RANGARAJAN T M

Scopus Publications

Morpholine as a privileged scaffold for neurodegenerative disease therapeutics
Saranya Kattil Parmbil, Sunil Kumar, T. M. Rangarajan, Della Grace Thomas Parambi, Naseer Maliyakkal, Anél Petzer, Jacobus P. Petzer, Bijo Mathew
Rsc Advances, 2026
The review emphasizes the importance of morpholine derivatives in advancing CNS therapeutics and their potential role in addressing unmet medical needs in neuropsychiatric disorder treatments.
Oxime functionalized Chalcones: Unveiling a new class of Chalcones with potent Antiplasmodial activity against blood-stages of Plasmodium falciparum in culture
Reeta Chaudhary, Ayushee, Vinoth Rajendran, T.M. Rangarajan
Bioorganic and Medicinal Chemistry Letters, 2025
Deep Eutectic Solvents (DESs): Emerging viable solvent systems for transition-metal-catalyzed cross-coupling reactions
Sharda Pasricha, Pragya Gahlot, T.M. Rangarajan, Shikha, Deepak, Harsh Pahuja, Divya Yadav, Pratham, Khushboo Pilania, Sachid Anand
Journal of Molecular Liquids, 2025
Unveiling the choline chloride-thiourea (1 : 1) DES as a greener medium and reagent for pyrimidinethione synthesis from α,β-unsaturated carbonyl compounds
Apeksha Singhal, Ankit Yadav, Shashwat Vashisht, Khushi Tyagi, T. M. Rangarajan, Sharda Pasricha
Organic and Biomolecular Chemistry, 2025
The first example of a choline chloride : thiourea (1 : 1) DES has been reported in organic synthesis as a solvent and reactant for obtaining 3,4-dihydropyrimidine-2(1H)-thiones from the corresponding chalcones in moderate to good yields.
Greener media for nano catalysts in Suzuki Miyaura reaction
Sharda Pasricha, Sachidanand, Abhay Srivastava, Srishti Yadav, Ann Sunny, Nikita Tuwani, T.M. Rangarajan, Kavita Mittal
Coordination Chemistry Reviews, 2025
Recent Progress in Synthetic and Natural Catechol-O-methyltransferase Inhibitors for Neurological Disorders
Sandeep Bindra, Ananya Datta, Haya Khader Ahmad Yasin, Riya Rachel Thomas, Shailesh Verma, Ankita Patel, Della Grace Thomas Parambi, Suraj N. Mali, T. M. Rangarajan, Bijo Mathew
ACS Omega, 2024
-methyltransferase (COMT) inhibitors have played a crucial role in the development of potent and selective drugs for the treatment of Parkinson's disease, depression, and anxiety disorders. This review provides a comprehensive analysis of the structure-activity relationship (SAR) of COMT inhibitors, highlighting key structural features and pharmacophoric elements that govern their potency, selectivity, and pharmacokinetic properties. This review also discusses the application of SAR principles in the design and optimization of COMT inhibitors. Our analysis reveals the emergence of novel chemical scaffolds and the potential for COMT inhibitors to address unmet medical needs in neurology and psychiatry. This Perspective serves as a valuable resource for clinicians and researchers, providing insights into the rational design of COMT inhibitors and the development of next-generation therapeutics.
Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry
Namitha Chandran, Kuntal Bose, Amrutha Chandran Thekkantavida, Riya Rachel Thomas, Karthika Anirudhan, Sandeep Bindra, Sooraj Sura, Haydara Ammar Hasan, Sunil Kumar, T. M. Rangarajan, Abdullah G. Al‐Sehemi, Prashant Gahtori, Hoon Kim, Bijo Mathew
Chemistryselect, 2024
Oximes, belonging to imines with the general formula of RR'C=NOH, are produced by the nucleophilic addition reaction between hydroxylamine with ketones or aldehydes, yielding corresponding aldoxime and ketoxime. The presence of hydrogen bond acceptor and donor is the classical feature of oxime‐containing structural framework. This review presents a summary of the role of oximes and its structure activity relationships including antimicrobial, anticancer, anti‐inflammatory, antihyperglycemic, insecticidal agents, along with their involvement in the treatment of organophosphorus poisoning. The review also focused on the pharmacological profile of lead molecules of several classes of oxime‐containing compounds.
Optimal exploitation of supported heterogenized Pd nanoparticles for C-C cross-coupling reactions
Abhay Srivastava, Harsimar Kaur, Harsh Pahuja, T.M. Rangarajan, Rajender S. Varma, Sharda Pasricha
Coordination Chemistry Reviews, 2024
A Comprehensive Review of the Docking Studies of Chalcone for the Development of Selective MAO-B Inhibitors
Athulya Krishna, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Ashutosh Kumar Singh, Leena K. Pappachen, T.M. Rangarajan, Mohamed A. Abdelgawad, Bijo Mathew
CNS and Neurological Disorders Drug Targets, 2024
Monoamine oxidase B is a crucial therapeutic target for neurodegenerative disorders like Alzheimer's and Parkinson's since they assist in disintegrating neurotransmitters such as dopamine in the brain. Pursuing efficacious monoamine oxidase B inhibitors is a hot topic, as contemporary therapeutic interventions have many shortcomings. Currently available FDA-approved monoamine oxidase inhibitors like safinamide, selegiline and rasagiline also have a variety of side effects like depression and insomnia. In the quest for a potent monoamine oxidase B inhibitor, sizeable, diverse chemical entities have been uncovered, including chalcones. Chalcone is a renowned structural framework that has been intensively explored for its monoamine oxidase B inhibitory activity.The structural resemblance of chalcone (1,3-diphenyl-2-propen-1-one) based compounds and 1,4-diphenyl- 2-butene, a recognized MAO-B inhibitor, accounts for their MAO-B inhibitory activity. Therefore, multiple revisions to the chalcone scaffold have been attempted by the researchers to scrutinize the implications of substitutions onthe molecule's potency. In this work, we outline the docking investigation results of various chalcone analogues with monoamine oxidase B available in the literature until now to understand the interaction modes and influence of substituents. Here we focused on the interactions between reported chalcone derivatives and the active site of monoamine oxidase B and the influence of substitutions on those interactions. Detailed images illustrating the interactions and impact of the substituents or structural modifications on these interactions were used to support the docking results.
“Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders
Amritha Manoharan, Jayalakshmi Jayan, T. M. Rangarajan, Kuntal Bose, Feba Benny, Reshma Susan Ipe, Sunil Kumar, Neelima Kukreti, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Hoon Kim, Bijo Mathew
ACS Omega, 2023
Click chemistry is a set of easy, atom-economical reactions that are often utilized to combine two desired chemical entities. Click chemistry accelerates lead identification and optimization, reduces the complexity of chemical synthesis, and delivers extremely high yields without undesirable byproducts. The most well-known click chemistry reaction is the 1,3-dipolar cycloaddition of azides and alkynes to form 1,2,3-triazoles. The resulting 1,2,3-triazoles can serve as both bioisosteres and linkers, leading to an increase in their use in the field of drug discovery. The current Review focuses on the use of click chemistry to identify new molecules for treating neurodegenerative diseases and in other areas such as peptide targeting and the quantification of biomolecules.
An efficient method to access spiro pseudoindoxyl ketones: evaluation of indoxyl and their N-benzylated derivatives for inhibition of the activity of monoamine oxidases
Karuppaiah Perumal, Jiseong Lee, Sesuraj Babiola Annes, Subburethinam Ramesh, T. M. Rangarajan, Bijo Mathew, Hoon Kim
Rsc Advances, 2023
Exploration of a new class of monoamine oxidase B inhibitors by assembling benzyloxy pharmacophore on halogenated chalcones
Ashutosh Kumar Singh, Seong‐Min Kim, Jong Min Oh, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, T. M. Rangarajan, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Daniela Trisciuzzi, Orazio Nicolotti, Hoon Kim, Bijo Mathew
Chemical Biology and Drug Design, 2023
Langlois Reagent: An Efficient Trifluoromethylation Reagent
T. M. Rangarajan, Sharda Pasricha, K. Anusha, Megha Mahesh, Shikha Shikha
Synopen, 2023
Solid-Supported Heterogenized Palladium Nanoparticles: Propitious Vehicles for Sonogashira Cross-Coupling Reaction
T. M. Rangarajan, Sharda Pasricha, Abhay Srivastava, Nishita Avasthi, Sachid Anand, Divya Yadav
Synopen, 2023
Two dimensional-QSAR and molecular dynamics studies of a selected class of aldoxime- and hydroxy-functionalized chalcones as monoamine oxidase-B inhibitors
Bijo Mathew, Veerasamy Ravichandran, Seenivasan Raghuraman, T. M. Rangarajan, Mohamed A. Abdelgawad, Iqrar Ahmad, Harun M. Patel, Hoon Kim
Journal of Biomolecular Structure and Dynamics, 2023
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
Sachithra Thazhathuveedu Sudevan, Jong Min Oh, Mohamed A. Abdelgawad, Mohammed A. S. Abourehab, T. M. Rangarajan, Sunil Kumar, Iqrar Ahmad, Harun Patel, Hoon Kim, Bijo Mathew
Scientific Reports, 2022
FDA-Approved Trifluoromethyl Group-Containing Drugs: A Review of 20 Years
Aathira Sujathan Nair, Ashutosh Kumar Singh, Astik Kumar, Sunil Kumar, Sunitha Sukumaran, Vishal Payyalot Koyiparambath, Leena K. Pappachen, T. M. Rangarajan, Hoon Kim, Bijo Mathew
Processes, 2022
Revealing the role of the benzyloxy pharmacophore in the design of a new class of monoamine oxidase-B inhibitors
Sachithra T. Sudevan, T. M. Rangarajan, Abdullah G. Al‐Sehemi, Aathira S. Nair, Vishal P. Koyiparambath, Bijo Mathew
Archiv Der Pharmazie, 2022
Aldoxime- and hydroxy-functionalized chalcones as highly potent and selective monoamine oxidase-B inhibitors
Jong Min Oh, T.M. Rangarajan, Reeta Chaudhary, Nicola Gambacorta, Orazio Nicolotti, Sunil Kumar, Bijo Mathew, Hoon Kim
Journal of Molecular Structure, 2022
Development of 2D, 3D-QSAR and Pharmacophore Modeling of Chalcones for the Inhibition of Monoamine Oxidase B
Bijo Mathew, Marcus Tullius Scotti, Chonny Herrera-Acevedo, Sanal Dev, T.M. Rangarajan, Mohamed Saheer Kuruniyan, Punnoth Poonkuzhi Naseef, Luciana Scotti
Combinatorial Chemistry and High Throughput Screening, 2022
Recent Updates on Pyrazoline Derivatives as Promising Candidates for Neuropsychiatric and Neurodegenerative Disorders
T. M. Rangarajan, Bijo Mathew
Current Topics in Medicinal Chemistry, 2021
Replacement of chalcone-ethers with chalcone-thioethers as potent and highly selective monoamine oxidase-b inhibitors and their protein-ligand interactions
Bijo Mathew, Jong Min Oh, Ahmed Khames, Mohamed A. Abdelgawad, T. M. Rangarajan, Lekshmi R. Nath, Clement Agoni, Mahmoud E. S. Soliman, Githa Elizabeth Mathew, Hoon Kim
Pharmaceuticals, 2021
Deciphering the detailed structure–activity relationship of coumarins as Monoamine oxidase enzyme inhibitors—An updated review
Vishal Payyalot Koyiparambath, Krishnendu Prayaga Rajappan, T. M. Rangarajan, Abdullah G. Al‐Sehemi, Mehboobali Pannipara, Vaishnav Bhaskar, Aathira Sujathan Nair, Sachithra Thazhathuveedu Sudevan, Sunil Kumar, Bijo Mathew
Chemical Biology and Drug Design, 2021
Current Progress in Quinazoline Derivatives as Acetylcholinesterase and Monoamine Oxidase Inhibitors
Nisha Abdul Rehuman, Abdullah G. Al‐Sehemi, Della Grace Thomas Parambi, T. M. Rangarajan, Orazio Nicolotti, Hoon Kim, Bijo Mathew
Chemistryselect, 2021
(Hetero-)(arylidene)arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors
Ashique Palakkathondi, Jong Min Oh, Sanal Dev, T. M. Rangarajan, Swafvan Kaipakasseri, Fathima Sahla Kavully, Nicola Gambacorta, Orazio Nicolotti, Hoon Kim, Bijo Mathew
ACS Combinatorial Science, 2020
An Easy Access to Oxime Ethers by Pd-Catalyzed C—O Cross-Coupling of Activated Aryl Bromides with Ketoximes and Chalcone Oximes
Reeta, T. M. Rangarajan, Raj Pal Singh, R. P. Singh, Manjula Singh
Chinese Journal of Chemistry, 2020
Novel class of chalcone oxime ethers as potent monoamine oxidase-B and acetylcholinesterase inhibitors
Jong Min Oh, T. M. Rangarajan, Reeta Chaudhary, Rishi Pal Singh, Manjula Singh, Raj Pal Singh, Anna Rita Tondo, Nicola Gambacorta, Orazio Nicolotti, Bijo Mathew, Hoon Kim
Molecules, 2020
Efficient solvent- And temperature-tuned access to aldoxime ethers and phenolic functions by Pd-catalyzed C-O cross-coupling of aldoximes with aryl bromides and bromo-chalcones
Reeta Reeta, T. M. Rangarajan, Kumar Kaushik, Rishi Pal Singh, Manjula Singh, Raj Pal Singh
New Journal of Chemistry, 2020
Synthesis of novel chalcones through palladium-catalyzed C–O cross-coupling reaction of bromo-chalcones with ethyl acetohydroxamate and their antiplasmodial evaluation against Plasmodium falcipuram in vitro
Reeta, Rajendran Vinoth, T.M. Rangarajan, Ayushee, Rishi Pal Singh, Manjula Singh
Bioorganic Chemistry, 2019
Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer’s disease
Reeta, Seung Cheol Baek, Jae Pil Lee, T.M. Rangarajan, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim, Bijo Mathew
CNS and Neurological Disorders Drug Targets, 2019
Synthesis and evaluation of antiplasmodial activity of 2,2,2-trifluoroethoxychalcones and 2-fluoroethoxy chalcones against plasmodium falciparum in culture
Kavita Devi, Vinoth Rajendran, Ayushee, T. Rangarajan, Rishi Singh, Prahlad Ghosh, Manjula Singh
Molecules, 2018
Palladium-Catalyzed Rapid Methoxylation and Deuteriomethoxylation of Bromo–chalcones: Uncovering the Catalytic Activity of the Pd/tBuXPhos Catalyst System
Reeta, T. M. Rangarajan, Ayushee, Rishi Pal Singh, R. P. Singh
Chemistryselect, 2016
A general and efficient Pd-catalyzed rapid 2-fluoroethoxylation of bromo-chalcones
T.M. Rangarajan, Kavita Devi, Akhilesh K. Verma, Rishi Pal Singh, Raj Pal Singh
Journal of Fluorine Chemistry, 2016
A general, mild and efficient palladium-catalyzed 2,2,2-trifluoroethoxylation of activated aryl bromides and bromo-chalcones: Bromo-chalcones a new coupling partner in cross-coupling reaction
T.M. Rangarajan, Kavita Devi, Ayushee, Ashok K. Prasad, Rishi Pal Singh
Tetrahedron, 2015
Mild and efficient palladium/BrettPhos-catalyzed methoxylation and deuteriomethoxylation of activated aryl bromides
T.M. Rangarajan, Raju Brahma, Ayushee, Ashok K. Prasad, Akhilesh K. Verma, Rishi Pal Singh
Tetrahedron Letters, 2015
BrettPhos ligand supported palladium-catalyzed C-O bond formation through an electronic pathway of reductive elimination: Fluoroalkoxylation of activated aryl halides
T. M. Rangarajan, Rajendra Singh, Raju Brahma, Kavita Devi, Rishi Pal Singh, R. P. Singh, Ashok K. Prasad
Chemistry A European Journal, 2014
Anodic oxidation of alkane carboxylates and perfluoroalkane carboxylates at platinum and graphite anodes: Product selectivity and mechanistic aspects
T. M. Rangarajan, David Velayutham, Michael Noel
Ionics, 2011
Products formed at intermediate stages of electrochemical perfluorination of propionyl and n-butyryl chlorides. Further evidence in support of NiF 3 mediated free radical pathway
T.M. Rangarajan, S. Sathyamoorthi, D. Velayutham, M. Noel, R.P. Singh, Raju Brahma
Journal of Fluorine Chemistry, 2011

RECENT SCHOLAR PUBLICATIONS

Morpholine as a privileged scaffold for neurodegenerative disease therapeutics
SK Parmbil, S Kumar, TM Rangarajan, DGT Parambi, N Maliyakkal, ...
RSC advances 16 (14), 12408-12443 , 2026
2026
Citations: 1
Oxime functionalized Chalcones: Unveiling a new class of Chalcones with potent Antiplasmodial activity against blood-stages of Plasmodium falciparum in culture
R Chaudhary, V Rajendran, TM Rangarajan
Bioorganic & medicinal chemistry letters 121, 130143 , 2025
2025
Deep eutectic solvents (DESs): emerging viable solvent systems for transition-metal-catalyzed cross-coupling reactions
S Pasricha, P Gahlot, TM Rangarajan, H Pahuja, D Yadav, K Pilania, ...
Journal of Molecular Liquids 426, 127287 , 2025
2025
Citations: 7
Greener media for nano catalysts in Suzuki Miyaura reaction
S Pasricha, A Srivastava, S Yadav, A Sunny, N Tuwani, TM Rangarajan, ...
Coordination Chemistry Reviews 528, 216431 , 2025
2025
Citations: 11
Unveiling the choline chloride–thiourea (1: 1) DES as a greener medium and reagent for pyrimidinethione synthesis from α, β-unsaturated carbonyl compounds
A Singhal, A Yadav, S Vashisht, K Tyagi, TM Rangarajan, S Pasricha
Organic & Biomolecular Chemistry 23 (20), 4951-4959 , 2025
2025
Citations: 3
Recent Progress in Synthetic and Natural Catechol- O -methyltransferase Inhibitors for Neurological Disorders
S Bindra, A Datta, HKA Yasin, RR Thomas, S Verma, A Patel, ...
ACS omega 9 (44), 44005-44018 , 2024
2024
Citations: 4
Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry
BM . Chandran, K. Bose, A. C. Thekkantavida, R. R. Thomas, K. Anirudhan, S ...
ChemistrySelect 9 , 2024
2024
Citations: 21
A comprehensive review of the docking studies of chalcone for the development of selective MAO-B inhibitors
A Krishna, S Kumar, ST Sudevan, AK Singh, LK Pappachen, ...
CNS & Neurological Disorders-Drug Targets-CNS & Neurological Disorders) 23 … , 2024
2024
Citations: 10
Optimal exploitation of supported heterogenized Pd nanoparticles for CC cross-coupling reactions
A Srivastava, H Kaur, H Pahuja, TM Rangarajan, RS Varma, S Pasricha
Coordination Chemistry Reviews 507, 215763 , 2024
2024
Citations: 44
Two dimensional-QSAR and molecular dynamics studies of a selected class of aldoxime-and hydroxy-functionalized chalcones as monoamine oxidase-B inhibitors
B Mathew, V Ravichandran, S Raghuraman, TM Rangarajan, ...
Journal of Biomolecular Structure and Dynamics 41 (19), 9256-9266 , 2023
2023
Citations: 15
“Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders
A Manoharan, J Jayan, TM Rangarajan, K Bose, F Benny, RS Ipe, ...
ACS omega 8 (47), 44437-44457 , 2023
2023
Citations: 34
Exploration of a new class of monoamine oxidase B inhibitors by assembling benzyloxy pharmacophore on halogenated chalcones
AK Singh, SM Kim, JM Oh, MA Abdelgawad, MM Ghoneim, ...
Chemical Biology & Drug Design 102 (2), 271-284 , 2023
2023
Citations: 11
Langlois Reagent: An Efficient Trifluoromethylation Reagent
K Anusha, M Mahesh, S Shikha, TM Rangarajan, S Pasricha
SynOpen 7 (01), 65-68 , 2023
2023
Citations: 1
Green Acetylation of Primary Aromatic Amines
S Pasricha, TM Rangarajan
Resonance 28 (2), 325-331 , 2023
2023
Citations: 4
Solid-supported heterogenized palladium nanoparticles: Propitious vehicles for Sonogashira cross-coupling reaction
A Srivastava, N Avasthi, S Anand, D Yadav, TM Rangarajan, S Pasricha
SynOpen 7 (01), 43-45 , 2023
2023
Citations: 8
An efficient method to access spiro pseudoindoxyl ketones: evaluation of indoxyl and their N-benzylated derivatives for inhibition of the activity of monoamine oxidases
K Perumal, J Lee, SB Annes, S Ramesh, TM Rangarajan, B Mathew, ...
RSC advances 13 (36), 24925-24935 , 2023
2023
Citations: 2
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
HKBM Sachithra Thazhathuveedu Sudevan, Jong Min Oh, Mohamed A. Abdelgawad ...
scientific reports 12, 22404 , 2022
2022
Citations: 36
FDA-approved trifluoromethyl group-containing drugs: A review of 20 years
AS Nair, AK Singh, A Kumar, S Kumar, S Sukumaran, VP Koyiparambath, ...
Processes 10 (10), 2054 , 2022
2022
Citations: 201
Development of 2D, 3D-QSAR and pharmacophore modeling of chalcones for the inhibition of monoamine oxidase B
B Mathew, C Herrera-Acevedo, S Dev, TM Rangarajan, MS Kuruniyan, ...
Combinatorial Chemistry & High Throughput Screening 25 (10), 1731-1744 , 2022
2022
Citations: 6
Revealing the role of the benzyloxy pharmacophore in the design of a new class of monoamine oxidase‐B inhibitors
BM Sachithra T. Sudevan,T. M. Rangarajan, Abdullah G. Al-Sehemi, Aathira S ...
Arch Pharm. , 2022
2022
Citations: 24

MOST CITED SCHOLAR PUBLICATIONS

FDA-approved trifluoromethyl group-containing drugs: A review of 20 years
AS Nair, AK Singh, A Kumar, S Kumar, S Sukumaran, VP Koyiparambath, ...
Processes 10 (10), 2054 , 2022
2022
Citations: 201
BrettPhos Ligand Supported Palladium‐Catalyzed C O Bond Formation through an Electronic Pathway of Reductive Elimination: Fluoroalkoxylation of Activated Aryl Halides
TM Rangarajan, R Singh, R Brahma, K Devi, RP Singh, RP Singh, ...
Chemistry–A European Journal 20 (44), 14218-14225 , 2014
2014
Citations: 72
Deciphering the detailed structure-activity relationship of coumarins as Monoamine oxidase enzyme inhibitors-An updated review
K Vishal Payyalot, PR Krishnendu, TM Rangarajan, GAS Abdullah, ...
Chemical Biology & Drug Design , 2021
2021
Citations: 58
Novel class of chalcone oxime ethers as potent monoamine oxidase-B and acetylcholinesterase inhibitors
JM Oh, TM Rangarajan, R Chaudhary, RP Singh, M Singh, RP Singh, ...
Molecules 25 (10), 2356 , 2020
2020
Citations: 53
Optimal exploitation of supported heterogenized Pd nanoparticles for CC cross-coupling reactions
A Srivastava, H Kaur, H Pahuja, TM Rangarajan, RS Varma, S Pasricha
Coordination Chemistry Reviews 507, 215763 , 2024
2024
Citations: 44
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
HKBM Sachithra Thazhathuveedu Sudevan, Jong Min Oh, Mohamed A. Abdelgawad ...
scientific reports 12, 22404 , 2022
2022
Citations: 36
“Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders
A Manoharan, J Jayan, TM Rangarajan, K Bose, F Benny, RS Ipe, ...
ACS omega 8 (47), 44437-44457 , 2023
2023
Citations: 34
Mild and efficient palladium/BrettPhos-catalyzed methoxylation and deuteriomethoxylation of activated aryl bromides
TM Rangarajan, R Brahma, AK Prasad, AK Verma, RP Singh
Tetrahedron Letters 56 (17), 2234-2237 , 2015
2015
Citations: 31
Ethyl acetohydroxamate incorporated chalcones: unveiling a novel class of chalcones for multitarget monoamine oxidase-B inhibitors against Alzheimer’s disease
SC Baek, JP Lee, TM Rangarajan, RP Singh, M Singh, GF Mangiatordi, ...
CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS … , 2019
2019
Citations: 29
A general, mild and efficient palladium-catalyzed 2, 2, 2-trifluoroethoxylation of activated aryl bromides and bromo-chalcones: bromo-chalcones a new coupling partner in cross …
TM Rangarajan, K Devi, AK Prasad, RP Singh
Tetrahedron 71 (43), 8307-8314 , 2015
2015
Citations: 27
Revealing the role of the benzyloxy pharmacophore in the design of a new class of monoamine oxidase‐B inhibitors
BM Sachithra T. Sudevan,T. M. Rangarajan, Abdullah G. Al-Sehemi, Aathira S ...
Arch Pharm. , 2022
2022
Citations: 24
Current Progress in Quinazoline Derivatives as Acetylcholinesterase and Monoamine Oxidase Inhibitors
DBM Nisha Abdul Rehuman, Prof. Abdullah G. Al-Sehemi, Dr. Della Grace Thomas ...
ChemistrySelect 6 (28), 7162-7182 , 2021
2021
Citations: 24
Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry
BM . Chandran, K. Bose, A. C. Thekkantavida, R. R. Thomas, K. Anirudhan, S ...
ChemistrySelect 9 , 2024
2024
Citations: 21
Recent updates on pyrazoline derivatives as promising candidates for neuropsychiatric and neurodegenerative disorders
TM Rangarajan, B Mathew
Current Topics in Medicinal Chemistry 21 (30), 2695-2714 , 2021
2021
Citations: 19
Two dimensional-QSAR and molecular dynamics studies of a selected class of aldoxime-and hydroxy-functionalized chalcones as monoamine oxidase-B inhibitors
B Mathew, V Ravichandran, S Raghuraman, TM Rangarajan, ...
Journal of Biomolecular Structure and Dynamics 41 (19), 9256-9266 , 2023
2023
Citations: 15
Aldoxime-and hydroxy-functionalized chalcones as highly potent and selective monoamine oxidase-B inhibitors
JM Oh, TM Rangarajan, R Chaudhary, N Gambacorta, O Nicolotti, ...
Journal of Molecular Structure 1250, 131817 , 2022
2022
Citations: 15
Replacement of chalcone-ethers with chalcone-thioethers as potent and highly selective monoamine oxidase-B inhibitors and their protein-ligand interactions
B Mathew, JM Oh, A Khames, MA Abdelgawad, TM Rangarajan, LR Nath, ...
Pharmaceuticals 14 (11), 1148 , 2021
2021
Citations: 15
Products formed at intermediate stages of electrochemical perfluorination of propionyl and n-butyryl chlorides. Further evidence in support of NiF3 mediated free radical pathway
TM Rangarajan, S Sathyamoorthi, D Velayutham, M Noel, RP Singh, ...
Journal of Fluorine Chemistry 132 (2), 107-113 , 2011
2011
Citations: 14
Greener media for nano catalysts in Suzuki Miyaura reaction
S Pasricha, A Srivastava, S Yadav, A Sunny, N Tuwani, TM Rangarajan, ...
Coordination Chemistry Reviews 528, 216431 , 2025
2025
Citations: 11
Exploration of a new class of monoamine oxidase B inhibitors by assembling benzyloxy pharmacophore on halogenated chalcones
AK Singh, SM Kim, JM Oh, MA Abdelgawad, MM Ghoneim, ...
Chemical Biology & Drug Design 102 (2), 271-284 , 2023
2023
Citations: 11

RANGARAJAN T M

EDUCATION

RESEARCH INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS