Overview of Emerging Technologies in Education Ramchandra Alias Ameet Chate, Ganesh R. Chate, Gourav V. Kulkarni, Uttam U. Deshpande, Vaibhav R. Chate, Raviraj M. Kulkarni Designing Inclusive Classrooms Integrating Emerging Technologies for Equity and Social Justice, 2026 In this chapter, an effort is made to highlight the application of new technologies in the education sector. Emerging technologies in education are transforming conventional educational systems to the next level, thereby enhancing the understanding capabilities of educational systems. The new technologies such as augmented reality, virtual reality, and artificial intelligence help in personalized learning and immersive experiences. IoT helps in smart classrooms for better understanding during and after class hours. The benefits of using these new technologies in the education sector and also challenges in adapting them are discussed in this chapter. These technologies also help in getting better feedback which is the most essential aspect of continuous improvement and focused learning with more interaction. Educators also learn these new technologies to improve the teaching and learning process. These emerging technologies not only improve understanding capability but also will cultivate an innovative mindset.
Targeting B-raf/MEK signaling in melanocytic carcinoma using HPLC-MS/MS characterized metabolites from Valeriana wallichii Rhizome Charushila V. Balikai, Raviraj M. Kulkarni, Kiran Thabaj, Shankar Gharge, Rohini S. Kavalapure, Shyam S. Desai Pharmacological Research Modern Chinese Medicine, 2025 • HPLC-MS/MS profiling of Valeriana wallichii identified chlorogenic and quinic acids as major bioactive compounds. • Network pharmacology and molecular docking revealed chlorogenic acid targets BRAF and MEK via MAPK and PI3K-Akt pathways. • 100-ns molecular dynamics confirmed stable dual inhibition of BRAF/MEK by chlorogenic acid. • Ultrasonicated extract showed significant cytotoxicity (IC₅₀ = 172.8 μg/mL) and membrane disruption in A375 melanoma cells. Valeriana wallichii (mǎ lù róng cǎo), a traditional medicinal herb native to southwestern China, holds promise as a source of novel anticancer agents. This study explores its therapeutic potential against A375 human melanoma cells through an integrated in silico , in vitro pharmacological approach. High-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) profiling of the ultrasonication-assisted hydroalcoholic extract identified key phytoconstituents, notably chlorogenic acid and quinic acid. Network pharmacology analysis linked these metabolites to critical signaling pathways involved in skin cancer progression, particularly the MAPK, PI3K-Akt, and Ras pathways. Target prediction and protein interaction networks further revealed modulation of key nodes such as BRAF and MEK. Molecular docking highlighted strong binding affinities of chlorogenic acid at the ATP-binding domains of both BRAF (CYS532, ASP594, LYS483, GLY534) and MEK (SER150, ALA95), with interaction energies comparable to reference inhibitors dabrafenib and DS03090629. Molecular dynamics simulations (100 ns) confirmed the stable occupation of these active sites by chlorogenic acid, supporting its potential as a dual BRAF/MEK inhibitor. ADME predictions revealed favorable drug-like properties for the major compounds. In vitro cytotoxicity assays on A375 melanoma cells demonstrated significant antiproliferative effects of the V. wallichii extract obtained via ultrasonication (IC₅₀ = 172.8 ± 1.07 μg/mL), with scanning electron microscopy indicating enhanced cell membrane disruption, likely due to improved bioactive extraction efficiency. Collectively, these findings underscore the potential of Valeriana wallichii rhizome metabolites, particularly chlorogenic acid, as multitargeted therapeutic agents in melanocytic carcinoma. This study provides scientific validation for the traditional use of V. wallichii in Chinese medicine and lays the groundwork for its development as a modern pharmacological intervention targeting BRAF/MEK signaling in skin cancer.
NATURAL CLAY MINERALS FOR REMOVAL OF CATIONIC DYE: KINETIC, ADSORPTION, AND THERMODYNAMIC STUDY Shilpa Yakkerimath, Raviraj M. Kulkarni, Sanjaykumar V. Divekar, Vaibhav R. Chate, Purandara Bekal Kunkangar Rasayan Journal of Chemistry, 2024 In recent years managing ecological changes and comprehending diverse anthropogenic contributions towards pollution is now of great concern due to industrialization. Therefore, creating an environmentally friendly solution for dealing with harmful substances like Methylene Blue in water has become a critical issue. This experimental investigation aims to design and assess the unmodified clay mineral of the Panchaganga River flood zone for the removal of MB by batch tests. The removal of MB was examined by optimizing all the variables, further XRD, SEM, EDX, BET, and FTIR, were all used to meticulously examine the NC before and after adsorption. Methylene Blue content was determined by UV-visible spectrophotometrically, and the mechanism of NC’s adsorption to MB in water was examined by modeling isotherm and kinetics studies. At pH 7.00 to 8.00, the NC showed a high extraction of MB due to negatively charged clay surface (Si-O- ), (Al-O- ). The adsorption capacity qm obtained was 88.8 mg/g (Langmuir). The kinetics study showed that the adsorption mechanism follows pseudo-2nd-order indicating chemisorption as a rate-determining step, moreover, adsorption also occurs via the intra-particle-diffusion process due to small pores on NC. The study demonstrates that the NC exhibits significant efficacy in efficiently removing the cationic dye (MB) pollutant from waste-water systems.
Kinetic, adsorption, and thermodynamic study of removal of Cr6+ by iron-rich natural clay minerals Shilpa Yakkerimath, Raviraj M. Kulkarni, Sanjaykumar V. Divekar, Vaibhav R. Chate, Kunkangar Purandara Bekal Desalination and Water Treatment, 2024 The study explores the adsorption behavior of unmodified natural clay as an ecologically acceptable procedure in the treatment of toxic elements such as Cr6+ in wastewater. Batch experiments were conducted by stirring 30 ml of a Cr6+ solution and natural clay for 3 hours at different temperatures, pH, Cr6+ loadings, and concentrations. Characterization of natural clay before and after adsorption was studied by XRD, FTIR, and BET for surface area, SEM, and EDX for surface topography. The Cr6+ content was analyzed by UV-visible spectrophotometer further, the mechanism of the process was illustrated by isotherm and kinetic studies. Cr6+ maximum sorption capacity obtained was 12.3 mg/g at pH 3. The overall process followed the Langmuir model elucidating monolayer adsorption as a major, in addition kinetics study (pseudo-2nd-order) describes accurately that chemisorption is a rate-controlling stage. Thermodynamics measurements indicated a spontaneous and endothermic process involved throughout the adsorption. Therefore, the study highlights the efficacy of unmodified natural clay as an efficient adsorbent for the elimination of Cr6+ from aqueous solution.
Investigations on material removal rate of reduced graphene oxide coated copper electrodes for electric discharge machining Suraj Patil, Maharudra Patil, Raviraj Kulkarni, Vinayak Malik Advances in Materials and Processing Technologies, 2024 In the present work, the reduced graphene oxide (RGO) nanoparticles have been synthesised by modified Hummer’s technique. The RGO powder thus obtained was characterised by X-Ray diffraction analysis (XRD), Raman spectroscopy, scanning electron microscopy (SEM) and transmission electront microscopy (TEM). Raman spectra showed the D-band at Raman shift of 1354 cm−1 and G-band at 1606 cm−1 of RGO. TEM analysis exhibited the RGO structure in nanometres. The prepared nanoparticles were mixed with alcohol to form a paste and was coated on standard Copper electrode for experimentation on Electric Discharge Machine (EDM). The influence of process parameters like current, pulse on and pulse-off on the material removal rate were studied using L9 Orthogonal Array of Taguchi Technique using Minitab18.0. Substantial improvement in material removal rate at current of 20 amperes, pulse on time of 90 microseconds and pulse off time of 1 microsecond. It was also found that current and pulse off were significant factors that influenced the material removal rate.
Methods for fabrication of ceramic coatings Vijaykumar S. Bhamare, Raviraj M. Kulkarni Advanced Flexible Ceramics Design Properties Manufacturing and Emerging Applications, 2023
Self-cleaning ceramic coatings Rashmi C. Kulkarni, Prasanna S. Koujalagi, Raviraj M. Kulkarni Advanced Ceramic Coatings for Emerging Applications, 2023
Internet of Things-based disaster management system Prasad M. Pujar, Umesh M. Kulkarni, Raviraj M. Kulkarni, Harish H. Kenchannavar Nanotechnology Based Smart Remote Sensing Networks for Disaster Prevention, 2022
Natural aerogels for pollutant removal Sandeep R. Kurundawade, Ramesh S. Malladi, Raviraj M. Kulkarni, Aftab Aslam Parwaz Khan Advances in Aerogel Composites for Environmental Remediation, 2021
Optoelectronic properties of alumina–tin oxide nanocomposites deposited on 1d carbon backbone Nanosistemi Nanomateriali Nanotehnologii, 2021
Aerogel and its composites: Fabrication and properties Mohammad Omaish Ansari, Aftab Aslam Parwaz Khan, Mohammad Shahnawaze Ansari, Anish Khan, Raviraj M. Kulkarni, Vijaykumar S. Bhamare Advances in Aerogel Composites for Environmental Remediation, 2021
Kinetics of oxidative degradation and deamination of atenolol by aqueous alkaline permanganate Indian Journal of Chemistry Section A Inorganic Physical Theoretical and Analytical Chemistry, 2005
Free radical intervention, deamination and decarboxylation in ruthenium(III) catalysed oxidation of rac-serine by alkalyne permanganate Oxidation Communications, 2002
Kinetics and mechanism of palladium(II) catalysed oxidation of ethylenediaminetetraacetic acid by N-chlorosuccinimide in aqueous alkaline medium Oxidation Communications, 2001
