Ali Karamyan

@razi.ac.ir

Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran

Ali Karamyan


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https://researchid.co/ali.karamyan

RESEARCH, TEACHING, or OTHER INTERESTS

Veterinary, Small Animals
3

Scopus Publications

24

Scholar Citations

2

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • Perceptions, behaviours, and practices of dog owners for giving treats: A cross sectional investigation
    Leila Tabrizian, Mahdi Pourmahdi Borujeni, Reza Avizeh, Mohammad Reza Zalaki Ghorbanipour, Majid Zakerian, Ali Karamian, Reza Azargoun
    Journal of Veterinary Behavior, 2025
  • Potential of the ImageJ software in the differentiation of various types of canine lymphadenopathies with fine needle aspiration cytology (FNAC)
    Zahra Nikousefat, Mohammad Hashemnia, Ali Karamyan
    Comparative Clinical Pathology, 2018
  • A novel intracellular pH-responsive formulation for FTY720 based on PEGylated graphene oxide nano-sheets
    Elham Masoudipour, Soheila Kashanian, Nasim Maleki, Ali Karamyan, Kobra Omidfar
    Drug Development and Industrial Pharmacy, 2018
    Objective: This study was performed to investigate a novel pH-responsive nanocarrier based on modified nano graphene oxide (nGO) to promote the acid-triggered intracellular release of a poorly soluble drug, FTY720. Methods: To synthesize a drug conjugated to modified nGO, first the polyethylene glycol (PEG) was conjugated to nGO, then the produced PEG-nGO was functionalized with the anticancer drug, FTY720, through amide bonding. It was characterized by the scanning electron microscopy (SEM), the atomic force microscopy (AFM), the Fourier transform infrared (FTIR) spectroscopy and the UV–vis spectroscopy. In vitro drug release of the FTY720-conjugated PEG-nGO was evaluated at pH 7.4 and 4.6 PBS at 37 °C. Furthermore, the antineoplastic action of unloaded and drug-loaded carrier against the human breast adenocarcinoma cell line MCF7 was explored using MTT and BrdU assays. Results: Characterization methods indicated successful drug deposition on the surface of nGO. In vitro, drug release results revealed a significantly faster release of FTY720 from PEG-nGO at acidic pH, compared with physiological pH. The proliferation assays proved that the unloaded nGO had no significant cytotoxicity against MCF7 cells, while free FTY720- and FTY720-loaded PEG-nGO had an approximately equal cytotoxic effect on the MCF7 cells. It was found that the extended release characteristic of FTY720 was well fitted to Korsmeyer–Peppas model and the release profile of FTY720 from PEG-nGO is diffusion controlled. Conclusion: PEGylated GO can act as a pH-responsive drug carrier to improve the efficacy of anticancer drug delivery.

RECENT SCHOLAR PUBLICATIONS

  • Perceptions, behaviours, and practices of dog owners for giving treats: A cross sectional investigation
    L Tabrizian, MP Borujeni, R Avizeh, MRZ Ghorbanipour, M Zakerian, ...
    Journal of Veterinary Behavior 78, 1-11 , 2025
    2025
    Citations: 1
  • Comparison of electrocardiogram parameters in chest compression only resuscitation and interposed abdominal compression resuscitation in dogs with experimentally induced …
    A Karamyan, R Avizeh, H Imani, M Razi Jalali
    Iranian Veterinary Journal 18 (2), 45-55 , 2022
    2022
  • Potential of the ImageJ software in the differentiation of various types of canine lymphadenopathies with fine needle aspiration cytology (FNAC)
    Z Nikousefat, M Hashemnia, A Karamyan
    Comparative Clinical Pathology 27 (3), 643-648 , 2018
    2018
    Citations: 3
  • A novel intracellular pH-responsive formulation for FTY720 based on PEGylated graphene oxide nano-sheets
    E Masoudipour, S Kashanian, N Maleki, A Karamyan, K Omidfar
    Drug development and industrial pharmacy 44 (1), 99-108 , 2018
    2018
    Citations: 20

MOST CITED SCHOLAR PUBLICATIONS

  • A novel intracellular pH-responsive formulation for FTY720 based on PEGylated graphene oxide nano-sheets
    E Masoudipour, S Kashanian, N Maleki, A Karamyan, K Omidfar
    Drug development and industrial pharmacy 44 (1), 99-108 , 2018
    2018
    Citations: 20
  • Potential of the ImageJ software in the differentiation of various types of canine lymphadenopathies with fine needle aspiration cytology (FNAC)
    Z Nikousefat, M Hashemnia, A Karamyan
    Comparative Clinical Pathology 27 (3), 643-648 , 2018
    2018
    Citations: 3
  • Perceptions, behaviours, and practices of dog owners for giving treats: A cross sectional investigation
    L Tabrizian, MP Borujeni, R Avizeh, MRZ Ghorbanipour, M Zakerian, ...
    Journal of Veterinary Behavior 78, 1-11 , 2025
    2025
    Citations: 1
  • Comparison of electrocardiogram parameters in chest compression only resuscitation and interposed abdominal compression resuscitation in dogs with experimentally induced …
    A Karamyan, R Avizeh, H Imani, M Razi Jalali
    Iranian Veterinary Journal 18 (2), 45-55 , 2022
    2022