Mechanical Engineering, Multidisciplinary, Health Information Management
91
Scopus Publications
1316
Scholar Citations
20
Scholar h-index
53
Scholar i10-index
Scopus Publications
Skeletal muscle tissue engineering using magnetic nanoparticles: a comprehensive review Nipun Jain, Sudipto Datta, Prerana Singh, Dileep Pathote, Samir Das, Ranjit Barua, Darren Player Journal of Materials Chemistry B, 2026 Skeletal muscle tissue engineering (SMTE) is a promising tissue therapy that can innovatively address the challenges arising from trauma, diseases, or congenital disabilities.
Fabrication of vascular-like conduits in gel structures by robotic needle navigation system Ranjit Barua, Anwita Sarkar, Ankita Das, Priyanka Das, Amit Roy Chowdhury, Pallab Datta Bioinspired Biomimetic and Nanobiomaterials, 2026 Vascular networks are essential for the long-term survival of implanted grafts. Under physiological conditions, these networks include arteries, veins, and capillaries, which transport vital fluids, gases, and nutrients – such as blood, oxygen, carbon dioxide, and minerals – to the cells. However, creating vascular channels within bioengineered grafts remains a significant engineering challenge. In this study, we investigated an alternative biomanufacturing method for generating straight and curved vascular channels by employing a needle navigation process, which mimics the vascularization process inside a biocompatible polymer poly(vinyl alcohol) gel. The stability of the channels fabricated via this process was studied. Cells were seeded inside the manufactured artificial vascular channels, and their viability was measured over time. These results indicate the preliminary potential of the needle navigation method for the fabrication of viable vascular-like conduits in bioengineered grafts.
Smart biomaterials and intelligent scaffolds for wound healing in tissue engineering Ranjit Barua, Sudipto Datta Biophysics Reviews, 2026 The complicated procedures of wound healing include multiple interconnected phases, both cellular and molecular, with the objective of restoring and rebuilding the injured tissue. New and inventive materials in tissue engineering and materials science are producing active protective and adaptable wound dressings, whereas traditional wound dressings are passive and protective. These novel materials react to mechanical, metabolic, and bioelectric changes in the environment and wound tissue. By doing so, they emulate the changing extracellular matrix, stimulating angiogenesis, collagen deposition, and re-epithelialization. The stimulation of wound healing and tissue engineering has been the development of smart polymers, bioactive nanocomposites, and biofunctional hydrogels that revolutionize wound care with responsive behaviors to environmental changes of temperature, pH, enzymes, and electrical potential, alongside sustained drug delivery and improved mechanical strength. Also, intelligent scaffolds, designed through advanced additive manufacturing techniques and microfabrication techniques, possess hierarchical structures that optimize routes for cellular migration and vascularization. Innovation in predictive, real-time, and adaptive therapeutic material design and wound care is made possible by the integration of artificial intelligence (AI), computational modeling, and biosensor technologies. Machine learning can be used to anticipate scaffold qualities and possible in vivo results based on biological performance, parameters, degradation rate, and management data. The most recent developments in smart biomaterials and intelligent scaffolds for wound healing are covered in this review, along with descriptions of the different material classes, design approaches, functional mechanisms, AI-related developments in regenerative medicine, and suggested self-regulating systems for intelligent wound care. It discusses the emerging smart wound care systems, anticipated clinical utility, and proposed solutions to translational challenges on self-regulating intelligent wound care systems. The shift of biomaterials from passive healing to self-responsive active healing systems is a remarkable transitioning, which has repositioned smart materials at the forefront of regenerative medicine.
Regulating the positioning of needles into hydrogel frameworks to produce vascularized tissue-engineered structures Ranjit Barua, Sumit Bhowmik, Sudipto Datta Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, 2026 One significant barrier to the translation of tissue-engineered constructions is vascularization. It is still difficult for manufacturing science to directly fabricate hollow, vascular-like channels inside tissue-like gel materials. Using a robotic-arm controlled 3D printer to move user-defined needle tips through the gel materials is one suggested technique. In order to create the hollow channel inside gels and forecast the amount of insertion force and deflection, the needle gel interaction-related contact phenomenon was both simulated and empirically validated in this work. The geometric shape of the needle tip, speed variations, and gel characteristics are some of the factors that affect needle navigation. It was discovered that high needle diameters produced enormous insertion forces, and that insertion force increased as needle speed increased. Conversely, it was discovered that as the diameter and insertion velocity of the needle increased, the deflection of the needle decreased. Furthermore, a bevel-shaped needle tip displayed a greater deflection than a conical needle tip because of its non-isometric shape. The manufacturing methodology for creating hollow channels for vascularization in tissue-engineered structures and subsurface, enclosed microfluidic research is further developed as a result of this paper.
Polylactic-Co-Glycolic Acid (PLGA)-Based Composites through Additive Manufacturing Techniques for Biomedical Applications Ranjit Barua, Arbind Prasad, Sudipto Datta Biomedical Implementation of Additive Manufacturing Techniques, 2026 Polymeric composites based on polylactic-co-glycolic acid (PLGA) have gained prominence in biomedical industries due to their biodegradability, biocompatibility, and tunable mechanical characteristics. These properties make PLGA composites suitable for use in conjunction with AM to fabricate intricate topologies required for medical applications. In this chapter, an attempt has been made to discuss the general trends of PLGA-based composites and their future potential in biomedical applications, including tissue engineering, drug delivery, and regenerative medicine. These topics include the physical and chemical characteristics of PLGA, the repertoire of techniques applicable to the creation of these composites, and the implementation of these composites into current state-of-the-art biomedical applications. Furthermore, the chapter also considers issues arising from the thermal instability of PLGA during processing, biocompatibility for long-term implantation, and the challenge of scaling up manufacturing processes. The future directions section also comments on current research and possible further enhancements of smart materials and personalized medicine that enable the improvement of PLGA-based composite characteristics. Therefore, PLGA composites represent a new concept based on a multifunctional and highly versatile substrate capable of potentially transforming the future of healthcare.
3D Printing in Hard Tissue Engineering Ranjit Barua, Arbind Prasad, Bidyanand Mahto, Sudipto Datta Biomedical Implementation of Additive Manufacturing Techniques, 2026 Three-dimensional printing, or more specifically additive manufacturing, has been established as a revolutionary technology in the field of hard tissue engineering that presents new opportunities for the repair and reconstruction of vital tissues within the human body including bone and dental tissues. In this chapter, an overview of the following chapters is presented for hard tissue engineering, particularly regarding the incorporation of 3D printing techniques, materials, processes, and applications. Biocompatible polymers, ceramics, and metal-based materials are highlighted here to depict the application of constructing scaffolds with mechanical and biological features similar to natural tissues. In addition, the manufacturing and construction of scaffolds are discussed with a focus on important characteristics such as pore size, mechanical properties, and biocompatibility. Such examples highlight the clinical possibilities of printing technologies in the treatment of bone defects, craniofacial bone reconstruction, and dental applications. Even though major improvements have been made, some issues—such as biocompatibility, mechanical property and the problems associated with regulations—still exist. This chapter summarizes and looks to the future, primarily focusing on smart materials, new multifunctional material printers, and the use of artificial intelligence to increase the individuality and efficiency of the produced implants.
Additive Manufacturing of PLA-Based Biocomposites for Biomedical Applications Ranjit Barua, Sumit Bhowmik, Deepanjan Das, Sudipto Datta Biomedical Implementation of Additive Manufacturing Techniques, 2026 Innovations in manufacturing, such as AM, have transformed the fabrication of intricate and individualized medical instruments, especially concerning the synthesis of PLA-based biocomposites for biomedical uses. Polylactic acid (PLA) is an aliphatic, biodegradable, and biocompatible thermoplastic; therefore, it can be used to produce medical implants, tissue engineering scaffolds, and drug delivery carriers. The addition of assorted bioactive fillers and reinforcements into the PLA matrices has improved the mechanical properties, bioactivity, and practical applications of the resulting biocomposites. This abstract presents a brief overview of the current development of novel processing strategies, material alteration for PLA-based biocomposites, and their application in the biomedical field. This form of application emphasizes the capabilities of these materials in enhancing patient treatment, as well as the challenges involved in improving their performance in real healthcare settings. The conclusions provided thereby highlight the need for further research to optimize the potential of PLA-based biocomposites in the context of emerging personalized medicine.
Processing, Characterization, and Classification of Polymer Nanocomposites in Sustainable and Renewable Energy Sector Sustainable Composites for Future Trends in Renewable Energy, 2026
Revolutionizing drug evaluation system with organ-on-a-chip and artificial intelligence: A critical review Ranjit Barua, Deepanjan Das, Nirmalendu Biswas Biomicrofluidics, 2025 Organ-on-a-chip (OoC) and artificial intelligence (AI) are among the radical shifts that are being experienced in the use of innovation in the pharmaceutical industries at the moment. This review assesses how these novel paradigms may be integrated to transform the drug assessment processes in the pharmaceutical and biomedical sectors. Organ-on-a-chip, which can be defined as a microphysiological system that integrates the physiological and pathological states of human organs, is a more adequate model for drug testing than 2D culture and animal models. At the same time, AI adds to the OoC platforms more enhanced processing, analytical, and predictive capabilities, as well as automatic working modes. AI assists in the task of parsing the amount of biological information that OoC systems generate, thus increasing the speed and accuracy of success and toxicity of drugs. This review article demonstrates the current state of OoC and AI systems, discusses the practical use of drug approvals, highlights the challenges that have been overcome, and outlines opportunities for future research. Finally, this article discusses the opportunities arising from the integration of OoC and AI in drug research and development, emphasizing the potential to enhance personalized treatments for complex diseases.
Clinical Translational Studies and Challenges of Bioabsorbable Polymeric Composites Bioabsorbable Polymers for Drug Carriers and Fixation Devices, 2025
Plastic recycling for energy production Nipun Jain, Yusuf Olatunji Waidi, Ranjit Barua, Vilay Vannaladsaysy, Arbind Prasad, Sudipto Datta Biodegradable Waste Processing for Sustainable Developments, 2024
Nanowires for bio-sensing applications Nipun Jain, Ranjit Barua, Yusuf Olatunji Waidi, Sudipto Datta Next Generation Materials for Sustainable Engineering, 2024
Frontiers in Microfluidics and Lab-on-a-Chip Technology: Disease Modeling and Drug Screening R Barua Cambridge Scholars Publishing , 2026 2026
Artificial Organs and Bionic Technology: Breakthroughs in Bioengineering and Regenerative Solutions R Barua Cambridge Scholars Publishing , 2026 2026
Fabrication of vascular-like conduits in gel structures by robotic needle navigation system R Barua, A Sarkar, A Das, P Das, AR Chowdhury, P Datta Bioinspired, Biomimetic and Nanobiomaterials 15 (1), 14-20 , 2026 2026
Smart biomaterials and intelligent scaffolds for wound healing in tissue engineering R Barua, S Datta Biophysics Reviews 7 (1) , 2026 2026
Regulating the positioning of needles into hydrogel frameworks to produce vascularized tissue-engineered structures R Barua, S Bhowmik, S Datta Proceedings of the Institution of Mechanical Engineers, Part H: Journal of … , 2026 2026
Skeletal muscle tissue engineering using magnetic nanoparticles: a comprehensive review N Jain, S Datta, P Singh, D Pathote, S Das, R Barua, D Player Journal of Materials Chemistry B , 2026 2026 Citations: 1
Processing, Characterization, and Classification of Polymer Nanocomposites in Sustainable and Renewable Energy Sector BM Ranjit Barua, Deepanjan Das, Arbind Prasad, Sachin Latiyan, Sudipto Datta Sustainable Composites for Future Trends in Renewable Energy, 18-35 , 2026 2026
Revolutionizing drug evaluation system with organ-on-a-chip and artificial intelligence: A critical review R Barua, D Das, N Biswas Biomicrofluidics 19 (6) , 2025 2025 Citations: 3
Clinical Translation Studies of Resorbable Composites for Implant S Datta, R Barua, B Mahto, A Prasad Resorbable Polymers for Bioimplants and Fixation Devices, 371-379 , 2025 2025
Additive Manufacturing of Artificial Organs Using Resorbable Polymeric Composites A Prasad, R Barua, B Mahto, S Datta Resorbable Polymers for Bioimplants and Fixation Devices, 265-281 , 2025 2025
Advanced 3D-Printed Drug-Eluting Resorbable Implants and Fixation Devices S Datta, R Barua, B Mahto, A Prasad Resorbable Polymers for Bioimplants and Fixation Devices, 85-103 , 2025 2025
Dynamics of compound droplet splitting in Poiseuille flow across microfluidic channels D Das, R Barua, N Biswas Physics of Fluids 37 (10) , 2025 2025 Citations: 1
Marangoni effect on compound droplet inside bifurcated micro-confinement D Das, R Barua, N Biswas Physics of Fluids 37 (10) , 2025 2025 Citations: 4
Recent advances in the fabrication of vascularized tissues and blood vessels: A state-of-the-art review R Barua, S Datta, D Das, S Sarkar, N Biswas Physics of Fluids 37 (10) , 2025 2025 Citations: 7
Stainless steel-based biomaterial for orthopedic fixations S Latiyan, R Barua, D Pathote, V Vannaladsaysy, S Datta High-Performance Metallic Biomaterials: Surface Modification and Coating of … , 2025 2025
Surface modification of bone screws, reconstruction surgeries D Pathote, R Barua, S Latiyann, P Dash, S Datta High-Performance Metallic Biomaterials: Surface Modification and Coating of … , 2025 2025
Emerging application of modern additively manufactured medical implants R Barua, A Prasad, SM Bhasney High-Performance Metallic Biomaterials: Surface Modification and Coating of … , 2025 2025
Design strategy of metallic biomaterials for biomedical applications P Dash, R Barua, D Pathote, S Latiyan, S Datta High-Performance Metallic Biomaterials: Surface Modification and Coating of … , 2025 2025
Human Calcification Mechanisms: From Physiology to Pathology R Barua Cambridge Scholars Publishing , 2025 2025
Robotic Surgical Innovations in Calcification: Innovations and Future Prospects R Barua Cambridge Scholars Publishing , 2025 2025 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
Application of Artificial Intelligence in Modern Healthcare System S Datta, R Barua, J Das Alginates - Recent Uses of This Natural Polymer , 2019 2019 Citations: 76
Importance of Alginate Bioink for 3D Bioprinting in Tissue S Datta, R Barua, J Das Alginates: Recent Uses of This Natural Polymer, 109 , 2020 2020 Citations: 65
Innovations in minimally invasive surgery: The rise of smart flexible surgical robots R Barua Emerging technologies for health literacy and medical practice, 110-131 , 2024 2024 Citations: 48
3D printing in modern healthcare: an overview of materials, methods, applications, and challenges S Datta, R Barua Emerging technologies for health literacy and medical practice, 132-152 , 2024 2024 Citations: 46
Emerging Advancement of 3D Bioprinting Technology in Modern Medical Science and Vascular Tissue Engineering Education R Barua, A Sarkar, S Datta Handbook of Research on Instructional Technologies in Health Education and … , 2023 2023 Citations: 38
Alginates—recent uses of this natural polymer S Datta, R Barua, J Das London: IntechOpen , 2020 2020 Citations: 32
Force modeling to develop a novel method for fabrication of hollow channels inside a gel structure R Barua, H Giria, S Datta, A Roy Chowdhury, P Datta Proceedings of the Institution of Mechanical Engineers, Part H: Journal of … , 2020 2020 Citations: 31
Design and development of alginate: Poly-l-lysine scaffolds by 3D bio printing and studying their mechanical, structural and cell viability properties. S Datta, R Barua, R Sarkar, A Barui, P Datta ICAME 2018 IOP Conference Series Materials Science and Engineering 402 (1), 1-9 , 2018 2018 Citations: 28
Smart biodegradable and bio-based polymeric biomaterials for biomedical applications S Das, S Datta, A Barman, R Barua Modeling, Characterization, and Processing of Smart Materials, 56-82 , 2023 2023 Citations: 27
Analysis of surgical needle insertion modeling and viscoelastic tissue material interaction for minimally invasive surgery (MIS) R Barua, S Das, S Datta, P Datta, AR Chowdhury Materials Today: Proceedings 57 (01), 259-264 , 2022 2022 Citations: 27
Scaffolds and tissue engineering applications by 3D bio-printing process: a new approach R Barua, S Datta, P Datta, AR Chowdhury Design, Development, and Optimization of Bio-Mechatronic Engineering … , 2019 2019 Citations: 27
Metals, polymers, ceramics, composites biomaterials used in additive manufacturing for biomedical applications YO Waidi, R Barua, S Datta Modeling, Characterization, and Processing of Smart Materials, 165-184 , 2023 2023 Citations: 25
Study of the Current Trends of CAD (Computer-Aided Detection) in Modern Medical Imaging R Barua, J Mondal Machine Learning and AI Techniques in Interactive Medical Image Analysis, 35-50 , 2023 2023 Citations: 25
A review on electro-rheological fluid (er) and its various technological applications S Datta, R Barua, J Das Extremophilic microbes and metabolites-diversity, bioprospecting and … , 2020 2020 Citations: 25
Importance of 3D Printing Technology in Medical Fields R Barua, S Datta, A Roychowdhury, P Datta Additive Manufacturing Technologies From an Optimization Perspective , 2019 2019 Citations: 24
Emergent applications of organ-on-a-chip (OOAC) technologies with artificial vascular networks in the 21st century R Barua, N Biswas, D Das Emerging Technologies for Health Literacy and Medical Practice, 198-219 , 2024 2024 Citations: 23
Fluorescent nanomaterials and its application in biomedical engineering S Datta, R Barua Modeling and Simulation of Functional Nanomaterials for Forensic … , 2023 2023 Citations: 20
Experimental and simulation investigation of surgical needle insertion into soft tissue mimic biomaterial for minimally invasive surgery (MIS) R Barua, S Das, A RoyChowdhury, P Datta Proceedings of the Institution of Mechanical Engineers, Part H: Journal of … , 2022 2022 Citations: 20
Study of the surgical needle and biological soft tissue interaction phenomenon during insertion process for medical application: A Survey R Barua, S Datta, A RoyChowdhury, P Datta Proceedings of the Institution of Mechanical Engineers, Part H: Journal of … , 2022 2022 Citations: 20
Study and Application of Machine Learning Methods in Modern Additive Manufacturing Processes R Barua, S Datta, P Datta, A RoyChowdhury Applications of Artificial Intelligence in Additive Manufacturing, 75-95 , 2021 2021 Citations: 20
