Chemical Profiling and Multi-Bioactive Potential of Onosma nigricaulis Gün Binzet, Pınar Küce Çevik, Ismail Koyuncu, Rıza Binzet Chemistryselect, 2026 ABSTRACT In Turkish folk medicine, Onosma species are used to treat wounds, burns, and ulcers. This study investigated the chemical composition and biological activities of ethanolic (EE) and petroleum ether (PEE) extracts from the endemic Onosma nigricaulis (Boraginaceae). GC–MS analysis identified 25 and 21 compounds in EE and PEE, representing over 90% of total extract content. The major constituents of EE were palmitic acid (25.84%), linolenic acid (19.36%), and γ‐sitosterol (11.25%), while PEE mainly contained linolenyl alcohol (16.48%), γ‐sitosterol (15.50%), and palmitic acid (14.69%). FT‐IR spectra confirmed the presence of hydroxyl, carbonyl, and alkyl functional groups, supporting the GC–MS results. Antioxidant potential was evaluated using DPPH andreducing power assays, where EE exhibited stronger activity, achieving 72.53% inhibition at 800 µg/mL. Both extracts showed antimicrobial activity against Escherichia coli , Enterococcus faecalis , and Candida albicans , with EE displaying lower MIC values (5.09–6.09 mg/mL). Cytotoxicity assessment via MTT assay revealed significant dose‐dependent effects, with IC 50 values of 35.38 µg/mL for A549 and 57.30 µg/mL for DU‐145 cells. These results highlight O. nigricaulis as a promising natural source of bioactive compounds with antioxidant, antimicrobial, and anticancer potential.
Supercritical CO2 Extracts of Onosma Decorticans Riedl: Phytochemical Profiling and Antioxidant, Antibacterial, and Anticancer Activities Metin Yıldırım, Gun Binzet, Rıza Binzet, Erdal Yabalak Chemistryselect, 2026 This study investigated the chemical composition, antioxidant activity, and in vitro cytotoxicity inducing potential of supercritical CO 2 extracts obtained at different pressures from the aerial parts of Onosma decorticans (Boraginaceae). The extract produced at 100 bar (O 100 ) was characterized by LC–MS/MS, identifying 19 phytochemicals, with fumaric acid, cyranoside, cosmosiin, and quinic acid detected as the predominant constituents. Antioxidant activity was evaluated using the DPPH radical scavenging assay, with ascorbic acid (AA) as positive controls. At 400 µg/mL, O 100 and O 150 scavenged 65% ± 3.1% and 43% ± 5.2% of DPPH radicals, respectively, indicating moderate antioxidant capacity. Dose–response analysis revealed statistically significant radical scavenging activity compared to the control at 50 µg/mL for O 100 and 150 µg/mL for O 150 ( p < 0.05).
New taxa of Onosma L. (Boraginaceae, Lithospermeae) from Iran Farideh Attar, Mansour Mirtadzadini, Rıza Binzet, Arash Sotoodeh Adansonia, 2025 Nouveaux taxons d'Onosma L. (Boraginaceae, Lithospermeae) d'Iran. Cette étude décrit trois nouvelles espèces du genre Onosma L. (Boraginaceae), appartenant à la section Onosma L., sous-section Asterotricha (Boiss.) Gürke, en Iran. Ces espèces, identifiées comme O. ligniclada Attar & Mirtadzadini, sp. nov., O. elymaitica Attar & Mirtadzadini, sp. nov. et O. farsistanica Attar & Mirtadzadini, sp. nov., ont été distinguées sur la base de preuves morphologiques et phylogénétiques détaillées. Onosma ligniclada Attar & Mirtadzadini, sp. nov. et O. elymaitica Attar & Mirtadz., sp. nov., originaires de la province d'Ilam, présentent des caractéristiques morphologiques distinctes de leurs espèces les plus proches connues, à savoir O. albo-rosea Fisch. & C.A.Mey., O. iransharii Ghahr. & Attar et O. bilabiata Boiss. & Buhse respectivement. Cette différenciation repose sur des variations concernant l'habitus, la couleur et la taille de la corolle, ainsi que la morphologie foliaire des pousses stériles et l'indument des feuilles. En revanche, O. farsistanica Attar & Mirtadz., sp. nov., identifié dans les forêts de Quercus L. de la province de Fars (Quercus brantii var. persica (Jaub. & Spach) Zohary), se distingue nettement de son espèce la plus apparentée, O. bilabiata, notamment en termes d'habitat, de port, de caractéristiques des tubercules, ainsi que de dimensions du calice et de la corolle. En outre, cet article fournit une documentation photographique, une carte de distribution, des évaluations de conservation selon les critères de l'UICN et une clé diagnostique pour ces nouvelles espèces.
Onosma rutila (Boraginaceae) Plant Extract: Chemical Composition, Biological Analysis, and Film Forming Potential With Polymers Riza Binzet, Gun Binzet, Ersan Turunc, Pınar Küce Cevik, Didem Demir, Hakan Arslan Chemistry and Biodiversity, 2025 This study aimed to integrate the ethanolic extract obtained from the aerial parts of endemic Onosma rutila as a new bioactive ingredient into polymeric films and to produce biofunctional composite thin films for use in biomedical applications. Initially, the definition of the plant extract was carried out in terms of chemical composition and biological activities. The main component of the extract was revealed as 9,12‐octadecadienoic acid (15.90%). Antimicrobial activity was evaluated against a total of five microorganisms by the well diffusion method and microdilution technique. MIC99 results showed the lowest inhibition against Candida albicans, suggesting a stronger antifungal effect than antibacterial activity. Also, the 2,2‐diphenyl‐1‐picrylhydrazyl scavenging activity of O. rutila, ascorbic acid, and butylated hydroxytoluene at 500 µg/mL showed values of 87.63, 90.13, and 46.82%, respectively. In the next phase, the extract, which was revealed to be an effective biological agent, was incorporated into the polymer solutions prepared based on chitosan and polyvinyl alcohol at different ratios to produce a series of thin films. For application purposes, the thin films' chemical compositions, water retention capacities, and morphological properties were determined and their potential for use as wound dressing material was evaluated.
Onosma sanninensis (Boraginaceae), a new species from the Mount Sannine Central Lebanon RAMY MAALOUF, RIZA BINZET Phytotaxa, 2025 In this study, a new species of Onosma (Boraginaceae: Lithospermeae), subsect. Asterotricha, from Mount Sannine, Lebanon, is described and illustrated. This new species was conclusively identified through a comprehensive analysis of morphological features and geographical distributions compared across herbarium specimens from multiple collections. The new species is closely related to O. caerulescens and O. inexspectata, but it is different with 1–2 terminal cymes, smaller bracts, longer pedicels in fruit, larger calyx in flower and fruit, different corolla color, smaller anthers, and different pollen shape. Additionally, geographical distributions and map, an image of the holotype specimen, diagnostic characters, detailed photographs, habitat descriptions, and an identification key for the new species, O. caerulescens, and O. inexspectata are provided, along with a vernacular name and IUCN conservation status.
Anatomical, morphological and palynological studies of some Onosma L. (Boraginaceae) taxa endemic to Anatolia Pakistan Journal of Botany, 2017
Effects of salinity stress on chlorophyll and carotenoid contents and stomata size of grafted and ungrafted galia C8 melon cultivar Pakistan Journal of Botany, 2017
The determination of total antioxidant activity, phenolics and pigments during vegetative and reproductive periods of onosma species Bulgarian Journal of Agricultural Science, 2015
Morphological, anatomical and palynological study of centaurea calcitrapa L. ssp. cilicica (Boiss. & Bal.) Wagenitz and centaurea solstitialis L. ssp. carneola (Boiss.) Wagenitz endemic for Turkey Pakistan Journal of Botany, 2010
