Dr. Sateesh Alavala

Dr. Sateesh Alavala received his PhD in pharmaceutical science with a specialisation in pharmacology and toxicology from the CSIR-Indian Institute of Chemical Technology in Hyderabad, India. He received his Bachelor of pharmacy degree from Kakatiya University in Warangal and his master's in pharmacology from Sri Venkateswara University in Tirupati, Andhra Pradesh. From March 2017 to March 2022, he worked as an INSPIRE Fellow at the CSIR-Indian Institute of Chemical Technology in Hyderabad, India, where he made important contributions to inflammatory disorder research. His research, particularly in inflammopharmacology, has received widespread attention, with multiple peer-reviewed papers and an h-index of 10. He also has an international patent and a book chapter. In 2014, his extraordinary presentation during his master's examinations earned him an outstanding grade. He also received the Pratibha award from the Department of Higher Education, Government of Andhra Pradesh. He was award

EDUCATION

PhD Pharmaceutical Science

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Behavioral Neuroscience, Toxicology, Drug Discovery

Scopus Publications

Heavy metal toxicity as a driver of endoplasmic reticulum stress and dysfunction
Pritha Ghosh, Lokesh Murumulla, Shrabani Das, Sateesh Alavala, Suresh Challa
FEBS Journal, 2026
Heavy metals like lead, cadmium, arsenic, mercury and chromium are persistent environmental contaminants recognised for their harmful effects on human health. Among their various toxicological effects, recent studies have identified endoplasmic reticulum (ER) as a critical target of HM‐induced cellular damage. This review explores the contribution of HMs in disrupting ER homeostasis, with a particular focus on ER dysfunctions, ER stress mechanisms, calcium regulation, and ER–mitochondria crosstalk. ER stress occurs when its protein‐folding capacity is exceeded, activating the unfolded protein response (UPR). Persistent ER stress, commonly induced by HM exposure, triggers apoptosis and contributes to several neurological diseases. A central aspect of HM‐mediated ER dysfunctions involves the imbalance of ER Ca 2+ homeostasis, which disrupts cellular signalling and promotes oxidative stress. Additionally, HMs impair ER–mitochondrial communication and energy metabolism, eventually amplifying apoptotic signals. This review systematically explores how HMs contribute to ER stress by altering molecular chaperone expression, Ca 2+ handling, and inter–organelle crosstalk. Furthermore, it explores the therapeutic potential of selected bioactive compounds, which have shown promising effects in mitigating HM‐induced ER dysfunction. These compounds exert protective actions by modulating ER stress signalling pathways. Collectively, this review highlights the need for further studies on treating damage caused by heavy metals. Understanding the interplay between ER dysfunctions and HM toxicity offers valuable insights into the development of new and more advanced therapeutic approaches for neurodegenerative and other chronic diseases linked to toxic HM exposure.
Stevioside alleviates high-fat diet-induced MASLD in Apo-E‑/‑ mice by modulating the TGF-β signaling
Sateesh Alavala, Nidhi Sharma, Rajendra Sangaraju, Suresh Challa, Ramakrishna Sistla, Sai Balaji Andugulapati
Journal of Nutritional Biochemistry, 2026
Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition
Parimala Devi Ganthala, Sateesh Alavala, Naveen Chella, Sai Balaji Andugulapati, Nagendra Babu Bathini, Ramakrishna Sistla
Colloids and Surfaces B Biointerfaces, 2022
Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways
Rajendra Sangaraju, Sateesh Alavala, Nasiruddin Nalban, Mahesh Kumar Jerald, Ramakrishna Sistla
International Immunopharmacology, 2021
Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats
Sateesh Alavala, Nasiruddin Nalban, Rajendra Sangaraju, Madhusudana Kuncha, Mahesh Kumar Jerald, Eswar Kumar Kilari, Ramakrishna Sistla
Inflammopharmacology, 2020
Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice
Nasiruddin Nalban, Rajendra Sangaraju, Sateesh Alavala, Salma Mukhtar Mir, Mahesh Kumar Jerald, Ramakrishna Sistla
Cardiovascular Toxicology, 2020
Protective effect of galangin against dextran sulfate sodium (DSS)-induced ulcerative colitis in Balb/c mice
Rajendra Sangaraju, Nasiruddin Nalban, Sateesh Alavala, Vinoth Rajendran, Mahesh Kumar Jerald, Ramakrishna Sistla
Inflammation Research, 2019
Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice
Sateesh Alavala, Rajendra Sangaraju, Nasiruddin Nalban, Bidya Dhar Sahu, Mahesh Kumar Jerald, Eswar Kumar Kilari, Ramakrishna Sistla
European Journal of Pharmacology, 2019
Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability
Burri Nagaraju, Jeshma Kovvuri, C. Ganesh Kumar, Sunitha Rani Routhu, Md. Adil Shareef, Manasa Kadagathur, Praveen Reddy Adiyala, Sateesh Alavala, Narayana Nagesh, Ahmed Kamal
Bioorganic and Medicinal Chemistry, 2019
Therapeutic Targeting of Oxidative Stress and Inflammation in Asthma and COPD and Pharmacological Interventions with Phytochemicals
Nasiruddin Nalban, Sateesh Alavala, Rajendra Sangaraju, Salma Mukhtar Mir, Ramakrishna Sistla
Oxidative Stress in Lung Diseases Volume 1, 2019
Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability
M.P. Narasimha Rao, Burri Nagaraju, Jeshma Kovvuri, Sowjanya Polepalli, Sateesh Alavala, M.V.P.S. Vishnuvardhan, P. Swapna, Vijaykumar D. Nimbarte, Jerripothula K. Lakshmi, Nishant Jain, Ahmed Kamal
Bioorganic Chemistry, 2018
Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni
Bhaskar Rao Adari, Sateesh Alavala, Sara A. George, Harshadas M. Meshram, Ashok K. Tiwari, Akella V.S. Sarma
Food Chemistry, 2016

RECENT SCHOLAR PUBLICATIONS

Heavy metal toxicity as a driver of endoplasmic reticulum stress and dysfunction
P Ghosh, L Murumulla, S Das, S Alavala, S Challa
The FEBS Journal, 1-39 , 2026
2026
Stevioside alleviates high-fat diet-induced MASLD in Apo-E–/–mice by modulating the TGF-β signaling
S Alavala, N Sharma, R Sangaraju, S Challa, R Sistla, SB Andugulapati
The Journal of Nutritional Biochemistry 147, 110125 , 2025
2025
Citations: 4
Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition
PD Ganthala, S Alavala, N Chella, SB Andugulapati, NB Bathini, R Sistla
Colloids and Surfaces B: Biointerfaces 211, 112305 , 2022
2022
Citations: 74
Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways
R Sangaraju, S Alavala, N Nalban, MK Jerald, R Sistla
International immunopharmacology 96, 107754 , 2021
2021
Citations: 64
Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats
S Alavala, N Nalban, R Sangaraju, M Kuncha, MK Jerald, EK Kilari, ...
Inflammopharmacology 28 (6), 1579-1597 , 2020
2020
Citations: 67
Arbutin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting TLR-4/NF-κB pathway in mice
N Nalban, R Sangaraju, S Alavala, SM Mir, MK Jerald, R Sistla
Cardiovascular Toxicology 20 (3), 235-248 , 2020
2020
Citations: 49
Therapeutic targeting of oxidative stress and inflammation in asthma and COPD and pharmacological interventions with phytochemicals
N Nalban, S Alavala, R Sangaraju, SM Mir, R Sistla
Oxidative Stress in Lung Diseases: Volume 1, 429-449 , 2019
2019
Citations: 11
Protective effect of galangin against dextran sulfate sodium (DSS)-induced ulcerative colitis in Balb/c mice
R Sangaraju, N Nalban, S Alavala, V Rajendran, MK Jerald, R Sistla
Inflammation Research 68 (8), 691-704 , 2019
2019
Citations: 75
Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice
S Alavala, R Sangaraju, N Nalban, BD Sahu, MK Jerald, EK Kilari, ...
European Journal of Pharmacology 855, 192-201 , 2019
2019
Citations: 64
Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability
B Nagaraju, J Kovvuri, CG Kumar, SR Routhu, MA Shareef, M Kadagathur, ...
Bioorganic & medicinal chemistry 27 (5), 708-720 , 2019
2019
Citations: 61
Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability
MPN Rao, B Nagaraju, J Kovvuri, S Polepalli, S Alavala, ...
Bioorganic chemistry 76, 420-436 , 2018
2018
Citations: 34
Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni
BR Adari, S Alavala, SA George, HM Meshram, AK Tiwari, AVS Sarma
Food chemistry 200, 154-158 , 2016
2016
Citations: 72
Metal salts assisted enzyme-based extraction of stevioside from the leaves of Stevia rebaudiana Bertoni
AB Rao, SA George, S Alavala, HM Meshram, KC Shekar
Advances in Bioscience and Biotechnology 6 (12), 734 , 2015
2015
Citations: 13

MOST CITED SCHOLAR PUBLICATIONS

Protective effect of galangin against dextran sulfate sodium (DSS)-induced ulcerative colitis in Balb/c mice
R Sangaraju, N Nalban, S Alavala, V Rajendran, MK Jerald, R Sistla
Inflammation Research 68 (8), 691-704 , 2019
2019
Citations: 75
Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition
PD Ganthala, S Alavala, N Chella, SB Andugulapati, NB Bathini, R Sistla
Colloids and Surfaces B: Biointerfaces 211, 112305 , 2022
2022
Citations: 74
Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni
BR Adari, S Alavala, SA George, HM Meshram, AK Tiwari, AVS Sarma
Food chemistry 200, 154-158 , 2016
2016
Citations: 72
Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats
S Alavala, N Nalban, R Sangaraju, M Kuncha, MK Jerald, EK Kilari, ...
Inflammopharmacology 28 (6), 1579-1597 , 2020
2020
Citations: 67
Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways
R Sangaraju, S Alavala, N Nalban, MK Jerald, R Sistla
International immunopharmacology 96, 107754 , 2021
2021
Citations: 64
Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice
S Alavala, R Sangaraju, N Nalban, BD Sahu, MK Jerald, EK Kilari, ...
European Journal of Pharmacology 855, 192-201 , 2019
2019
Citations: 64
Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability
B Nagaraju, J Kovvuri, CG Kumar, SR Routhu, MA Shareef, M Kadagathur, ...
Bioorganic & medicinal chemistry 27 (5), 708-720 , 2019
2019
Citations: 61
Arbutin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting TLR-4/NF-κB pathway in mice
N Nalban, R Sangaraju, S Alavala, SM Mir, MK Jerald, R Sistla
Cardiovascular Toxicology 20 (3), 235-248 , 2020
2020
Citations: 49
Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability
MPN Rao, B Nagaraju, J Kovvuri, S Polepalli, S Alavala, ...
Bioorganic chemistry 76, 420-436 , 2018
2018
Citations: 34
Metal salts assisted enzyme-based extraction of stevioside from the leaves of Stevia rebaudiana Bertoni
AB Rao, SA George, S Alavala, HM Meshram, KC Shekar
Advances in Bioscience and Biotechnology 6 (12), 734 , 2015
2015
Citations: 13
Therapeutic targeting of oxidative stress and inflammation in asthma and COPD and pharmacological interventions with phytochemicals
N Nalban, S Alavala, R Sangaraju, SM Mir, R Sistla
Oxidative Stress in Lung Diseases: Volume 1, 429-449 , 2019
2019
Citations: 11
Stevioside alleviates high-fat diet-induced MASLD in Apo-E–/–mice by modulating the TGF-β signaling
S Alavala, N Sharma, R Sangaraju, S Challa, R Sistla, SB Andugulapati
The Journal of Nutritional Biochemistry 147, 110125 , 2025
2025
Citations: 4
Heavy metal toxicity as a driver of endoplasmic reticulum stress and dysfunction
P Ghosh, L Murumulla, S Das, S Alavala, S Challa
The FEBS Journal, 1-39 , 2026
2026