão (: Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil
    Renato André Zan, Ângela Fernandes, Stephanie Jedoz, Taofiq Oludemi, Ricardo C. Calhelha, Tânia C. S. P. Pires, Maria José Alves, Roberto Carlos Campos Martins, Lillian Barros, Isabel C. F. R. Ferreira
    Food and Function, 2018
  • Isolation and identification of phenolic compounds from eryngium glaziovianum stem by countercurrent chromatography with off-line HPLC-DAD detection
    Aline C. J. de S. Wuillda, Marcelo Trovó, Roberto Carlos C. Martins, Fernanda das N. Costa
    Revista Virtual De Quimica, 2018
  • Antitrypanosomal acetylene fatty acid derivatives from the seeds of Porcelia macrocarpa (Annonaceae)
    Luciana De Á. Santos, Alberto Cavalheiro, Andre Tempone, Daniela Correa, Tatiana Alexandre, Natalia Quintiliano, André Rodrigues-Oliveira, Diogo Oliveira-Silva, Roberto Martins, João Lago
    Molecules, 2015
  • Chemical and biological evaluation of essential oils from two species of myrtaceae - Eugenia uniflora L. and plinia trunciflora (O. Berg) kausel
    João Henrique G. Lago, Elisângela Dutra Souza, Bruna Mariane, Renata Pascon, Marcelo A. Vallim, Roberto Carlos C. Martins, Adriana A. Baroli, Bianca A. Carvalho, Marisi G. Soares, Roberta T. dos Santos, Patricia Sartorelli
    Molecules, 2011
  • Variation in the amounts of volatile constituents of Cymbopogon citratus (DC) Staf, Poaceae, collected in different regions of São Paulo State
    Marcos R. Furlan, Roberto Carlos C. Martins, Eliana Rodrigues, Nayara Scalco, Giuseppina Negri, João Henrique G. Lago
    Revista Brasileira De Farmacognosia, 2010
  • Trypanocidal tetrahydrofuran lignans from inflorescences of Piper solmsianum
    Roberto C.C. Martins, João Henrique G. Lago, Sergio Albuquerque, Massuo J. Kato
    Phytochemistry, 2003
  • Phenylpropanoids and tetrahydrofuran lignans from Piper solmsianum
    Roberto C.C. Martins, Leandro R. Latorre, Patrı́cia Sartorelli, Massuo J. Kato
    Phytochemistry, 2000
  • Constituents of the essential oil of eugenia nitida cam b. (Myrtaceae)
    Roberto C. C. Martins, Leila V. Alegrio, Rosane X. Castro, Ronoel L.O. Godoy
    Journal of Essential Oil Research, 1999