Identification of salt-tolerant cowpea genotypes using ISSR markers and proteome analysis Muthuswamy Anusuyadevi Frontiers in Bioscience Elite, 2019 Soil salinity globally affects the productivity of staple food crops. Therefore, an understanding of the molecular mechanisms that lead to salt tolerance induced by antioxidant mechanisms can assist in the development of salt-tolerant crops. To decipher the molecular fingerprint of salt resistance, in this study, six salt-tolerant cowpea genotypes at the seedling stage were assessed for their antioxidant responses, yield, genetic polymorphism and proteomics under salt stress. Leaves and roots showed distinct tissue-specific responses to salinity, and leaves showed a better protection against salt stress-induced oxidative stress than roots. Inter simple sequence repeat (ISSR) fingerprinting allowed molecular discrimination between salt-tolerant cowpea genotypes. Proteome analysis of cowpea leaves under salt stress revealed up-regulation of ATP synthase, vacuolar ATPase, pentatricopeptide repeat protein, flavanone 3-hydroxylase and outer envelope pore protein. Thus, ISSR and proteome analysis allow the identification of salt-tolerant cowpea cultivars.
Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer’s disease Muthuswamy Anusuyadevi Frontiers in Bioscience Landmark, 2018 Alzheimer disease (AD) is a widespread neurodegenerative condition that leads to progressive cognitive dysfunction in elderly population. Despite several attempts aimed at molecular determinants of AD, effective disease modifying treatment options are highly limited. Recently, use of natural supplements has gained considerable attention in AD research due to their cost effective and long lasting health beneficial properties. Resveratrol (RSV) is a naturally occurring polyphenolic compound found majorly in grapes. RSV has been shown to exert a plethora of medical benefits due to its anti-oxidant, anti-aging, anti-inflammatory, anti-malignant and neuroprotective properties. In particular, RSV has been shown to increase memory performance. The neuroprotective effect of RSV has strongly been linked to the depolymerization of amyloid β fibrils. However, the molecular targets of RSV remain the subject of investigation. This review was aimed to comprehend the existing knowledge on the neuroprotective effects of RSV and recent progress made on understanding the role RVS in the regulation of neural plasticity through a molecular target Sirtuin 1, a potential homeostatic regulator in AD.
Resveratrol Intervenes Cholesterol-And Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer's Disease Mohan Sathya, Ponnusamy Moorthi, Palanisamy Premkumar, Mahesh Kandasamy, Kesavan Swaminathan Jayachandran, Muthuswamy Anusuyadevi Journal of Alzheimer S Disease, 2017 Deterioration of cholesterol metabolism has recently been a frontier subject of investigation in the field of Alzheimer's disease (AD). Though amyloid-β protein precursor (AβPP) primes the pathological cascade, changes in cholesterol levels and its intermediates, geranyl geranyl pyrophosphate and farnesyl pyrophosphate, is expected to have a different consequence on AβPP processing and amyloid-β (Aβ) generation. However, the use of statins (HMG-COA reductase inhibitor) has been widely implicated in slowing down the pathogenic progression of AD, while the epidemiological reports on its biological effect remains controversial. Considering this fact, the choice of drug that could maintain cholesterol homeostasis without altering its biosynthesis may yield a better therapeutic efficacy on AD. Thus, the present study focused on determining the influence of cholesterol and isoprenoids on amyloidogenic-cleavage of AβPP, in addition to resveratrol as a potent therapeutic drug in CHO-APPswe cell lines. High levels of cholesterol were found to enhance the maturation of AβPP and altered the expression and subcellular localization of ADAM10, BACE1, and PS1 thereby promoting Aβ generation, whereas high isoprenoids increased both maturation as well as amyloidogenic-cleavage of AβPP, which was evident through β-CTF production. Interestingly, the therapeutic efficacy of resveratrol maintained cholesterol homeostasis and reduced the amyloidogenic burden through its ability to enhance SIRT1 expression and thereby regulating differential expression of AD determinants.
Association Studies of Specific Cholesterol Related Genes (APOE, LPL, and CETP) with Lipid Profile and Memory Function: A Correlative Study among Rural and Tribal Population of Dharmapuri District, India Sabapathy Periyasamy, Mohan Sathya, Chennakesavan Karthick, Mahesh Kandasamy, Sellathamby Shanmugaapriya, Jeyavelu Tamilselvan, Kesavan Swaminathan Jayachandran, Muthuswamy Anusuyadevi Journal of Alzheimer S Disease, 2017 Epidemiological studies state that dementia has multiple etiologies including genetic mutation, genetic variation, and environmental factors. Accumulating evidence suggests that dysregulation of cholesterol homeostasis is the major etiological factor in initiating neurodegeneration. Apolipoprotein E (APOE) polymorphic alleles and associated polymorphism of lipoprotein lipase (LPL) and cholesteryl ester transfer protein (CETP) that are important components in regulating cholesterol metabolism are implicated in neurodegenerative diseases. Therefore, the current study focused on identifying the association between several common polymorphism (viz., APOE, CETP, and LPL) to that of change in serum lipid levels and memory symptoms. Volunteer subjects aged 50 and above from rural and tribal areas of the Dharmapuri district, Tamilnadu, India were chosen for the current study and polymorphism was analyzed using PCR-RFLP. Fasting lipid profile and memory function using simplified version of Global Clinical Dementia rating were assessed. Significant difference in the major lipid profile parameters were observed (TC, TGL, LDL, VLDL) among rural and tribal populations that were associated with significant genotypic variation of APOE, CETP, and LPL. Regression analysis revealed significant risk for memory loss that are dependent on age and genetic variants like CETP. These data predict positive correlation between cholesterol-associated genes and their relationship to altered lipid profile and memory symptoms, which possibly link gene-polymorphism and susceptibility ratio for aging and dementia.
BACE1 in Alzheimer's disease M. Sathya, P. Premkumar, C. Karthick, P. Moorthi, K.S. Jayachandran, M. Anusuyadevi Clinica Chimica Acta, 2012
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MOST CITED SCHOLAR PUBLICATIONS
BACE1 in Alzheimer's disease M Sathya, P Premkumar, C Karthick, P Moorthi, KS Jayachandran, ... Clinica chimica acta 414, 171-178 , 2012 2012.0 Citations: 143
Resveratrol intervenes cholesterol-and isoprenoid-mediated amyloidogenic processing of AβPP in familial Alzheimer’s disease M Sathya, P Moorthi, P Premkumar, M Kandasamy, KS Jayachandran, ... Journal of Alzheimer’s Disease 60 (s1), S3-S23 , 2017 2017.0 Citations: 52
Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer's disease. M Sathya, T Gobinath, A Salomy, M Nisha, M Kandasamy, M Essa,M, ... Frontiers in Bioscience (Landmark edition) 1 (23), 1380-1390 , 2018 2018.0 Citations: 24
Selection of Salt Tolerant Cowpea Genotypes Based on Salt Tolerant Indices of Morpho-biochemical Traits ML Mini, M Sathya, K Arulvadivookarasi, KS Jayachandran, ... Current Trends in Biotechnology and Pharmacy 9 (4), 306-316 , 2015 2015.0 Citations: 19
Identification of salt-tolerant cowpea genotypes using ISSR markers and proteome analysis M Mini, M Sathya, M Essa, M Al-Sadi, S Jayachandran, M Anusuyadevi Frontiers in Bioscience-Elite 11 (1), 130-149 , 2019 2019.0 Citations: 10
Association Studies of specific cholesterol related genes (APOE, LPL, and CETP) with lipid profile and memory function: a correlative study among rural and tribal population of … S Periyasamy, M Sathya, C Karthick, M Kandasamy, S Shanmugaapriya, ... Journal of Alzheimer’s Disease 60 (s1), S195-S207 , 2017 2017.0 Citations: 8
Revisiting the Concept of Alzheimer’s Disease as Type 3 Diabetes Mellitus-A Critical Examination of Neuro-metabolic Link M Sathya, P Sangeetha, V Senthamarai Selvi, K Rekha Indian Journal of Clinical Biochemistry, 1-13 , 2026 2026.0
Exploring the Link Between Insulin Resistance and Waist‑Calf Ratio in Type 2 Diabetes Mellitus S Mohan, K Rekha Journal of Multidisciplinary Health and Innovative Technology , 2025 2025.0
A COMPARATIVE STUDY OF PROPOFOL VERSUS ETOMIDATE AS INDUCTION AGENTS TO EVALUATE HAEMODYNAMIC CHANGES DURING ABDOMINAL SURGERY AD Laxmi, RG Soundhar, K Rekha, S Ilango, S Mohan, M Reshma Int J Acad Med Pharm 7 (5), 829-835 , 2025 2025.0
Shaping The Future of Healthcare with Artificial Intelligence: Current Trends and Beyond Sathya M,Rekha K,Beula Jenifer D. Afr. J. Biomed 27, 9986 - 9992 , 2024 2024.0
BACE1 expression in post-natal brain regions : where goes wrong? M Sathya, MS Venkatesh, K Gayathri, P Moorthi, KS Jayachandran, ... 2nd International conference on Central Nervous system disorders and … , 2016 2016.0
Dysregulation in cholesterol homeostasis altered APP cleavage pattern in FAD model: Protective role of Resveratrol M Sathya, P Premkumar, KS Jayachandran, M Anusuyadevi 2 nd International conference on Central Nervous system disorders and … , 2016 2016.0
FREQUENCY OF REJECTION AND HIGH-RISK SURGERIES BASED ON PREANAESTHETIC EVALUATION S Mohan, M Reshma mortality 2, 3 , 0
