arash hedayat

@mui.ac.ir

arash hedayat


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https://researchid.co/arash.he

RESEARCH, TEACHING, or OTHER INTERESTS

Hematology, Oncology
5

Scopus Publications

58

Scholar Citations

5

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Efficacy and safety of Apixaban for the prevention of thrombosis in arteriovenous grafts
    Arash Hedayat, Aidin Esrafilian Soltani, Mahdi Hakiminezhad, Fateme Zareian, Mandana Saneian, Mohamad Moradmand, Sahand Abrishami, Mohamad Hosein Tabatabaei Nodoushan, Ali Pouriayevali, Mahdi Mohebbi, Helia Ghorbani
    European Journal of Translational Myology, 2024
    This research aims to fill a vital gap in existing studies by evaluating the efficacy and safety of Apixaban, a direct oral anticoagulant, in the prevention of arteriovenous graft (AVG) thrombosis, thereby offering substantial insights into alternative anticoagulant options for hemodialysis patients. Conducted as a multi-center, randomized, double-blind, placebo-controlled trial, this study involved end-stage renal disease (ESRD) patients who had recently received polytetrafluoroethylene grafts. Participants were assigned to receive either Apixaban at a dose of 2.5 mg twice daily or a placebo. The primary outcome measure was the occurrence of graft thrombosis, while secondary outcomes focused on the incidence and severity of bleeding. Analytical methods included Kaplan-Meier estimates, Cox proportional hazards models, and conventional statistical tests. With 96 patients enrolled, the study found that Apixaban significantly reduced the incidence of AVG thrombosis compared to placebo (16.7% vs. 62.5%, P < 0.0001). Notably, this reduction in thrombosis incidence was not accompanied by an increase in bleeding events, thus affirming the safety profile of Apixaban as established in prior research. Apixaban is identified as an efficacious alternative to traditional anticoagulants in the prevention of AVG thrombosis among hemodialysis patients, representing a notable advancement in the care of individuals with ESRD. The results of this study support further investigations into the optimal dosing strategies specifically tailored for this patient demographic.
  • Association of lymphocyte subsets with mortality in severe COVID-19 pneumonia patients
    Farzaneh Ashrafi, Pardis Nematollahi, Mehrzad Salmasi, Arash Hedayat, Babak Amra
    Journal of Clinical Laboratory Analysis, 2021
    BackgroundFew studies have investigated the alterations in the T and B cell counts and related subgroups in pulmonary infections especially COVID‐19. Here, we aimed to evaluate total T and B lymphocytes and T cell subgroup counts to find the possible correlation between number of these cells and severity and mortality in COVID‐19 patients.MethodsThis study was performed on 40 patients with severe COVID‐19 infection confirmed by reverse transcription‐polymerase chain reaction (RT‐PCR) and chest HRCT in August 2020. By the time of admission, T lymphocytes profile in peripheral blood was investigated using multicolor flow cytometry. The total number of T lymphocytes, CD4+ T cells, CD8+ T cells, and B lymphocytes were calculated. Expression of CD2, CD3, CD5, and CD7 as pan T cell surface markers and expression of CD38 and HLA‐DR as activated markers on T lymphocytes were also evaluated.ResultsNine patients (22.5%) died during the study and 16 patients (40%) were admitted to ICU. Deceased patients demonstrated lower amounts of T cell count and CD4+ T cell count (with a marginal difference (p = 0.07)) compared with survived patients at the time of admission. The chance of mortality was significantly higher for patients with CD7 loss (OR = 14.89). A marginally significant relationship was also indicated between CD4<200/ml and mortality (OR = 8.65), but no other significant relationships were observed between variables and ICU admission.ConclusionAltogether, CD7 loss on T lymphocytes and CD4+ T cell count below 200/ml revealed a significant relationship with mortality. Considering T lymphocytes and T cell subgroup count could have a predictive value for patients suffering from COVID‐19.
  • Effects of laparoscopic sleeve gastrectomy and Roux-En-Y gastric bypass on the improvement of sleep quality, daytime sleepiness, and obstructive sleep apnea in a six-month follow-up
    Tanaffos, 2020
  • The association of anthropometric indices and cardiac function in healthy adults
    Javad Shahabi, Mohammad Garakyaraghi, Davood Shafie, A. Khaledifar, Arash Hedayat, M. Givi, G. Yadegarfar
    Arya Atherosclerosis, 2019
    BACKGROUND Obesity is a major risk factor for many diseases including cardiovascular diseases (CVDs). Recently, it has been shown that upper body obesity can predict CVDs per se. In this study, we aimed to determine the association between indicators of upper body obesity and echocardiographic indices. METHODS In this cross-sectional study conducted in Hajar Hospital in Shahrekord, Iran, from March to August 2014, 80 healthy adults were included. Participants’ neck circumference (NC), waist circumference (WC), body mass index (BMI), and blood pressure were measured. Echocardiography was performed for all participants, and echocardiographic indices such as early (E’) and late (A') diastolic tissue velocity, early (E) and late (A) transmitral flow velocity, E/E’ ratio, pulmonary arterial pressure (PAP), and left atrial volume (LAV) were recorded. The association between these indices were investigated using bivariate Pearson correlation coefficient. RESULTS For men, NC had a significant correlation with LAV, systolic blood pressure (SBP), diastolic blood pressure (DBP), PAP, and A', and a negative correlation with E′. WC had a significant correlation with LAV, SBP, and PAP, and a negative correlation with E′, while BMI had a significant correlation with LAV, PAP, SBP, A, and A’. For women, NC had a significant positive correlation with LAV, A, ejection fraction (EF), SBP, PAP, and A’, and a negative correlation with E′ and E/E′. WC had a significant positive correlation with LAV, DBP, PAP, A, A’, and a negative correlation with E′, while BMI had a significant correlation with LAV, EF, SBP, PAP, E’, A, and A’. CONCLUSION The positive correlation of NC with SBP, A, and A', as well as NC, WC, and BMI with LAV and PAP in both sexes, and the negative correlation of NC with E′ show the importance of these measures in estimation of metabolic and cardiovascular risk factors.
  • The effect of curcumin pill in treatment of non-alcoholic fatty liver disease: A clinical trial study
    Bahram Pakzad, Arash Hedayat, Mehdi Ahmadian, Amin Bagheri-Ghalehsalimi, Mojtaba Akbari
    Journal of Isfahan Medical School, 2017
    Background: Non-alcoholic fatty liver disease (NAFLD) is the most common type of liver disease across the world. Due to the high prevalence of NAFLD, some patients tend to use herbal medicines for its treatment. The aim of the present study was to evaluate the effects of curcumin pill on NAFLD. Methods: In this clinical trial study, 100 patients with NAFLD were enrolled. Then, their height, weight, and body mass index were measured, and liver function tests and liver ultrasound were performed, too. The patients were then divided into two groups of case and control, and received curcumin and placebo for eight weeks, respectively. Before and after intervention, fasting blood sugar (FBS), lipid profile levels [including total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL)], human C-reactive protein (hCRP) level, and liver markers such as aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine transaminase (ALT) were measured and recorded again. Data were analyzed and compared between two groups using SPSS software. Findings: There was no significant difference between the two groups in terms of gender, age, clinical features, total cholesterol, triglyceride, LDL, HDL, FBS, liver function markers such as ALP, ALT, and AST, and hCRP, and fatty liver grade at the onset of the study (P > 0.050). However, the level of ALT, AST, and hCRP significantly reduced in the case group after the intervention (P < 0.001). Conclusion: According to the results of the present study, it seems that curcumin can be recommended for appropriate treatment of NAFLD.

RECENT SCHOLAR PUBLICATIONS

  • Efficacy and safety of Apixaban for the prevention of thrombosis in arteriovenous grafts
    A Hedayat, AE Soltani, M Hakiminezhad, F Zareian, M Saneian, ...
    European Journal of Translational Myology 34 (1), 12029 , 2024
    2024
    Citations: 9
  • Association of lymphocyte subsets with mortality in severe COVID‐19 pneumonia patients
    F Ashrafi, P Nematollahi, M Salmasi, A Hedayat, B Amra
    Journal of Clinical Laboratory Analysis 35 (11), e24046 , 2021
    2021
    Citations: 20
  • Effects of laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass on the improvement of sleep quality, daytime sleepiness, and obstructive sleep apnea in a six-month …
    F Ghiasi, AB Ghaleh, B Amra, B Kalidari, A Hedayat, SR Alavi
    Tanaffos 19 (1), 50 , 2020
    2020
    Citations: 13
  • The effect of curcumin pill in treatment of non-alcoholic fatty liver disease: a clinical trial study.
    B Pakzad, A Hedayat, M Ahmadian, A Bagheri-Ghalehsalimi, M Akbari
    2019
    Citations: 7
  • The association of anthropometric indices and cardiac function in healthy adults
    J Shahabi, M Garakyaraghi, D Shafie, A Khaledifar, A Hedayat, M Givi, ...
    ARYA atherosclerosis 15 (1), 9 , 2019
    2019
    Citations: 8
  • High Expression Apoptotic Proteins; P53, FAS, and BAX Associated with Down Regulation BCL-2 in Tuberculosis Granulomas: An Immunohistochemistry Study
    S Karimi, B Kalidari, F Mohammadi, A Mirafsharieh, A Hedayat, P Tabarsi, ...
    TANAFFOS (Respiration) 4 (1 (winter)), 11-19 , 2005
    2005
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • Association of lymphocyte subsets with mortality in severe COVID‐19 pneumonia patients
    F Ashrafi, P Nematollahi, M Salmasi, A Hedayat, B Amra
    Journal of Clinical Laboratory Analysis 35 (11), e24046 , 2021
    2021
    Citations: 20
  • Effects of laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass on the improvement of sleep quality, daytime sleepiness, and obstructive sleep apnea in a six-month …
    F Ghiasi, AB Ghaleh, B Amra, B Kalidari, A Hedayat, SR Alavi
    Tanaffos 19 (1), 50 , 2020
    2020
    Citations: 13
  • Efficacy and safety of Apixaban for the prevention of thrombosis in arteriovenous grafts
    A Hedayat, AE Soltani, M Hakiminezhad, F Zareian, M Saneian, ...
    European Journal of Translational Myology 34 (1), 12029 , 2024
    2024
    Citations: 9
  • The association of anthropometric indices and cardiac function in healthy adults
    J Shahabi, M Garakyaraghi, D Shafie, A Khaledifar, A Hedayat, M Givi, ...
    ARYA atherosclerosis 15 (1), 9 , 2019
    2019
    Citations: 8
  • The effect of curcumin pill in treatment of non-alcoholic fatty liver disease: a clinical trial study.
    B Pakzad, A Hedayat, M Ahmadian, A Bagheri-Ghalehsalimi, M Akbari
    2019
    Citations: 7
  • High Expression Apoptotic Proteins; P53, FAS, and BAX Associated with Down Regulation BCL-2 in Tuberculosis Granulomas: An Immunohistochemistry Study
    S Karimi, B Kalidari, F Mohammadi, A Mirafsharieh, A Hedayat, P Tabarsi, ...
    TANAFFOS (Respiration) 4 (1 (winter)), 11-19 , 2005
    2005
    Citations: 1