Dr. Santosh Nirupadaya Mathapati

@jnmc.edu

Assistant Professor, Department of Surgical Oncology
Jawaharlal Nehru Medical College

Dr. Santosh Nirupadaya Mathapati


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https://researchid.co/santoshmathapati

RESEARCH, TEACHING, or OTHER INTERESTS

Oncology, Surgery
4

Scopus Publications

39

Scholar Citations

2

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Comparison of Lower Urinary Tract Function Before and After Undergoing Open Abdominal Hysterectomy: A Prospective Cohort Study
    Vikram Prabha, Saurabh Uplenchwar, Santosh Nirupadayya Mathapati, Mrityunjay Chandrashekhar Metgud
    Nephro Urology Monthly, 2025
    Background: Radical hysterectomies are known to affect the lower urinary tract, with the intensity being directly proportional to the radicality of the hysterectomy. Currently, very few studies suggest that a reduction in the radicality of hysterectomy might decrease urological morbidity. Objectives: The present study primarily aimed to compare the uroflowmetry parameters and symptoms score (ICIQ-FLUTS) in patients before and after undergoing open abdominal hysterectomy and secondarily to compare the results in the present study with those in the literature worldwide. Methods: This prospective cohort study was conducted in Belagavi, Karnataka, India, from February 2023 to July 2024 on 30 patients. Uroflowmetry and ICIQ-FLUTS were recorded 1 day preoperatively and postoperatively on days 10, 30, 90, and 180. Data were entered in Excel and analyzed using SPSS version 22.0. Intergroup comparisons of continuous means were performed using one-way ANOVA, and intragroup comparisons were analyzed post hoc using LSD analysis. Results: In the 30 samples collected, the mean age was 51.90 ± 11.98 years, and the mean time for surgery was 1 hour 39 minutes ± 33 minutes. Twenty percent, 43.33%, and 36.7% of patients underwent Wertheim’s hysterectomy, simple hysterectomy, and total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAHBSO) + omentectomy/bilateral pelvic lymph node dissection (PLND), respectively. The mean blood transfusion required was 0.2 pints. Time for surgery and the need for blood transfusion were considered surrogates for the complexity of surgery. No statistically significant difference was noted when the results were compared as per the study protocol. Conclusions: Current nerve-sparing hysterectomies are associated with minimal urological morbidities and provide a good quality of life, and thus should be performed whenever possible. However, the results are not generalizable.
  • Lympho-vascular invasion in oral cavity cancers – A bridge between tumour biology and clinical outcomes
    Sapna Krishnamurthy, Imtiaz Ahmed, Kumar Vinchurkar, Mahesh Kalloli, Adarsh Sanikop, Raghavendra Sagar, Santosh Mathapathi, Rohan Bhise
    Oral Oncology Reports, 2024
    Various histo-pathological prognostic factors have been identified in oral cavity squamous cell carcinomas (OCSCC). One such factor is the status of lympho-vascular invasion (LVI). We carried out this analysis to evaluate the association of LVI with other prognostic factors and the clinical outcomes. Data of patients with OCSCC who underwent curative intent surgery from January-2017 to December-2019 at our institute were retrospectively evaluated. The association of LVI with various tumour-node related prognostic factors and its effect on overall and disease-free survival (OS, DFS) were analyzed. of the total 234 patients, 71 % (166) had Bucco-alveolar-complex primary. 62.8 % (147) had locoregionally advanced disease. 91.5 % (214) required adjuvant treatment. The LVI positivity was 77.4 %, 63.3 % in tumour size >3cm/<3 cm, 85 %, 59.7 % in depth of infiltration >1cm/<1 cm, 82.4 %, 57.6 % in T3-T4/T1-2, 91.9 %, 59.9 % in grade 3/others and 96.8 %, 13.8 % in perineural invasion present/absent, respectively (p < 0.05). In the presence of LVI, lymph node positivity was 60.6 %, N2–N3 were 41.9 % and extra-capsular extension was 26.9 % as compared to LVI negative – 5.4 %, 5.4 % and 4.1 % respectively (p < 0.05). With median follow up of 37.3 months, 2year OS and DFS were 76.6 % and 75.5 % respectively. The 2year OS and DFS for the LVI-positive group were 70.4 % and 69.3 % compared to 90.6 % and 89.3 % for LVI-negative (p = 0.00). Loco-regional and distal (any) recurrence was seen in 20.9 % (49) and 7.3 % (17), the same for LVI-positive was 25.6 % (41) and 10 % (16) compared to 10.8 % (8) and 1.4 % (1) for LVI-negative (p < 0.05). In oral cavity cancers, there is positive association of LVI with various tumour-node related prognostic factors and clinical outcomes. • Lympho-vascular invasion (LVI) is a very important prognostic factor in oral cavity cancers. • LVI positivity can predict tumour biology, need for adjuvant treatment and survival outcomes. • Our study demonstrates a positive association of LVI with other risk factors and outcomes.
  • Oncoplastic Breast Reconstruction in Breast Conservation Surgery: Improving the Oncological and Aesthetic Outcomes
    Santosh N. Mathapati, Ashish Goel, Sandeep Mehta, Juhi Aggarwal, R. Aravindan, Vikash Nayak, Sangram K. Panda, Pankaj K. Pande, Kapil Kumar
    Indian Journal of Surgical Oncology, 2019
  • Polypropelene mesh eroding transverse colon following laparoscopic ventral hernia repair
    ManashRanjan Sahoo, Suryakanta Bisoi, Santosh Mathapati
    Journal of Minimal Access Surgery, 2013
    Polypropylene mesh when used in laparoscopic ventral hernia repair can produce the worst complication such as enterocutaneous fistula. We report an interesting case of incisional hernia operated with laparoscopic polypropylene mesh hernioplasty who subsequently developed an enterocutaneous fistula 1 month after surgery. A fistulogram showed dye entering into the transverse colon. On exploration, the culprit polypropylene mesh was found to have eroded into the mid-transverse colon causing the fistula. Resection and end-to-end anastomosis of the colon were done with the removal of the mesh. On literature review, polypropylene mesh erosion in to transverse colon is rare.

RECENT SCHOLAR PUBLICATIONS

  • Comparison of Lower Urinary Tract Function Before and After Undergoing Open Abdominal Hysterectomy: A Prospective Cohort Study
    V Prabha, S Uplenchwar, SN Mathapati, MC Metgud
    Nephro-Urology Monthly 17 (17), e164689 , 2025
    2025
  • Lympho-vascular invasion in oral cavity cancers–A bridge between tumour biology and clinical outcomes
    S Krishnamurthy, I Ahmed, K Vinchurkar, M Kalloli, A Sanikop, R Sagar, ...
    Oral Oncology Reports 11, 100477 , 2024
    2024
    Citations: 2
  • Oncoplastic breast reconstruction in breast conservation surgery: improving the oncological and aesthetic outcomes
    SN Mathapati, A Goel, S Mehta, J Aggarwal, R Aravindan, V Nayak, ...
    Indian Journal of Surgical Oncology 10 (2), 303-308 , 2019
    2019
    Citations: 20
  • Polypropelene mesh eroding transverse colon following laparoscopic ventral hernia repair
    MR Sahoo, S Bisoi, S Mathapati
    Journal of Minimal Access Surgery 9 (1), 40-41 , 2013
    2013
    Citations: 17

MOST CITED SCHOLAR PUBLICATIONS

  • Oncoplastic breast reconstruction in breast conservation surgery: improving the oncological and aesthetic outcomes
    SN Mathapati, A Goel, S Mehta, J Aggarwal, R Aravindan, V Nayak, ...
    Indian Journal of Surgical Oncology 10 (2), 303-308 , 2019
    2019
    Citations: 20
  • Polypropelene mesh eroding transverse colon following laparoscopic ventral hernia repair
    MR Sahoo, S Bisoi, S Mathapati
    Journal of Minimal Access Surgery 9 (1), 40-41 , 2013
    2013
    Citations: 17
  • Lympho-vascular invasion in oral cavity cancers–A bridge between tumour biology and clinical outcomes
    S Krishnamurthy, I Ahmed, K Vinchurkar, M Kalloli, A Sanikop, R Sagar, ...
    Oral Oncology Reports 11, 100477 , 2024
    2024
    Citations: 2
  • Comparison of Lower Urinary Tract Function Before and After Undergoing Open Abdominal Hysterectomy: A Prospective Cohort Study
    V Prabha, S Uplenchwar, SN Mathapati, MC Metgud
    Nephro-Urology Monthly 17 (17), e164689 , 2025
    2025