Beucher

@lab-cobra.fr

Assistant Professor - Chemistry/INSA Rouen Normandie
INSA Rouen Normandie - UMR 6064 CARMeN

Beucher


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https://researchid.co/hbeucher

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Chemistry, Catalysis
14

Scopus Publications

280

Scholar Citations

8

Scholar h-index

8

Scholar i10-index

Scopus Publications

  • Electro-Mediated Redox Functionalization of Conjugated 1,3-Dienes
    Ophélie Montiège, Jean‐François Brière, Cédric Schneider, Hélène Beucher
    Advanced Synthesis and Catalysis, 2026
    Conjugated 1,3‐dienes are abundant, readily available raw materials and key structural motifs in natural or bioactive molecules. The direct conversion of these versatile building blocks into value‐added products is an attractive area in synthetic chemistry. However, their selective functionalization remains a major challenge due to intrinsic regio‐ and stereoselectivity issues arising from multiple reactive sites. Traditional approaches, mostly involving two‐electron mediated transition‐metal catalysis, have faced challenges and motivated the development of new redox strategies, predominantly based on photocatalytic approaches. In this context, electrosynthesis has recently emerged as a competent and environmentally friendly alternative, allowing the generation of reactive metallic or open‐shelf organic radical intermediates under mild redox conditions. This comprehensive review provides an overview of electro‐mediated transformations of conjugated 1,3‐dienes, with an emphasis on the mechanisms involved. It is organized in three main sections encompassing hydrofunctionalization, two‐component difunctionalization and multicomponent processes.
  • Recent advances of asymmetric catalytic transformations of alkylidene Meldrum's acid derivatives
    Hélène Beucher, Vincent Levacher, Sylvain Oudeyer, Jean-François Brière
    Chemical Communications, 2025
    This account highlights the recent developments of catalytic enantioselective transformations of AMA towards the construction of valuable chiral molecules and heterocycles.
  • Regio- and Stereoselective Electro-Mediated Carboalkoxylation of 1,3-Dienes
    Ophélie Montiège, Marion Siccardi, Morgane Sanselme, Cédric Schneider, Jean-François Brière, Hélène Beucher
    Organic Letters, 2024
    1,3-Dienes are versatile raw materials for building molecular complexity. We report herein mild conditions for the regio- and stereoselective [only the ( E ) isomer obtained] 1,4-carboalkoxylation of 1,3-dienes. This electrochemical multicomponent reaction provides an eco-efficient and straightforward access to a diverse range of ( E )-polyfunctionalized allyl ether products, without requiring any metal catalyst.
  • Catalytic enantioselective synthesis of cyclopropyl α-amino carboxylates and phosphonates
    Hélène Beucher, Ismail Alahyen, Alex Talbot, Thomas Poisson, Philippe Jubault
    Organic Chemistry Frontiers, 2024
    Herein, the catalytic asymmetric synthesis of tetra-substituted cyclopropyl α-amino carboxylates and cyclopropyl α-amino phosphonates is reported.
  • Iron-catalyzed decarboxylative radical addition to chiral azomethine imines upon visible light
    Arona Fall, Mihaela Magdei, Mariia Savchuk, Sylvain Oudeyer, Hélène Beucher, Jean-François Brière
    Chemical Communications, 2024
    Eco-efficient LMCT based redox-neutral iron-catalyzed decarboxylative radical addition to chiral azomethine imines upon visible light.
  • Vinylogous and stereoselective domino synthesis of pyrano[2,3-c]pyrroles from alkylidene meldrum's acids
    Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, Hélène Beucher, Jean-François Brière
    Organic and Biomolecular Chemistry, 2024
    An expeditious diatereoselective synthesis of pyrano[2,3-c]pyrroles thanks to a domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction to alkylidene Meldrum's acid derivatives.
  • An Organocatalytic and Stereoselective Vinylogous Domino Process towards Thiochromans
    Pierre Milbeo, Arthur Lebrêne, Mariia Savchuk, Giang Vo‐Thanh, Sylvain Oudeyer, Hélène Beucher, Jean‐François Brière
    Chemistry A European Journal, 2023
    A highly diastereoselective organocatalyzed domino vinylogous sulfa‐Michael‐aldol‐cyclocondensation (VMAC) reaction has been developed using alkylidene Meldrum's acid as dienes highlighting two vinylogous steps, an unprecedented sulfa‐1,6‐conjugate addition and a diastereoselective aldol reaction triggering a formal (4+2) cycloaddition. This work opens a new route towards bio‐relevant and original tricyclic thiochroman derivatives.
  • Recent Advances in Catalytic and Technology-Driven Radical Addition to N,N-Disubstituted Iminium Species
    Sylvain Oudeyer, Vincent Levacher, Hélène Beucher, Jean-François Brière
    Molecules, 2023
    Recently, radical chemistry has grown exponentially in the toolbox of organic synthetic chemists. Upon the (re)introduction of modern catalytic and technology-driven strategies, the implementation of highly reactive radical species is currently facilitated while expanding the scope of numerous synthetic methodologies. In this context, this review intends to cover the recent advances in radical-based transformations of N,N-disubstituted iminium substrates that encompass unique reactivities with respect to imines or protonated iminium salts. In particular, we have focused on the literature concerning the dipole type substrates, such as nitrones or azomethine imines, together with the chemistry of N+-X− (X = O, NR) azaarenium dipoles, which proved to be very versatile platforms in that field of research. The N-alkylazaarenium salts were been considered, which demonstrated specific reactivity profiles in radical chemistry.
  • Chelation-assisted C-C bond activation of biphenylene by gold(i) halides
    Hélène Beucher, Johannes Schörgenhumer, Estíbaliz Merino, Cristina Nevado
    Chemical Science, 2021
    Pyridine and phosphine directing groups promote the C–C activation of biphenylene by readily available gold(i) halides rendering a new entry to (N^C^C)- and (P^C)-gold(iii) species.
  • Phosphorescent κ3-(N^C^C)-Gold(III) Complexes: Synthesis, Photophysics, Computational Studies and Application to Solution-Processable OLEDs
    Hélène Beucher, Sudhir Kumar, Roopender Kumar, Estíbaliz Merino, Wei‐Hsu Hu, Gerrit Stemmler, Sergio Cuesta‐Galisteo, Jorge A. González, Léonard Bezinge, Jakub Jagielski, Chih‐Jen Shih, Cristina Nevado
    Chemistry A European Journal, 2020
    Efficient OLED devices have been fabricated using organometallic complexes of platinum group metals. Still, the high material cost and low stability represent central challenges for their application in commercial display technologies. Based on its innate stability, gold(III) complexes are emerging as promising candidates for high‐performance OLEDs. Here, a series of alkynyl‐, N‐heterocyclic carbene (NHC)‐ and aryl‐gold(III) complexes stabilized by a κ3‐(N^C^C) template have been prepared and their photophysical properties have been characterized in detail. These compounds exhibit good photoluminescence quantum efficiency (ηPL) of up to 33 %. The PL emission can be tuned from sky‐blue to yellowish green colors by variations on both the ancillary ligands as well as on the pincer template. Further, solution‐processable OLED devices based on some of these complexes display remarkable emissive properties (ηCE 46.6 cd.A−1 and ηext 14.0 %), thus showcasing the potential of these motifs for the low‐cost fabrication of display and illumination technologies.
  • Highly Efficient Green Solution Processable Organic Light-Emitting Diodes Based on a Phosphorescent κ3-(N^C^C)Gold(III)-Alkynyl Complex
    Hélène Beucher, Sudhir Kumar, Estíbaliz Merino, Wei-Hsu Hu, Gerrit Stemmler, Sergio Cuesta-Galisteo, Jorge A. González, Jakub Jagielski, Chih-Jen Shih, Cristina Nevado
    Chemistry of Materials, 2020
  • κ3-(N^C^C)Gold(III) Carboxylates: Evidence for Decarbonylation Processes
    Hélène Beucher, Estíbaliz Merino, Alexandre Genoux, Thomas Fox, Cristina Nevado
    Angewandte Chemie International Edition, 2019
  • Minisci-Photoredox-Mediated α-Heteroarylation of N-Protected Secondary Amines: Remarkable Selectivity of Azetidines
    Cyril Bosset, Hélène Beucher, Guillaume Bretel, Elisabeth Pasquier, Laurence Queguiner, Cyril Henry, Ann Vos, James P. Edwards, Lieven Meerpoel, Didier Berthelot
    Organic Letters, 2018
  • Rhodium-catalyzed cyclopropanation of fluorinated olefins: A straightforward route to highly functionalized fluorocyclopropanes
    Amandine Pons, Hélène Beucher, Pavel Ivashkin, Gérald Lemonnier, Thomas Poisson, André B. Charette, Philippe Jubault, Xavier Pannecoucke
    Organic Letters, 2015

RECENT SCHOLAR PUBLICATIONS

  • Electro‐Mediated Redox Functionalization of Conjugated 1, 3‐Dienes
    O Montiège, JF Brière, C Schneider, H Beucher
    Advanced Synthesis & Catalysis 368 (6), e70362 , 2026
    2026
  • Actes de la 9ème édition du colloque Pédagogie et Formation du Groupe INSA
    JP Kotowicz, N Delestre, V Hordey, N Matheu, H Paris, FS Touhami, ...
    Colloque Pédagogie et Formation du Groupe INSA, hal-05514577 , 2026
    2026
  • Nickel-catalyzed direct cyanoalkylation of ketones.
    A Coffinet, J Yang, J Rio, M Savchuk, H Beucher, S Oudeyer, H Gérard, ...
    Journées de Chimie Organique (JCO 2025) , 2025
    2025
  • Recent advances of asymmetric catalytic transformations of alkylidene Meldrum's acid derivatives
    H Beucher, V Levacher, S Oudeyer, JF Brière
    Chemical Communications 61 (36), 6555-6566 , 2025
    2025
    Citations: 3
  • Regio-and Stereoselective Electro-Mediated Carboalkoxylation of 1, 3-Dienes
    O Montiege, M Siccardi, M Sanselme, C Schneider, JF Brière, H Beucher
    Organic Letters 26 (51), 11105-11110 , 2024
    2024
    Citations: 2
  • Sels d’ammoniums quaternaires chiraux en organocatalyse: des outils polyvalents pour la synthèse asymétrique
    H Beucher, V Levacher, S Oudeyer, JF Brière
    L'Actualité Chimique 497, 23-25 , 2024
    2024
  • Catalytic enantioselective synthesis of cyclopropyl α-amino carboxylates and phosphonates
    H Beucher, I Alahyen, A Talbot, T Poisson, P Jubault
    Organic Chemistry Frontiers 11 (20), 5859-5867 , 2024
    2024
    Citations: 4
  • Vinylogous and stereoselective domino synthesis of pyrano [2, 3-c] pyrroles from alkylidene meldrum's acids
    M Savchuk, G Vo-Thanh, S Oudeyer, H Beucher, JF Brière
    Organic & Biomolecular Chemistry 22 (15), 2948-2952 , 2024
    2024
    Citations: 1
  • Iron-catalyzed decarboxylative radical addition to chiral azomethine imines upon visible light
    A Fall, M Magdei, M Savchuk, S Oudeyer, H Beucher, JF Brière
    Chemical Communications 60 (49), 6316-6319 , 2024
    2024
    Citations: 20
  • An Organocatalytic and Stereoselective Vinylogous Domino Process towards Thiochromans
    P Milbeo, A Lebrêne, M Savchuk, G Vo‐Thanh, S Oudeyer, H Beucher, ...
    Chemistry–A European Journal 29 (42), e202301311 , 2023
    2023
    Citations: 4
  • Recent Advances in Catalytic and Technology-Driven Radical Addition to N , N -Disubstituted Iminium Species
    S Oudeyer, V Levacher, H Beucher, JF Brière
    Molecules 28 (3), 1071 , 2023
    2023
    Citations: 15
  • Synthesis and Applications of Cyclometalated Gold (III) Complexes
    H Beucher
    University of Zurich , 2021
    2021
  • Chelation-assisted C–C bond activation of biphenylene by gold (< scp> i</scp>) halides
    H Beucher, J Schörgenhumer, E Merino, C Nevado
    2021
  • Chelation-assisted C–C bond activation of biphenylene by gold (I) halides
    H Beucher, J Schörgenhumer, E Merino, C Nevado
    Chemical Science 12 (45), 15084-15089 , 2021
    2021
    Citations: 12
  • Phosphorescent κ 3 ‐(N^C^C)‐Gold(III) Complexes: Synthesis, Photophysics, Computational Studies and Application to Solution‐Processable OLEDs
    H Beucher, S Kumar, R Kumar, E Merino, WH Hu, G Stemmler, ...
    Chemistry–A European Journal 26 (72), 17604-17612 , 2020
    2020
    Citations: 25
  • Highly Efficient Green Solution Processable Organic Light-Emitting Diodes Based on a Phosphorescent κ 3 -(N^C^C)Gold(III)-Alkynyl Complex
    H Beucher, S Kumar, E Merino, WH Hu, G Stemmler, S Cuesta-Galisteo, ...
    Chemistry of Materials 32 (4), 1605-1611 , 2020
    2020
    Citations: 46
  • Highly Efficient Green Solution Processable Organic Light-Emitting Diodes
    H Beucher, S Kumar, E Merino, WH Hu, G Stemmler, S Cuesta-Galisteo, ...
    2020
  • κ 3 ‐(N^C^C)Gold(III) Carboxylates: Evidence for Decarbonylation Processes
    H Beucher, E Merino, A Genoux, T Fox, C Nevado
    Angewandte Chemie 131 (27), 9162-9165 , 2019
    2019
    Citations: 28
  • Minisci-photoredox-mediated α-heteroarylation of N-protected secondary amines: remarkable selectivity of azetidines
    C Bosset, H Beucher, G Bretel, E Pasquier, L Queguiner, C Henry, A Vos, ...
    Organic letters 20 (19), 6003-6006 , 2018
    2018
    Citations: 77
  • Rhodium-catalyzed cyclopropanation of fluorinated olefins: a straightforward route to highly functionalized fluorocyclopropanes
    A Pons, H Beucher, P Ivashkin, G Lemonnier, T Poisson, AB Charette, ...
    Organic Letters 17 (7), 1790-1793 , 2015
    2015
    Citations: 43

MOST CITED SCHOLAR PUBLICATIONS

  • Minisci-photoredox-mediated α-heteroarylation of N-protected secondary amines: remarkable selectivity of azetidines
    C Bosset, H Beucher, G Bretel, E Pasquier, L Queguiner, C Henry, A Vos, ...
    Organic letters 20 (19), 6003-6006 , 2018
    2018
    Citations: 77
  • Highly Efficient Green Solution Processable Organic Light-Emitting Diodes Based on a Phosphorescent κ 3 -(N^C^C)Gold(III)-Alkynyl Complex
    H Beucher, S Kumar, E Merino, WH Hu, G Stemmler, S Cuesta-Galisteo, ...
    Chemistry of Materials 32 (4), 1605-1611 , 2020
    2020
    Citations: 46
  • Rhodium-catalyzed cyclopropanation of fluorinated olefins: a straightforward route to highly functionalized fluorocyclopropanes
    A Pons, H Beucher, P Ivashkin, G Lemonnier, T Poisson, AB Charette, ...
    Organic Letters 17 (7), 1790-1793 , 2015
    2015
    Citations: 43
  • κ 3 ‐(N^C^C)Gold(III) Carboxylates: Evidence for Decarbonylation Processes
    H Beucher, E Merino, A Genoux, T Fox, C Nevado
    Angewandte Chemie 131 (27), 9162-9165 , 2019
    2019
    Citations: 28
  • Phosphorescent κ 3 ‐(N^C^C)‐Gold(III) Complexes: Synthesis, Photophysics, Computational Studies and Application to Solution‐Processable OLEDs
    H Beucher, S Kumar, R Kumar, E Merino, WH Hu, G Stemmler, ...
    Chemistry–A European Journal 26 (72), 17604-17612 , 2020
    2020
    Citations: 25
  • Iron-catalyzed decarboxylative radical addition to chiral azomethine imines upon visible light
    A Fall, M Magdei, M Savchuk, S Oudeyer, H Beucher, JF Brière
    Chemical Communications 60 (49), 6316-6319 , 2024
    2024
    Citations: 20
  • Recent Advances in Catalytic and Technology-Driven Radical Addition to N , N -Disubstituted Iminium Species
    S Oudeyer, V Levacher, H Beucher, JF Brière
    Molecules 28 (3), 1071 , 2023
    2023
    Citations: 15
  • Chelation-assisted C–C bond activation of biphenylene by gold (I) halides
    H Beucher, J Schörgenhumer, E Merino, C Nevado
    Chemical Science 12 (45), 15084-15089 , 2021
    2021
    Citations: 12
  • Catalytic enantioselective synthesis of cyclopropyl α-amino carboxylates and phosphonates
    H Beucher, I Alahyen, A Talbot, T Poisson, P Jubault
    Organic Chemistry Frontiers 11 (20), 5859-5867 , 2024
    2024
    Citations: 4
  • An Organocatalytic and Stereoselective Vinylogous Domino Process towards Thiochromans
    P Milbeo, A Lebrêne, M Savchuk, G Vo‐Thanh, S Oudeyer, H Beucher, ...
    Chemistry–A European Journal 29 (42), e202301311 , 2023
    2023
    Citations: 4
  • Recent advances of asymmetric catalytic transformations of alkylidene Meldrum's acid derivatives
    H Beucher, V Levacher, S Oudeyer, JF Brière
    Chemical Communications 61 (36), 6555-6566 , 2025
    2025
    Citations: 3
  • Regio-and Stereoselective Electro-Mediated Carboalkoxylation of 1, 3-Dienes
    O Montiege, M Siccardi, M Sanselme, C Schneider, JF Brière, H Beucher
    Organic Letters 26 (51), 11105-11110 , 2024
    2024
    Citations: 2
  • Vinylogous and stereoselective domino synthesis of pyrano [2, 3-c] pyrroles from alkylidene meldrum's acids
    M Savchuk, G Vo-Thanh, S Oudeyer, H Beucher, JF Brière
    Organic & Biomolecular Chemistry 22 (15), 2948-2952 , 2024
    2024
    Citations: 1
  • Electro‐Mediated Redox Functionalization of Conjugated 1, 3‐Dienes
    O Montiège, JF Brière, C Schneider, H Beucher
    Advanced Synthesis & Catalysis 368 (6), e70362 , 2026
    2026
  • Actes de la 9ème édition du colloque Pédagogie et Formation du Groupe INSA
    JP Kotowicz, N Delestre, V Hordey, N Matheu, H Paris, FS Touhami, ...
    Colloque Pédagogie et Formation du Groupe INSA, hal-05514577 , 2026
    2026
  • Nickel-catalyzed direct cyanoalkylation of ketones.
    A Coffinet, J Yang, J Rio, M Savchuk, H Beucher, S Oudeyer, H Gérard, ...
    Journées de Chimie Organique (JCO 2025) , 2025
    2025
  • Sels d’ammoniums quaternaires chiraux en organocatalyse: des outils polyvalents pour la synthèse asymétrique
    H Beucher, V Levacher, S Oudeyer, JF Brière
    L'Actualité Chimique 497, 23-25 , 2024
    2024
  • Synthesis and Applications of Cyclometalated Gold (III) Complexes
    H Beucher
    University of Zurich , 2021
    2021
  • Chelation-assisted C–C bond activation of biphenylene by gold (< scp> i</scp>) halides
    H Beucher, J Schörgenhumer, E Merino, C Nevado
    2021
  • Highly Efficient Green Solution Processable Organic Light-Emitting Diodes
    H Beucher, S Kumar, E Merino, WH Hu, G Stemmler, S Cuesta-Galisteo, ...
    2020