Global Health Policies for Hepatocellular Carcinoma: A Cross-Sectional Study Douglas Chee, Christen En Ya Ong, Darren J.H. Tan, Jörn M. Schattenberg, George N. Ioannou, Daniel Q. Huang, Ng Cheng Han, Rachid Ould Gougam, Federico Piñero, Ken Liu, Simone I. Strasser, Sven M. Francque, M.L. Ferraz, Antonin Wilson Ndjitoyap Ndam, Marc Bilodeau, Jie Li, Fanpu Ji, Andres Gomez-Aldana, Robin German Prieto-Ortiz, Petr Hříbek, Mbendi Nlombi Charles, Mohamed El-Kassas, Abate Bane Shewaye, Mengistu Erkie Minaye, Jean-Frédéric Blanc, Yaw Asante Awuku, Evangelos Cholongitas, Roberto Zuchini, Ritza Germain, Jimmy Che-To Lai, Rashid N. Lui, Anand V. Kulkarni, Shivaram Prasad Singh, Irsan Hasan, Cosmas Rinaldi Adithya Lesmana, Reza Malekzadeh, Ziv Ben-Ari, Gianpaolo Vidili, Franco Trevisani, Takumi Kawaguchi, Nobuharu Tamaki, Amos Otedo, Yeong Yeh Lee, Ruveena Rajaram, Soek-Siam Tan, Maria Sarai Gonzalez Huezo, Muhammad Ismail, Soe Thiha Maung, Aung Hlaing Bwa, Tien Huey Lim, Edward N. Okeke, Zaigham Abbas, Wasim Jafri, P. Martin Padilla-Machaca, Janus P. Ong, Mara Teresa Panlilio, Jose Guillain E. Cataluña, Jose Presa Ramos, Beom Kyung Kim, Khalid A. Alswat, Ibrahima Diallo, Mohamed Abdulkadir Hassan-Kadle, Anuradha S. Dassanayake, Madunil Anuk Niriella, Hasitha S. Wijewantha, Per Stål, Nicolas Goossens, Jia-Horng Kao, Tung-Hung Su, Yao-Chun Hsu, Hyasinta Jaka, Apichat Kaewdech, Ulus Salih Akarca, Ponsiano Ocama, David J. Pinato, Karn Wijarnpreecha, Veeral Ajmera, Hirokazu Takahashi, Mark Muthiah, Ju Dong Yang, C. Wendy Spearman, Peter Jepsen Clinical Gastroenterology and Hepatology, 2026
Cholangiocarcinoma 2026: status quo, unmet needs and priorities Jesus M. Banales, Pedro M. Rodrigues, Silvia Affò, Jesper B. Andersen, Patricia Aspichueta, Luke Boulter, John Bridgewater, Diego F. Calvisi, Andres Cardenas, Vincenzo Cardinale, Guido Carpino, Cédric Coulouarn, Cristina Dopazo, Julien Edeline, Luca Fabris, Trine Folseraas, Alejandro Forner, Benjamin Goeppert, Mathias Heikenwalder, Timothy J. Kendall, Shahid A. Khan, Heinz-Josef Klümpen, Bas Groot Koerkamp, Angela Lamarca, Stacie Lindsey, Ana Lleo, Tom Luedde, Rocio I. R. Macias, Helen Morement, Jean-Charles Nault, Paula Olaizola, Maria J. Perugorria, Chiara Raggi, Lorenza Rimassa, Anna Saborowski, Juan W. Valle, Mathew Vithayathil, Arndt Vogel, Chiara Braconi, , Abel Sanchez, Adelaida La Casta, Aldo J. Montano-Loza, Alessandra Elvevi, Alessandro Parisi, Alexander Link, Ana Landa-Magdalena, Andres Munoz, Anthony Turpin, Anu Ustav, Apinya Jusakul, Arun Valsan, Benjamin Dwyer, Bogdan S. Ungureanu, Bruno Sangro, Christoph Schramm, Cindy Neuzillet, Constantino Fondevila, David J. Pinato, David Malka, Domingo Balderramo, Elide Gutierrez, Elisa Lozano, Emmanuel Boleslawski, Enrique Carrera Estupinan, Ernesto Sparrelid, Eugenio Gaudio, Fatima Higuera De La Tijera, Flavio Rocha, Florence Troisfontaine, Francesca Ratti, Frank Lammert, Gianpaolo Vidili, Gonzalo Sapisochin, Gregory B. Lesinski, Gregory Gores, Hannes Jansson, Hassan Malik, Jan Philipp Jonas, Javier Diaz Ferrer, Javier Vaquero, Jens U. Marquardt, Joana Espírito Santo, Jorge Adeva, Joris Erdmann, Jose J. G. Marin, Juan Carlos Roa, Juli Busquets, Juozas Kupcinskas, Krzysztof Zieniewicz, Lara Heij, Laura Goff, Laura Izquierdo-Sanchez, Leonardo G. Da Fonseca, Luca Maroni, Luis Bujanda, Mairéad G. McNamara, Marco Carbone, Marco Marzioni, Marco Rengo, Maria Melanie Deutsch, Mariano Ponz, Mario Strazzabosco, Markus Peck-Radosavljevic, Massimiliano Cadamuro, Massimiliano Salati, Massimo Colombo, Matei Mandea, Matias A. Avila, Matthias Evert, Mina Komuta, Mitesh Borad, Mohamed Bouattour, Mohamed El-Kassas, Monica I. Meneses-Medina, Monica Niger, Monique Verstegen, Nabeel Bardeesy, Nilofer Azad, Olivier Detry, Olivier Scatton, P. Martin Padilla-Machaca, Pilar Acedo, Pim B. Olthof, Piotr Milkiewicz, Rachel Guest, Rachna Shroff, Robert Montal, Robin Kate Kelley, Ruidong Xue, Sergio Gradilone, Shishir K. Maithel, Silvestre Vicent, Siwanon Jirawatnotai, Stefano Caruso, Stephanie Roessler, Stephen L. Chan, Stephen P. Pereira, Teresa Macarulla, Thomas Gruenberger, Tian V. Tian, Tim F. Greten, Tudor Mocan, Tushar Patel, Umair Mahmood, Umberto Cillo, Vera Megdanova, Victor Lopez-Lopez Nature Reviews Gastroenterology and Hepatology, 2026
Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis Jonel Trebicka, Ferran Aguilar, Alberto Queiroz Farias, Juan-José Lozano, Cristina Sánchez-Garrido, Eva Usón-Raposo, Carlos de la Peña-Ramirez, Julia Sidorova, Anna Curto-Vilalta, Patricia Sierra-Casas, Patricia Momoyo Zitelli, Maria Papp, Gustavo Pereira, Paolo Caraceni, Luciana L Goncalves, Carlo Alessandria, Aldo Torre, Wim Laleman, Adrián Gadano, Salvatore Piano, Angelo Z Mattos, Wenyi Gu, Maximilian Joseph Brol, Robert Schierwagen, Frank Erhard Uschner, Julia Fischer, Liliana S C Mendes, Victor Vargas, Mario R Alvares-da-Silva, Raj Mookerjee, Paolo L Bittencourt, Carlos Benitez, Agustín Albillos, Cláudia Couto, Manuel Mendizabal, Rafael Bañares, Claudio L Toledo, Daniel F Mazo, Martin Janicko, Mauricio Castillo-Barradas, Pedro Martin Padilla Machaca, Pietro Gatti, Adelina Zarela-Lozano Miranda, René Malé-Velázquez, Alexander Zipprich, André Castro-Lyra, Thierry Gustot, William Bernal, Alexander L Gerbes, Rajiv Jalan, Javier Fernández, Paolo Angeli, Flair Jose Carrilho, Joan Claria, Richard Moreau, Vicente Arroyo Gut, 2025 Background and aimsQuantifying systemic inflammation (SI) in acutely decompensated cirrhosis (ADC) is of major importance because SI is a driver of the most severe forms of ADC, including acute-on-chronic liver failure (ACLF). Blood biomarkers of SI already evaluated in ADC failed to appropriately assess SI in ADC. We aimed to investigate whether gene expression related to circulating immune cells could quantify SI in ADC.MethodsStandard biomarkers (white cell count, C reactive protein, cytokines) and genome-wide RNA expression (RNA-sequencing) were obtained in blood from 700 patients with ADC at the time of their hospital admission. A composite score based on standard biomarkers of SI (Chronic Liver Failure-Standard Biomarkers Composite (CLIF-SBC) score) and a gene score (CLIF-Systemic Inflammation Gene (SIG) score) composed of the 28 top differentially expressed immune cell-related genes in the comparison between high-severity and low-severity clinical phenotypes were computed. Among the 700 patients, the CLIF-SIG score was repeated once during follow-up in 375 patients, and 3 times or more in 46 patients.ResultsThe CLIF-SIG score was more accurate in reflecting clinical severity induced by SI than the CLIF-SBC score (area under the curve 0.803 vs 0.658). A CLIF-SIG score of 0.386 (Youden Index) was the best cut-off level discriminating patients with poor outcomes from the others, in all clinical scenarios. Sequential measurement of the CLIF-SIG score showed that 78% of patients were admitted at the peak or descending part of the SI-wave. ACLF developed during hospitalisation in 80% of patients with a CLIF-SIG score >0.386 on admission.ConclusionsIn patients with ADC, the CLIF-SIG score is an accurate estimator of SI, clinical course severity and prognosis.
Variceal gastrointestinal bleeding: epidemiology, pathogenesis, management and prophylaxis Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2025
Latin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation Liana Codes, Rodrigo Zapata, Manuel Mendizabal, Alfeu de Medeiros Fleck Junior, Juan Carlos Restrepo, Leonardo de Lucca Schiavon, Luiz Marcelo Sá Malbouisson, Wellington Andraus, Adrian Gadano, P. Martin Padilla-Machaca, Alejandra Villamil, Raquel Silveira Bello Stucchi, Graciela Elia Castro-Narro, Josefina Pages, Debora Raquel Benedita Terrabuio, Alvaro Urzúa, Mário Guimarães Pessoa, Victoria Mainardi, Rodolpho Pedro, Oscar Imventarza, Solange Gerona, Rodrigo Wolff, Edson Abdala, Laura Tenorio, Eira Cerda-Reyes, Fernando Cairo, Mario Uribe, Paulo Lisboa Bittencourt, Ricardo Chong, Norma Marlene Perez Figueroa, John Byron Abad González, Pablo Coste Murillo Annals of Hepatology, 2025 Liver transplantation (LT) is a well-established therapy for patients with decompensated cirrhosis and early-stage hepatocellular carcinoma. Liver transplantation activity varies sharply across Latin American (LATAM) countries due to differences in resources, expertise, and funding and local attitudes toward organ donation and transplantation. This current guidance of postoperative care after LT is the first position paper of the Latin American Association for the Study of the Liver (ALEH) Special Interest Group (SIG), drawing evidence-based recommendations regarding immediate and long-term postoperative care of LT recipients, taking into consideration their applicability in Latin America.
A New Routine Immunity Score (RIS2020) to Predict Severe Infection in Solid-Organ Transplant Recipients E. Sarmiento, I. Ezzahouri, Maricela Jimenez-Lopez, Kristofer M. Limay Carré, Rocio Alonso, C. Ortiz-Bautista, M. Salcedo Plaza, M. L. Rodríguez-Ferrero, P. Padilla-Machaca, A. Cerron, J. Chaman, Ana P. Vionnet Salvo, J. Carbone Annals of Transplantation, 2025 Background Infection is a cause of morbidity and mortality in solid-organ transplantation (SOT). We evaluated a new score that is applied during the first month after transplantation. The score comprises biomarkers of innate and acquired immunity to predict infections in SOT. Material/Methods Prospectively collected blood samples from 377 heart, liver, or kidney recipients were analyzed at 2 centers in Madrid (Spain) and Lima (Peru). Biomarkers were tested before transplantation and at days 7 and 30 after transplantation. During the first 6 months after transplantation, 183 (48.5%) patients developed severe infections (bacterial infections and/or CMV disease). Risk for severe infection was assessed using logistic regression analysis. We designed a score, the routine immunity score (RIS2020), which is based on the sum of the hazard ratios (HRs) of each biomarker. Results The risk factors for severe infection were as follows: Moderate IgG hypogammaglobulinemia (IgG <600 mg/dL at days 7 or 30, HR 2.07, 95% CI 1.37–3.12, p=0.0005, 2 points), CD4 <400 cells/uL at day 30 (HR 1.76, 95% CI 1.03–3.04, p=0.039, 2 points), C3 <80 mg/dL at day 30 (HR 2.18, 95% CI 1.16–4.06, p=0.014, 2 points), and CRP >3 mg/dL at day 30 (HR 2.11, 95% CI 1.12–3.97, p=0.02, 2 points). In patients with ≥4 points, the HR for infection was 5.18 (95% CI 3.06–8.75; p<0.001). RIS2020 was an independent predictor of severe infection in multivariate models. Conclusions An immunological score combining moderate IgG hypogammaglobulinemia and other parameters of innate and acquired immunity could better identify the risk for severe infection in SOT.
A global action agenda for turning the tide on fatty liver disease Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Quentin M. Anstee, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Amalia Gastaldelli, Hannes Hagström, Terry T.K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Norah A. Terrault, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Jörn M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi, and Hepatology, 2024 Background and Aims: Fatty liver disease is a major public health threat due to its very high prevalence and related morbidity and mortality. Focused and dedicated interventions are urgently needed to target disease prevention, treatment, and care. Approach and Results: We developed an aligned, prioritized action agenda for the global fatty liver disease community of practice. Following a Delphi methodology over 2 rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the action priorities using Qualtrics XM, indicating agreement using a 4-point Likert-scale and providing written feedback. Priorities were revised between rounds, and in R2, panelists also ranked the priorities within 6 domains: epidemiology, treatment and care, models of care, education and awareness, patient and community perspectives, and leadership and public health policy. The consensus fatty liver disease action agenda encompasses 29 priorities. In R2, the mean percentage of “agree” responses was 82.4%, with all individual priorities having at least a super-majority of agreement (> 66.7% “agree”). The highest-ranked action priorities included collaboration between liver specialists and primary care doctors on early diagnosis, action to address the needs of people living with multiple morbidities, and the incorporation of fatty liver disease into relevant non-communicable disease strategies and guidance. Conclusions: This consensus-driven multidisciplinary fatty liver disease action agenda developed by care providers, clinical researchers, and public health and policy experts provides a path to reduce fatty liver disease prevalence and improve health outcomes. To implement this agenda, concerted efforts will be needed at the global, regional, and national levels.
Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America Alberto Queiroz Farias, Anna Curto Vilalta, Patricia Momoyo Zitelli, Gustavo Pereira, Luciana L. Goncalves, Aldo Torre, Juan Manuel Diaz, Adrian C. Gadano, Angelo Z. Mattos, Liliana S.C. Mendes, Mario R. Alvares-da-Silva, Paulo L. Bittencourt, Carlos Benitez, Claudia Alves Couto, Manuel Mendizabal, Claudio L. Toledo, Daniel F.C. Mazo, Mauricio Castillo Barradas, Eva M. Uson Raposo, P. Martín Padilla-Machaca, Adelina Zarela Lozano Miranda, René Malé-Velázquez, André Castro Lyra, Milagros B. Dávalos-Moscol, José L. Pérez Hernández, Rafael O. Ximenes, Giovanni Faria Silva, Oscar A. Beltrán-Galvis, María S. González Huezo, Fernando Bessone, Tarciso D.S. Rocha, Eduardo Fassio, Carlos Terra, Juan I. Marín, Patricia Sierra Casas, Carlos de la Peña-Ramirez, Ferran Aguilar Parera, Flavia Fernandes, Maria da Penha Zago-Gomes, Osvely Méndez-Guerrero, Sebastián Marciano, Angelo A. Mattos, Joao C. Oliveira, Gabriel T.S. Guerreiro, Liana Codes, Marco Arrese, Mateus J. Nardelli, Marcelo O. Silva, Renato Palma-Fernandez, Camila Alcantara, Cristina Sánchez Garrido, Jonel Trebicka, Thierry Gustot, Javier Fernández, Joan Clària, Rajiv Jalan, Paolo Angeli, Vicente Arroyo, Richard Moreau, Flair J. Carrilho, Caroline Marcondes Ferreira, Debora R. Benedita Terrabuio, Roberto M. Fernandes da Costa, Izabelle Venturini Signorelli, Caroline A. Pinto, Alma Estanes-Hernández, Jesús Ruiz Manriquez, María N. Gutierrez-Acevedo, Agustina M. Martinez-Garmendia, M. Ligia Aparecida, Everton Macêdo, Augusto Mantovani, Larisse Longo, Eduardo Garcia Vilela, María G. Valderrama, Michelle V.S. Santos-Rondon, Bertha Cardenas, Jorge Garavito Rentería, Lilian Montserrat Torres-Made, Laura C. Tenorio Castillo, José M. Aquino Ramos, María de Fátima Higuera de la Tijera, Rodrigo S. Aires, Diana C. Salinas-Gómez, Francisca Allendes, Fernando C. Schacher, Guilherme John Neto, Raúl Castro Valdivia, Josefina Pagés, Juan P. Roblero, Hugo Fainboim, Fernanda Fernandes Souza, Luis Colombato, Renata de Mello Peres, Larissa O. Miranda, Jade C. Oliveira, Leyla Nazal Ortiz, Daniela Simian, Gabriel Mezzano Puentes, Rita de Cássia Martins Alves da Silva, Iaarah Montalvo Gordon, Luis A. Chi Cervera, Marcos A. Girala Salomón, María T. Cuevas, Pedro Montes, Máximo J. Cattaneo Buteler Gastroenterology, 2023 BACKGROUND & AIMS Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (e.g., Covid-19). This study aimed to investigate the association of genetic ancestry and race with acute-on-chronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure and high risk of short-term death. METHODS This prospective cohort study analyzed a comprehensive set of data including genetic ancestry and race, among several others, in 1274 patients with acutely decompensated cirrhosis (ADC) who were nonelectively admitted to 44 hospitals from 7 Latin American countries. RESULTS 395 (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without ACLF (22.6% vs 12.9% and 53.4% vs 59.6%, respectively). The median percentage of African genetic ancestry was low among patients with ACLF and among those without. In terms of race, a higher percentage of patients with ACLF than patients without ACLF were Native Americans and a lower percentage of patients with ACLF than patients without were European Americans or African Americans. In multivariable analyses that adjusted for differences in sociodemographic and clinical characteristics, the odds ratio for ACLF at enrollment was 1.08 (95% confidence interval [CI], 1.03-1.13) with Native American genetic ancestry and 2.57 (95% CI, 1.84-3.58) for Native American race vs. European American race. CONCLUSIONS In a large cohort of Latin American patients with ADC, increasing percentages of Native American ancestry and Native American race were factors independently associated with ACLF at enrollment.
A global research priority agenda to advance public health responses to fatty liver disease Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Hannes Hagström, Terry T.-K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Veronica Miller, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Jörn M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi, Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Hannes Hagström, Terry T-K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Veronica Miller, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Jörn M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi, Fredrik Aberg, Leon Adams, Khalid Al-Naamani, Reda M. Albadawy, Zinaida Alexa, Michael Allison, Faisal A. Alnaser, Khalid Alswat, Mario Reis Alvares-da-Silva, Domenico Alvaro, Michele Alves-Bezerra, Raul J. Andrade, Quentin M. Anstee, Yaw Asante Awuku, Oidov Baatarkhuu, Gyorgy Baffy, Shokhista Bakieva, Meena B. Bansal, Robert Barouki, Rachel L. Batterham, Cynthia Behling, Renata Belfort-DeAguiar, Annalisa Berzigotti, Michael Betel, Cristiana Bianco, Emanuele Bosi, Jerome Boursier, Elizabeth M. Brunt, Elisabetta Bugianesi, Christopher J. Byrne, Maria Cecilia Cabrera Cabrejos, Stephen Caldwell, Rotonya Carr, Marlen Ivón Castellanos Fernández, Laurent Castera, Maria Gabriela Castillo-López, Cyrielle Caussy, Eira Cerda-Reyes, Antonio Ceriello, Wah- Kheong Chan, Yoosoo Chang, Phunchai Charatcharoenwitthaya, Norberto Chavez-Tapia, Raymond T. Chung, Massimo Colombo, Kirsten Coppell, Helma P. Cotrim, Antonio Craxi, Javier Crespo, Anuradha Dassanayake, Nicholas O. Davidson, Robert De Knegt, Victor de Ledinghen, Münevver Demir, Hailemichael Desalegn, Moises Diago, John F. Dillon, Bruce Dimmig, M. Ashworth Dirac, Melisa Dirchwolf, Jean-François Dufour, Karel Dvorak, Mattias Ekstedt, Mohamed El-Kassas, Osama M. Elsanousi, Ahmed M. Elsharkawy, Reda Elwakil, Wayne Eskridge, Mohammed Eslam, Gamal Esmat, Jian- Gao Fan, Maria Lucia Ferraz, Robert Flisiak, Davide Fortin, Yasser Fouad, Scott L. Freidman, Michael Fuchs, Adrian Gadano, Amalia Gastaldelli, Anja Geerts, Andreas Geier, Jacob George, Lynn H. Gerber, Hasmik Ghazinyan, Liana Gheorghe, Denise Giangola Kile, Marcos Girala, George Goh Boon Bee, Nicolas Goossens, Isabel Graupera, Henning Grønbæk, Saeed Hamid, Vanessa Hebditch, Zachary Henry, Ingrid J. Hickman, L. Ansley Hobbs, Samantha L. Hocking, Wolf Peter Hofmann, Ramazan Idilman, Paula Iruzubieta, Scott Isaacs, Vasily A. Isakov, Mona H. Ismail, Mohammad H. Jamal, Helen Jarvis, Peter Jepsen, François Jornayvaz, K.C. Sudhamshu, Satoru Kakizaki, Saul Karpen, Takumi Kawaguchi, Shelley E. Keating, Yousef Khader, Seung Up Kim, Won Kim, David E. Kleiner, Ger Koek, Narcisse Patrice Joseph Komas, Loreta A. Kondili, Bart G. Koot, Marko Korenjak, Eleni Kotsiliti, Yiannoula Koulla, Carina Kugelmas, Marcelo Kugelmas, Asma Labidi, Naomi F. Lange, Joel E. Lavine, Mariana Lazo, Nathalie Leite, Han-Chieh Lin, Undram Lkhagvaa, Michelle T. Long, Patricio Lopez-Jaramillo, Adelina Lozano, Maria Paula Macedo, Reza Malekzadeh, Giulio Marchesini, Sebastian Marciano, Kim Martinez, Sophia E. Martínez Vázquez, Lyudmila Mateva, José M. Mato, Charles Mbendi Nlombi, Alexis Gorden McCary, Jeff McIntyre, Martin McKee, Juan M. Mendive, Ivana Mikolasevic, Pamela S. Miller, Tamara Milovanovic, Terri Milton, Rosalba Moreno-Alcantar, Timothy R. Morgan, Ayesha Motala, Jean Muris, Carla Musso, Edna J. Nava-González, Francesco Negro, Alexander V. Nersesov, Brent A. Neuschwander-Tetri, Dafina Nikolova, Suzanne Norris, Katja Novak, Ponsiano Ocama, Janus P. Ong, Arlinking Ong-Go, Charles Onyekwere, Martin Padilla, Raluca Pais, Calvin Pan, Arturo Panduro, Manas K. Panigrahi, Georgios Papatheodoridis, Imran Paruk, Keyur Patel, Carlos Penha Gonçalves, Marlene Pérez Figueroa, Juanita Pérez-Escobar, Juan M. Pericàs, Gianluca Perseghin, Mário Guimarães Pessoa, Salvatore Petta, Claudia Pinto Marques Souza de Oliveira, Dorairaj Prabhakaran, Nikolaos Pyrsopoulous, Atoosa Rabiee, Alnoor Ramji, Vlad Ratziu, Natarajan Ravendhran, Katrina Ray, Michael Roden, Stefano Romeo, Manuel Romero-Gómez, Yaron Rotman, Samir Rouabhia, Ian A. Rowe, Shakhlo Sadirova, Maryam Salem Alkhatry, Riina Salupere, Sanjaya K. Satapathy, Jeffrey B. Schwimmer, Giada Sebastiani, Lynn Seim, Yosuke Seki, Abdel Karim Serme, David Shapiro, Lali Sharvadze, Jonathan E. Shaw, Isaac Thom Shawa, Thrivikrama Shenoy, Oren Shibolet, Yusuke Shimakawa, Jay H. Shubrook, Shivaram Prasad Singh, Edford Sinkala, Lubomir Skladany, Igor Skrypnyk, Myeong Jun Song, Silvia Sookoian, Kannan Sridharan, Norbert Stefan, Jonathan G. Stine, Nikolaos Stratakis, Dhastagir Sultan Sheriff, Shikha S. Sundaram, Gianluca Svegliati-Baroni, Mark G. Swain, Frank Tacke, Shahrad Taheri, Soek-Siam Tan, Elliot B. Tapper, Giovanni Targher, Eugen Tcaciuc, Maja Thiele, Dina Tiniakos, Ieva Tolmane, Aldo Torre, Esther A. Torres, Sombat Treeprasertsuk, Michael Trenell, Svetlana Turcan, Adela Turcanu, Jonas Valantinas, Laurens A. van Kleef, Jose Antonio Velarde Ruiz Velasco, Mette Vesterhus, Eduardo Vilar-Gomez, Imam Waked, Julia Wattacheril, Heiner Wedemeyer, Fonda Wilkins, José Willemse, Robert J. Wong, Yusuf Yilmaz, Hannele Yki-Järvinen, Ming-Lung Yu, Volkan Yumuk, Müjdat Zeybel, Kenneth I. Zheng, Ming-Hua Zheng Journal of Hepatology, 2023 BACKGROUND & AIMS: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community. METHODS: Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a three-day in-person meeting. Following a Delphi methodology, over two rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the priorities, via Qualtrics XM, indicating agreement using a four-point Likert-scale and providing written feedback. The core group revised the draft priorities between rounds. In R2, panellists also ranked the priorities within six domains: epidemiology, models of care, treatment and care, education and awareness, patient and community perspectives, and leadership and public health policy. RESULTS: The consensus-built fatty liver disease research agenda encompasses 28 priorities. The mean percentage of 'agree' responses increased from 78.3 in R1 to 81.1 in R2. Five priorities received unanimous combined agreement ('agree' + 'somewhat agree'); the remaining 23 priorities had >90% combined agreement. While all but one of the priorities exhibited at least a super-majority of agreement (>66.7% 'agree'), 13 priorities had <80% 'agree', with greater reliance on 'somewhat agree' to achieve >90% combined agreement. CONCLUSIONS: Adopting this multidisciplinary consensus-built research priorities agenda can deliver a step-change in addressing fatty liver disease, mitigating against its individual and societal harms and proactively altering its natural history through prevention, identification, treatment, and care. This agenda should catalyse the global health community's efforts to advance and accelerate responses to this widespread and fast-growing public health threat. IMPACT AND IMPLICATIONS: An estimated 38% of adults and 13% of children and adolescents worldwide have fatty liver disease, making it the most prevalent liver disease in history. Despite substantial scientific progress in the past three decades, the burden continues to grow, with an urgent need to advance understanding of how to prevent, manage, and treat the disease. Through a global consensus process, a multidisciplinary group agreed on 28 research priorities covering a broad range of themes, from disease burden, treatment, and health system responses to awareness and policy. The findings have relevance for clinical and non-clinical researchers as well as funders working on fatty liver disease and non-communicable diseases more broadly, setting out a prioritised, ranked research agenda for turning the tide on this fast-growing public health threat.
Chronic hepatitis C in hemodialysis patients: Prevalence and liver fibrosis impact in the National Center for Renal Health in Peru P. Martin Padilla-Machaca, Eduardo Luna-Victoria, Ada Cabrera, Juan-Carlos Gómez-De la Torre, Rocio Galloso, Pedro Montes Iliver, 2022 Background: Hepatitis C (HCV) remains a serious public health problem in high-risk persons such as patients on chronic hemodialysis. We aimed to estimate the serological prevalence of HCV, the HCV viral load and genotype, and liver fibrosis stage among patients on chronic hemodialysis at the National Renal Health Center in Lima, Peru. Methods: From June 2019 to March 2021, all patients who received chronic hemodialysis were invited to participate. Subjects who provided written informed consent were enrolled. Patients with HCV-positive serology underwent determination of HCV viral load. Samples from subjects with detectable viral load, underwent determination of HCV genotype. Then, HCV infected subjects underwent determination of liver fibrosis using transitional elastography (Fibroscan 402): Metavir score: F0-F1: 2.5-7.5 kPa, F2: 7.6-9.5 Kpa, F3: 9.6-12 Kpa, F4 (Cirrhosis): 12.1-75 Kpa. Results: Of the 303 subjects invited to participate, 174 (57.4%) subjects gave their written consent. Mean age was 52 years (range 22-91) and 116 (66.6%) were male. HCV serology was positive in 35.1% of patients (61/174); however, the prevalence of positive serology with detectable viral load was 20.11% (35/174). Genotype 1a was the most prevalent (85%). The majority (83.6%) of subjects with detectable viral load had values lower than 800.000 IU/mL. Twenty-nine of those 35 subjects underwent elastography evaluation, and 13 (44.8%) of them were found to have stage F2-F4 fibrosis. Conclusions: The prevalence of HCV at the largest reference center for hemodialysis in Lima remains high, with GT1a predominance, viral load usually below 800,000 IU/mL and significant liver fibrosis.
Performance of pre-transplant criteria in prediction of hepatocellular carcinoma progression and waitlist dropout Federico Piñero, Marcos Thompson, Ilka Boin, Aline Chagas, Emilio Quiñonez, Carla Bermúdez, Mario Vilatobá, Luisa Santos, Margarita Anders, Sergio Hoyos Duque, Agnaldo Soares Lima, Josemaría Menendez, Martín Padilla, Jaime Poniachik, Rodrigo Zapata, Martín Maraschio, Ricardo Chong Menéndez, Linda Muñoz, Diego Arufe, Rodrigo Figueroa, Simone R. Perales, Claudia Maccali, Rodrigo Vergara Sandoval, Lucas McCormack, Adriana Varón, Sebastián Marciano, Juan Mattera, Flair Carrilho, Marcelo Silva Liver International, 2022
The establishment of public health policies and the burden of non-alcoholic fatty liver disease in the Americas Luis Antonio Díaz, Eduardo Fuentes-López, Gustavo Ayares, Francisco Idalsoaga, Jorge Arnold, Andrea Márquez-Lomas, Carolina A Ramírez, María Paz Medel, Francisca Viñuela, Lucas Lacalle, Juan Pablo Roblero, Catterina Ferreccio, Mariana Lazo, Mayur Brahmania, Ashwani K Singal, Melisa Dirchwolf, Nahum Méndez-Sánchez, Norberto Chavez-Tapia, Patricia Guerra, Juan Carlos Restrepo, Claudia P Oliveira, Julissa Lombardo, Abel Sánchez, Martín Elizondo, Martín Tagle, Martín Padilla, Marco Sánchez, Enrique Carrera, Marcos Girala, Omega Chery, Marlen Castellanos-Fernández, Francisco Barrera, Jeffrey V Lazarus, Patrick S Kamath, Ramon Bataller, Marco Arrese, Juan Pablo Arab Lancet Gastroenterology and Hepatology, 2022
Global multi-stakeholder endorsement of the MAFLD definition Nahum Méndez-Sánchez, Elisabetta Bugianesi, Robert G Gish, Frank Lammert, Herbert Tilg, Mindie H Nguyen, Shiv K Sarin, Núria Fabrellas, Shira Zelber-Sagi, Jian-Gao Fan, Gamal Shiha, Giovanni Targher, Ming-Hua Zheng, Wah-Kheong Chan, Shlomo Vinker, Takumi Kawaguchi, Laurent Castera, Yusuf Yilmaz, Marko Korenjak, C Wendy Spearman, Mehmet Ungan, Melissa Palmer, Mortada El-Shabrawi, Hans-Juergen Gruss, Jean-François Dufour, Anil Dhawan, Heiner Wedemeyer, Jacob George, Luca Valenti, Yasser Fouad, Manuel Romero‐Gomez, Mohammed Eslam, Maria Lorena Abate, Bahaa Abbas, Ahmed Amr Abbassy, Waleed Abd El Ghany, Amira Abd Elkhalek, Emad Abd ElMajeed, Mohammad Abdalgaber, Mohamed AbdAllah, Marwa Abdallah, Nourhan Abdallah, Shereen Abdelaleem, Yasser Abdelghani, Wael Abdelghany, Safaa Mohamed Abdelhalim, Wafaa Abdelhamid, Nehal Abdelhamid, Nadia A. Abdelkader, Elsayed Abdelkreem, Aly Mohamed Abdelmohsen, Awny Ali Abdelrahman, Sherief M Abd-elsalam, Doaa Abdeltawab, Abdulbaset Abduh, Nada Abdulhakam, Maheeba Abdulla, Navid Abedpoor, Ludovico Abenavoli, Fredrik Åberg, Omala Ablack, Mostafa Abo elftouh, Yousry Esam-Eldin Abo-Amer, Ashraf Aboubkr, Alaa Aboud, Amr M. Abouelnaga, Galal A. Aboufarrag, Ashraf Aboutaleb, Leticia Abundis, Gupse Adalı, Enrique Adames, Leon Adams, Danjuma Adda, Noor Adel, Nada Adel, Muhammad Adel Sayed, Taiba Jibril Afaa, Nawal Afredj, Gulnara Aghayeva, Alessio Aghemo, Carlos A. Aguilar-Salinas, Golo Ahlenstiel, Walid Ahmady, Wafaa Ahmed, Amira Ahmed, Samah Nasser Ahmed, Heba Mostafa Ahmed, Rasha Ahmed, Elmar Aigner, Mesut Akarsu, Maisam Akroush, Umit Akyuz, Mamun Al Mahtab, Tahani Al Qadiri, Yusriya Al Rawahi, Razzaq AL rubaee, Muna Al Saffar, Shahinul Alam, Zaid Al-Ani, Agustín Albillos, Mohamed Alboraie, Said Al-Busafi, Mohamed Al-Emam, Jawaher Alharthi, Kareem Ali, Basma Abdelmoez Ali, Mohammad Ali, Raja Affendi Raja Ali, Anna Alisi, Ali Raad AL-Khafaji, Maryam Alkhatry, Rocio Aller, Yahya Almansoury, Khalid Al-Naamani, Alaa Alnakeeb, Anna Alonso, Saleh A. Alqahtani, Leina Alrabadi, Khalid Alswat, Mahir Altaher, Turki Altamimi, Jose Altamirano, Mario R. Alvares-da-Silva, Elsragy Adel M. Aly, Amgad Alzahaby, Ahmed Alzamzamy, Keisuke Amano, Maysa A. Amer, Mona A. Amin, Sayed A. Amin, Ashraf A. Amir, Javier Ampuero, Noha Anas, Pietro Andreone, Soa Fy Andriamandimby, Mahmoud Anees, Peltec Angela, Manal Antonios, Wael Arafat, Jose Moreno Araya, Juan Armendariz-Borunda, Matthew J. Armstrong, Hassan Ashktorab, Patricia Aspichueta, Fathia Assal, Mira Atef, Dina Attia, Hoda Atwa, Reham Awad, Mohyeldeen Abd Elaziz Awad, Sally Awny, Obafemi Awolowo, Yaw Asante Awuku, Ibrahim Ayada, Than Than Aye, Sherif Ayman, Hedy Ayman, Hesham Ayoub, Hosny M. Azmy, Romiro P. Babaran, Omneya Badreldin, Ahmed Badry, İbrahim Halil Bahçecioğlu, Amira Bahour, Jiajia Bai, Yasemin Balaban, Muthuswamy Balasubramanyam, Khaled Bamakhrama, Jesus M Banales, Babu Bangaru, Jianfeng Bao, Jorge Suazo Barahona, Salma Barakat, Sandra Maria Barbalho, Bikwa Barbra, Beatriz Barranco, Francisco Barrera, Ulrich Baumann, Shamardan Bazeed, Eva Bech, Aourarh Benayad, Andreas Benesic, David Bernstein, Fernando Bessone, Susie Birney, Cyrille Bisseye, Martin Blake, Bilal Bobat, Leonilde Bonfrate, Dmitry S Bordin, Francisco Bosques-Padilla, Jerome Boursier, Boushab Mohamed Boushab, David Bowen, Patricia Medina Bravo, Paul N Brennan, Bisi Bright, Ilse Broekaert, Xabier Buque, Diego Burgos-Santamaría, Julio Burman, Luca Busetto, Chris D. Byrne, Patricia Anne I. Cabral-Prodigalidad, Guillermo Cabrera-Alvarez, Wei Cai, Francesca Cainelli, Ali Riza Caliskan, Ali Canbay, Ana Cano-Contreras, Hai-Xia Cao, Zhujun Cao, Andres Carrion, Francesca Carubbi, Teresa Casanovas, Marlen Ivón Castellanos Fernández, Jin Chai, Siew Pheng Chan, Phunchai Charatcharoenwitthaya, Norberto Chavez-Tapia, Kazuaki Chayama, Jinjun Chen, Lin Chen, Zhong-Wei Chen, Huiting Chen, Sui-Dan Chen, Qiang Chen, Yaxi Chen, Gang Chen, En-Quang Chen, Fei Chen, Fei Chen, Pei-Jer Chen, Robert Cheng, Wendy Cheng, Jack Tan Wei Chieh, Imad Chokr, Evangelos Cholongitas, Ashok Choudhury, Abhijit Chowdhury, Evaristus Sunday Chukwudike, Stefano Ciardullo, Michelle Clayton, Karine Clement, Marie Michelle Cloa, Cecilia Coccia, Cristina Collazos, Massimo Colombo, Arif Mansur Cosar, Helma Pinchemel Cotrim, Joris Couillerot, Alioune Coulibaly, Gonzalo Crespo, Javier Crespo, Maria Cruells, Ian Homer Y. Cua, Hesham K. Dabbous, George N Dalekos, Patricia D'Alia, Li Dan, Viet Hang Dao, Mostafa Darwish, Christian Datz, Milagros B Davalos-Moscol, Heba Dawoud, Blanca Olaechea de Careaga, Robert de Knegt, Victor de Ledinghen, Janaka de Silva, Nabil Debzi, Marie Decraecker, Elvira Del Pozo, Teresa C Delgado, Manuel Delgado-Blanco, Łukasz Dembiński, Adilson Depina, Moutaz Derbala, Hailemichael Desalegn, Christèle Desbois-Mouthon, Mahmoud Desoky, Anouk Dev, Agostino Di Ciaula, Moisés Diago, Ibrahima Diallo, Luis Antonio Díaz, Melisa Dirchwolf, Paola Dongiovanni, Andrriy Dorofeyev, Xiaoguang Dou, Mark W. Douglas, Michael Doulberis, Cecil K. Dovia, Adam Doyle, Ivana Dragojević, Joost PH Drenth, Xuefei Duan, Audrius Dulskas, Dan L Dumitrascu, Oliver Duncan, Vincent Dusabejambo, Rev. Shem N.A. Dwawhi, Sho Eiketsu, Doaa El Amrousy, Ahmed El Deeb, Ghada El Deriny, Hesham Salah El Din, Salwa El Kamshishy, Mohamed El Kassas, Maissa El Raziky, Osama A Elagamy, Wafaa Elakel, Dina Elalfy, Hanaa Elaraby, Heba ElAwady, Reda Elbadawy, Hanaa Hassan Eldash, Manal S. Eldefrawy, Carol Lezama Elecharri, Amel Elfaramawy, Mohammed Elfatih, Mahmoud Elfiky, Mohamed Elgamsy, Mohamed Elgendy, Mohamed A. El-Guindi, Nagi Elhussieny, Ahmed Maher Eliwa, Zeineb Elkabbany, Hesham El-Khayat, Nehal M. El-Koofy, Alaa Elmetwalli, Amr Elrabat, Fathiya El-Raey, Fatma Elrashdy, Medhat Elsahhar, Esraa M. Elsaid, Shimaa Elsayed, Hany Elsayed, Aly Elsayed, Amr M. Elsayed, Hamdy Elsayed, Magdy El-Serafy, Ahmed M. Elsharkawy, Reem Yehia Elsheemy, Eman Elsayed Elshemy, Sara Elsherbini, Naglaa Eltoukhy, Reda Elwakil, Ola Emad, Shaimaa Emad, Mohamed Embabi, Ilkay Ergenç, Tatiana Ermolova, Gamal Esmat, Doaa M. Esmat, Enrique Carrera Estupiñan, Said Ettair, Tcaciuc Eugen, Mohammed Ezz-Eldin, Lidia Patricia Valdivieso Falcón, Yu-Chen Fan, Samah Fandari, Mahmoud Farag, Taghreed Mohamed Farahat, Eman M. Fares, Michael Fares, Eduardo Fassio, Hayam Fathy, Dina Fathy, Wael Fathy, Soheir Fayed, Dan Feng, Gong Feng, Miguel Fernández-Bermejo, Cristina Targa Ferreira, Javier Díaz Ferrer, Alastair Forbes, Rabab Fouad, Hanan M. Fouad, Tove Frisch, Hideki Fujii, Shuhei Fukunaga, Shinya Fukunishi, Hacer Fulya, Masato Furuhashi, Yasmine Gaber, Augusto Jose G. Galang, Jacqueline Cordova Gallardo, Rocío Galloso, Mahmoud Gamal, Reham Gamal, Hadeel Gamal, Jian Gan, Anar Ganbold, Xin Gao, George Garas, Tony Garba, Miren García-Cortes, Carmelo García-Monzón, Javier García-Samaniego, Amalia Gastaldelli, Manuel Gatica, Elizabeth Gatley, Tamar Gegeshidze, Bin Geng, Hasmik Ghazinyan, Salma Ghoneem, Luca Giacomelli, Gianluigi Giannelli, Edoardo G. Giannini, Matthew Giefer, Pere Ginès, Marcos Girala, Pablo J Giraudi, George Boon-Bee Goh, Ahmed Ali Gomaa, Benbingdi Gong, Dina Hilda C. Gonzales, Humberto C. Gonzalez, Maria Saraí Gonzalez-Huezo, Isabel Graupera, Ivica Grgurevic, Henning Grønbæk, Xuelian Gu, Lin Guan, Ibrahima Gueye, Alice Nanelin Guingané, Ozen Oz Gul, Cuma Bulent Gul, Qing Guo, Pramendra Prasad Gupta, Ahmet Gurakar, Juan Carlos Restrepo Gutierrez, Ghada Habib, Azaa Hafez, Emilia Hagman, Eman Halawa, Osama Hamdy, Abd Elkhalek Hamed, Dina H. Hamed, Saeed Hamid, Waseem Hamoudi, Yu Han, James Haridy, Hanan Haridy, David C H Harris Harris, Michael Hart, Fuad Hasan, Almoutaz Hashim, Israa Hassan, Ayman Hassan, Essam Ali Hassan, Adel Ahmed Hassan, Magda Shehata Hassan, Fetouh Hassanin, Alshymaa Hassnine, John Willy Haukeland, Amr Ismael M. Hawal, Jinfan He, Qiong He, Yong He, Fang-Ping He, Mona Hegazy, Adham Hegazy, Osama Henegil, Nelia Hernández, Manuel Hernández-Guerra, Fatima Higuera-de-la-Tijera, Ibrahim Hindy, Keisuke Hirota, Lee Chi Ho, Alexander Hodge, Mohamed Hosny, Xin Hou, Jiao-Feng Huang, Yan Huang, Zhifeng Huang, Yuan Huang, Ang Huang, Yuan Huang, Xiao-Ping Huang, Sheng Hui-ping, Bela Hunyady, Mennatallah A. Hussein, Osama Hussein, Shahinaz Mahmoud Hussien, Luis Ibáñez-Samaniego, Jamal Ibdah, Luqman Ibrahim, Miada Ibrahim, Ibrahim Ibrahim, Maria E. Icaza-Chávez, Sahar Idelbi, Ramazan Idilman Idilman, Mayumi Ikeda, Giuseppe Indolfi, Federica Invernizzi, Iram Irshad, Hasan Mohamed Ali Isa, Natacha Jreige Iskandar, Abdulrahman Ismaiel, Mariam Ismail, Zulkifli Ismail, Faisal Ismail, Hideki Iwamoto, Kathryn Jack, Rachael Jacob, Fuad Jafarov, Wasim Jafri, Helen Jahshan, Prasun K Jalal, Ligita Jancoriene, Martin Janicko, Hiruni Jayasena, Meryem Jefferies, Vivekanand Jha, Fanpu Ji, Yaqiu Ji, Jidong Jia, Changtao Jiang, Ni Jiang, Zong-zhe Jiang, Xing Jin, Yi Jin, Xu Jing, Qian Jingyu, Maia Jinjolava, FX Himawan Haryanto Jong, Alina Jucov, Ibecheole Julius, Mona Kaddah, Yoshihiro Kamada, Abobakr kamal, Enas Mohamed Kamal, Ashraf Sayed Kamel, Jia-Horng Kao, Maja Karin, Thomas Karlas, Mohammad Kashwaa, Leolin Katsidzira, Eda Kaya, M.Azzam Kayasseh, Bernadette Keenan, Caglayan Keklikkiran, William Keml, Deia K. Khalaf, Rofida Khalefa, Sherin Khamis, Doaa Khater, Hamed khattab, Anatoly Khavkin, Olga Khlynova, Nabil Khmis, Nazarii Kobyliak, Apostolos Koffas, Kazuhiko Koike, Kenneth Y.Y. Kok, Tomas Koller, Narcisse Patrice Komas, Nataliya V. Korochanskaya, Yannoula Koulla, Shunji Koya, Colleen Kraft, Bledar Kraja, Marcin Krawczyk, Mohammad Shafi Kuchay, Anand V Kulkarni, Ashish Kumar, Manoj Kumar, Sulaiman Lakoh, Philip Lam, Ling Lan, Naomi F. Lange, Kamran Bagheri Lankarani, Nicolas Lanthier, Kateryna Lapshyna, Sameh A. Lashen, Konang Nguieguia Justine Laure, Leonid Lazebnik, Didier Lebrec, Samuel S. Lee, Way Seah Lee, Yeong Yeh Lee, Diana Julie Leeming, Nathalie Carvalho Leite, Roberto Leon, Cosmas Rinaldi Adithya Lesmana, Junfeng Li, Qiong Li, Jun Li, Yang-Yang Li, Yufang Li, Lei Li, Min Li, Yiling li, Huiqing Liang, Tang Lijuan, Seng Gee Lim, Lee-Ling Lim, Shumei Lin, Han-Chieh Lin, Rita Lin, Rania Lithy, Yaru Liu, Yuanyuan Liu, Xin Liu, Wen-Yue Liu, Shourong Liu, Ken Liu, Tian Liu, Amedeo Lonardo, Mariana Bravo López, Eva López-Benages, Patricio Lopez-Jaramillo, Huimin Lu, Lun Gen Lu, Yan Lu, John Lubel, Rashid Lui, Iulianna Lupasco, Elena Luzina, Xiao-Hui Lv, Kate Lynch, Hong-Lei Ma, Mariana Verdelho Machado, Nonso Maduka, Katerina Madzharova, Russellini Magdaong, Sanjiv Mahadeva, Amel Mahfouz, Nik Ritza Kosai Nik Mahmood, Eman Mahmoud, Mohamed Mahrous, Rakhi Maiwall, Ammar Majeed, Avik Majumdar, Loey Mak, Madiha M Maklouf, Reza Malekzadeh, Claudia Mandato, Alessandra Mangia, Jake Mann, Hala Hussien Mansour, Abdellah Mansouri, Alessandro Mantovani, Jun qian Mao, Flor Maramag, Giulio Marchesini, Claude Marcus, Rui António Rocha Tato Marinho, Maria L Martinez-Chantar, Antonieta A. Soares Martins, Rana Marwan, Karen Frances Mason, Ghadeer Masoud, Mohamed Naguib Massoud, Maria Amalia Matamoros, Rosa Martín Mateos, Asmaa Mawed, Jean Claude Mbanya, Charles Mbendi, Lone McColaugh, Duncan McLeod, Juan Francisco Rivera Medina, Ahmed Megahed, Mai Mehrez, Iqbal Memon, Shahin Merat, Randy Mercado, Ahmed Mesbah, Taoufik Meskini, Mayada Metwally, Rasha Metwaly, Lei Miao, Eileen Micah, Luca Miele, Vladimir Milivojevic, Tamara Milovanovic, Yvonne L. Mina, Milan Mishkovik, Amal Mishriki, Tim Mitchell, Alshaimaa Mohamed, Mona Mohamed, Sofain Mohamed, Shady Mohammed, Ahmed Mohammed, Viswanathan Mohan, Sara Mohie, Aalaa Mokhtar, Reham Moniem, Mabel Segura Montilla, Jose Antonio Orozco Morales, María María Sánchez Morata, Jose Maria Moreno-Planas, Silvia Morise, Sherif Mosaad, Mohamed Moselhy, Alaa Mohamed Mostafa, Ebraheem Mostafa, Nezha Mouane, Nasser Mousa, Hamdy Mahfouz Moustafa, Abeer Msherif, Kate Muller, Christopher Munoz, Ana Beatriz Muñoz-Urribarri, Omar Alfaro Murillo, Feisul Idzwan Mustapha, Emir Muzurović, Yehia Nabil, Shaymaa Nafady, Ayu Nagamatsu, Atsushi Nakajima, Dan Nakano, Yuemin Nan, Fabio Nascimbeni, Mirella S. Naseef, Nagwa Nashat, Taran Natalia, Francesco Negro, Alexander V. Nersesov, Manuela Neuman, Masolwa Ng'wanasayi, Yan Ni, Amanda Nicoll, Takashi Niizeki, Dafina Nikolova, Wang Ningning, Madunil Niriella, K.A Nogoibaeva, Rozeena Nordien, Catherine O Sullivan, James O'Beirne, Solomon Obekpa, Ponsiano Ocama, Missiani Ochwoto, Michael Promise Ogolodom, Olusegun Ojo, Nana Okrostsvaridze, Claudia P. Oliveira, Raul Contreras Omaña, Omneya M. Omar, Hanaa Omar, Mabroka Omar, Salma Omran, Reham Omran, Marian Muse Osman, Nevin Owise, Theobald Owusu-Ansah, P. Martín Padilla- Machaca, Sirish Palle, Ziyan Pan, Xiao-Yan Pan, Qiuwei Pan, Apostolis Papaefthymiou, Feliciano Chanana Paquissi, Gabriella Par, Arit Parkash, Diana Payawal, Kevork M. Peltekian, Xuebin Peng, Liang Peng, Ying Peng, Rahul Pengoria, Martina Perez, José Luis Pérez, Norma Marlene Pérez, Marcello Persico, Mário Guimarães Pessoa, Salvatore Petta, Mathew Philip, Maria Corina Plaz Torres, Naveen Polavarapu, Jaime Poniachik, Piero Portincasa, Chunwen Pu, Tuğrul Pürnak, Edhie Purwanto, Xiaolong Qi, Xingshun Qi, Zibing Qian, Zhao Qiang, Zengpei Qiao, Liang Qiao, Alberto Queiroz, Atoosa Rabiee, Manal Radwan, Alain Marcel Rahetilahy, Yasmin Ramadan, Dina Ramadan, Anis Safura Ramli, Grant A. Ramm, Ao Ran, Ivan Rankovic, Huiying RAO, Sara Raouf, Sayantan Ray, Nancy Reau, Ahmed Refaat, Thomas Reiberger, Jose M Remes-Troche, Eira Cerda Reyes, Ben Richardson, Ezequiel Ridruejo, Sergio Riestra Jimenez, Ibrahim Rizk, Stuart Roberts, Juan Pablo Roblero, Jorge Alberto Prado Robles, Don Rockey, Manuel Rodríguez, Heriberto Rodríguez Hernández, Eva Román, Fernando Gomes Romeiro, Stefano Romeo, Jose Miguel Rosales-Zabal, Georgina R. Roshdi, Natalia Rosso, Andres Ruf, Patricia Cordero Ruiz, Nelia R. Runes, Andrea Ruzzenente, Marno Ryan, Ahmed Saad, Eman BE Sabbagh, Meriam Sabbah, Shimaa Saber, Reham Sabrey, Ramy Sabry, Maysaa Abdallah Saeed, Dina Said, Ebada M Said, Mohammad Amin Sakr, Yara Salah, Rabab Maamoun Salama, Asmaa Salama, Hussein Saleh, Ahmed Saleh, Ahmed Salem, Ahmed Thabet Salem, Alkassoum Salifou, Aso Faeq Salih, Abdallah Salman, Hanen Samouda, Faisal Sanai, Juan Francisco Sánchez-Ávila, Lakshumanan Sanker, Tomoya Sano, Miquel Sanz, Tobokalova Saparbu, Rohit Sawhney, Fatma Sayed, Sayed A. Sayed, Ashraf Othman Sayed, Manar Sayed, Giada Sebastiani, Laura Secadas, Khawaja Qamaruddin Sediqi, Sameh Seif, Nady Semida, Ebubekir Şenateş, Elena Daniela Serban, Lawrence Serfaty, Wai-Kay Seto, Ikram Sghaier, Min Sha, Hamada M. Shabaan, Lobna Shalaby, Inass Shaltout, Ala I. Sharara, Vishal Sharma, Isaac Thom Shawa, Ahmed Shawkat, Nehal Shawky, Osama Shehata, Sinead Sheils, Abate Bane Shewaye, Guojun Shi, Junping Shi, Shigeo Shimose, Tomotake Shirono, Lan Shou, Ananta Shrestha, Guanghou Shui, William Sievert, Solveig Sigurdardottir, Mostafa Mohamed Sira, Riyadh Siradj, Cecilia Sison, Linda Smyth, Reham Soliman, Jose D Sollano, Roger Sombie, Mark Sonderup, Siddharth Sood, German Soriano, Catherine A M Stedman, Oksana Stefanyuk, Davor Štimac, Simone Strasser, Pavel Strnad, Katherine Stuart, Wen Su, Minghua Su, Yoshio Sumida, Shuji Sumie, Dan-Qin Sun, Jing Sun, Hiroyuki Suzuki, Gianluca Svegliati-Baroni, Mohamed Osman Swar, S. TAHARBOUCHT, Zenab Taher, Saori Takamura, Lin Tan, Soek-Siam Tan, Tawesak Tanwandee, Sara Tarek, Ghelimici Tatiana, Federica Tavaglione, Gina Y. Tecson, Hoi-Poh Tee, Rolf Teschke, Mostafa Tharwat, Vo Duy Thong, Mark Thursz, Tulari Tine, Claudio Tiribelli, Ieva Tolmane, Jing Tong, Marco Tongo, Mamdouh Torkie, Aldo Torre, Esther A Torres, Meri Trajkovska, Sombat Treeprasertsuk, Tsubasa Tsutsumi, Thomas Tu, Josep A. Tur, Dilara Turan, Svetlana Turcan, Svetlana Turkina, Engin Tutar, Christian Tzeuton, Rose Ugiagbe, Ahmet Uygun, Michele Vacca, Pietro Vajro, David Van der Poorten, Laurens A. Van Kleef, Eliza Vashakidze, Carlos Moctezuma Velazquez, Mirtha Infante Velazquez, Sandro Vento, Veronique Verhoeven, Umberto Vespasiani-Gentilucci, Shireene Ratna Vethakkan, Josep Vilaseca, Libor Vítek, Ance Volkanovska, Michael Wallace, Wang Wan, Yan Wang, Ying Wang, Xiaolin Wang, Xuemei Wang, Chengyan Wang, Chunjiong Wang, Mingjie Wang, Pelden Wangchuk, Martin Weltman, MaryFrances White, Johannes Wiegand, Mohamed-Naguib Wifi, Alan Wigg, Markus Wilhelmi, Remon William, Henning Wittenburg, Shengjie Wu, Abdu Mohammed Wubeneh, Hongping Xia, Jian Xiao, Xiao Xiao, Wang Xiaofeng, Wanyuan Xiong, Liang Xu, Jie Xu, Weiguo Xu, Jing-Hang Xu, Keshu Xu, Yumin Xu, Shi-Hao Xu, Meng Xu, Aimin Xu, Chengfu Xu, Hongmei Yan, Jingyi Yang, Rui-Xu Yang, Yating Yang, Qinhe Yang, Naibin Yang, Jia Yao, Justine Yara, Serkan Yaraş, Nimet Yılmaz, Ramy Younes, Huda younes, Sona Young, Farah Youssef, Yanyan Yu, Ming-Lung Yu, Jing Yuan, Zhang Yue, Man-Fung Yuen, Wang Yun, Nonka Yurukova, Serag Zakaria, Samy Zaky, Maia Zaldastanishvili, Rodrigo Zapata, Nazanin Zare, Enver Zerem, Nema Zeriban, Xu Zeshuai, Huijie Zhang, Xuemei Zhang, Yupei Zhang, Wen-Hua Zhang, Xuchen Zhang, Yon-ping Zhang, Yuexin Zhang, Zhan-qing Zhang, Jingmin Zhao, Rong-Rong Zhao, Hongwei Zhao, Chao Zheng, Yijie Zheng, Ruidan Zheng, Tian-Lei Zheng, Kenneth Zheng, Xi Qiao Zhou, Yongjian Zhou, Yu-Jie Zhou, Hong Zhou, Ling Zhou, Yongning Zhou, Long dong Zhu, Yong Fen Zhu, Yueyong Zhu, Pei-Wu Zhu, Ebtesam Ziada, David Ziring, Li Ziyi, Shanshan Zou, Zhengsheng Zou, Huaibin Zou, Roberto Zuart Ruiz Lancet Gastroenterology and Hepatology, 2022
Comparison of different prognostic scores for patients with cirrhosis hospitalized with SARS-CoV-2 infection Manuel Mendizabal, Ezequiel Ridruejo, Federico Piñero, Margarita Anders, Martín Padilla, Luis G. Toro, Aldo Torre, Pedro Montes, Alvaro Urzúa, Esteban Gonzalez Ballerga, María Dolores Silveyra, Douglas Michelato, Javier Díaz, Mirta Peralta, Josefina Pages, Sandro Ruiz García, Isabel Gutierrez Lozano, Yuridia Macias, Daniel Cocozzella, Norberto Chavez-Tapia, Martín Tagle, Alejandra Dominguez, Adriana Varón, Emilia Vera Pozo, Fátima Higuera-de la Tijera, Carla Bustios, Damián Conte, Nataly Escajadillo, Andrés J Gómez, Laura Tenorio, Mauricio Castillo Barradas, Maria Isabel Schinoni, Fernando Bessone, Fernando Contreras, Leyla Nazal, Abel Sanchez, Matías García, Julia Brutti, María Cecilia Cabrera, Godolfino Miranda-Zazueta, German Rojas, Maximo Cattaneo, Graciela Castro-Narro, Fernando Rubinstein, Marcelo O. Silva Annals of Hepatology, 2021
Liver transplantation in the Intensive Care Unit: twenty years experience in a center medium income on Peru Carmen Ana Cerron Cabezas, Rosa Luz Lopez Martinez, Gino Salcedo Bermudez, Pedro Martin Padilla Machaca, Bertha Eliana Cardenas Ramirez, Wilmer Bacilio Calderon, Omar Mantilla Cruzatti, Jose Rivera Romani, Alfonso Solar Peche, Augudberto Montufar Valer, Saul Espinoza Rivera, Carlos Felix Rondon Leyva, Jose Carlos Chaman Ortiz Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2021
Clinical practice guidelines for the diagnosis and management chronic infection of hepatitis viral C of the Peruvian Health Social Security (EsSalud) Milagros Davalos, María Cabrera Cabrejos, César García Delgado, Martin Padilla, Carlos Yanar Pereda Vejarano, Romina Andrea Vera Mujica, Jorge Huaringa-Marcelo, Jose Montes-Alvis, Sergio Goicochea-Lugo, Naysha Becerra-Chauca, Wendy Nieto-Gutierrez, David Garcia-Gomero, Lesly Chavez Rimache, Alejandro Piscoya, Adrian V. Hernandez, Alvaro Taype-Rondan, Raúl Timaná-Ruiz, Lourdes Carrera Acosta Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2021
Recurrence of hepatocellular carcinoma after liver transplantation: Prognostic and predictive factors of survival in a Latin American cohort Claudia Maccali, Aline L. Chagas, Ilka Boin, Emilio Quiñonez, Sebastián Marciano, Mario Vilatobá, Adriana Varón, Margarita Anders, Sergio Hoyos Duque, Agnaldo S. Lima, Josemaría Menendez, Martín Padilla‐Machaca, Jaime Poniachik, Rodrigo Zapata, Martín Maraschio, Ricardo Chong Menéndez, Linda Muñoz, Diego Arufe, Rodrigo Figueroa, Alejandro Soza, Martín Fauda, Simone R. Perales, Rodrigo Vergara Sandoval, Carla Bermudez, Oscar Beltran, Isabel Arenas Hoyos, Lucas McCormack, Francisco Juan Mattera, Adrián Gadano, Jose H. Parente García, Claudia Megumi Tani, Luiz Augusto Carneiro D’Albuquerque, Flair J. Carrilho, Marcelo Silva, Federico Piñero Liver International, 2021
Liver transplantation for hepatocellular carcinoma: impact of expansion criteria in a multicenter cohort study from a high waitlist mortality region Federico Piñero, Margarita Anders, Ilka F. Boin, Aline Chagas, Emilio Quiñonez, Sebastián Marciano, Mario Vilatobá, Luisa Santos, Sergio Hoyos Duque, Agnaldo Soares Lima, Josemaría Menendez, Martín Padilla, Jaime Poniachik, Rodrigo Zapata, Alejandro Soza, Martín Maraschio, Ricardo Chong Menéndez, Linda Muñoz, Diego Arufe, Rodrigo Figueroa, Elaine Cristina Ataide, Claudia Maccali, Rodrigo Vergara Sandoval, Carla Bermudez, Luis G. Podesta, Lucas McCormack, Adriana Varón, Adrián Gadano, Juan Mattera, Federico Villamil, Fernando Rubinstein, Flair Carrilho, Marcelo Silva Transplant International, 2021
Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease Juan Pablo Arab, Melisa Dirchwolf, Mário Reis Álvares-da-Silva, Francisco Barrera, Carlos Benítez, Marlene Castellanos-Fernandez, Graciela Castro-Narro, Norberto Chavez-Tapia, Daniela Chiodi, Helma Cotrim, Kenneth Cusi, Claudia Pinto Marques Souza de Oliveira, Javier Díaz, Eduardo Fassio, Solange Gerona, Marcos Girala, Nelia Hernandez, Sebastián Marciano, Walter Masson, Nahum Méndez-Sánchez, Nathalie Leite, Adelina Lozano, Martín Padilla, Arturo Panduro, Raymundo Paraná, Edison Parise, Marlene Perez, Jaime Poniachik, Juan Carlos Restrepo, Andrés Ruf, Marcelo Silva, Martín Tagle, Monica Tapias, Kenia Torres, Eduardo Vilar-Gomez, José Eduardo Costa Gil, Adrian Gadano, Marco Arrese Annals of Hepatology, 2020
Direct-Acting Antivirals and Hepatocellular Carcinoma: No Evidence of Higher Wait-List Progression or Posttransplant Recurrence Federico Piñero, Ilka Boin, Aline Chagas, Emilio Quiñonez, Sebastián Marciano, Mario Vilatobá, Luisa Santos, Margarita Anders, Sergio Hoyos Duque, Agnaldo Soares Lima, Josemaría Menendez, Martín Padilla, Jaime Poniachik, Rodrigo Zapata, Martín Maraschio, Ricardo Chong Menéndez, Linda Muñoz, Diego Arufe, Rodrigo Figueroa, Manuel Mendizabal, Sahara Hurtado Gomez, Raquel Stucchi, Claudia Maccali, Rodrigo Vergara Sandoval, Carla Bermudez, Lucas McCormack, Adriana Varón, Adrián Gadano, Juan Mattera, Fernando Rubinstein, Flair Carrilho, Marcelo Silva Liver Transplantation, 2020
Impact of COVID-19 on liver disease and the public health in Peru Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2020
Portal vein thrombosis in patients undergoing to liver transplantation Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2019
Peruvian experience in the treatment of chronic hepatites C with the new direct acting antiviral drugs Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2019
A changing etiologic scenario in liver transplantation for hepatocellular carcinoma in a multicenter cohort study from Latin America Federico Piñero, Paulo Costa, Yuri Longatto Boteon, Sergio Hoyos Duque, Sebastian Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Martín Maraschio, Luis G. Podestá, Lucas McCormack, Adrian Gadano, Ilka S.F. Fatima Boin, Parente García, Marcelo Silva Clinics and Research in Hepatology and Gastroenterology, 2018
Liver transplant and hepatocellular carcinoma in Peru: outcome after 15 years in the transplant department of the Guillermo Almenara Hospital - EsSalud Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2018
Hepatopulmonar syndrome and liver transplantation: experience in the transplantation department of the Guillermo Almenara Irigoyen National Hospital - EsSalud Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2018
Autoimmune hepatitis recurrence after liver transplantation: 15 years experience in Peru Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2018
Latin American association for the study of the liver recommendations on treatment of hepatitis C Nahum Méndez-Sánchez, Raymundo Paraná, Hugo Cheinquer, Angelo Alves de Mattos, Adrian Gadano, Marcelo Silva, Mario G. Pessôa, Maria L. Gomes-Ferraz, Alejandro Soza, M. Cassia Mendes-Correa, Norberto C. Chávez-Tapia, Lucy Dagher, Martín Padilla, Nelia Hernandez, Juan F. Sánchez-Avila, Fernando Contreras, Henrique S. Moraes-Coelho, Edison R. Parise, Fernando Bessone, Misael Uribe Annals of Hepatology, 2014
[10 years of liver transplantation in Peru]. Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2010
Significance of the "isolated anti-hBc" serological pattern determined by the serological response to the vaccination against hepatitis B Revista De Gastroenterologia Del Peru Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 2005
