Roberto Di Gesù

@fondazionerimed.eu

Principal Investigator, Musculoskeletal Tissue Engineering (MsTE) lab.
Ri.MED foundation

Roberto Di Gesù


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https://researchid.co/rdigesu
I am the principal investigator of the musculoskeletal tissue engineering lab. at Foundation, a biomedical and biotechnology
center of excellence in Palermo, Italy. I have been a visiting research scientist at University of Pittsburgh and at Children's Hospital of Philadelphia, two of the top research institutions in the US. I initially graduated from Pharmacy School, then continued to complete my PhD in Biotechnology at University of Palermo working on bone tissue engineering and on drug delivery for cancer and Alzheimer's. During my first postdoc, I developed polymeric drug delivery systems (DDS) to treat maculopathy. Then I worked for two years as a senior scientist at Merck in Rome, developing an anti-cancer monoclonal antibody currently commercialized in the US as Bavencio. Then, I joined the University of Bologna working on electrospun DDS for spinal cord injuries. In I am engineering 3D in vitro models to study and treat musculoskeletal disorders.

EDUCATION

PhD, PharmD

RESEARCH, TEACHING, or OTHER INTERESTS

Biomedical Engineering, Biotechnology, Bioengineering
27

Scopus Publications

499

Scholar Citations

12

Scholar h-index

14

Scholar i10-index

Scopus Publications

  • Tissue engineering for tendon and ligament repair: Insights and advances
    Francesca Romano, Francesco Lopresti, Roberto Di Gesù, Vincenzo La Carrubba
    View, 2025
    Diseases and injuries affecting tendons (Ts) and ligaments (Ls) are among the most frequently diagnosed musculoskeletal disorders. Although many of these are not life threatening, they can cause severe debilitation, ultimately leading to substantial reductions in the patients’ mobility and quality of life. Even though the relevant advances in surgical and rehabilitative approaches to treat T/Ls diseases, the incidence of complications associated with those approaches is still too high, making T/Ls diseases an unmet clinical need. Currently, there is no consensus on an effective therapeutic strategy able to promote a complete T/Ls healing process. Over the past decade, there has been a growing interest in developing tissue‐engineered T constructs as viable graft alternatives. In this review, we aim to delve into the latest advancements in the field of tissue engineering for T repair. The most advanced technologies such as electrospinning, 3D printing, melt electrowriting, and hybrid fabrication techniques have been discussed, adopting critical connections with biological and biomolecular aspects. Furthermore, this review provides comprehensive insights into current strategies, and future directions, of T/Ls regeneration using tissue engineering approaches, thus paving the way to the development of new effective approaches to T/Ls diseases.
  • Engineering a Human-Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation
    Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane
    Advanced Healthcare Materials, 2025
    Tissue engineering offers new hope for treating biliary defects. Several scaffolds have been proposed, but their properties have not been fully investigated. In this study, the design, fabrication, and characterization of a novel common bile duct (CBD)‐like prototype are described. This prototype combines two biocompatible biomaterials, methacrylated type I collagen (CollMA) and poly(ε‐caprolactone) (PCL), along with biliary epithelial cells. CollMA supports the organization of biliary epithelial cells into a functional biliary‐like epithelium, as shown by histological, functional, and proteomic assays, while PCL provides mechanical strength. The biological and mechanical phases of the prototype are integrated into a multiphasic tubular scaffold using molding and electrospinning techniques. The final CBD‐like prototype consists of three interpenetrating phases: from innermost to outermost, these are biliary epithelial cell‐laden CollMA, PCL, and CollMA. This design overcomes challenges seen in multilayer constructs, such as interlayer delamination and lack of homogeneity. The prototype remains stable under physiological conditions, enables bile flow without leakage, and exhibits bile acid transport and modification activities, warranting future in vivo preclinical evaluation. In an ex vivo human blood assay, the acellular prototype elicited a favorable immune response, limiting inflammation and promoting sustained release of epidermal growth factor (EGF), indicating its potential to support regenerative processes.
  • Engineered collagen-coated scaffolds for tendon regeneration: a multifunctional drug delivery approach
    Chiara Di Marco, Francesca Romano, Francesco Lopresti, Simona Campora, Albert Comelli, Roberto Di Gesù, Vincenzo La Carrubba
    International Journal of Biological Macromolecules, 2025
    Tendon injuries rank among the most common musculoskeletal disorders, with their incidence rising steadily due to increased sports participation and an aging population. Current surgical treatments often fall short of clinical expectations due to poor biocompatibility, suboptimal mechanical properties, and frequent post-surgical fibrosis. Tissue engineering, however, offers promising alternatives by using biocompatible scaffolds that mimic the native tendon structure. This study aimed to develop an advanced tendon-like bundle replicating the microarchitecture and mechanical strength of native tendons. The scaffold was constructed from aligned electrospun poly-lactic acid (PLA) microfibers and designed to function as a drug delivery system for Rolipram, an antifibrotic agent. To improve cell-scaffold interactions, the scaffolds were coated with type-I collagen, a primary component of the tendon extracellular matrix (ECM). Morphological analyses confirmed the successful fabrication of smooth, well-aligned, bead-free fibers with controlled diameters, closely resembling the natural orientation and dimensions of tendon collagen fibers. Drug release was monitored for both uncoated and collagen-coated electrospun mats, with no burst release observed. Histological analysis demonstrated effective cellular infiltration by human tenocytes, with cells distributed throughout the scaffold after 14 days in culture. These results underscore the potential of tendon-like scaffolds as a promising platform for tendon repair, setting the stage for further optimization.
  • Biofabrication of an in situ hypoxia-delivery scaffold for cartilage regeneration
    R Di Gesù, A Palumbo Piccionello, G Vitale, S Buscemi, S Panzavolta, M F Di Filippo, A Leonarda, M Cuccia, A Di Prima, R Gottardi
    Biofabrication, 2025
    Osteoarthritis (OA) is a debilitating joint condition affecting millions of people worldwide, triggering painful chondral defects (CDs) that ultimately compromise the overarching patients’ quality of life. Currently, several reconstructive cartilage techniques (RCTs) (i.e.: matrix-assisted autologous chondrocytes implantation has been developed to overcome the total joint replacement limitations in the treatment of CDs. However, there is no consensus on the effectiveness of RCTs in the long term, as they do not provide adequate pro-regenerative stimuli to ensure complete CDs healing. In this study, we describe the biofabrication of an innovative scaffold capable to promote the CDs healing by delivering pro-regenerative hypoxic cues at the cellular/tissue level, to be used during RCTs. The scaffold is composed of a gelatin methacrylate (GelMA) matrix doped with hypoxic seeds of GelMA functionalized with a fluorinated oxadiazole (GelOXA), which ensures the delivery of hypoxic cues to human articular chondrocytes (hACs) embedded within the scaffold. We found that the GelMA/GelOXA scaffold preserved hACs viability, maintained their native phenotype, and significantly improved the production of type II collagen. Besides, we observed a reduction in type I and type X collagen, characteristic of unhealthy cartilage. These findings pave the way for the regeneration of healthy, hyaline-like cartilage, by delivering hypoxic cues even under normoxic conditions. Furthermore, the GelMA/GelOXA scaffold’s ability to deliver healing signals directly to the injury site holds great potential for treating OA and related CDs, and has the potential to revolutionize the field of cartilage repair and regenerative medicine.
  • Engineered collagen-coated scaffolds for tendon repair: a novel drug delivery system
    Convegno Nazionale Di Bioingegneria, 2025
  • Peptide direct growth on poly(acrylic acid)/poly(vinyl alcohol) electrospun fibers coated with branched poly(ethylenimine): A solid-phase approach for scaffolds biofunctionalization
    Anna Liguori, Junwei Zhao, Roberto Di Gesù, Rossella De Marco, Chiara Gualandi, Natalia Calonghi, Antonino Pollicino, Luca Gentilucci, Maria Letizia Focarete
    Colloids and Surfaces B Biointerfaces, 2024
    Due to their resemblance to the fibrillar structure of the extracellular matrix, electrospun nanofibrous meshes are currently used as porous and mechanically stable scaffolds for cell culture. In this study, we propose an innovative methodology for growing peptide sequences directly onto the surface of electrospun nanofibers. To achieve this, electrospun fibers were produced from a poly(acrylic acid)/poly(vinyl alcohol) blend that was thermally crosslinked and subjected to a covalent coating of branched poly(ethylenimine). The exposed amino functionalities on the fiber surface were then used for the direct solid-phase synthesis of the RGD peptide sequence. In contrast to established strategies, mainly involving the grafting of pre-synthesized peptides onto the polymer chains before electrospinning or onto the nanofibers surface, this method allows for the concurrent synthesis and anchoring of peptides to the substrate, with potential applications in combinatorial chemistry. The incorporation of this integrin-binding motive significantly enhanced the nanofibers' ability to capture human cervical carcinoma (HeLa) cells, selected as a proof of concept to assess the functionalities of the developed material.
  • Novel half Salphen cobalt(iii) complexes: synthesis, DNA binding and anticancer studies
    Riccardo Bonsignore, Elisa Trippodo, Roberto Di Gesù, Anna Paola Carreca, Simona Rubino, Angelo Spinello, Alessio Terenzi, Giampaolo Barone
    Dalton Transactions, 2024
    Novel DNA binding half Salphen cobalt(iii)complexes with promising anticancer activity on 3D cultured models.
  • A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-Physiological Loads
    Elisa Capuana, Davide Marino, Roberto Di Gesù, Vincenzo La Carrubba, Valerio Brucato, Rocky S. Tuan, Riccardo Gottardi
    Cells Tissues Organs, 2023
    Articular cartilage is crucially influenced by loading during development, health, and disease. However, our knowledge of the mechanical conditions that promote engineered cartilage maturation or tissue repair is still incomplete. Current in vitro models that allow precise control of the local mechanical environment have been dramatically limited by very low throughput, usually just a few specimens per experiment. To overcome this constraint, we have developed a new device for the high throughput compressive loading of tissue constructs: the High Throughput Mechanical Activator for Cartilage Engineering (HiT-MACE), which allows the mechanoactivation of 6 times more samples than current technologies. With HiT-MACE we were able to apply cyclic loads in the physiological (e.g., equivalent to walking and normal daily activity) and supra-physiological range (e.g., injurious impacts or extensive overloading) to up to 24 samples in one single run. In this report, we compared the early response of cartilage to physiological and supra-physiological mechanical loading to the response to IL-1β exposure, a common but rudimentary in vitro model of cartilage osteoarthritis. Physiological loading rapidly upregulated gene expression of anabolic markers along the TGF-β1 pathway. Notably, TGF-β1 or serum was not included in the medium. Supra-physiological loading caused a mild catabolic response while IL-1β exposure drove a rapid anabolic shift. This aligns well with recent findings suggesting that overloading is a more realistic and biomimetic model of cartilage degeneration. Taken together, these findings showed that the application of HiT-MACE allowed the use of larger number of samples to generate higher volume of data to effectively explore cartilage mechanobiology, which will enable the design of more effective repair and rehabilitation strategies for degenerative cartilage pathologies.
  • A Mesoscale 3D Culture System for Native and Engineered Biphasic Tissues: Application to the Osteochondral Unit
    Irene Chiesa, Roberto Di Gesù, Kalon J. Overholt, Riccardo Gottardi
    Methods in Molecular Biology, 2022
  • Generation of hepatobiliary cell lineages from human induced pluripotent stem cells: Applications in disease modeling and drug screening
    Mattia Pasqua, Roberto Di Gesù, Cinzia Maria Chinnici, Pier Giulio Conaldi, Maria Giovanna Francipane
    International Journal of Molecular Sciences, 2021
    The possibility to reproduce key tissue functions in vitro from induced pluripotent stem cells (iPSCs) is offering an incredible opportunity to gain better insight into biological mechanisms underlying development and disease, and a tool for the rapid screening of drug candidates. This review attempts to summarize recent strategies for specification of iPSCs towards hepatobiliary lineages —hepatocytes and cholangiocytes—and their use as platforms for disease modeling and drug testing. The application of different tissue-engineering methods to promote accurate and reliable readouts is discussed. Space is given to open questions, including to what extent these novel systems can be informative. Potential pathways for improvement are finally suggested.
  • Klebsiella pneumoniae lipopolysaccharides serotype o2afg induce poor inflammatory immune responses ex vivo
    Matteo Bulati, Rosalia Busà, Claudia Carcione, Gioacchin Iannolo, Giuseppina Di Mento, Nicola Cuscino, Roberto Di Gesù, Antonio Palumbo Piccionello, Silvestre Buscemi, Anna Paola Carreca, Floriana Barbera, Francesco Monaco, Francesca Cardinale, Pier Giulio Conaldi, Bruno Douradinha
    Microorganisms, 2021
  • Application of a Hyperelastic 3D Printed Scaffold for Mesenchymal Stem Cell-Based Fabrication of a Bizonal Tendon Enthesis-like Construct
    Riccardo Gottardi, Kim Moeller, Roberto Di Gesù, Rocky S. Tuan, Martijn van Griensven, Elizabeth R. Balmayor
    Frontiers in Materials, 2021
  • Design and in vitro study of a dual drug-loaded delivery system produced by electrospinning for the treatment of acute injuries of the central nervous system
    Luisa Stella Dolci, Rosaria Carmela Perone, Roberto Di Gesù, Mallesh Kurakula, Chiara Gualandi, Elisa Zironi, Teresa Gazzotti, Maria Teresa Tondo, Giampiero Pagliuca, Natalia Gostynska, Vito Antonio Baldassarro, Maura Cescatti, Luciana Giardino, Maria Letizia Focarete, Laura Calzà, Nadia Passerini, Maria Laura Bolognesi
    Pharmaceutics, 2021
  • 3D printing for tissue engineering in otolaryngology
    Roberto Di Gesù, Abhinav P. Acharya, Ian Jacobs, Riccardo Gottardi
    Connective Tissue Research, 2020
  • Endothelial cells support osteogenesis in an in vitro vascularized bone model developed by 3D bioprinting
    Irene Chiesa, Carmelo De Maria, Anna Lapomarda, Gabriele Maria Fortunato, Francesca Montemurro, Roberto Di Gesù, Rocky S Tuan, Giovanni Vozzi, Riccardo Gottardi
    Biofabrication, 2020
  • Biodegradable electrospun fibers enriched with struvite crystal seeds for the recovery of phosphorous and nitrogen
    Roberto Di Gesù, Chiara Gualandi, Andrea Zucchelli, Anna Liguori, Laura Paltrinieri, Maria Letizia Focarete
    European Polymer Journal, 2020
  • Biofabrication and characterization of a biphasic construct to study osteochondral tissue in vitro
    Convegno Nazionale Di Bioingegneria, 2020
  • Electrospun scaffolds in tendons regeneration: A review
    R. Di Gesù, G. Amato, R. Gottardi
    Muscles Ligaments and Tendons Journal, 2019
  • Advances in multidrug delivery from electrospun nanomaterials
    Roberto Di Gesù, Andrea Merlettini, Chiara Gualandi, Maria Letizia Focarete
    Core Shell Nanostructures for Drug Delivery and Theranostics Challenges Strategies and Prospects for Novel Carrier Systems, 2018
  • Correction to: Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells [Journal of Nanobiotechnology, 12, (2014), (21)] Doi: 10.1186/1477-3155-12-21
    Roberto Di Gesù, Maria Luisa Bondì, Antonina Azzolina, Emanuela Fabiola Craparo, Chiara Botto, Erika Amore, Gaetano Giammona, Melchiorre Cervello
    Journal of Nanobiotechnology, 2018
  • Controlled and sustained release of a corticosteroid drug from block copolymers synthetized by ATRP
    Graziella Valenti, Stefania La Carta, Giovanni Mazzotti, Marco Rapisarda, Stefania Perna, Roberto Di Gesù, Loris Giorgini, Domenico Carmelo Carbone, Giuseppe Recca, Paola Rizzarelli
    Polymer Engineering and Science, 2017
  • Controlled release of cortisone drugs from block copolymers synthetized by ATRP
    G. Valenti, S. La Carta, G. Mazzotti, M. Rapisarda, S. Perna, R. Di Gesù, L. Giorgini, D. Carbone, G. Recca, P. Rizzarelli
    Aip Conference Proceedings, 2016
  • Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells
    Maria Bondì, Antonina Azzolina, Emanuela Craparo, Chiara Botto, Erika Amore, Gaetano Giammona, Melchiorre Cervello
    Journal of Nanobiotechnology, 2014
  • Lipid nanocarriers containing ester prodrugs of flurbiprofen preparation, physical-chemical characterization and biological studies
    M. L. Bondì, E. F. Craparo, P. Picone, G. Giammona, R. Di Gesù, M. Di Carlo
    Journal of Biomedical Nanotechnology, 2013
  • Lipid nanoparticles for drug targeting to the brain
    Maria Luisa Bondì, Roberto Di Gesù, Emanuela Fabiola Craparo
    Methods in Enzymology, 2012
  • Lipid nanoparticles as delivery vehicles for the Parietaria judaica major allergen Par j 2.
    Maria Luisa Bondì, Montana, Bonura, Colombo, Emanuela Fabiola Craparo, Giammona, Roberto di Gesù
    International Journal of Nanomedicine, 2011
  • Curcumin entrapped into lipid nanosystems inhibits neuroblastoma cancer cell growth and activates Hsp70 protein
    M. Bondì, E. Craparo, P. Picone, M. Carlo, R. Gesu, G. Capuano, G. Giammona
    Current Nanoscience, 2010

RECENT SCHOLAR PUBLICATIONS

  • Tissue engineering for tendon and ligament repair: Insights and advances
    F Romano, F Lopresti, RD Gesù, V La Carrubba
    View 6 (6), 20250063 , 2025
    2025
    Citations: 1
  • TUNABLE SMART BIOMATERIAL FOR CARTILAGE REGENERATION (ULTRACART REGENERA)
    R Di Gesù, G Burriesci, F Lopresti, F Romano, S Di Leonardo, ...
    Orthopaedic Proceedings 107 (SUPP_8), 13-13 , 2025
    2025
  • INNOVATIVE ELECTROSPUN SCAFFOLDS FOR TENDON REGENERATION: A NOVEL APPROACH TO PREVENT POST-SURGICAL FIBROSIS
    F Romano, F Lopresti, C Di Marco, V La Carrubba, R Di Gesù
    Orthopaedic Proceedings 107 (SUPP_6), 100-100 , 2025
    2025
  • Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation
    M Pasqua, M Barbuto, M Calligaris, R Di Gesù, D Pagano, R Busà, ...
    Advanced Healthcare Materials 14 (21), 2501660 , 2025
    2025
    Citations: 1
  • Biofabrication of an in situ hypoxia-delivery scaffold for cartilage regeneration
    R Di Gesù, A Palumbo Piccionello, G Vitale, S Buscemi, S Panzavolta, ...
    Biofabrication 17 (2), 025025 , 2025
    2025
    Citations: 6
  • Engineered collagen-coated scaffolds for tendon regeneration: a multifunctional drug delivery approach
    F Di Marco, C., Romano, F Lopresti, S Campora, A Comelli, R Di Gesù, ...
    International Journal of Biological Macromolecules 315 (144445) , 2025
    2025
    Citations: 4
  • Scaffold for cartilage regeneration
    R Di Gesù, A Palumbo Piccionello, R Gottardi
    IT Patent P024171IT-01 , 2024
    2024
  • Peptide direct growth on poly (acrylic acid)/poly (vinyl alcohol) electrospun fibers coated with branched poly (ethylenimine): A solid-phase approach for scaffolds …
    A Liguori, J Zhao, R Di Gesù, R De Marco, C Gualandi, N Calonghi, ...
    Colloids and Surfaces B: Biointerfaces 241, 114052 , 2024
    2024
    Citations: 3
  • Novel half Salphen cobalt(III) complexes: synthesis, DNA binding and anticancer studies
    BG Bonsignore R., Trippodo E., Di Gesù R., Carreca A.P., Rubino S., Spinello ...
    Dalton Transaction , 2024
    2024
    Citations: 14
  • Implantable composition for use in cartilage defects repair in post-surgery rehabilitation
    R Di Gesù, R Gottardi
    US Patent WO2024251364, P023293WO-01 , 2023
    2023
  • BIOFABRICATION OF A TRIPHASIC VASCULO-OSSEOUS-CHONDRAL CONSTRUCT TO MODEL THE OSTEOCHONDRAL COMPLEX IN VITRO
    I Chiesa, C De Maria, A Lapomarda, GM Fortunato, PM Geheret, ...
    TISSUE ENGINEERING PART A 28, S156-S157 , 2022
    2022
  • A mesoscale 3D culture system for native and engineered biphasic tissues: application to the osteochondral unit
    I Chiesa, R Di Gesù, KJ Overholt, R Gottardi
    Organ-on-a-Chip: Methods and Protocols, 267-281 , 2021
    2021
    Citations: 3
  • Klebsiella pneumoniae Lipopolysaccharides Serotype O2afg Induce Poor Inflammatory Immune Responses Ex Vivo
    M Bulati, R Busà, C Carcione, G Iannolo, G Di Mento, N Cuscino, ...
    Microorganisms 9 (6), 1317 , 2021
    2021
    Citations: 36
  • Design and In Vitro Study of a Dual Drug-Loaded Delivery System Produced by Electrospinning for the Treatment of Acute Injuries of the Central Nervous System
    BML Dolci L.S., Perone R.C., Di Gesù R., Kurakula M., Gualandi C., Zironi E ...
    https://doi.org/10.3390/pharmaceutics13060848 13 (6), 848-867 , 2021
    2021
    Citations: 17
  • Generation of Hepatobiliary Cell Lineages from Human Induced Pluripotent Stem Cells: Applications in Disease Modeling and Drug Screening
    M Pasqua, R Di Gesù, CM Chinnici, PG Conaldi, MG Francipane
    International Journal of Molecular Sciences 22 (15), 8227 , 2021
    2021
    Citations: 8
  • A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-physiological Loads
    GR Capuana E., Marino D., Di Gesù R., La Carrubba V., Brucato V., Rocky S.T.
    Cells, Tissues, Organs , 2021
    2021
    Citations: 24
  • Application of a Hyperelastic 3D Printed Scaffold for Mesenchymal Stem Cell-based Fabrication of a Bizonal Tendon Enthesis-like Construct
    R Gottardi, K Moeller, R Di Gesù, RS Tuan, M van Griensven, ...
    Frontiers in Materials 8, 21 , 2021
    2021
    Citations: 22
  • Endothelial cells support osteogenesis in an in vitro vascularized bone model developed by 3D bioprinting
    I Chiesa, C De Maria, A Lapomarda, GM Fortunato, F Montemurro, ...
    Biofabrication 12 (2), 025013 , 2020
    2020
    Citations: 127
  • Biodegradable electrospun fibers enriched with struvite crystal seeds for the recovery of phosphorous and nitrogen
    R Di Gesù, C Gualandi, A Zucchelli, A Liguori, L Paltrinieri, ML Focarete
    European Polymer Journal 122, 109389 , 2020
    2020
    Citations: 10
  • Biofabrication and characterization of a biphasic construct to study osteochondral tissue in vitro
    I Chiesa, C De Maria, A Lapomarda, GM Fortunato, F Montemurro, ...
    Convegno Nazionale di Bioingegneria, 155-158 , 2020
    2020

MOST CITED SCHOLAR PUBLICATIONS

  • Endothelial cells support osteogenesis in an in vitro vascularized bone model developed by 3D bioprinting
    I Chiesa, C De Maria, A Lapomarda, GM Fortunato, F Montemurro, ...
    Biofabrication 12 (2), 025013 , 2020
    2020
    Citations: 127
  • Lipid nanoparticles for drug targeting to the brain
    ML Bondì, R Di Gesù, EF Craparo
    Methods in enzymology 508, 229-251 , 2012
    2012
    Citations: 68
  • 3D Printing for Tissue Engineering in Otolaryngology
    R Di Gesù, A Acharya, I Jacobs, R Gottardi
    Connective Tissue Research 60 , 2019
    2019
    Citations: 50
  • Klebsiella pneumoniae Lipopolysaccharides Serotype O2afg Induce Poor Inflammatory Immune Responses Ex Vivo
    M Bulati, R Busà, C Carcione, G Iannolo, G Di Mento, N Cuscino, ...
    Microorganisms 9 (6), 1317 , 2021
    2021
    Citations: 36
  • Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells (vol 12, 21, 2014)
    R Di Gesu, ML Bondi, A Azzolina, EF Craparo, C Botto, E Amore, ...
    JOURNAL OF NANOBIOTECHNOLOGY 16 , 2018
    2018
    Citations: 32
  • A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-physiological Loads
    GR Capuana E., Marino D., Di Gesù R., La Carrubba V., Brucato V., Rocky S.T.
    Cells, Tissues, Organs , 2021
    2021
    Citations: 24
  • Application of a Hyperelastic 3D Printed Scaffold for Mesenchymal Stem Cell-based Fabrication of a Bizonal Tendon Enthesis-like Construct
    R Gottardi, K Moeller, R Di Gesù, RS Tuan, M van Griensven, ...
    Frontiers in Materials 8, 21 , 2021
    2021
    Citations: 22
  • Curcumin entrapped into lipid nanosystems inhibits neuroblastoma cancer cell growth and activates Hsp70 protein
    ML Bondì, EF Craparo, P Picone, MD Carlo, RD Gesu, G Capuano, ...
    Current Nanoscience 6 (5), 439-445 , 2010
    2010
    Citations: 21
  • Design and In Vitro Study of a Dual Drug-Loaded Delivery System Produced by Electrospinning for the Treatment of Acute Injuries of the Central Nervous System
    BML Dolci L.S., Perone R.C., Di Gesù R., Kurakula M., Gualandi C., Zironi E ...
    https://doi.org/10.3390/pharmaceutics13060848 13 (6), 848-867 , 2021
    2021
    Citations: 17
  • Novel half Salphen cobalt(III) complexes: synthesis, DNA binding and anticancer studies
    BG Bonsignore R., Trippodo E., Di Gesù R., Carreca A.P., Rubino S., Spinello ...
    Dalton Transaction , 2024
    2024
    Citations: 14
  • Lipid nanoparticles as delivery vehicles for the Parietaria judaica major allergen Par j 2
    ML Bondì, G Montana, EF Craparo, R Di Gesù, G Giammona, A Bonura, ...
    International Journal of Nanomedicine, 2953-2962 , 2011
    2011
    Citations: 14
  • Advances in multidrug delivery from electrospun nanomaterials
    R Di Gesù, A Merlettini, C Gualandi, ML Focarete
    Core-Shell Nanostructures for Drug Delivery and Theranostics, 405-430 , 2018
    2018
    Citations: 13
  • Biodegradable electrospun fibers enriched with struvite crystal seeds for the recovery of phosphorous and nitrogen
    R Di Gesù, C Gualandi, A Zucchelli, A Liguori, L Paltrinieri, ML Focarete
    European Polymer Journal 122, 109389 , 2020
    2020
    Citations: 10
  • Electrospun Scaffolds in Tendons Regeneration: a review.
    R Di Gesù, G Amato, R Gottardi
    Muscles, Ligaments & Tendons Journal (MLTJ) 9 (4) , 2019
    2019
    Citations: 10
  • Lipid nanocarriers containing ester prodrugs of flurbiprofen preparation, physical-chemical characterization and biological studies
    ML Bondì, EF Craparo, P Picone, G Giammona, R Di Gesù, M Di Carlo
    Journal of Biomedical Nanotechnology 9 (2), 238-246 , 2013
    2013
    Citations: 9
  • Generation of Hepatobiliary Cell Lineages from Human Induced Pluripotent Stem Cells: Applications in Disease Modeling and Drug Screening
    M Pasqua, R Di Gesù, CM Chinnici, PG Conaldi, MG Francipane
    International Journal of Molecular Sciences 22 (15), 8227 , 2021
    2021
    Citations: 8
  • Biofabrication of an in situ hypoxia-delivery scaffold for cartilage regeneration
    R Di Gesù, A Palumbo Piccionello, G Vitale, S Buscemi, S Panzavolta, ...
    Biofabrication 17 (2), 025025 , 2025
    2025
    Citations: 6
  • Engineered collagen-coated scaffolds for tendon regeneration: a multifunctional drug delivery approach
    F Di Marco, C., Romano, F Lopresti, S Campora, A Comelli, R Di Gesù, ...
    International Journal of Biological Macromolecules 315 (144445) , 2025
    2025
    Citations: 4
  • Controlled and sustained release of a corticosteroid drug from block copolymers synthetized by ATRP
    P Valenti, G., La Carta, S., Mazzotti, G., Rapisarda, M., Perna, S., Di Gesù ...
    Polymer Engineering and Science , 2017
    2017
    Citations: 4
  • Peptide direct growth on poly (acrylic acid)/poly (vinyl alcohol) electrospun fibers coated with branched poly (ethylenimine): A solid-phase approach for scaffolds …
    A Liguori, J Zhao, R Di Gesù, R De Marco, C Gualandi, N Calonghi, ...
    Colloids and Surfaces B: Biointerfaces 241, 114052 , 2024
    2024
    Citations: 3