Romana R Gerner

@tum.de

ZIEL Institute for Food and Health, Clinical Microbiome Laboratory
Technical University of Munich

Romana R Gerner


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https://researchid.co/rgerner

RESEARCH, TEACHING, or OTHER INTERESTS

Immunology and Microbiology, Infectious Diseases, Hematology, Gastroenterology
36

Scopus Publications

4932

Scholar Citations

28

Scholar h-index

33

Scholar i10-index

Scopus Publications

  • Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies
    Marwa Abdel Hamid, Lorenz M. Pammer, Silvia Oberparleiter, Michael Günther, Arno Amann, Rebecca A. Gruber, Anna Mair, Fabienne I. Nocera, Steffen Ormanns, Kai Zimmer, Romana R. Gerner, Florian Kocher, Samuel M. Vorbach, Dominik Wolf, Jakob M. Riedl, Florian Huemer, Andreas Seeber
    Npj Precision Oncology, 2025
    Despite advances in metastatic colorectal cancer (mCRC) treatment, long-term survival remains poor, particularly in right-sided colorectal cancer (RCRC), which has a worse prognosis compared to left-sided CRC (LCRC). This disparity is driven by the complex biological diversity of these malignancies. RCRC and LCRC differ not only in clinical presentation and outcomes but also in their underlying molecular and genetic profiles. This article offers a detailed literature review focusing on the distinctions between RCRC and LCRC. We explore key differences across embryology, anatomy, pathology, omics, and the tumor microenvironment (TME), providing insights into how these factors contribute to prognosis and therapeutic responses. Furthermore, we examine the therapeutic implications of these differences, considering whether the conventional classification of CRC into right- and left-sided forms should be refined. Recent molecular findings suggest that this binary classification may overlook critical biological complexities. Therefore, we propose that future approaches should integrate molecular insights to better guide personalized treatments, especially anti-EGFR therapies, and improve patient outcomes.
  • Uniting against enteric invaders: IgA meets its microbial ally
    Sophia Adlkirchner, Romana R. Gerner
    Cell Host and Microbe, 2025
  • IL-22-dependent responses and their role during Citrobacter rodentium infection
    Karine Melchior, Romana R. Gerner, Suzana Hossain, Sean-Paul Nuccio, Cristiano Gallina Moreira, Manuela Raffatellu
    Infection and Immunity, 2024
    The mouse pathogen Citrobacter rodentium is utilized as a model organism for studying infections caused by the human pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) and to elucidate mechanisms of mucosal immunity. In response to C. rodentium infection, innate lymphoid cells and T cells secrete interleukin (IL)-22, a cytokine that promotes mucosal barrier function. IL-22 plays a pivotal role in enabling mice to survive and recover from C. rodentium infection, although the exact mechanisms involved remain incompletely understood. Here, we investigated whether particular components of the host response downstream of IL-22 contribute to the cytokine’s protective effects during C. rodentium infection. In line with previous research, mice lacking the IL-22 gene ( Il22 −/− mice) were highly susceptible to C. rodentium infection. To elucidate the role of specific antimicrobial proteins modulated by IL-22, we infected the following knockout mice: S100A9 −/− (calprotectin), Lcn2 −/− (lipocalin-2), Reg3b −/− (Reg3β), Reg3g −/− (Reg3γ), and C3 −/− (C3). All knockout mice tested displayed a considerable level of resistance to C. rodentium infection, and none phenocopied the lethality observed in Il22 −/− mice. By investigating another arm of the IL-22 response, we observed that C. rodentium -infected Il22 −/ − mice exhibited an overall decrease in gene expression related to intestinal barrier integrity as well as significantly elevated colonic inflammation, gut permeability, and pathogen levels in the spleen. Taken together, these results indicate that host resistance to lethal C. rodentium infection may depend on multiple antimicrobial responses acting in concert, or that other IL-22-regulated processes, such as tissue repair and maintenance of epithelial integrity, play crucial roles in host defense to attaching and effacing pathogens.
  • lipocalin-2 expression identifies an intestinal regulatory neutrophil population during acute graft-versus-host disease
    Marie Czech, Sophia Schneider, Nina Peltokangas, Nadia El Khawanky, Sakhila Ghimire, Geoffroy Andrieux, Jan Hülsdünker, Máté Krausz, Michele Proietti, Lukas M. Braun, Tamina Rückert, Marlene Langenbach, Dominik Schmidt, Ina Martin, Valentin Wenger, Enrique de Vega, Eileen Haring, Mohsen Pourjam, Dietmar Pfeifer, Annette Schmitt-Graeff, Bodo Grimbacher, Konrad Aumann, Brigitte Kircher, Herbert Tilg, Manuela Raffatellu, Erik Thiele Orberg, Georg Häcker, Justus Duyster, Natalie Köhler, Ernst Holler, David Nachbaur, Melanie Boerries, Romana R. Gerner, Dominic Grün, Robert Zeiser
    Science Translational Medicine, 2024
    Acute graft-versus-host disease (aGVHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), for which therapeutic options are limited. Strategies to promote intestinal tissue tolerance during aGVHD may improve patient outcomes. Using single-cell RNA sequencing, we identified a lipocalin-2 (LCN2)–expressing neutrophil population in mice with intestinal aGVHD. Transfer of LCN2-overexpressing neutrophils or treatment with recombinant LCN2 reduced aGVHD severity, whereas the lack of epithelial or hematopoietic LCN2 enhanced aGVHD severity and caused microbiome alterations. Mechanistically, LCN2 induced insulin-like growth factor 1 receptor (IGF-1R) signaling in macrophages through the LCN2 receptor SLC22A17, which increased interleukin-10 (IL-10) production and reduced major histocompatibility complex class II (MHCII) expression. Transfer of LCN2-pretreated macrophages reduced aGVHD severity but did not reduce graft-versus-leukemia effects. Furthermore, LCN2 expression correlated with IL-10 expression in intestinal biopsies in multiple cohorts of patients with aGVHD, and LCN2 induced IGF-1R signaling in human macrophages. Collectively, we identified a LCN2-expressing intestinal neutrophil population that reduced aGVHD severity by decreasing MHCII expression and increasing IL-10 production in macrophages. This work provides the foundation for administration of LCN2 as a therapeutic approach for aGVHD.
  • Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice
    Adriana Vasquez Ayala, Chia-Yun Hsu, Renee E. Oles, Kazuhiko Matsuo, Luke R. Loomis, Ekaterina Buzun, Marvic Carrillo Terrazas, Romana R. Gerner, Hsueh-Han Lu, Sohee Kim, Ziyue Zhang, Jong Hwee Park, Paul Rivaud, Matt Thomson, Li-Fan Lu, Booki Min, Hiutung Chu
    Journal of Experimental Medicine, 2024
    Type I interferons (IFNs) exert a broad range of biological effects important in coordinating immune responses, which have classically been studied in the context of pathogen clearance. Yet, whether immunomodulatory bacteria operate through IFN pathways to support intestinal immune tolerance remains elusive. Here, we reveal that the commensal bacterium, Bacteroides fragilis, utilizes canonical antiviral pathways to modulate intestinal dendritic cells (DCs) and regulatory T cell (Treg) responses. Specifically, IFN signaling is required for commensal-induced tolerance as IFNAR1-deficient DCs display blunted IL-10 and IL-27 production in response to B. fragilis. We further establish that IFN-driven IL-27 in DCs is critical in shaping the ensuing Foxp3+ Treg via IL-27Rα signaling. Consistent with these findings, single-cell RNA sequencing of gut Tregs demonstrated that colonization with B. fragilis promotes a distinct IFN gene signature in Foxp3+ Tregs during intestinal inflammation. Altogether, our findings demonstrate a critical role of commensal-mediated immune tolerance via tonic type I IFN signaling.
  • Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity
    Chia-Hao Lin, Cheng-Jang Wu, Sunglim Cho, Rasika Patkar, William J. Huth, Ling-Li Lin, Mei-Chi Chen, Elisabeth Israelsson, Joanne Betts, Magdalena Niedzielska, Shefali A. Patel, Han G. Duong, Romana R. Gerner, Chia-Yun Hsu, Matthew Catley, Rose A. Maciewicz, Hiutung Chu, Manuela Raffatellu, John T. Chang, Li-Fan Lu
    Nature Immunology, 2023
  • Murine Models of Salmonella Infection
    Gregory T. Walker, Romana R. Gerner, Sean‐Paul Nuccio, Manuela Raffatellu
    Current Protocols, 2023
    The pathogen Salmonella enterica encompasses a range of bacterial serovars that cause intestinal inflammation and systemic infections in humans. Mice are a widely used infection model due to their relative simplicity and versatility. Here, we provide standardized protocols for culturing the prolific zoonotic pathogen S. enterica serovar Typhimurium for intragastric inoculation of mice to model colitis or systemic dissemination, along with techniques for direct extraintestinal infection. Furthermore, we present procedures for quantifying pathogen burden and for characterizing the immune response by analyzing tissue pathology, inflammatory markers, and immune cells from intestinal tissues. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Murine colitis model utilizing oral streptomycin pretreatment and oral S. Typhimurium administrationBasic Protocol 2: Intraperitoneal injection of S. Typhimurium for modeling extraintestinal infectionSupport Protocol 1: Preparation of S. Typhimurium inoculumSupport Protocol 2: Preparation of mixed S. Typhimurium inoculum for competitive infectionBasic Protocol 3: Assessment of S. Typhimurium burdenSupport Protocol 3: Preservation and pathological assessment of S. Typhimurium–infected tissuesSupport Protocol 4: Measurement of inflammatory marker expression in intestinal tissues by qPCRSupport Protocol 5: Preparation of intestinal content for inflammatory marker quantification by ELISASupport Protocol 6: Immune cell isolation from Salmonella‐infected intestinal tissues
  • Siderophore Immunization Restricted Colonization of Adherent-Invasive Escherichia coli and Ameliorated Experimental Colitis
    Romana R. Gerner, Suzana Hossain, Artur Sargun, Kareem Siada, Grant J. Norton, Tengfei Zheng, Wilma Neumann, Sean-Paul Nuccio, Elizabeth M. Nolan, Manuela Raffatellu
    Mbio, 2022
    Adherent-invasive Escherichia coli (AIEC) is abnormally prevalent in patients with ileal Crohn’s disease and exacerbates intestinal inflammation, but treatment strategies that selectively target AIEC are unavailable. Iron is an essential micronutrient for most living organisms, and bacterial pathogens have evolved sophisticated strategies to capture iron from the host environment.
  • Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity
    Robert H. Mills, Parambir S. Dulai, Yoshiki Vázquez-Baeza, Consuelo Sauceda, Noëmie Daniel, Romana R. Gerner, Lakshmi E. Batachari, Mario Malfavon, Qiyun Zhu, Kelly Weldon, Greg Humphrey, Marvic Carrillo-Terrazas, Lindsay DeRight Goldasich, MacKenzie Bryant, Manuela Raffatellu, Robert A. Quinn, Andrew T. Gewirtz, Benoit Chassaing, Hiutung Chu, William J. Sandborn, Pieter C. Dorrestein, Rob Knight, David J. Gonzalez
    Nature Microbiology, 2022
  • Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut
    Judith Behnsen, Hui Zhi, Allegra T. Aron, Vivekanandan Subramanian, William Santus, Michael H. Lee, Romana R. Gerner, Daniel Petras, Janet Z. Liu, Keith D. Green, Sarah L. Price, Jose Camacho, Hannah Hillman, Joshua Tjokrosurjo, Nicola P. Montaldo, Evelyn M. Hoover, Sean Treacy-Abarca, Benjamin A. Gilston, Eric P. Skaar, Walter J. Chazin, Sylvie Garneau-Tsodikova, Matthew B. Lawrenz, Robert D. Perry, Sean-Paul Nuccio, Pieter C. Dorrestein, Manuela Raffatellu
    Nature Communications, 2021
    Zinc is an essential cofactor for bacterial metabolism, and many Enterobacteriaceae express the zinc transporters ZnuABC and ZupT to acquire this metal in the host. However, the probiotic bacterium Escherichia coli Nissle 1917 (or “Nissle”) exhibits appreciable growth in zinc-limited media even when these transporters are deleted. Here, we show that Nissle utilizes the siderophore yersiniabactin as a zincophore, enabling Nissle to grow in zinc-limited media, to tolerate calprotectin-mediated zinc sequestration, and to thrive in the inflamed gut. We also show that yersiniabactin’s affinity for iron or zinc changes in a pH-dependent manner, with increased relative zinc binding as the pH increases. Thus, our results indicate that siderophore metal affinity can be influenced by the local environment and reveal a mechanism of zinc acquisition available to commensal and pathogenic Enterobacteriaceae.
  • Harnessing iron acquisition machinery to target enterobacteriaceae
    Artur Sargun, Romana R Gerner, Manuela Raffatellu, Elizabeth M Nolan
    Journal of Infectious Diseases, 2021
  • Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
    Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T. R. Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R. Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A. Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R. Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E. Adolph
    Nature Communications, 2020
  • CD8 T cells drive anorexia, dysbiosis, and blooms of a commensal with immunosuppressive potential after viral infection
    Lara Labarta-Bajo, Anna Gramalla-Schmitz, Romana R. Gerner, Katelynn R. Kazane, Gregory Humphrey, Tara Schwartz, Karenina Sanders, Austin Swafford, Rob Knight, Manuela Raffatellu, Elina I. Zúñiga
    Proceedings of the National Academy of Sciences of the United States of America, 2020
  • Iron at the host-microbe interface
    Romana R. Gerner, Sean-Paul Nuccio, Manuela Raffatellu
    Molecular Aspects of Medicine, 2020
  • Targeting NAD immunometabolism limits severe graft-versus-host disease and has potent antileukemic activity
    Romana R. Gerner, Sophie Macheiner, Simon Reider, Kerstin Siegmund, Felix Grabherr, Lisa Mayr, Bernhard Texler, Patrizia Moser, Maria Effenberger, Hubert Schwaighofer, Alexander R. Moschen, Brigitte Kircher, Herbert Oberacher, Robert Zeiser, Herbert Tilg, David Nachbaur
    Leukemia, 2020
  • Gut pain sensors help to combat infection
    Romana R. Gerner, Manuela Raffatellu
    Nature, 2020
  • Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis
    Victoria Klepsch, Romana R Gerner, Sebastian Klepsch, William J Olson, Herbert Tilg, Alexander R Moschen, Gottfried Baier, Natascha Hermann-Kleiter
    Gut, 2018
  • The Intestinal Microbiota in Colorectal Cancer
    Herbert Tilg, Timon E. Adolph, Romana R. Gerner, Alexander R. Moschen
    Cancer Cell, 2018
  • A Worm's Gut Feelings: Neuronal Muscarinic and Epithelial Canonical Wnt Pathways Promote Antimicrobial Defense
    Romana R. Gerner, Manuela Raffatellu
    Immunity, 2018
  • Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease
    Christoph Grander, Timon E Adolph, Verena Wieser, Patrick Lowe, Laura Wrzosek, Benedek Gyongyosi, Doyle V Ward, Felix Grabherr, Romana R Gerner, Alexandra Pfister, Barbara Enrich, Dragos Ciocan, Sophie Macheiner, Lisa Mayr, Matthias Drach, Patrizia Moser, Alexander R Moschen, Gabriel Perlemuter, Gyongyi Szabo, Anne Marie Cassard, Herbert Tilg
    Gut, 2018
  • NAD metabolism fuels human and mouse intestinal inflammation
    Romana R Gerner, Victoria Klepsch, Sophie Macheiner, Kathrin Arnhard, Timon E Adolph, Christoph Grander, Verena Wieser, Alexandra Pfister, Patrizia Moser, Natascha Hermann-Kleiter, Gottfried Baier, Herbert Oberacher, Herbert Tilg, Alexander R Moschen
    Gut, 2018
  • Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation
    Alexander R. Moschen, Timon E. Adolph, Romana R. Gerner, Verena Wieser, Herbert Tilg
    Trends in Endocrinology and Metabolism, 2017
  • Treatment with α-1-Antitrypsin for Steroid-Refractory Acute Intestinal Graft-Versus-Host Disease: A Report of 2 Cases
    Romana Raphaela Gerner, Clemens Feistritzer, Alexander Rupert Moschen, Brigitte Kircher, Patrizia Moser, Herbert Tilg, David Nachbaur
    Transplantation, 2016
  • Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations
    Alexander R. Moschen, Romana R. Gerner, Jun Wang, Victoria Klepsch, Timon E. Adolph, Simon J. Reider, Hubert Hackl, Alexandra Pfister, Johannes Schilling, Patrizia L. Moser, Sarah L. Kempster, Alexander Swidsinski, Dorothea Orth−Höller, Günter Weiss, John F. Baines, Arthur Kaser, Herbert Tilg
    Cell Host and Microbe, 2016
  • Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease
    Verena Wieser, Piotr Tymoszuk, Timon Erik Adolph, Christoph Grander, Felix Grabherr, Barbara Enrich, Alexandra Pfister, Lisa Lichtmanegger, Romana Gerner, Mathias Drach, Patrizia Moser, Heinz Zoller, Günter Weiss, Alexander Rupert Moschen, Igor Theurl, Herbert Tilg
    Journal of Hepatology, 2016
  • Adult Human and Mouse Ovaries Lack DDX4-Expressing Functional Oogonial Stem Cells
    Hua Zhang, Sarita Panula, Sophie Petropoulos, Daniel Edsgärd, Kiran Busayavalasa, Lian Liu, Xin Li, Sanjiv Risal, Yan Shen, Jingchen Shao, Meng Liu, Susann Li, Dongdong Zhang, Xiaoxi Zhang, Romana Raphaela Gerner, Mona Sheikhi, Pauliina Damdimopoulou, Rickard Sandberg, Iyadh Douagi, Jan-Åke Gustafsson, Lin Liu, Fredrik Lanner, Outi Hovatta, Kui Liu
    Obstetrical and Gynecological Survey, 2016
  • Lipocalin-2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response
    Manfred Nairz, Andrea Schroll, David Haschka, Stefanie Dichtl, Thomas Sonnweber, Igor Theurl, Milan Theurl, Ewald Lindner, Egon Demetz, Malte Aßhoff, Rosa Bellmann‐Weiler, Raphael Müller, Romana R. Gerner, Alexander R. Moschen, Nadja Baumgartner, Patrizia L. Moser, Heribert Talasz, Herbert Tilg, Ferric C. Fang, Günter Weiss
    European Journal of Immunology, 2015
  • Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells
    Hua Zhang, Sarita Panula, Sophie Petropoulos, Daniel Edsgärd, Kiran Busayavalasa, Lian Liu, Xin Li, Sanjiv Risal, Yan Shen, Jingchen Shao, Meng Liu, Susann Li, Dongdong Zhang, Xiaoxi Zhang, Romana Raphaela Gerner, Mona Sheikhi, Pauliina Damdimopoulou, Rickard Sandberg, Iyadh Douagi, Jan-Åke Gustafsson, Lin Liu, Fredrik Lanner, Outi Hovatta, Kui Liu
    Nature Medicine, 2015
  • Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2
    Ivan Tancevski, Manfred Nairz, Kristina Duwensee, Kristina Auer, Andrea Schroll, Christiane Heim, Clemens Feistritzer, Julia Hoefer, Romana R Gerner, Alexander R Moschen, Ingrid Heller, Petra Pallweber, Xiaorong Li, Markus Theurl, Egon Demetz, Anna M Wolf, Dominik Wolf, Philipp Eller, Andreas Ritsch, Guenter Weiss
    EMBO Molecular Medicine, 2014
  • Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
    Alexander R. Moschen, Verena Wieser, Romana R. Gerner, Alexandra Bichler, Barbara Enrich, Patrizia Moser, Christoph F. Ebenbichler, Susanne Kaser, Herbert Tilg
    Journal of Hepatology, 2013
  • Liver complications in inflammatory bowel diseases
    V. Wieser, R. Gerner, A.R. Moschen, H. Tilg
    Digestive Diseases, 2013
  • Metabolic inflammation: Role of cytokines in the crosstalk between adipose tissue and liver1
    Romana R. Gerner, Verena Wieser, Alexander R. Moschen, Herbert Tilg
    Canadian Journal of Physiology and Pharmacology, 2013
  • Targeting T and B lymphocytes in inflammatory bowel diseases: Lessons from clinical trials
    R.R. Gerner, A.R. Moschen, H. Tilg
    Digestive Diseases, 2013
  • A key role for Pre-B cell colony-enhancing factor in experimental hepatitis
    Alexander R. Moschen, Romana Gerner, Andrea Schroll, Teresa Fritz, Arthur Kaser, Herbert Tilg
    Hepatology, 2011
  • Pre-B cell colony enhancing factor/NAMPT/visfatin and its role in inflammation-related bone disease
    Alexander R. Moschen, Sabine Geiger, Romana Gerner, Herbert Tilg
    Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis, 2010
  • Pre-b cell colony enhancing factor/nampt/visfatin in inflammation and obesityrelated disorders
    Alexander R. Moschen, Romana R. Gerner, Herbert Tilg
    Current Pharmaceutical Design, 2010

RECENT SCHOLAR PUBLICATIONS

  • Immunomodulatory metabolites define long-term gut microbiome recovery after allogeneic HCT and associate with improved survival and reduced relapse related mortality
    A Schwarz, T Eismann, T Zheng, S Holzinger, A Denk, S Goeldel, ...
    medRxiv, 2026.03. 26.26349381 , 2026
    2026
  • Escherichia coli shapes intestinal B-cell responses and influences susceptibility to Inflammatory Bowel Disease
    S Adlkirchner, V Becker, V Betz, K Muhlschlegel, M Hubersberger, ...
    JOURNAL OF CROHNS & COLITIS 20 , 2026
    2026
  • DOP144 Escherichia coli shapes intestinal B-cell responses and influences susceptibility to Inflammatory Bowel Disease
    S Adlkirchner, V Becker, V Betz, K Mühlschlegel, M Hubersberger, ...
    Journal of Crohn’s and Colitis 20 (Supplement_1), jjaf231. 181 , 2026
    2026
  • The role of microbial metabolites in fecal microbiota transplantation in patients with acute gvhd of the gut
    A Schwarz, S Holzinger, P Herhaus, M Verbeek, K Neuhaus, K Kleigrewe, ...
    Blood 146 (Supplement 1), 4236-4236 , 2025
    2025
  • Commensal Escherichia coli colonization triggers Peyer’s patch development
    RR Gerner, GT Walker, SM Klaus, K Melchior, S Hossain, K Siada, ...
    bioRxiv, 2025.10. 06.680803 , 2025
    2025
  • Uniting against enteric invaders: IgA meets its microbial ally
    S Adlkirchner, RR Gerner
    Cell Host & Microbe 33 (6), 932-934 , 2025
    2025
  • Multidimensional differences of right-and left-sided colorectal cancer and their impact on targeted therapies
    MA Hamid, LM Pammer, S Oberparleiter, M Günther, A Amann, ...
    NPJ precision oncology 9, 116 , 2025
    2025
    Citations: 17
  • Multidimensional differences of right-and left-sided colorectal cancer and their impact on targeted therapies
    M Abdel Hamid, LM Pammer, S Oberparleiter, M Günther, A Amann, ...
    npj Precision Oncology 9 (1), 116 , 2025
    2025
    Citations: 20
  • Clonal Hematopoiesis and Immune Cell Phenotypes as Predictive Biomarkers of CAR-T Therapy Outcomes in Multiple Myeloma
    A Purcarea, S Baumann, S Stein, J Ferstl, F Bassermann, RR Gerner, ...
    2025
  • Loss of Microbiota-Derived Metabolites Is Associated with Mucosal-Barrier-Injury Bloodstream Infection in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
    S Göldel, T Zheng, T Eismann, M Tiefgraber, M Urban, A Schwarz, ...
    Blood 144 (Supplement 1), 4904-4904 , 2024
    2024
  • CCL28 modulates neutrophil responses during infection with mucosal pathogens
    GT Walker, A Perez-Lopez, S Silva, MH Lee, E Bjånes, N Dillon, ...
    Elife 13, e78206 , 2024
    2024
    Citations: 7
  • IL-22-dependent responses and their role during Citrobacter rodentium infection
    K Melchior, RR Gerner, S Hossain, SP Nuccio, CG Moreira, M Raffatellu
    Infection and immunity 92 (5), e00099-24 , 2024
    2024
    Citations: 19
  • Lipocalin-2 expression identifies an intestinal regulatory neutrophil population during acute graft-versus-host disease
    M Czech, S Schneider, N Peltokangas, N El Khawanky, S Ghimire, ...
    Science translational medicine 16 (735), eadi1501 , 2024
    2024
    Citations: 31
  • Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice
    A Vasquez Ayala, CY Hsu, RE Oles, K Matsuo, LR Loomis, E Buzun, ...
    Journal of Experimental Medicine 221 (1), e20230063 , 2023
    2023
    Citations: 52
  • Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of T H 17 cell immunity
    CH Lin, CJ Wu, S Cho, R Patkar, WJ Huth, LL Lin, MC Chen, E Israelsson, ...
    Nature immunology 24 (12), 2108-2120 , 2023
    2023
    Citations: 44
  • Murine Models of Salmonella Infection
    GT Walker, RR Gerner, SP Nuccio, M Raffatellu
    Current protocols 3 (7), e824 , 2023
    2023
    Citations: 40
  • Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity
    CH Lin, CJ Wu, S Cho, R Patkar, LL Lin, MC Chen, E Israelsson, J Betts, ...
    bioRxiv , 2023
    2023
    Citations: 3
  • Siderophore Immunization Restricted Colonization of Adherent-Invasive Escherichia
    RR Gerner, S Hossain, A Sargun
    mBio, 13 (5) , 2022
    2022
  • Siderophore immunization restricted colonization of adherent-invasive Escherichia coli and ameliorated experimental colitis
    RR Gerner, S Hossain, A Sargun, K Siada, GJ Norton, T Zheng, ...
    MBio 13 (5), e02184-22 , 2022
    2022
    Citations: 27
  • Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity
    RH Mills, PS Dulai, Y Vázquez-Baeza, C Sauceda, N Daniel, RR Gerner, ...
    Nature microbiology 7 (2), 262-276 , 2022
    2022
    Citations: 389

MOST CITED SCHOLAR PUBLICATIONS

  • The intestinal microbiota in colorectal cancer
    H Tilg, TE Adolph, RR Gerner, AR Moschen
    Cancer cell 33 (6), 954-964 , 2018
    2018
    Citations: 910
  • Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease
    C Grander, TE Adolph, V Wieser, P Lowe, L Wrzosek, B Gyongyosi, ...
    Gut 67 (5), 891-901 , 2018
    2018
    Citations: 702
  • Lipocalin-2: a master mediator of intestinal and metabolic inflammation
    AR Moschen, TE Adolph, RR Gerner, V Wieser, H Tilg
    Trends in Endocrinology & Metabolism 28 (5), 388-397 , 2017
    2017
    Citations: 418
  • Lipocalin 2 protects from inflammation and tumorigenesis associated with gut microbiota alterations
    AR Moschen, RR Gerner, J Wang, V Klepsch, TE Adolph, SJ Reider, ...
    Cell host & microbe 19 (4), 455-469 , 2016
    2016
    Citations: 391
  • Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity
    RH Mills, PS Dulai, Y Vázquez-Baeza, C Sauceda, N Daniel, RR Gerner, ...
    Nature microbiology 7 (2), 262-276 , 2022
    2022
    Citations: 389
  • Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
    L Mayr, F Grabherr, J Schwärzler, I Reitmeier, F Sommer, T Gehmacher, ...
    Nature communications 11 (1), 1775 , 2020
    2020
    Citations: 306
  • NAD metabolism fuels human and mouse intestinal inflammation
    RR Gerner, V Klepsch, S Macheiner, K Arnhard, TE Adolph, C Grander, ...
    Gut 67 (10), 1813-1823 , 2018
    2018
    Citations: 212
  • Pre-B cell colony enhancing factor/NAMPT/visfatin in inflammation and obesity-related disorders
    A R Moschen, R R Gerner, H Tilg
    Current pharmaceutical design 16 (17), 1913-1920 , 2010
    2010
    Citations: 165
  • Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells
    H Zhang, S Panula, S Petropoulos, D Edsgärd, K Busayavalasa, L Liu, ...
    Nature medicine 21 (10), 1116-1118 , 2015
    2015
    Citations: 154
  • Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
    AR Moschen, V Wieser, RR Gerner, A Bichler, B Enrich, P Moser, ...
    Journal of hepatology 59 (6), 1315-1322 , 2013
    2013
    Citations: 118
  • Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease
    V Wieser, P Tymoszuk, TE Adolph, C Grander, F Grabherr, B Enrich, ...
    Journal of Hepatology 64 (4), 872-880 , 2016
    2016
    Citations: 111
  • Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver
    RR Gerner, V Wieser, AR Moschen, H Tilg
    Canadian journal of physiology and pharmacology 91 (11), 867-872 , 2013
    2013
    Citations: 102
  • Pre-B cell colony enhancing factor/NAMPT/visfatin and its role in inflammation-related bone disease
    AR Moschen, S Geiger, R Gerner, H Tilg
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 690 (1 … , 2010
    2010
    Citations: 101
  • Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut
    J Behnsen, H Zhi, AT Aron, V Subramanian, W Santus, MH Lee, ...
    Nature Communications 12 (1), 7016 , 2021
    2021
    Citations: 92
  • Lipocalin‐2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response
    M Nairz, A Schroll, D Haschka, S Dichtl, T Sonnweber, I Theurl, M Theurl, ...
    European journal of immunology 45 (11), 3073-3086 , 2015
    2015
    Citations: 77
  • Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity. Nat Microbiol 7: 262–276
    RH Mills, PS Dulai, Y Vázquez-Baeza, C Sauceda, N Daniel, RR Gerner, ...
    2022
    Citations: 55
  • Liver complications in inflammatory bowel diseases
    V Wieser, R Gerner, AR Moschen, H Tilg
    Digestive diseases 31 (2), 233-238 , 2013
    2013
    Citations: 54
  • Iron at the host-microbe interface
    RR Gerner, SP Nuccio, M Raffatellu
    Molecular Aspects of Medicine 75, 100895 , 2020
    2020
    Citations: 53
  • Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice
    A Vasquez Ayala, CY Hsu, RE Oles, K Matsuo, LR Loomis, E Buzun, ...
    Journal of Experimental Medicine 221 (1), e20230063 , 2023
    2023
    Citations: 52
  • Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis
    V Klepsch, RR Gerner, S Klepsch, WJ Olson, H Tilg, AR Moschen, G Baier, ...
    Gut 67 (8), 1434-1444 , 2018
    2018
    Citations: 48