Management Information Systems, Management Science and Operations Research, General Decision Sciences
9
Scopus Publications
179
Scholar Citations
5
Scholar h-index
5
Scholar i10-index
Scopus Publications
Interactions Among Circadian Rhythms, Aging, and Neurodegenerative Diseases Shampa Ghosh, Krishna Kumar Singh, Prashant Verma, Amit Kumar Pandey, Jitendra Kumar Sinha Alzheimer S and Dementia, 2025 Background Circadian rhythms are critical homeostatic mechanisms in biological systems, regulating a wide range of physiological processes including metabolism, endocrinology, and cognitive functions. In most individuals, these rhythms are significantly altered with aging, such as reduced variability in sleep‐wake cycles and changes in their timing. These disruptions can accelerate age‐related physiological decline, which is associated with increased oxidative stress and inflammatory responses. It is assumed that relationships between circadian mechanisms and aging processes determine the onset and progression of neurodegenerative disorders. Method This work synthesizes current research on the physiological role of circadian rhythms and their modulation with advancing age. It examines how age‐associated circadian disruptions contribute to neurodegenerative diseases by altering metabolic and physiological pathways. The focus is on reviewing literature that connects circadian health with neurodegeneration through biological clocks' regulation of redox balance and other metabolic functions. Result The evidence from research shows that age‐related disruptions in circadian rhythms not only predispose individuals to neurodegenerative diseases but also promote the rate of disease progression. This disruption leads to deregulation in antioxidative and inflammatory responses, affecting neuronal health and functionality. Age‐related changes in circadian control are known to affect cognitive and emotional behaviors, critical in neurodegenerative diseases like Alzheimer's and Parkinson's disease. Conclusion Understanding complex relationships of circadian rhythmicity with the process of aging is essential in designing adequate interventions to delay the emergence and severity of neurodegenerative diseases. Through this review, it should be possible to identify pathways where circadian disruption intervention could be valuable in allowing healthier aging to prevent, at least partially, or even delay onset or development of neurodegenerative diseases. Further studies into circadian biology in the context of aging could open the gates for novel preventions and therapy that enhances life quality in elderly populations.
Sleep and Immune System Crosstalk: Implications for Inflammatory Homeostasis and Disease Pathogenesis Krishna Kumar Singh, Shampa Ghosh, Anisha Bhola, Prashant Verma, Aparajita Dasgupta Amist, Hitaishi Sharma, Punya Sachdeva, Jitendra Kumar Sinha Annals of Neurosciences, 2025 Background Sleep and immune function are interconnected aspects of health that mutually impact each other in disease development and inflammatory homeostasis. Different aspects of immunology are regulated by different sleep characteristics, impacting on specific aspects of immune function including cytokine production and T-cell activity. Ongoing disruptions of sleep have been linked to heightened inflammation and are suspected in the pathogenesis and disease course of a range of life-style-related illnesses, including diabetes and neurodegenerative diseases. Summary This review provides a comprehensive overview of knowledge on the interaction of sleep with the immune system, its modulation of inflammatory balance, and the pathogenesis of many diseases. It emphasizes how sleep deficiency compromises immune function by means of a systemic, low-grade inflammatory response, while adequate sleep promotes intense immune responses and thus enables efficient pathogen clearance and the maintenance of immune memory. The mutual influence of sleep on the immune system underlines its critical involvement in health preservation and the course of disease. Key Message Sleep plays an indispensable role in immune health, mediating the efficiency of immune responses and the course of the regulation of inflammation. Chronic sleep deprivation can result in a low-grade inflammation that substantially contributes to the onset and exacerbation of metabolic and neurodegenerative disorders. The intimate linkage between sleep and immune function can be one strategic approach to therapy, improving health outcomes by leveraging this sleep-immune connection.
Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes Sajal Raj Singh, Rakesh Bhaskar, Shampa Ghosh, Bhuvaneshwar Yarlagadda, Krishna Kumar Singh, Prashant Verma, Sonali Sengupta, Mitko Mladenov, Nikola Hadzi-Petrushev, Radoslav Stojchevski, Jitendra Kumar Sinha, Dimiter Avtanski Cancers, 2025 Cancer is complex because of the critical imbalance in genetic regulation as characterized by both the overexpression of oncogenes (OGs), mainly through mutations, amplifications, and translocations, and the inactivation of tumor-suppressor genes (TSGs), which entail the preservation of genomic integrity by inducing apoptosis to counter the malignant growth. Reviewing the intricate molecular interplay between OGs and TSGs draws attention to their cell cycle, apoptosis, and cancer metabolism regulation. In the present review, we discuss seminal discoveries, such as Knudson’s two-hit hypothesis, which framed the field’s understanding of cancer genetics, leading to the next breakthroughs with next-generation sequencing and epigenetic profiling, revealing novel insights into OG and TSG dysregulation with opportunities for targeted therapy. The key pathways, such as MAPK/ERK, PI3K/AKT/mTOR, and Wnt/β-catenin, are presented in the context of tumor progression. Importantly, we further highlighted the advances in therapeutic strategies, including inhibitors of KRAS and MYC and restoration of TSG function, despite which mechanisms of resistance and tumor heterogeneity pose daunting challenges. A high-level understanding of interactions between OG-TSGs forms the basis for effective, personalized cancer treatment—something to strive for in better clinical outcomes. This synthesis should integrate foundational biology with translation and, in this case, contribute to the ongoing effort against cancer.
Translational Advances in Oncogene and Tumor-Suppressor Gene Research Radoslav Stojchevski, Edward Agus Sutanto, Rinni Sutanto, Nikola Hadzi-Petrushev, Mitko Mladenov, Sajal Raj Singh, Jitendra Kumar Sinha, Shampa Ghosh, Bhuvaneshwar Yarlagadda, Krishna Kumar Singh, Prashant Verma, Sonali Sengupta, Rakesh Bhaskar, Dimiter Avtanski Cancers, 2025 Cancer, characterized by the uncontrolled proliferation of cells, is one of the leading causes of death globally, with approximately one in five people developing the disease in their lifetime. While many driver genes were identified decades ago, and most cancers can be classified based on morphology and progression, there is still a significant gap in knowledge about genetic aberrations and nuclear DNA damage. The study of two critical groups of genes—tumor suppressors, which inhibit proliferation and promote apoptosis, and oncogenes, which regulate proliferation and survival—can help to understand the genomic causes behind tumorigenesis, leading to more personalized approaches to diagnosis and treatment. Aberration of tumor suppressors, which undergo two-hit and loss-of-function mutations, and oncogenes, activated forms of proto-oncogenes that experience one-hit and gain-of-function mutations, are responsible for the dysregulation of key signaling pathways that regulate cell division, such as p53, Rb, Ras/Raf/ERK/MAPK, PI3K/AKT, and Wnt/β-catenin. Modern breakthroughs in genomics research, like next-generation sequencing, have provided efficient strategies for mapping unique genomic changes that contribute to tumor heterogeneity. Novel therapeutic approaches have enabled personalized medicine, helping address genetic variability in tumor suppressors and oncogenes. This comprehensive review examines the molecular mechanisms behind tumor-suppressor genes and oncogenes, the key signaling pathways they regulate, epigenetic modifications, tumor heterogeneity, and the drug resistance mechanisms that drive carcinogenesis. Moreover, the review explores the clinical application of sequencing techniques, multiomics, diagnostic procedures, pharmacogenomics, and personalized treatment and prevention options, discussing future directions for emerging technologies.
Neuroprotective Potential of Free Radical-Scavenging Nanoparticles in Addressing Inflammation and Obesity Shampa Ghosh, Rakesh Bhaskar, Krishna Kumar Singh, Bhuvaneshwar Yarlagadda, Prashant Verma, Sung Soo Han, Shiv Dutt Purohit, Jitendra Kumar Sinha Iet Nanobiotechnology, 2025 Neuroprotection is well known for its strategies and interventions that help preserve the structure and function of neurons during a myriad of neurological challenges. It is fundamental in managing the complex relationship between neuroinflammation and obesity, both of which are significant factors affecting our neurological health. In the present review, we try to merge nanoparticles with artificial intelligence (AI) to tackle the neurological implications of both conditions. This review summarizes prior studies of free radical‐scavenging nanoparticles: polymeric, liposomal, ceria‐based, and quantum dots, and evaluates their reported efficacy in attenuating markers of neuroinflammation and neuronal dysfunction in preclinical models. We have also discussed AI applications, such as predictive modeling and real‐time monitoring, stating that they present a complementary role in themselves. There is recognition that the promise of nanoparticles in mitigating neurological problems underscores the potential of AI in upgrading neuroprotection. Early‐phase clinical trials of free radical‐scavenging nanoparticles have highlighted the importance of patient stratification to optimize personalized treatment regimens. Furthermore, we advocate coordinated efforts in education, awareness, and research to integrate scientific findings, public policy, and technology innovation, thereby holistically addressing neuroinflammation and obesity at the individual level.
Skills Augmenting Online Shopping Behavior: A Study of Need for Cognition Positive Segment Prashant Verma, Shruti Jain Business Perspectives and Research, 2015 The present study takes into account “need for cognition” (NFC), which represents the tendency of individuals to engage in and enjoy thinking. The NFC has been described as the need to structure relevant situation into meaningful, integrated ways and a need to understand and make a reasonable understanding of the experiential world. The article attempts to identify the specific skill dimensions, which operate in respondents who shop online and are positive on NFC, and try to seek difference in online shopping behavior of the respondents with different level of these skills. Principal Component Analysis, ANOVA, and confirmatory factor analysis were the statistics used in the study. Six factors were identified explaining dimensions operating in NFC positive segment, namely, preference for being advance user, confident user of latest in information technology, using it as tool for knowledge exploration, ability to assess behavior of program, efficient end user and knowledge of hardware. Significant difference in online shopping behavior was identified for users having skills clubbed under the dimension of confident user of latest in information technology.
Fix factor structure of online shopping skills in NFC positive segment consumers Prashant Verma, Shruti Jain International Journal of Cyber Behavior Psychology and Learning, 2014 This article attempts to identify dimensions of online shopping skills, which operate in respondents positive on need for cognition (NFC). Both EFA and CFA suggests six factors; preference for being advance user, confident user of latest in information technology, using IT as tool for knowledge exploration, ability to assess behaviour of program, efficient end user and knowledge of hardware. Respondent under ‘confident users of latest in information technology' has shown significant difference in online shopping behaviour.
Organisational Role Stress among Women in the Private Sector Shalini Srivastava, Prashant Verma Management and Labour Studies, 2008 Employees, who are married, are part of a family with members having at least two different careers and influence of at least two different organisations. In the context of married women employees it is increasingly difficult for them to find time to fulfil their commitment towards home, spouse, children, parents and friends. They are increasingly recognizing that work is infringing on their personal lives, and they are not happy about it. Recent studies suggest that employees want jobs that give them flexibility in their work schedules or work culture which facilitates better management of work-life conflicts. Organisations now often find women employee a part of their best performing teams, if they cannot be helped to achieve work-life balance, it will become increasingly difficult for management to attract and retain this human resource, which otherwise are capable and motivated. The present study intends to identify the major causes and remedies of work-life conflict which a working married woman face in the current scenario. It also intends to evaluate the importance of family-friendly work arrangements towards a joyful organisation. This paper attempts to investigate the intensity of organisational role stress which a married woman perceives as compared to an unmarried one. It further attempts to study the differences in the level of stress between married and unmarried women on several role stressors.
RECENT SCHOLAR PUBLICATIONS
Microglia's Dual Edge: Balancing Neuroprotection and Neurotoxicity in Health, Neurodegeneration, and Neuropsychiatric Disorders JK Sinha, KK Singh, P Verma, M Mahapatra, S Ghosh Alzheimer's & Dementia 21, e096620 , 2025 2025
Sleep and immune system crosstalk: implications for inflammatory homeostasis and disease pathogenesis KK Singh, S Ghosh, A Bhola, P Verma, AD Amist, H Sharma, P Sachdeva, ... Annals of Neurosciences 32 (3), 196-206 , 2025 2025 Citations: 58
Exploring the genetic orchestra of cancer: the interplay between oncogenes and tumor-suppressor genes SR Singh, R Bhaskar, S Ghosh, B Yarlagadda, KK Singh, P Verma, ... Cancers 17 (7), 1082 , 2025 2025 Citations: 43
Translational advances in oncogene and tumor-suppressor gene research R Stojchevski, EA Sutanto, R Sutanto, N Hadzi-Petrushev, M Mladenov, ... Cancers 17 (6), 1008 , 2025 2025 Citations: 20
Neuroprotective Potential of Free Radical‐Scavenging Nanoparticles in Addressing Inflammation and Obesity S Ghosh, R Bhaskar, KK Singh, B Yarlagadda, P Verma, SS Han, ... IET nanobiotechnology 2025 (1), 6805313 , 2025 2025 Citations: 1
Hierarchical Healthcare Facility Location at the Subdistrict Level in Western Uttar Pradesh: A Heuristic Approach P Verma, S Datta Advances in Social Sciences Research Journal 8 (4) , 2021 2021
Critical success factors for better healthcare: an MCDM approach P Verma, S Dutta International Journal of Technology Marketing 15 (2-3), 287-315 , 2021 2021 Citations: 3
Is Volatility Uniform Across the Stock Market? Evidences from Select Indices of NSE P Sarkar, S., & Verma NMIMS Management Review 29, 23-51 , 2016 2016 Citations: 2
A Study of Factors Driving Indian Youth's Intention to Purchase Online S Jain, P Verma Online] Accessed May 2, 2018 , 2016 2016 Citations: 3
Skills augmenting online shopping behavior: A study of need for cognition positive segment P Verma, S Jain Business Perspectives and Research 3 (2), 126-145 , 2015 2015 Citations: 32
Fix factor structure of online shopping skills in nfc positive segment consumers P Verma, S Jain International Journal of Cyber Behavior, Psychology and Learning (IJCBPL) 4 … , 2014 2014 Citations: 2
A study of general role stress among IT/ITeS professional in India S Bhatt, P Verma Asia Pacific Business Review 4 (1), 105-114 , 2008 2008 Citations: 15
A Study of Mental Well Being and Academic Anxiety among School Children In Relation to their Emotional Intelligence. P Verma, S., Sharma, V., & Verma MINDSCAPES-Global Perspectives on Psychology in Mental Health. Bangalore … , 2007 2007
Food Grain Production in India and its Significance in GDP P Verma, A Varma Journal of Management Development and Information Technology 4 , 2006 2006
An Analysis of Problems Faced by Private Professional Institutions of Western U.P. N Gupta, P Verma Indian Journal of Technical Education 28 (2) , 2005 2005
MOST CITED SCHOLAR PUBLICATIONS
Sleep and immune system crosstalk: implications for inflammatory homeostasis and disease pathogenesis KK Singh, S Ghosh, A Bhola, P Verma, AD Amist, H Sharma, P Sachdeva, ... Annals of Neurosciences 32 (3), 196-206 , 2025 2025 Citations: 58
Exploring the genetic orchestra of cancer: the interplay between oncogenes and tumor-suppressor genes SR Singh, R Bhaskar, S Ghosh, B Yarlagadda, KK Singh, P Verma, ... Cancers 17 (7), 1082 , 2025 2025 Citations: 43
Skills augmenting online shopping behavior: A study of need for cognition positive segment P Verma, S Jain Business Perspectives and Research 3 (2), 126-145 , 2015 2015 Citations: 32
Translational advances in oncogene and tumor-suppressor gene research R Stojchevski, EA Sutanto, R Sutanto, N Hadzi-Petrushev, M Mladenov, ... Cancers 17 (6), 1008 , 2025 2025 Citations: 20
A study of general role stress among IT/ITeS professional in India S Bhatt, P Verma Asia Pacific Business Review 4 (1), 105-114 , 2008 2008 Citations: 15
Critical success factors for better healthcare: an MCDM approach P Verma, S Dutta International Journal of Technology Marketing 15 (2-3), 287-315 , 2021 2021 Citations: 3
A Study of Factors Driving Indian Youth's Intention to Purchase Online S Jain, P Verma Online] Accessed May 2, 2018 , 2016 2016 Citations: 3
Is Volatility Uniform Across the Stock Market? Evidences from Select Indices of NSE P Sarkar, S., & Verma NMIMS Management Review 29, 23-51 , 2016 2016 Citations: 2
Fix factor structure of online shopping skills in nfc positive segment consumers P Verma, S Jain International Journal of Cyber Behavior, Psychology and Learning (IJCBPL) 4 … , 2014 2014 Citations: 2
Neuroprotective Potential of Free Radical‐Scavenging Nanoparticles in Addressing Inflammation and Obesity S Ghosh, R Bhaskar, KK Singh, B Yarlagadda, P Verma, SS Han, ... IET nanobiotechnology 2025 (1), 6805313 , 2025 2025 Citations: 1
Microglia's Dual Edge: Balancing Neuroprotection and Neurotoxicity in Health, Neurodegeneration, and Neuropsychiatric Disorders JK Sinha, KK Singh, P Verma, M Mahapatra, S Ghosh Alzheimer's & Dementia 21, e096620 , 2025 2025
Hierarchical Healthcare Facility Location at the Subdistrict Level in Western Uttar Pradesh: A Heuristic Approach P Verma, S Datta Advances in Social Sciences Research Journal 8 (4) , 2021 2021
A Study of Mental Well Being and Academic Anxiety among School Children In Relation to their Emotional Intelligence. P Verma, S., Sharma, V., & Verma MINDSCAPES-Global Perspectives on Psychology in Mental Health. Bangalore … , 2007 2007
Food Grain Production in India and its Significance in GDP P Verma, A Varma Journal of Management Development and Information Technology 4 , 2006 2006
An Analysis of Problems Faced by Private Professional Institutions of Western U.P. N Gupta, P Verma Indian Journal of Technical Education 28 (2) , 2005 2005
