Antidiabetic activity of Cassia angustifolia Vahl. and Raphanus sativus Linn. leaf extracts Deepti Kaushalkumar Jani, Sunita Goswami Journal of Traditional and Complementary Medicine, 2020 • Senna and radish leaf extracts reduced hyperglycemia in diabetic animals. • Treatment with study extracts improved lipid profile and decreased atherogenicity. • Treatment reduced insulin resistance and ameliorated pancreatic histology. • Antidiabetic action attributed to synergistic effect of phytoconstituents.
Screening of ten herbal extracts to compare and investigate effect on glucose lowering and anorexic activity in wistar rats Deepti Kaushalkumar Jani, Sunita Goswami Asian Journal of Pharmaceutical and Clinical Research, 2017 Objective: Metabolic disorders are of growing concern with increasing quest for herbal medicines as treatment option. The current study is planned to screen ten herbal extracts, prepared from parts of chosen six herbal plants, to compare and investigate their antihyperglycemic and anorexic potential.Methods: Qualitative phytochemical investigation was done as per standard procedures. Acute oral toxicity study performed as per OECD 420 guideline. Glucose Tolerance Test (method optimization) was performed to select appropriate glucose load to induce hyperglycemia. Antihyperglycemic activity was evaluated by Glucose Tolerance Test (single dose and multiple dose study) and anorexic potential was screened by food intake measurement using Wistar rats.Results: All herbs were found safe in acute oral toxicity study. Glucose Tolerance Test method optimization study signaled use of 3 g/kg glucose load for induction of hyperglycemia in single and multiple dose studies. In single dose study, L. acutangula fruit extract and in multiple dose study, S. melongena, M. oleifera & R. communis extracts were found to produce significant glucose lowering effect as compared to glucose control group. Results of food intake measurement showed significant appetite suppression with extracts of W. somnifera, S. melongena, M. oleifera & R. communis. Conclusion: Present study throws light on the effectiveness of experimental herbal extracts as antihyperglycemic and anorexic agents. This also, helps in identifying potent indigenous herbs for further study.
Evaluation of anxiolytic and antidepressant activity of sitagliptin and linagliptin in rats International Journal of Pharmacy and Technology, 2016
Beneficial effect of aspirin against interferon-α-2b—induced depressive behavior in Sprague Dawley rats Shailendra Bhatt, Kilambi Pundarikakshudu, Paresh Patel, Nirav Patel, Ashish Panchal, Gaurang Shah, Sunita Goswami Clinical and Experimental Pharmacology and Physiology, 2016 SummaryAccumulating data advocates that inflammatory mediators may contribute to depression in experimental models as well as in humans. Nonetheless, whether anti‐inflammatory treatments can prevent depression still remains controversial. To substantiate our hypothesis, we used an interferon‐α‐2b model of depression using Sprague Dawley rats. Interferon‐α‐2b is a cytokine which activates immune response and also produces depression. The animals were treated for 21 days with aspirin (10 mg/kg, per oral (p.o.)) dexamethasone (1 mg/kg p.o.) and amitriptyline (10 mg/kg p.o.). Amitriptyline was used as reference standard, and given concurrently with aspirin and dexamethasone to examine any synergy. Interferon‐α‐2b (6000 IU/kg, intraperitoneal (i.p.)) was administered in all the above groups daily, except normal control. Tests performed included sucrose preference test, behavioural tests like forced swim test, elevated plus maze, light dark box and locomotor activity along with biochemical estimations like serum cortisol and brain neurotransmitters. The rats in the group treated with Interferon‐α‐2b produced depressive behaviour in rats. We found that animals treated with aspirin decreased immobility time in forced swim test, increased sucrose preference, decreased serum cortisol and increased brain serotonin levels signifying antidepressant action. In contrast, there was no effect in groups treated with dexamethasone. Our results suggest that aspirin can serve as a potential antidepressant both individually and as adjuvant agent in the treatment of depression. Inhibition of the cyclo‐oxygenase‐2 levels and prostaglandins concentration or any other potential physiological and biochemical mechanisms may be involved in antidepressant effect.
Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats Shailendra Bhatt, Priyanka Shukla, Jibril Raval, Sunita Goswami Basic Clinical Pharmacology Toxicology, 2016 A large number of current studies indicate that inflammatory mediators may contribute to depression in experimental models as well as in human beings. Nevertheless, the subject, whether anti‐inflammatory treatments can prevent depression still remains controversial. In the present study, a chronic mild stress (CMS) model of male Sprague Dawley rats was used to investigate the role of anti‐inflammatory drugs in the treatment of depression. All the animals in different groups, except the normal control group, were exposed to CMS procedure for 28 days and concurrently treated with aspirin (10 mg/kg, p.o.), dexamethasone (1 mg/kg p.o.) and amitriptyline (10 mg/kg p.o., reference standard), respectively. Amitriptyline was also used in combination with aspirin and dexamethasone to inspect any synergistic effects. Tests performed towards the end of the study included sucrose preference test, behavioural tests like forced swim test, elevated plus‐maze, light/dark box, locomotor activity and biochemical estimations like serum cortisol and brain neurotransmitters. Disease control group (CMS‐treated) produced significant depressive behaviour in rats. The animals treated with aspirin showed increased sucrose preference, decreased immobility time in forced swim test, decreased serum cortisol and increased brain serotonin levels signifying antidepressant action. In contrast, there was aggravation of depressive behaviour in rats treated with dexamethasone. Together, these findings suggest that aspirin can serve as a potential antidepressant both individually and as adjunctive agent in the treatment of depression. Inhibition of the inflammatory mediators during stress procedures or any other potential physiological and biochemical mechanisms may be involved in its antidepressant effect.
A simple and reproducible estimation of some novel atypical antipsychotics by colorimetric method using bromocresol green as chromogen Der Pharmacia Lettre, 2015
Gastroprotective effects of β3-adrenoceptor agonists on water immersion plus restraint stress-induced gastric ulcer in rats Indian Journal of Pharmacology, 2004
Physiological role, distribution and pharmacological characteristics of β3-adrenoceptors: An overview Indian Journal of Pharmaceutical Sciences, 2003
Comparison of the profiles of β-adrenoceptor agonists in inhibiting histamine release from rat mast cells in vitro with their gastroprotective effects in rats Indian Drugs, 2001
RECENT SCHOLAR PUBLICATIONS
Potential effects of essential phospholipid and vitamin B12 in experimentally-induced arthritis in rats S Goswami, A Sharma, S Agrawal The Egyptian Rheumatologist 48 (1), 34-38 , 2026 2026
Novel tetracycline hybrids: synthesis, characterization, docking studies and in-vitro evaluation of antibacterial activity M Shah, B Suhagia, S Goswami, S Sagar, A Patwari Future Journal of Pharmaceutical Sciences 11 (1), 10 , 2025 2025 Citations: 3
Anti-Acne Activity of Minocycline Hybrids. M Shah, B Suhagia, S Goswami, A Patwari Journal of Young Pharmacists 17 (1) , 2025 2025 Citations: 1
PASS-ASSISTED PREDICTION OF NOVEL TETRACYCLINE HYBRIDS M SHAH, B SUHAGIA, S GOSWAMI Int J Curr Pharm Res 16 (6), 45-61 , 2024 2024
GLOBAL PERSPECTIVE ON EMERGING STRAIN OF INFLUENZA VIRUSES A Panchal, S Goswami Current Trends in Pharmaceutical Research 10 (2) , 2023 2023
Antidepressant Effect of Etoricoxib and Ibuprofen on chronic mild stress-induced depression in mice G Patel, S Goswami Asian Journal of Pharmacy and Pharmacology 8 (2), 36-45 , 2022 2022 Citations: 3
EARLY BIOMARKERS IN ACUTE KIDNEY INJURY-A REVIEW RP Shah, SS Goswami 2021
Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study B Pateliya, V Burade, S Goswami Naunyn-Schmiedeberg's Archives of Pharmacology 394 (9), 1949-1961 , 2021 2021 Citations: 20
Ameliorative effects of Triphala on mucosal damage in rat model of ulcerative colitis M Nariya, P Nariya, B Ravishankara, S Goswami 2021 Citations: 2
Naringenin and Metformin Enhance the Antitumor Effect of Doxorubicin Against Experimental Models of Breast Carcinoma B Pateliya, V Burade, S Goswami 2021
Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo B Pateliya, V Burade, S Goswami European journal of pharmacology 891, 173725 , 2021 2021 Citations: 49
Antidiabetic activity of Cassia angustifolia Vahl. and Raphanus sativus Linn. leaf extracts DK Jani, S Goswami Journal of traditional and complementary medicine 10 (2), 124-131 , 2020 2020 Citations: 40
Efficacy and Safety of Teneligliptin as Add on Therapy in Indian Type 2 Diabetes Mellitus Patients having Dyslipidemia MP Vinendra, SG Sunita J Diabetes Metab 10, 844 , 2020 2020 Citations: 1
Effect of senna and radish extracts on hepatic function in high fat diet fed and diabetic rats. JD Kaushalkumar, S Goswami 2019
Effect of Senna and Radish Extracts on Hepatic Function in High Fat Diet Fed and Diabetic Rats DK Jani, S Goswami Journal of drug delivery and therapeutics 9, 1164-1167 , 2019 2019 Citations: 2
PRELIMINARY SCREENING OF PSYCHOPHARMACOLOGICAL EFFECTS AND TOXICITY TESTING OF TENSNIL SYRUP IN SWISS ALBINO MICE M Shah Krishna, M Vandana, S Goswami Sunita 2017
Ameliorative effect of Raphanus sativus and Cassia angustifolia in experimentally induced hyperlipidemia and cardiovascular risk reduction D Jani, S Goswami Int J PharmTech Res 10 (4), 273 , 2017 2017 Citations: 11
Screening of ten herbal extracts to compare and investigate effect on glucose lowering and anorexic activity in wistar rats DK JANI, S GOSWAMI SCREENING 10 (12) , 2017 2017 Citations: 4
Beneficial effect of aspirin against interferon‐α‐2b—induced depressive behavior in Sprague Dawley rats S Bhatt, K Pundarikakshudu, P Patel, N Patel, A Panchal, G Shah, ... Clinical and Experimental Pharmacology and Physiology 43 (12), 1208-1215 , 2016 2016 Citations: 14
Investigation of the effects of vanilloids in chronic fatigue syndrome K Sarvaiya, S Goswami Brain Research Bulletin 127, 187-194 , 2016 2016 Citations: 10
MOST CITED SCHOLAR PUBLICATIONS
Treatment of inflammatory bowel disease (IBD) AB Pithadia, S Jain Pharmacological Reports 63 (3), 629-642 , 2011 2011 Citations: 629
5-Hydroxytryptamine receptor subtypes and their modulators with therapeutic potentials AB Pithadia, SM Jain Journal of clinical medicine research 1 (2), 72 , 2009 2009 Citations: 133
Gastroprotective effect of Benincasa hispida fruit extract MA Rachchh, SM Jain Indian journal of pharmacology 40 (6), 271-275 , 2008 2008 Citations: 130
A review on recent advances in dry eye: Pathogenesis and management AS Bhavsar, SG Bhavsar, SM Jain Oman journal of ophthalmology 4 (2), 50-56 , 2011 2011 Citations: 129
Study of Mimusops elengi bark in experimental gastric ulcers PJ Shah, MS Gandhi, MB Shah, SS Goswami, D Santani Journal of ethnopharmacology 89 (2-3), 305-311 , 2003 2003 Citations: 122
Quantification of Baicalein, Chrysin, Biochanin-A and Ellagic Acid in Root Bark of Oroxylum indicum by RP-HPLC with UV Detection. M Zaveri, A Khandhar, S Jain Eurasian Journal of Analytical Chemistry 3 (2) , 2008 2008 Citations: 93
Antihyperlipidemic activity of Clitoria ternatea and Vigna mungo in rats YB Solanki, SM Jain Pharmaceutical biology 48 (8), 915-923 , 2010 2010 Citations: 67
Immunostimulant Activity of n -Butanol Fraction of Root Bark of Oroxylum indicum , vent. M Zaveri, P Gohil, S Jain Journal of immunotoxicology 3 (2), 83-99 , 2006 2006 Citations: 63
Gastroprotective effect of β3 adrenoceptor agonists ZD 7114 and CGP 12177A in rats R Sevak, A Paul, S Goswami, D Santani Pharmacological research 46 (4), 351-356 , 2002 2002 Citations: 56
Antiulcer Activity of the Root Bark of Oroxylum indicum . Against Experimental Gastric Ulcers M Khandhar, M Shah, D Santani, S Jain Pharmaceutical biology 44 (5), 363-370 , 2006 2006 Citations: 50
Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo B Pateliya, V Burade, S Goswami European journal of pharmacology 891, 173725 , 2021 2021 Citations: 49
Antidiabetic activity of Cassia angustifolia Vahl. and Raphanus sativus Linn. leaf extracts DK Jani, S Goswami Journal of traditional and complementary medicine 10 (2), 124-131 , 2020 2020 Citations: 40
Role of aspirin and dexamethasone against experimentally induced depression in rats S Bhatt, P Shukla, J Raval, S Goswami Basic & clinical pharmacology & toxicology 119 (1), 10-18 , 2016 2016 Citations: 37
Anti-inflammatory and analgesic activity of root bark of Oroxylum indicum Vent M Zaveri, S Jain Journal of Global Pharma Technology 2 (4), 79-87 , 2010 2010 Citations: 37
Gastroprotective effects of root bark of Oroxylum indicum, vent. M Zaveri, S Jain Journal of Natural Remedies 7 (2), 269-277 , 2007 2007 Citations: 36
Mechanism of action of antiulcer activity of bark extracts of Manilkara hexandra against experimentally induced gastric ulcers in rats JS Shah, MB Shah, SS Goswami, DD Santani Pharmacognosy Magazine 2 (5), 46-51 , 2006 2006 Citations: 34
Effect of Manilkara hexandra ( Roxb .) Dubard against experimentally‐induced gastric ulcers MB Shah, SS Goswami, DD Santani Phytotherapy Research: An International Journal Devoted to Pharmacological … , 2004 2004 Citations: 33
Immunostimolatory activities of Vigna mungo L. extract in male Sprague–Dawley rats YB Solanki, SM Jain Journal of immunotoxicology 7 (3), 213-218 , 2010 2010 Citations: 30
Role of Mitogen‐Activated Protein (MAP) Kinases in Cardiovascular Diseases N Pandya, D Santani, S Jain Cardiovascular drug reviews 23 (3), 247-254 , 2005 2005 Citations: 26
Oral cancer screening at workplace in India—one-year follow-up PA Uplap, GA Mishra, P Majumdar, SD Gupta, PS Rane, PK Sadalge, ... Indian Journal of Community Medicine 36 (2), 133-138 , 2011 2011 Citations: 24
