V S N Malleswara Rao Peram

Scopus Publications

Therapeutic targeting of glioblastoma via tumor-suppressor miRNAs delivered by milk-derived exosomes
Sanjana Kotabagi, Vijay M. Kumbar, Raghavi Marakatti, Trupti Janivarad, Krutika Lolsure, Manjula I Kambi, Malleswara Rao Peram, Ramesh Paranjape
Journal of Drug Delivery Science and Technology, 2026
Eco-friendly fabrication and characterization of polyherbal silver nanoparticle-loaded shampoo with enhanced antibacterial efficacy for the topical management of scalp and hair folliculitis
Sunil T. Galatage, Arehalli S. Manjappa, Somnath D. Bhinge, Rama Rao Vadapalli, Nagineni Sudarshan Rao, Brahmaiah Bonthagarala, Arige Sirisha, Malleswara Rao Peram, Machindra R. Holam, Utkarsh V. Nagvekar, Unnam Sambamoorthy, Priyanka Powar
Next Nanotechnology, 2026
Folliculitis is a common dermatological disorder characterized by inflammation and bacterial infection of hair follicles, most frequently caused by Staphylococcus aureus . The present study aimed to develop a polyherbal silver nanoparticle (PH-AgNPs)–loaded shampoo using a green synthesis approach to exploit phytochemical synergy for enhanced antibacterial efficacy in the management of scalp folliculitis. Silver nanoparticles were synthesized by reducing silver nitrate (AgNO₃) with an aqueous polyherbal extract containing Acacia concinna , Camellia oleifera , Emblica officinalis , and Sapindus mukorossi , which simultaneously acted as reducing and stabilizing agents. The synthesized PH-AgNPs were characterized using UV–visible spectroscopy, dynamic light scattering (DLS), zeta potential analysis, and energy-dispersive X-ray spectroscopy (EDX). The nanoparticles exhibited a mean particle size of 87 ± 2 nm, a polydispersity index of 0.218 ± 0.07, and a zeta potential of −33.2 ± 2.1 mV, indicating good colloidal stability. Antibacterial evaluation demonstrated potent activity against S. aureus , with a minimum inhibitory concentration (MIC) of 0.8 ± 0.06 µg/mL and a minimum bactericidal concentration (MBC) of 3.12 ± 0.5 µg/mL. Furthermore, PH-AgNPs significantly inhibited bacterial adhesion and biofilm formation in a dose-dependent manner, achieving complete biofilm inhibition at MBC within 48 h. Incorporation of PH-AgNPs into a shampoo base provides a green, polyherbal-synergistic topical nanotherapeutic system with promising potential for the treatment of bacterial folliculitis, warranting further in vivo and clinical investigations to confirm therapeutic safety and efficacy. • Polyherbal silver nanoparticles (PH-AgNPs) were synthesized using a green approach from Acacia concinna , Camellia oleifera , Emblica officinalis , and Sapindus mukorossi . • The synthesized PH-AgNPs showed nanoscale size (87 ± 2 nm) and high stability (zeta potential −33.2 ± 2.1 mV). • PH-AgNPs exhibited strong antibacterial activity against Staphylococcus aureus with MIC = 0.8 μg/mL and MBC = 3.12 μg/mL. • The PH-AgNPs effectively inhibited bacterial adhesion and biofilm formation, demonstrating potential for treating scalp folliculitis.
Correction: Phospholipid-Based Ultraflexible Nanovesicular Gel of Sertaconazole Nitrate for the Treatment of Skin Fungal Infections: Statistical Optimization, In Vitro and Preclinical Assessment (Gels, (2025), 11, 11, (909), 10.3390/gels11110909)
Malleswara Rao Peram, Sachin R. Patil, Vidyadhara Suryadevara, Srinivasa Rao Yarguntla, Smita Kamalakar, Preeti Patil, Kamala Kumari Paravastu, Anand Vishwas Deshmukh, Manohar Kugaji, Sameer Nadaf
Gels, 2026
The author Anand Vishwas Deshmukh was not included as an author in the original publication [...]
Prostate Specific Antigen (PSA): A critical biomarker in prostatic adenocarcinoma diagnosis and therapy
Shalaka R. Patki, Arehalli S. Manjappa, Shyam Sundar Pottabathula, Sunil T. Galatage, MalleswaraRao Peram, Mallikarjuna Reddy Kaipu
Role of Biomarkers in Cancer Diagnosis and Therapeutics, 2026
Sericin stabilized emulgel for improving therapeutic efficacy of quercetin in treatment of diabetic wound healing
Asmita Burud, Sunil Galatage, Arehalli Manjappa, Ahmad Salawi, Sameer Nadaf, Machindra Holam, Swapnil Harale, Ravindra Kumbhar, Malleswara Rao Peram, Vidyadhara Suryadevara
Journal of Dispersion Science and Technology, 2026
Emulsion stability is vital for effectiveness, ensuring uniform distribution of droplets and preventing phase separation. Instability can lead to inconsistent performance and reduced therapeutic benefits. Thus, our research endeavors were directed toward the design and characterization of a sericin (SN) stabilized quercetin (QRN) emulgel (EG), specifically tailored for diabetic wound healing. Employing a two-factor, 3-level factorial design SN-stabilized QRN emulgel (QSEG) was prepared and the influence of varying percentages of olive oil and SN on zeta potential, globule size, and entrapment efficiency (%) was scrutinized. The optimized QRN emulgel (QSEG), composed of 10% oil and 5% SN (QSE-6), showcased a diminutive globule size of 809.2 ± 21.3 nm alongside an elevated zeta potential of −42.9 ± 3.79 mV. Submicron-sized spherical globules were observed without any signs of coalescence, confirmed by surface morphology analysis. FTIR showed compatibility, while DSC and XRD confirmed that QRN was amorphized and evenly dispersed within the emulgel. In-vitro scratch assays manifested reduced intercellular distances and wound closure, indicative of potent wound healing attributes of QSEG. QSEG demonstrated notable antibacterial efficacy against Escherichia coli (E. coli), with minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of 3.125 ± 0.4 and 6.25 ± 1.2 μg/mL, respectively, surpassing that against Staphylococcus aureus (S.aureus). Cytotoxicity assays evidenced diminished toxicity toward fibroblast cells. Furthermore, in-vivo wound healing studies unveiled significant (p ˂ 0.001) enhancements with QSEG compared to QRN-treated and control groups. Our findings underscore SN’s role as a natural stabilizer, synergistically enhancing QSEG’s diabetic wound healing potential. Conclusively, QSEG emerges as a promising alternative to conventional diabetic wound healing treatments, offering inherent medicinal benefits.
Phyto-fabrication and characterization of silver nanoparticles from Trachyspermum ammi (Ajwain) seeds and assessment of their antifungal activity
Malleswara Rao Peram, Sunil Attimarad, Vijay M Kumbar, Vidyadhara Suryadevara, Chakravarthy Adusumalli, et al.
Indian Journal of Biochemistry and Biophysics, 2025
The rising incidence of fungal infections combined with the emergence of resistance to existing antifungal drugs highlight the urgent need for novel, safe, and eco-friendly therapeutic options. Green nanotechnology provides a sustainable way to build such alternatives. The present study reports an inexpensive, environmentally acceptable, and non-toxic green method for the biosynthesis of silver nanoparticles (AgNPs) utilizing aqueous seed extract of Trachyspermum ammi (TA). The biosynthesized T. ammiAgNPs (TA-AgNPs) were characterized using several sophisticated analytical techniques, and their antifungal efficacy was studied. The formation of AgNPs was visually represented by a shift from a light brown to a dark or red-brown color and confirmed by the surface plasmon resonance band at 419 nm. The particle size, polydispersity index, and zeta potential of AgNPs were found to be 101.5 nm, 0.270, and – 41.7 mV respectively. Studies using a transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDX), selected area electron diffraction (SAED) spectrum, and X-ray diffraction (XRD) confirmed that the biosynthesized AgNPs were spherical, contained elemental silver, and had a crystalline structure. The TA-AgNPs showed distinctive antioxidant potential, biocompatibility, and promising antifungal activity against Candida species and Aspergillus niger. The disc diffusion method demonstrated that TA-AgNP's gel had more pronounced antifungal activity than the commercially available Silverex™ ionic (silver nitrate 0.2% w/w) gel. In conclusion, the present work showed that TA seed extract mediated AgNPs gel could be the potential therapeutic agent for human fungal infections.
Phospholipid-Based Ultraflexible Nanovesicular Gel of Sertaconazole Nitrate for the Treatment of Skin Fungal Infections: Statistical Optimization, In Vitro and Preclinical Assessment
Malleswara Rao Peram, Sachin R. Patil, Vidyadhara Suryadevara, Srinivasa Rao Yarguntla, Smita Kamalakar, Preeti Patil, Kamala Kumari Paravastu, Manohar Kugaji, Sameer Nadaf
Gels, 2025
Sertaconazole nitrate (SN), a broad-spectrum antifungal agent, is clinically employed against diverse dermatophyte infections. Its therapeutic efficacy, however, is constrained by poor aqueous solubility (0.006 mg/mL) and insufficient skin penetration from current commercial formulations. To address these limitations, this research focused on developing, optimizing (using a 32 factorial design), and assessing a topical nanovesicular gel incorporating sertaconazole nitrate-loaded ultraflexible liposomes (SN-UFLs) to enhance antifungal performance. The vesicles exhibited near-spherical morphology, with sizes ranging from 104.40 ± 1.20 to 151.90 ± 2.14 nm, zeta potential (ZP) values between −21.50 ± 1.25 and −51.20 ± 2.25 mV, and entrapment efficiency (EE) values from 77.60 ± 2.50% to 86.04 ± 3.20%. The optimized SN-UFL formulation (OPT-SN-UFL) was then integrated into a carbopol gel base. This SN-UFL-Gel was characterized for pH (6.5 ± 0.20), viscosity (499.66 ± 15 cP), spreadability (205 ± 1.50%), extrudability (154.18 ± 2.48 g/cm2), and drug content (96.7 ± 2.50%), as well as ex vivo skin permeation, skin irritation potential, and in vitro and in vivo antifungal efficacy. Compared with the marketed formulation, higher drug permeation and skin deposition were observed for SN-UFL-Gel. The SN-UFL-Gel exhibited a larger zone of inhibition (25 ± 1.50 mm) against Candida albicans compared to the commercially available formulation (20 ± 1.72 mm). The in vivo animal studies showed that SN-UFL-Gel showed better antifungal activity by efficient inhibition of infection induced in rats with Trichophyton mentagrophytes. The SN-UFL-Gel showed no signs of skin irritation and was stable at 4 ± 1, 25 ± 2, and 40 ± 2 °C for 3 months. Conclusively, the current work divulged successful augmentation of the overall effectiveness of sertaconazole nitrate by using deformable liposomes as a promising nanocarrier.
Antimicrobial and antibiofilm activity of curcumin against oral pathogens: Potential for periodontal treatment
Vijay M. Kumbar, Malleswara Rao Peram, Manohar S. Kugaji, Sanjivini Patil, Manjula Kambimath, Shreya Magennavar, Mehmuda Hussain, Kishore G. Bhat, Ramesh Paranjape
Microbe Netherlands, 2025
Periodontitis, a prevalent oral disease, arises from a consortium of oral bacterial species that form biofilms on tooth surfaces, triggering host inflammatory responses and leading to clinical symptoms. Curcumin (CUR), a natural polyphenolic compound, has garnered significant attention for its therapeutic properties. This study investigates the antibacterial and antibiofilm activities of CUR against oral pathogens. Minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs), time-kill curves, anti-adhesion, and antibiofilm assays were performed against a panel of oral bacteria associated with dental caries and periodontal disease. The results demonstrate that CUR exhibits notable antimicrobial activity, with MIC and MBC values ranging from 15.62 to 31.25 µg/mL and 31.25–125 µg/mL, respectively, against various oral pathogens, including S. mutans, P. intermedia, and A. actinomycetemcomitans. Additionally, CUR showed significant antibiofilm activity, disrupting the formation and stability of oral bacterial biofilms, which are critical in conferring drug resistance to antimicrobial agents. The promising potential of curcumin for oral health underscores the need for further research to develop CUR-based formulations for oral healthcare regimens, potentially improving oral health outcomes.
Wound healing potential of green synthesized silver nanoparticles of Glycyrrhiza glabra linn root extract: A preclinical study
Laxman S. Vijapur, Mallappa Shalavadi, Anita R. Desai, Jayadev N. Hiremath, Avinash S. Gudigennavar, Somlingesh L. Shidramshettar, Shreyanka R. Hiremath, Malleswara Rao Peram, Bharatesh S. Kittur
Journal of Trace Elements and Minerals, 2025
The research emphasizes the eco-friendly and sustainable approach of nanoparticle synthesis, leveraging the medicinal properties inherent in Glycyrrhiza glabra extract, which is known for its antimicrobial, anti-inflammatory, and antioxidant properties. By combining the therapeutic potential of the plant extract with the wound-healing capabilities of silver nanoparticles, the study seeks to develop an innovative, biocompatible, and effective treatment for enhanced wound healing process in excision and incision rat model. Glycyrrhiza glabra Linn root was extracted with alcohol and utilized in the green synthesis of silver nanoparticles. The green synthesized nanoparticles were characterized, formulated into gel, and evaluated for their potential to heal wound in rat wound model. The results of the study showed that the detection of ultra-violet visible spectroscopy peaks at 412 nm and 403 nm. The presence of tannins, saponins, flavonoids, and phenols in plant extract caused the capping and bio-reduction of silver, as demonstrated by FTIR. Silver nanoparticles that were biosynthesized were in between 69.7 and 419.1 nm in size. The study's formulation of synthesized silver nanoparticles demonstrated significant wound healing potential by promoting wound contraction and accelerating healing after 21 days of study, which was demonstrated by histopathological evaluation and complete epithelialization with regenerated hair follicles and higher collagen tissue. The current study found that the biomolecules of Glycyrrhiza glabra Linn root alcoholic extract, which are responsible for augmenting the plant extract's capacity to heal wounds, were capped on silver nanoparticles.
BIO-CHEMICAL PROPERTIES OF CURCUMIN AND CURCUMIN ANALOGUE-2 AND CURCUMIN ANALOGUE-2 IN THE TREATMENT OF PERIODONTAL DISEASE.A NARRATIVE REVIEW
Ramanarayana Boyapati, Ravindranath Dhulipalla, Chaitanya Adurty, Malleswara Peram
Bulletin of Stomatology and Maxillofacial Surgery, 2025
Periodontitis is an inflammatory disease which affects both soft and hard tissues. Many treatment options have been employed to treat periodontitis out of which scaling and root planing are the standard procedures to initially reduce inflammation and improve tissue conditions. Although, scaling and root planing can reduce the inflammation, other agents or adjuncts should be used which can decrease the inflammation systemically or locally in an effective manner without side effects of using antibiotics. One of the traditional herbs used in Chinese and Indian ayurveda is Curcumin. Curcumin is known for its anti-inflammatory antioxidant and anti-microbial effect. As Curcumin is less stable with less bioavailabilty, there is need for formulation of Curcumin analogues which are long lasting, highly stable and also have high bioavailability. Curcumin analogue -2 is known to have high anti-inflammatory, antimicrobial and antioxidant effect which can combat with periodonto-pathogenic bacteria and the inflammation due to periodontal supporting tissues. Therefore, this review focuses on bio-chemical properties of Curcumin and its formulated Curcumin analogue -2 and mechanism of Curcumin analogue -2 in the treatment of periodontitis
Development of curcumin-loaded ultra deformable lipid vesicles for enhanced anti-melanoma activity: in vitro, ex-vivo, and cell line studies
Malleswara Rao Peram, Vidyadhara Suryadevara, Sachin Patil, Viswanadh Kunam, Vijay Kumbar, Pratiksha Babar, Sunil Galatage, Manjappa Arehalli
Journal of Dispersion Science and Technology, 2025
Green Synthesis of silver nanoparticles from clematis gouriana leaf extract: Physicochemical characterization and antibacterial activity determination for treatment of blood stream infections
Vinayak Yadav, Sunil T. Galatage, Arehalli S. Manjappa, Ahmad Salawi, Malleswara Rao Peram, Sameer J. Nadaf, Swapnil S. Harale
Microbe Netherlands, 2024
Acitretin-loaded nanoethosomal gel for the treatment of psoriasis: Formulation, optimization, in vitro, and in vivo assessment
Malleswara Rao Peram, Chandrakant Dhananjay, Nagesh Chandrasekhar, Vijay M Kumbar, Vidyadhara Suryadevara, Sachin R Patil, Sally A El-Zahaby
Journal of Dispersion Science and Technology, 2024
Formulation, Optimization, and Antioxidant Evaluation of Tetrahydrocurcumin-Loaded Ultradeformable Nanovesicular Cream
Ankita Kanshide, Malleswara Rao Peram, Nagesh Chandrasekhar, Arzoo Jamadar, Vijay Kumbar, Manohar Kugaji
Journal of Pharmaceutical Innovation, 2023
Formulation, Optimization, and Evaluation of Ultradeformable Nanovesicles for Effective Topical Delivery of Hydroquinone
Arzoo Toyeba Jamadar, Malleswara Rao Peram, Nagesh Chandrasekhar, Ankita Kanshide, Vijay M. Kumbar, Prakash V. Diwan
Journal of Pharmaceutical Innovation, 2023
Gingipain Genotyping as a Potential Predictor for the Assessment of Periodontal Health and Disease Condition
Manohar Kugaji, Kishore Bhat, Uday Muddapur, Vinayak Joshi, Malleswara Rao Peram, Vijay Kumbar
Hygiene, 2022
Curcumin-Encapsulated Nanomicelles Improve Cellular Uptake and Cytotoxicity in Cisplatin-Resistant Human Oral Cancer Cells
Vijay M. Kumbar, Uday Muddapur, Abdullatif Bin Muhsinah, Saad Ali Alshehri, Mohammed Merae Alshahrani, Ibrahim Abdullah Almazni, Manohar S. Kugaji, Kishore Bhat, Malleswara Rao Peram, Mater H. Mahnashi, Sameer J. Nadaf, Sheetalnath B. Rooge, Aejaz Abdullatif Khan, Ibrahim Ahmed Shaikh
Journal of Functional Biomaterials, 2022
Cancer stem cell traits in tumor spheres derived from primary laryngeal carcinoma cell lines
KishoreG Bhat, VijayMahadev Kumbar, UdayM Muddapur, HR Shwetha, ManoharS Kugaji, MalleswaraRao Peram, Santosh Dindawar
Contemporary Clinical Dentistry, 2021
Evaluation of anticancer and antioxidant activity of ethanolic extract of Ocimum sanctum on KB cell lines-an in-vitro study
Renuka Ammanagi, Vijayalakshmi Kotrashetti, Vijay Kumbar, Kishore Bhat, Sheethal Sanikop, Peram MR
Annals of Ayurvedic Medicine, 2021
Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis
Vijay M. Kumbar, Malleswara Rao Peram, Manohar S. Kugaji, Tejas Shah, Sanjivani P. Patil, Uday M. Muddapur, Kishore G. Bhat
Odontology, 2021
An rp-hplc method for quantitative analysis of linagliptin entrapped in nanotransfersomes and its application to skin permeation studies
Malleswara Rao Peram, Sachin R. Patil, Vijay M. Kumbar, Manohar S. Kugaji, Kishore G. Bhat, Prakash V. Diwan, Sunil Jalalpure
Current Pharmaceutical Analysis, 2021
Indirect Immunofluorescence and Tumorspheres Enrichment Technique for Identifying Cancer Stem Cell Markers in Cancer Cell Lines From Primary Oral Cancer Tissues: An In Vitro Study
Vijay M. Kumbar, Uday M. Muddapur, Kishore G. Bhat, Shwetha H.R., Manohar S. Kugaji, Malleswara Rao Peram
Journal of Advanced Oral Research, 2020
Comparison of Effects of Curcumin and Nano-curcumin on the Survival of Human-Derived Mesenchymal Stem Cells: An Experimental Study
Pinjari Hameeda, Sandeep Katti, Rajkishore Jammalamadugu, Kishore Bhatt, Malleswara Rao Peram, Vijay Kumbar
Journal of Advanced Oral Research, 2020
Variation in the occurrence of fima genotypes of porphyromonas gingivalis in periodontal health and disease
Manohar Kugaji, Uday Muddapur, Kishore Bhat, Vinayak Joshi, Manjunath Manubolu, Kavitha Pathakoti, Malleswara Rao Peram, Vijay Kumbar
International Journal of Environmental Research and Public Health, 2020
Quantitative Evaluation of Porphyromonas gingivalis in Indian Subjects With Chronic Periodontitis by Real-Time Polymerase Chain Reaction
Manohar S. Kugaji, Uday M. Muddapur, Kishore G. Bhat, Vinayak M. Joshi, Vijay M. Kumbar, Malleswara Rao Peram
Journal of Advanced Oral Research, 2019
Factorial design based curcumin ethosomal nanocarriers for the skin cancer delivery: in vitro evaluation
Malleswara Rao Peram, Sunil Jalalpure, Vijay Kumbar, Sachin Patil, Sumit Joshi, Kishore Bhat, Prakash Diwan
Journal of Liposome Research, 2019
Effect of Resveratrol on biofilm formation and virulence factor gene expression of Porphyromonas gingivalis in periodontal disease
Manohar S. Kugaji, Vijay M. Kumbar, Malleswara Rao Peram, Sanjivini Patil, Kishore G. Bhat, Prakash V. Diwan
APMIS, 2019
Development and validation of HPLC method to determine colchicine in pharmaceutical formulations and its application for analysis of solid lipid nanoparticles
Sumit Ashok Joshi, Sunil Satyappa Jalalpure, Amolkumar Ashok Kempwade, Malleswara Rao Peram
Current Pharmaceutical Analysis, 2018
Fabrication and in-vivo evaluation of lipid nanocarriers based transdermal patch of colchicine
Sumit Ashok Joshi, Sunil Satyappa Jalalpure, Amolkumar Ashok Kempwade, Malleswara Rao Peram
Journal of Drug Delivery Science and Technology, 2017
Single robust RP-HPLC analytical method for quantification of curcuminoids in commercial turmeric products, Ayurvedic medicines, and nanovesicular systems
Malleswara Rao Peram, Sunil S. Jalalpure, Sumit A. Joshi, Mahesh B. Palkar, Prakash V. Diwan
Journal of Liquid Chromatography and Related Technologies, 2017
Stability studies of pure and mixture form of curcuminoids by reverse phase-HPLC method under various experimental stress conditions
Malleswara R. Peram, Sunil S. Jalalpure, Mahesh B. Palkar, Prakash V. Diwan
Food Science and Biotechnology, 2017
Resolving identification issues of Saraca asoca from its adulterant and commercial samples using phytochemical markers
SandeepRamachandra Pai, Subarna Roy, Satisha Hegde, HarshaVasudev Hegde, SunilSatyappa Jalalpure, MalleswaraRao Peram
Pharmacognosy Magazine, 2017
Comparative TLC and RP-HPLC fingerprinting analysis of three sources of Mayurasikha: An ayurvedic drug
Indian Drugs, 2016
Chitosan encapsulated Curcumin nanoparticles as an effective drug delivery system for oral cancer treatment
Indian Drugs, 2015
Digestive diversity and kinetic intrigue among heated and unheated β-lactoglobulin species
Simon M. Loveday, Malleswara R. Peram, Harjinder Singh, Aiqian Ye, Geoffrey B. Jameson
Food and Function, 2014
In vitro gastric digestion of heat-induced aggregates of β-lactoglobulin
Malleswara R. Peram, Simon M. Loveday, Aiqian Ye, Harjinder Singh
Journal of Dairy Science, 2013
The role of high-resolution imaging in the evaluation of nanosystems for bioactive encapsulation and targeted nanotherapy
Kianoush Khosravi-Darani, Abbas Pardakhty, Hamid Honarpisheh, V.S.N. Malleswara Rao, M. Reza Mozafari
Micron, 2007
Microscopical investigations of nisin-loaded nanoliposomes prepared by Mozafari method and their bacterial targeting
Jean-Christophe Colas, Wanlong Shi, V.S.N. Malleswara Rao, Abdelwahab Omri, M. Reza Mozafari, Harjinder Singh
Micron, 2007
Buccoadhesive drug delivery system of isosorbide dinitrate: Formulation and evaluation
RC Doijad, FV Manvi, V.S.N Malleswara Rao, PS Patel
Indian Journal of Pharmaceutical Sciences, 2006
Sustained ophthalmic delivery of gatifloxacin from in situ gelling system
RC Doijad, FV Manvi, V.S.N Malleswara Rao, Prajakta Alase
Indian Journal of Pharmaceutical Sciences, 2006

RECENT SCHOLAR PUBLICATIONS

Sericin stabilized emulgel for improving therapeutic efficacy of quercetin in treatment of diabetic wound healing
A Burud, S Galatage, A Manjappa, A Salawi, S Nadaf, M Holam, S Harale, ...
Journal of Dispersion Science and Technology 47 (7), 1400-1420 , 2026
2026
Citations: 9
Eco-friendly fabrication and characterization of polyherbal silver nanoparticle-loaded shampoo with enhanced antibacterial efficacy for the topical management of scalp and hair …
PP Sunil T. Galatage, Arehalli S. Manjappa, Somnath D. Bhinge, Rama Rao ...
Next Nanotechnology 9, 100434 , 2026
2026
Implementation of Analytical Quality by Design (AQbD) in RP-HPLC Method Development for Quantification of Allopurinol in Pure and Commercial Formulations
MR Peram, A Kalungtkar, S Harale, S Galatage, V Suryadevara, ...
Current Pharmaceutical Analysis , 2026
2026
Phospholipid-Based Ultraflexible Nanovesicular Gel of Sertaconazole Nitrate for the Treatment of Skin Fungal Infections: Statistical Optimization, In Vitro and Preclinical …
MR Peram, SR Patil, V Suryadevara, SR Yarguntla, S Kamalakar, P Patil, ...
GELS 12 (4) , 2026
2026
Correction: Peram et al. Phospholipid-Based Ultraflexible Nanovesicular Gel of Sertaconazole Nitrate for the Treatment of Skin Fungal Infections: Statistical Optimization, In …
MR Peram, SR Patil, V Suryadevara, SR Yarguntla, S Kamalakar, P Patil, ...
Gels 12 (4), 275 , 2026
2026
Camptothecin loaded nano-ethanolic vesicles for the topical treatment of melanoma: Factorial design-based optimization, in vitro characterization and cell line studies
SS Harale, AS Manjappa, ST Galatage, SJ Nadaf, MR Peram, ...
Next Research 8, 101566 , 2026
2026
Therapeutic Targeting of Glioblastoma via Tumor-Suppressor miRNAs Delivered by Milk-Derived Exosomes
S Kotabagi, VM Kumbar, R Marakatti, T Janivarad, K Lolsure, M Kambi, ...
Journal of Drug Delivery Science and Technology 120, 108181 , 2026
2026
Prostate Specific Antigen (PSA): A critical biomarker in prostatic adenocarcinoma diagnosis and therapy
SR Patki, AS Manjappa, SS Pottabathula, ST Galatage, MR Peram, ...
Role of Biomarkers in Cancer Diagnosis and Therapeutics, 3-23 , 2026
2026
Deciphering the Mechanism of Curcumin-induced Apoptosis in Human Laryngeal Cancer: Involvement of MiRNA-203-Mediated Survivin Downregulation and Activation of the Mitochondrial …
VM Kumbar, MR Peram, S Rooge, MS Kugaji, S Ghagane, TY Mudaraddi, ...
Asian Journal of Pharmaceutical Research and Health Care 17 (4), 340-348 , 2025
2025
Phyto-fabrication and characterization of silver nanoparticles from Trachyspermum ammi (Ajwain) seeds and assessment of their antifungal activity
MR Peram, S Attimarad, VM Kumbar, V Suryadevara, C Adusumalli, ...
Indian Journal of Biochemistry and Biophysics (IJBB) 62 (12), 1429-1442 , 2025
2025
Citations: 1
Phospholipid-Based Ultraflexible Nanovesicular Gel of Sertaconazole Nitrate for the Treatment of Skin Fungal Infections: Statistical Optimization, In Vitro and Preclinical …
MR Peram, SR Patil, V Suryadevara, SR Yarguntla, S Kamalakar, P Patil, ...
gels 11 (11), 909 , 2025
2025
Citations: 3
Antimicrobial and Antibiofilm Activity of Curcumin Against Oral Pathogens: Potential for Periodontal Treatment
VM Kumbar, MR Peram, MS Kugaji, S Patil, M Kambimath, S Magennavar, ...
The Microbe 7, 100355 , 2025
2025
Citations: 5
Development of curcumin-loaded ultra deformable lipid vesicles for enhanced anti-melanoma activity: in vitro, ex-vivo, and cell line studies
MR Peram, V Suryadevara, S Patil, V Kunam, V Kumbar, P Babar, ...
Journal of Dispersion Science and Technology, 1-18 , 2025
2025
Citations: 8
BIO-CHEMICAL PROPERTIES OF CURCUMIN AND CURCUMIN ANALOGUE-2 AND CURCUMIN ANALOGUE-2 IN THE TREATMENT OF PERIODONTAL DISEASE.A NARRATIVE REVIEW
MRP Ramanarayana Boyapati, Ravindranath Dhulipalla, Chaitanya Adurty
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY 21 (2), 200-204 , 2025
2025
Experimental and theoretical investigation of thermodynamic and transport properties in binary mixtures at various temperatures (dibenzyl amine with 1-pentanol, 2-pentanol and …
MMKS G.S. Manukonda, Venkatarao V., Malleswararao P.S.V.N., Sambasiva Rao K.
Physics and Chemistry of Liquids 63 (4), 568-583 , 2025
2025
Citations: 1
Wound healing Potential of green synthesized silver nanoparticles of Glycyrrhiza glabra linn root extract: A Preclinical study
LS Vijapur, M Shalavadi, AR Desai, JN Hiremath, AS Gudigennavar, ...
Journal of Trace Elements and Minerals 11, 100214 , 2025
2025
Citations: 24
Green Synthesis of silver nanoparticles from clematis gouriana leaf extract: Physicochemical characterization and antibacterial activity determination for treatment of blood …
V Yadav, ST Galatage, AS Manjappa, A Salawi, MR Peram, SJ Nadaf, ...
The Microbe 5, 100197 , 2024
2024
Citations: 22
Acitretin-loaded nanoethosomal gel for the treatment of psoriasis: Formulation, optimization, in vitro, and in vivo assessment
MR Peram, C Dhananjay, N Chandrasekhar, VM Kumbar, V Suryadevara, ...
Journal of Dispersion Science and Technology 46 (1), 44-61 , 2024
2024
Citations: 13
Formulation, Optimization, and Antioxidant Evaluation of Tetrahydrocurcumin-Loaded Ultradeformable Nanovesicular Cream
A Kanshide, MR Peram, N Chandrasekhar, A Jamadar, V Kumbar, ...
Journal of Pharmaceutical Innovation 18, 980-998 , 2023
2023
Citations: 14
Formulation, Optimization, and Evaluation of Ultradeformable Nanovesicles for Effective Topical Delivery of Hydroquinone
AT Jamadar, MR Peram, N Chandrasekhar, A Kanshide, VM Kumbar, ...
Journal of Pharmaceutical Innovation 18 (2), 506-524 , 2023
2023
Citations: 19

MOST CITED SCHOLAR PUBLICATIONS

Microscopical investigations of nisin-loaded nanoliposomes prepared by Mozafari method and their bacterial targeting
JC Colas, W Shi, VSNM Rao, A Omri, MR Mozafari, H Singh
Micron 38 (8), 841-847 , 2007
2007
Citations: 277
In vitro gastric digestion of heat-induced aggregates of β-lactoglobulin
MR Peram, SM Loveday, A Ye, H Singh
Journal of dairy science 96 (1), 63-74 , 2013
2013
Citations: 180
Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis.
VM Kumbar, MR Peram, MS Kugaji, T Shah, SP Patil, U Mudapur, ...
Odontology 109 (1), 18-28 , 2021
2021
Citations: 133
Factorial design based curcumin ethosomal nanocarriers for the skin cancer delivery: in vitro evaluation
MR Peram, S Jalalpure, V Kumbar, S Patil, S Joshi, K Bhat, P Diwan
Journal of liposome research 29 (3), 291-311 , 2019
2019
Citations: 114
The role of high-resolution imaging in the evaluation of nanosystems for bioactive encapsulation and targeted nanotherapy
K Khosravi-Darani, A Pardakhty, H Honarpisheh, VSNM Rao, ...
Micron 38 (8), 804-818 , 2007
2007
Citations: 111
Effect of Resveratrol on biofilm formation and virulence factor gene expression of Porphyromonas gingivalis in periodontal disease
MS Kugaji, VM Kumbar, MR Peram, S Patil, KG Bhat, PV Diwan
Apmis 127 (4), 187-195 , 2019
2019
Citations: 92
Sustained ophthalmic delivery of gatifloxacin from in situ gelling system
RC Doijad, FV Manvi, VSNM Rao, P Alase
Indian Journal of Pharmaceutical Sciences 68 (6), 814-816 , 2006
2006
Citations: 79
Buccoadhesive drug delivery system of isosorbide dinitrate: Formulation and evaluation
RC Doijad, FV Manvi, V Rao, PS Patel
Indian journal of pharmaceutical sciences 68 (6), 744 , 2006
2006
Citations: 75
Single robust RP-HPLC analytical method for quantification of curcuminoids in commercial turmeric products, Ayurvedic medicines, and nanovesicular systems
MR Peram, SS Jalalpure, SA Joshi, MB Palkar, PV Diwan
Journal of Liquid Chromatography & Related Technologies 40 (10), 487-498 , 2017
2017
Citations: 57
Stability studies of pure and mixture form of curcuminoids by reverse phase-HPLC method under various experimental stress conditions
MR Peram, SS Jalalpure, MB Palkar, PV Diwan
Food Science and Biotechnology 26 (3), 591-602 , 2017
2017
Citations: 48
Fabrication and in-vivo evaluation of lipid nanocarriers based transdermal patch of colchicine
SA Joshi, SS Jalalpure, AA Kempwade, MR Peram
Journal of drug delivery science and technology 41, 444-453 , 2017
2017
Citations: 42
Curcumin-encapsulated nanomicelles improve cellular uptake and cytotoxicity in cisplatin-resistant human oral cancer cells
VM Kumbar, U Muddapur, A Bin Muhsinah, SA Alshehri, MM Alshahrani, ...
Journal of Functional Biomaterials 13 (4), 158 , 2022
2022
Citations: 37
Resolving identification issues of Saraca asoca from its adulterant and commercial samples using phytochemical markers
SR Satisha Hegde, Harsha Vasudev Hegde, Sunil Satyappa Jalalpure, Malleswara ...
Pharmacognosy Magazine 13 (50), 266-272 , 2017
2017
Citations: 35
Cancer stem cell traits in tumor spheres derived from primary laryngeal carcinoma cell lines
VM Kumbar, UM Muddapur, KG Bhat, HR Shwetha, MS Kugaji, MR Peram, ...
Contemporary Clinical Dentistry 12 (3), 247-254 , 2021
2021
Citations: 28
Development and validation of HPLC method to determine colchicine in pharmaceutical formulations and its application for analysis of solid lipid nanoparticles
SA Joshi, SS Jalalpure, AA Kempwade, MR Peram
Current Pharmaceutical Analysis 14 (1), 76-83 , 2018
2018
Citations: 25
Wound healing Potential of green synthesized silver nanoparticles of Glycyrrhiza glabra linn root extract: A Preclinical study
LS Vijapur, M Shalavadi, AR Desai, JN Hiremath, AS Gudigennavar, ...
Journal of Trace Elements and Minerals 11, 100214 , 2025
2025
Citations: 24
Green Synthesis of silver nanoparticles from clematis gouriana leaf extract: Physicochemical characterization and antibacterial activity determination for treatment of blood …
V Yadav, ST Galatage, AS Manjappa, A Salawi, MR Peram, SJ Nadaf, ...
The Microbe 5, 100197 , 2024
2024
Citations: 22
Variation in the Occurrence of fimA Genotypes of Porphyromonas gingivalis in Periodontal Health and Disease
M Kugaji, U Muddapur, K Bhat, V Joshi, M Manubolu, K Pathakoti, ...
International Journal of Environmental Research and Public Health 17 (6), 1826 , 2020
2020
Citations: 22
Digestive diversity and kinetic intrigue among heated and unheated β-lactoglobulin species
SM Loveday, MR Peram, H Singh, A Ye, GB Jameson
Food & function 5 (11), 2783-2791 , 2014
2014
Citations: 22
Formulation, Optimization, and Evaluation of Ultradeformable Nanovesicles for Effective Topical Delivery of Hydroquinone
AT Jamadar, MR Peram, N Chandrasekhar, A Kanshide, VM Kumbar, ...
Journal of Pharmaceutical Innovation 18 (2), 506-524 , 2023
2023
Citations: 19

V S N Malleswara Rao Peram

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