Tailoring Cu immobilized MCM-41-based mesostructured catalysts for selective hydrogenolysis of biomass-derived furfural Leela Prasad Yandrati, Swamy Sekhar Kaladi, Raveendra Gundeboyina, Ramakrishna Pothu, Vijaya Moli, B. Venkateswara Rao, Rajender Boddula, Rammohanrao Devulapalli, Harisekhar Mitta Catalysis Communications, 2024 The CuO-supported MCM-41 catalysts were prepared using a simple incipient wet impregnation method. The catalysts were investigated for hydrogenation of furfural to furfuryl alcohol synthesis. Among all the catalysts, the 2.5% CuO/MCM-41 catalyst shows the best catalytic performance with 92.5% conversion and 89% selectivity of furfuryl alcohol at 210 °C. The catalyst also demonstrated a high turnover frequency (TOF) of 154.4 h−1. The 2.5% CuO/MCM-41 catalyst remained stable for up to 20 h during the time on stream.
Introduction and Background of MXenes Srikanth Ponnada, Sarita Yadav, Demudu Babu Gorle, Indu Kumari, Battula Venkateswara Rao, Rakesh K. Sharma Mxene Nanocomposites Design Fabrication and Shielding Applications, 2023 MXenes are a family of two-dimensional inorganic compounds. These materials, discovered in 2011 by Prof. Yury Gogotsi's and Prof. Michel Barsoum's research groups at Drexel University, consist of a-few-atoms-thick layers of transition-metal carbides, nitrides and carbonitrides. MXenes exhibit a special combination of metallic conductivity of transition-metal carbides or nitrides and high hydrophilic nature of their hydroxyl- or oxygen-functional group terminated surfaces. MXenes are prepared via HF (hydrofluoric acid) etching of MAX phases, which includes a large family of ternary compounds consisting of transition metal (M), an A-group element (A) and a carbon and/or nitrogen (X). This chapter focuses on detailed introduction and background of different types of MXenes and their structures and properties.
Rapid Synthesis of 1-Aryl-3, 3-dimethyltriazenes by Using In Situ Generated Aryldiazonium Tetrafluoroborate Salts with “DMF-DMA” under Ambient Conditions Rajesh Akkineni, Sarma V. Markandeya, Avvari N. Prasad, Bhaskar Yamajala, Venkateswara Rao B, Shankar Chaudhari, Deepak Kumar, Sandip T. Gadge, Bhalchandra M. Bhanage Chemistryselect, 2022 Abstract An efficient and rapid method of synthesizing 1–3,3‐dimethyl triazenes has been developed. This method involves utilizing in situ generated aryldiazonium tetrafluoroborate salts using substituted aryl amines with “DMF‐DMA” (N,N‐Dimethylformamide‐dimethyl acetal) at room temperature. This reaction achieved good to excellent yields (68–95 %) under ambient conditions with a significantly faster rate. The proposed reaction was screened with various withdrawing, donating, and neutral groups containing aryldiazonium salts, and obtained products were confirmed by 1 H, 13 C NMR and mass spectroscopy techniques.
A novel stability-indicating HPLC method for the determination of enantiomeric purity of eluxadoline drug: Amylose tris(3,5-dichlorophenyl carbamate) stationary phase Sudhakar Yerra, Hemantkumar Sharma, Sreenivasulu B, Mohana Naidu K, Venkateswara Rao B Biomedical Chromatography, 2022 A simple and sensitive stability indicating chiral HPLC method has been developed and validated as per ICH guidelines for the determination of enantiomeric purity of Eluxadoline drug substance. The impact of different mobile phase compositions and CSP's on the separation of Eluxadoline enantiomer along with process and degradation related impurities have been studied. Homogeneity of Eluxadoline and stable results of Eluxadoline enantiomer in all degraded samples reveals the fact that the proposed method was specific (stability indicating). Amylose tris (3,5-dichlorophenyl carbamate) stationary phase column Chiralpak IE-3(150mm x 4.6mm), 3μm give better resolution with polar organic solvents than cellulose derivative, crown ether and zwitterion stationary phases and non-polar solvents. Mobile phase consisted of acetonitrile, tetrahydrofuran, methanol, butylamine and acetic acid in the ratio of 500:500:20:2:1.5 v/v/v/v/v. Isocratic elution was performedat a flow rate of 1.0 mL/min, 35°C column temperature, 10 μl injection volume and 240 nm UV detection. The USP resolution of Eluxadoline enantiomers was found to be more than 4.0 within 65mins run time. Eluxadoline enantiomer detector response linearity over the concentration range of 0.859-4.524 μg/mL was found to be R2 =0.9985. LOD and LOQ and average %recovery values were established as 0.283 μg/mL, 0.859μg/mL and 96.0, respectively.
A new facile synthesis of (2S,5S)-5-hydroxypipecolic acid hydrochloride Avula Mahesh Kumar, Rapolu Venkateshwarlu, Krishnaji Tadiparthi, B. Venkateswara Rao, Shiva Kumar Kota Balaji, Akula Raghunadh, Shambhu Nath Singh Synthetic Communications, 2022 A simple and efficient synthesis of (2S,5S)-5-Hydroxypipecolic acid hydrochloride is reported. The key features of the synthesis involve the asymmetric reduction of ketone using (S)-CBS oxazaborolidine and the use of commercially available methyl pyroglutamate as a starting material.
A novel reverse phase hplc method for the quantification of potential genotoxic impurities in doripenem monohydrate: A broad-spectrum carbapenem antibiotic drug Sudhakar Yerra, P.N. Kishore Babu, B. Sreenivasulu, Hemant Kumar Sharma, K. Mohana Naidu, B. Venkateswara Rao Asian Journal of Chemistry, 2021 A novel sensitive gradient reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the quantification of potential genotoxic impurities in doripenem monohydrate (DORIBAX) drug substance, namely mono-p-nitrobenzyl malonate, 1β-methyl bicyclic ketoester, desilylated β-keto ester, 1β-methyldiazoazetidinone, deprotected doripenem side chain, N-protected mercapto alcohol, protected doripenem and doripenem side chain. The analysis performed on Alliance Waters e2695 separation module on C18 (250 × 4.6) mm, 5 μm (make: Inertsil) column, oven temperature maintained at 40 ºC and UV detection at 270 nm. The separation was accomplished using buffer (pH 6.0 ± 0.05) and acetonitrile in the ratio of 98:2 v/v as mobile phase-A and acetonitrile as mobile phase-B, flow rate: 1.0 mL/min and injection volume: 50 μL. The proposed method was validated as per ICH guidelines in terms of limit of detection (LOD), limit of quantification (LOQ), linearity, precision, accuracy and specificity.
A novel approach for the synthesis of functionalized hydroxylamino derivative of dihydroquinazolinones Chikkanti Jaganmohan, Vinay Kumar K. P., Venkateshwarlu R., Sandeep Mohanty, Jaydeep Kumar, Venkateswara Rao B., Akula Raghunadh, Krishnaji Tadiparthi Synthetic Communications, 2020 A new metal-free and modular approach for the synthesis of various functionalized dihydroquinazolinones has been developed from isatoic anhydride, amines, 4-chloro-N-hydroxybenzimidoylchloride to yield up to 71%. The reaction has been screened in various bases, solvents at different temperatures. The substrate scope of the reaction has been studied with various amines and the possible reaction mechanism for this reaction has also been proposed. Graphical Abstract
In situ FTIR spectroscopic monitoring of the formation of the arene diazonium salts and its applications to the heck-matsuda reaction K. Sateesh Reddy, Bandi Siva, S. Divya Reddy, N. Reddy Naresh, T. V. Pratap, B. Venkateswara Rao, Yi-An Hong, B. Vijaya Kumar, A. Krishnam Raju, P. Muralidhar Reddy, Anren Hu Molecules, 2020 This study depicts the use of a fiber-optic coupled Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) probe for the in-depth study of arene diazonium salt formation and their utilization in the Heck–Matsuda reaction. The combination of these chemical reactions and in situ IR spectroscopy enabled us to recognize the optimum parameters for arene diazonium salt formation and to track the concentrations of reactants, products and intermediates under actual reaction conditions without time consuming HPLC analysis and the necessity of collecting the sample amid the reaction. Overall advantages of the proposed methodology include precise reaction times as well as identification of keto enol tautomerization in allylic alcohols supporting the ‘path a’ elimination mechanism in the Heck–Matsuda reaction.
Synthesis of 1-((5-oxo-4,5-Dihydro-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-3-carboxylic Acid-Application of Antibacterial activity Manuri Brahmayya, Dasi Samsonu, Alaparthi Venkateswara Rao, Nelli Srinivasa Rao, Battula Venkateswara Rao, Huan-Jung Fan Proceedings of the National Academy of Sciences India Section A Physical Sciences, 2019 Synthesis of 1-((5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl) methyl)-1H-1,2,4-triazole-3-carboxylic acid was accomplished starting with the commercially available 1,2,4-triazole-3-carboxylic acid. The conversion of hydrazide and carbon dioxide to 1,3,4-oxadiazole has been explained. Antibacterial activity also studied for some synthesized compounds.
A novel stability indicating RP-HPLC method development and validation for the determination of valsartan and hydrochlorothiazide in bulk and pharmaceutical formulations Indian Drugs, 2017
Evaluation of in-vivo anti-diarrheal and cytotoxic activity of ethanolic extract of Alsotinia scholoris leaves International Journal of Pharmaceutical Sciences Review and Research, 2016
A novel stability indicating RP-HPLC method development and validation for the determination of nebivolol and indapamide in bulk and pharmaceutical formulations Indian Drugs, 2016
A modified liquid chromatographic method development and validation for simultaneous estimation of atazanavir and ritonavir in bulk and tablet dosage form Der Pharmacia Lettre, 2016
Synthesis of 2-(1,3-substituted - 1H-pyrazol-4-y1)-1H-benzo(d)oxazoles by using ammonium chloride; as a mild and efficient catalyst International Journal of Pharma and Bio Sciences, 2016
Synthesis, biological evaluation of a novel derivative of ciprofloxacin and its method development and validation by UV spectroscopic method Der Pharmacia Lettre, 2016
Comparative hypoglycemic study of Aloe vera, Murraya koenigii and Azadirachta indica International Journal of Pharmacognosy and Phytochemical Research, 2015
Efficient one-pot synthesis of multi-substituted triazolopyrimidines by using DBU as basic catalyst via MCR's Der Pharma Chemica, 2015
Synthesis of 5-(3-aryl-1-phenyl-1H-pyrazol-4-y1)-1H-tetrazole byusing AgNo3 catalyst Der Pharma Chemica, 2015
Cytogenetic activity studies on some mangroves of Krishna-Godavari Estuary International Journal of Pharma and Bio Sciences, 2014
RP-HPLC method development and validation for the simultaneous estimation of metformin and sitagliptin in bulk and pharmaceutical formulations Der Pharmacia Lettre, 2014
Validated RP-HPLC method for the simultaneous estimation of atorvastain and ezetimibe in pure and pharmaceutical formulations Der Pharmacia Lettre, 2014
Synthesis and antifungal studies of bis-mono and difluorophenacyl azolium compounds Der Pharma Chemica, 2014
Multi component, one-pot synthesis of (1-(4-(1H-imidazol-1-yl) phenyl)-1, 2-dihydronaptho[1, 2-e] [1, 3]-3-thione and 3-one derivatives under microwaveassisted conditions Der Pharma Chemica, 2013
Zinc dimethylglyoxime complexes Der Pharma Chemica, 2013
UV spectrophotometic validation for identification and determination of losartan potassium in tablets International Journal of Pharmacy and Technology, 2012
RP-HPLC method development and validation for the determination of palonosetron hydrochloride International Journal of Pharmacy and Technology, 2012
Synthesis and antioxidant activity of Galloyltyrosine, derivatives from young leaves of Inga laurina International Journal of Pharma and Bio Sciences, 2011
First total synthesis of three anti-tyrosinase activity prenylated flavanones from dalea boliviana Journal of Chemical and Pharmaceutical Research, 2011
Synthesis and bioactivity evaluation of cinnamic acid esters from Oxalis pes-caprace Journal of Chemical and Pharmaceutical Research, 2011
Chemical constituents of Rhizophora mucronata of Andaman and Nicobar Islands Journal of the Indian Chemical Society, 2005
