Riju Mathew

@bcmch.org

Associate Professor, Medical Biochemistry
Believers Church Medical College Hospital

Riju Mathew


                  Download Compact PDF  
https://researchid.co/rijumathew

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, Clinical Biochemistry
5

Scopus Publications

44

Scholar Citations

4

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Association between ABO blood group and blood component transfusion requirements in dengue infection: a retrospective study from a tertiary hospital in Kerala, India
    Cleetus Cherupanakkal, Anupa Jacob, Jeby Jose Olickal, Jabiya Eliza Varughese, Ani Thampi, Anjali Anne Jacob, Riju Mathew, Gayathri Jayaprasad, Jisha Elsa Varghese
    BMJ Open, 2025
    Objective Platelet and fresh frozen plasma (FFP) transfusions are routinely employed in the management of severe dengue. Previous research has indicated a potential link between ABO blood groups and susceptibility to dengue, with evidence suggesting that mosquito vector feeding preferences may be influenced by host blood type. These factors could potentially impact transfusion demands during outbreaks. This retrospective study aimed to investigate the relationship between ABO blood groups and transfusion requirements in patients with dengue. Design Retrospective study. Setting The study was conducted at a tertiary care hospital in Kerala. Methods Clinical and laboratory data were reviewed for 199 patients confirmed with dengue who received blood component transfusions and compared with two control groups: 200 randomly selected patients with dengue who did not require transfusions and 200 patients without dengue who required transfusions, over a period spanning January 2015 to March 2023. Results Among transfused dengue cases, blood groups O (41.71%), A (28.14%) and B (23.12%) were most prevalent; however, no statistically significant association was observed between ABO blood group and transfusion requirement. Furthermore, the total volumes of FFP and platelet transfusions did not differ significantly across ABO groups among patients with dengue. Notably, platelet transfusions were significantly more frequent in dengue cases (92.0%) compared with transfused patients without dengue (35.5%), whereas FFP transfusions were more common in non-dengue transfused cases (84.5%) than in patients with dengue (44.7%). Patients with dengue also received significantly higher mean volumes of both FFP and platelets. Conclusion Despite earlier reports linking ABO blood types to dengue susceptibility, this study found no significant association with transfusion requirements, warranting confirmation through larger multicentre studies.
  • PREVALENCE OF SMALL DENSE LDL IN TYPE 2 DIABETES MELLITUS AND ITS CORRELATION WITH INFLAMMATORY MARKERS: A COMPREHENSIVE STUDY
    ANUSH N, SUKHDEEP KUMAR, RIJU MATHEW, PRANAV KUMAR PRABHAKAR
    Asian Journal of Pharmaceutical and Clinical Research, 2025
    Objectives: This research pursues to determine the incidence of elevated levels of sdLDL in T2DM patients and study its association with inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), and red cell distribution width (RDW).Methods: The study involved 158 participants, comprising both diabetic and non-diabetic individuals, recruited from a tertiary care facility. Blood samples underwent analysis for sdLDL levels using a two-step enzymatic technique. Inflammatory markers were estimated using nephelometry and chemiluminescent immunoassays. SPSS was employed for statistical analysis to establish relationships and significance levels.Results: Diabetic subjects demonstrated particularly higher sdLDL levels than non-diabetic controls (p < 0.001). A robust positive correlation was identified between sdLDL and hsCRP, Lp-PLA2, and RDW, suggesting a connection between sdLDL and systemic inflammation. Regression analysis further substantiated that elevated inflammatory marker levels were linked to increased sdLDL concentrations.Conclusion: The outcomes underline the crucial role of sdLDL in diabetic dyslipidemia and its strong relationship to inflammation. Estimation of sdLDL levels along with inflammatory biomarkers may improve cardiovascular risk assessment in diabetic patients. Therapeutic interventions, including lipid-lowering and anti-inflammatory approaches, could possibly reduce sdLDL-induced atherosclerosis.
  • Lipid Surrogate Markers of Small Dense LDL in Diabetic Patients
    Anush Nazar, Jasmin Anush, Riju Mathew, Pranav Kumar Prabhakar
    Aip Conference Proceedings, 2023
  • Clinical Utility of Small, Dense LDL as an Atherogenic Risk Marker
    Anush Nazar, Jasmin Anush, Riju Mathew, Pranav Kumar Prabhakar
    Biointerface Research in Applied Chemistry, 2023
    Low-density lipoprotein (LDL) has a major role in the origination and development of atherosclerosis and Cardio Vascular Diseases (CVD). Over the past few years, many studies have been concerned with different subclasses of LDLs and their atherogenicity. Low-density lipoproteins (LDLs) include many subclasses. The most common are large buoyant (LB), intermediate and small dense (sd) low-density lipoprotein particles. Small dense low-density lipoproteins attracted a lot of attention. Small dense LDL (sdLDL) has recently been proven to be more atherogenic than other lipoproteins containing apolipoprotein B, which have the potential to trigger atherosclerotic reactions. Many researchers have reported that small dense low-density lipoproteins are the superior biomarker for the prediction of atherosclerosis and CVDs regarding all other markers, including total low-density lipoprotein cholesterol(LDL-C), and total serum cholesterol, non-high-density lipoprotein (non-HDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride content. Circulating small dense, low-density lipoproteins go through several modifications in the blood, rendering them more atherogenic. These modifications may include glycation, oxidation, and desialylation. Modified particles are strong inducers of inflammation resulting in many cardiovascular diseases, making them the primary target during the treatment of coronary artery disease. This article will elaborate on the clinical utility of sdLDL as an early marker to predict atherosclerosis and CVDs, and why it is considered superior to other atherosclerotic markers.
  • Predictors of Severe COVID-19 Outcome: A Meta-Analysis of Common Laboratory Bio Markers
    Anush N, A Jasmin, Pranav K Prabhakar, Riju Mathew, C P Bineesh
    Ecs Transactions, 2022
    COVID-19 is a multisystem sickness caused by the complex interaction of inflammatory, immunological, and coagulative cascade. Risk assessment, choice of appropriate treatments, monitoring, and timely discharge are important aspects of COVID patient management. Along with proper clinical evaluation, laboratory markers can offer extra information that can have a substantial influence on these aspects of patient management. To identify potential markers of COVID-19-related mortality, a meta-analysis of papers concerning C-Reactive Protein (CRP), D-Dimer, Ferritin, Interleukin-6 (IL-6), Neutrophil-to-Lymphocyte ratio (N/L ratio), Procalcitonin, and mortality was conducted. D-Dimer and N/L ratio were found to be significantly different between the non-survivor and survivor groups. Overall meta-risk of death associated with the laboratory values was as follows: CRP HR 2.39 (1.05-3.74), D-Dimer HR 1.25 (1.03-2.48), Ferritin HR 3.37 (0.86-5.88), IL-6 HR 3.07 (-1.35-7.49), N/L ratio HR 1.20 (1.14-1.63), and Procalcitonin OR 3.60 (1.60-8.10). More study is needed to determine whether these laboratory biomarkers can be employed in the development of a clinical scoring system to help in patient triage.

RECENT SCHOLAR PUBLICATIONS

  • The Hidden Signal: Copper as an Underutilized Biomarker in Inflammation, Neurology, and Oncology
    R Mathew, S Joe
    ICME Journal of Laboratory Medicine P-ISSN: 3117-8065 E-ISSN: 3117-8073 1 (2 … , 2026
    2026
  • Laboratory Trends of Lipid Parameters in Patients with Lifestyle-Related Diseases
    R Mathew
    ICME Journal of Laboratory Medicine P-ISSN: 3117-8065 E-ISSN: 3117-8073 1 (1 … , 2026
    2026
  • The role of genomic instability in unexplained infertility: an overview
    MR Pillai AR, Thomas AM, George MM, Ninan NG, Antony S, Prince M, John A ...
    Journal of Infertility and Reproductive Biology 13 (2), 89-96 , 2025
    2025
  • Association between ABO blood group and blood component transfusion requirements in dengue infection: a retrospective study from a tertiary hospital in Kerala, India
    C Cleetus, O Anupa, Jacob' Jeby, Jose, V Jabiya, Eliza, T Ani, ...
    BMJ Open 15 (e106287) , 2025
    2025
  • Clinical Biochemistry Concepts and Technique
    DR Mathew
    ISBN 978-93-49712-21-8 1, 154 , 2025
    2025
  • DNA Damage in Type 2 Diabetes: A South Indian Perspective
    AR Pillai, A John, AA Jacob, R Mathew
    JMS SKIMS 27 (4), 4-9 , 2024
    2024
  • Small dense LDL as a biomarker in Type II diabetes: a comprehensive study.
    N Anush, S Kumar, J Anush, R Mathew, PK Prabhakar
    2024
  • Device to Detect Autoimmune Disorder Through Blood
    M Riju, T Sachin, PM Guru, S Neha, KJ Sanmati, SK Lanjhiyana, L Sweety, ...
    IN Patent App. 404078-001 , 2024
    2024
  • Prediabetes: A Review of Current Trends
    RM Swetha Anilkumar, Bineesh C P, Jans Jose
    Journal of Diabetes Research Reviews & Reports 6 (5), 1-4 , 2024
    2024
  • Non-motor Symptoms among Patients with Parkinson's Disease attending Multidisciplinary clinic in a Tertiary care hospital and its Association with Family Caregiver Burden
    ABV Roshin Mary Varkey, Riju Mathew, Ann George
    The International Neurourology Journal (Int Neurourol J, INJ) 27 (4), 1487-1494 , 2023
    2023
  • Device to detect sugar level through saliva
    M Riju, K Yasir, S Vivek, T Charu, M Ajita, S Varsha, A Rohini, Y Kadire, ...
    AU Patent 202,317,050 , 2023
    2023
  • Lipid surrogate markers of small dense LDL in diabetic patients
    A Nazar, J Anush, R Mathew, PK Prabhakar
    AIP Conference Proceedings 2800 (1), 020224 , 2023
    2023
  • Lipid Surrogate Markers of Small Dense LDL in Diabetic Patients
    N Anush, A Jasmin, M Riju, P Pranav, Kumar
    Proceedings of the International Conference on Materials for Emerging … , 2023
    2023
  • Role of Emerging Risk Markers in Cardiometabolic Syndrome
    S Joe, D Roy D, R Mathew, M K, J JS, J V, J R, A K K
    The Ciência & Engenharia - Science & Engineering Journal ISSN: 0103-944X 11 … , 2023
    2023
  • Predictors of Severe COVID-19 Outcome: A Meta-Analysis of Common Laboratory Biomarkers
    N Anush, A Jasmin, PK Prabhakar, R Mathew, CP Bineesh
    ECS Transactions 107 (1), 8531 , 2022
    2022
  • Clinical Utility of small, dense LDL as an atherogenic risk marker
    A Nazar, J Anush, R Mathew, PK Prabhakar
    2022
    Citations: 1
  • Role of LpPLA2 and hsCRP in the Early Prediction of Coronary Artery Disease (CAD)
    S Joe, KK Anilkumar, D Roy D, V Jeyapal, R Mathew
    International Journal of Medical Science and Current Research (IJMSCR) 4 (6 … , 2021
    2021
  • Awareness of Physical Therapeutic Procedures for Low Back Pain in Medical Staff Working In a Tertiary Care Hospital
    J Joshua Philipose, RM Varkey, R Mathew
    International Journal of Medical Science and Current Research (IJMSCR) 4 (6 … , 2021
    2021
  • Daily Monitoring of Discharge Process to Improve Quality of Healthcare Services: An Interventional Study
    EV Cherian, J Joseph, R Mathew, A David, GC Matteethra
    Believers Medical Journal 4 (1), 08-17 , 2021
    2021
  • Impact of continuous glucose monitoring with diabetic education on glycemic variability and HbA1c
    MV Mohan Varughese, Riju Mathew, Jessy Varghese, Cheryln Ann Chacko, Dona V ...
    International Journal of Advances in Medicine 7 (8), 1220-1226 , 2020
    2020

MOST CITED SCHOLAR PUBLICATIONS

  • Changes in inflammatory markers in bacterial-and nifedipine-induced gingival inflammation
    A George, SP George, S John, N George, S Joe, R Mathew
    Journal of international oral health: JIOH 7 (Suppl 2), 64 , 2015
    2015
    Citations: 12
  • Red Cell Distribution Width And High Sensitivity C-reactive Protein As Risk Markers In Hypertension
    J T K, R Mathew, J V, V T.
    International Journal of Medical Science and Public Health 1 (2), 138-142 , 2012
    2012
    Citations: 12
  • Assessment of Biomarkers of Coronary Heart Disease in Patients with Periodontitis
    A George, SP George, S John, A Mathew, S Joe, R Mathew
    Journal of International Oral Health 7 (11), 37-40 , 2015
    2015
    Citations: 6
  • Anti-Sa Antibody, Cyclic Citrullinated Peptide Antibody And Rheumatoid Factor As Diagnostic Markers Of Rheumatoid Arthritis
    G Prasanth, SR Padmaraj, R Mathew, T Vijayakumar
    International Journal of Scientific & Engineering Research (IJSER) 4 (2), 5 , 2013
    2013
    Citations: 4
  • A Comparison Of Egfr Using Serum Creatinine And Cystatin For The Assessment Of Renal Involvement In Hypertension.
    J T K, R Mathew, J V, V T.
    International Journal of Pharma and Bio Sciences 4 (1), 1-8 , 2013
    2013
    Citations: 3
  • Random urine microalbumin: creatinine ratio as a better diagnostic marker of progression of chronic kidney disease in the high risk population-A pilot study
    R Mathew, VR Pai, T Vijayakumar
    Int J Health Sci Res 5 (3), 183-8 , 2015
    2015
    Citations: 2
  • Comparative Evaluation Of Conventional And New Biomarkers Of Renal Involvement In Patients With Type 2 Diabetes Mellitus Andhypertension – A Pilot Study
    R Mathew, VR Pai, V T.
    Int J Pharm Bio Sci 4 (2), 742 - 750 , 2013
    2013
    Citations: 2
  • Clinical Utility of small, dense LDL as an atherogenic risk marker
    A Nazar, J Anush, R Mathew, PK Prabhakar
    2022
    Citations: 1
  • Genetic instabilities in H. pylori infected cardiovascular diseases
    V Viswanath, SR Padmaraj, D Roy
    International Journal of Scientific & Engineering Research 6 , 2015
    2015
    Citations: 1
  • Microalbuminuria and Red Cell Distribution Width as Predictive Markers of Renal Involvement in Hypertension
    TK Jithesh, R Mathew, V Jayapal, T Vijayakumar
    International Journal of Health and Rehabilitation Sciences (IJHRS) 1, 99-106 , 2012
    2012
    Citations: 1
  • The Hidden Signal: Copper as an Underutilized Biomarker in Inflammation, Neurology, and Oncology
    R Mathew, S Joe
    ICME Journal of Laboratory Medicine P-ISSN: 3117-8065 E-ISSN: 3117-8073 1 (2 … , 2026
    2026
  • Laboratory Trends of Lipid Parameters in Patients with Lifestyle-Related Diseases
    R Mathew
    ICME Journal of Laboratory Medicine P-ISSN: 3117-8065 E-ISSN: 3117-8073 1 (1 … , 2026
    2026
  • The role of genomic instability in unexplained infertility: an overview
    MR Pillai AR, Thomas AM, George MM, Ninan NG, Antony S, Prince M, John A ...
    Journal of Infertility and Reproductive Biology 13 (2), 89-96 , 2025
    2025
  • Association between ABO blood group and blood component transfusion requirements in dengue infection: a retrospective study from a tertiary hospital in Kerala, India
    C Cleetus, O Anupa, Jacob' Jeby, Jose, V Jabiya, Eliza, T Ani, ...
    BMJ Open 15 (e106287) , 2025
    2025
  • Clinical Biochemistry Concepts and Technique
    DR Mathew
    ISBN 978-93-49712-21-8 1, 154 , 2025
    2025
  • DNA Damage in Type 2 Diabetes: A South Indian Perspective
    AR Pillai, A John, AA Jacob, R Mathew
    JMS SKIMS 27 (4), 4-9 , 2024
    2024
  • Small dense LDL as a biomarker in Type II diabetes: a comprehensive study.
    N Anush, S Kumar, J Anush, R Mathew, PK Prabhakar
    2024
  • Device to Detect Autoimmune Disorder Through Blood
    M Riju, T Sachin, PM Guru, S Neha, KJ Sanmati, SK Lanjhiyana, L Sweety, ...
    IN Patent App. 404078-001 , 2024
    2024
  • Prediabetes: A Review of Current Trends
    RM Swetha Anilkumar, Bineesh C P, Jans Jose
    Journal of Diabetes Research Reviews & Reports 6 (5), 1-4 , 2024
    2024
  • Non-motor Symptoms among Patients with Parkinson's Disease attending Multidisciplinary clinic in a Tertiary care hospital and its Association with Family Caregiver Burden
    ABV Roshin Mary Varkey, Riju Mathew, Ann George
    The International Neurourology Journal (Int Neurourol J, INJ) 27 (4), 1487-1494 , 2023
    2023