Biotechnology, Agricultural and Biological Sciences, Drug Discovery, Molecular Biology
54
Scopus Publications
1489
Scholar Citations
21
Scholar h-index
39
Scholar i10-index
Scopus Publications
Novel Drug Molecules for Atherosclerosis from Ginkgo biloba, an Endangered Himalayan Herb, via Pharmacoinformatics Approaches Shiwani Chahal, Abhijit Debnath, Pooja Ridhal, Rajesh Kumar Singh, Akhilesh Mishra, Priyanka Siwach Current Pharmaceutical Biotechnology, 2026 Introduction: Atherosclerosis, a chronic inflammatory disease driven by lipid metabolism dysregulation and vascular dysfunction, is a major contributor to cardiovascular diseases (CVDs), which is the leading cause of global mortality. The present study was undertaken to explore the anti-atherosclerosis potential (targeting DPP-IV, ETB, and PPAR-α) of bioactive compounds from Ginkgo biloba L.; the corresponding commercially available drugs, viz. Evogliptin, Bosentan, and Bezafibrate were taken as controls. Methods: Swiss ADME and Protox-II were utilized to evaluate the safety and applicability of G. biloba compounds. MGL Tools and AutoDock Vina were used for molecular docking, followed by analysis with Discovery Studio Biovia. MD simulation was performed for chosen complexes, and the resulting compound was examined for PPI, GO, and KEGG network enrichment using the Shiny GO server. Results: Eight compounds were shortlisted by using SwissADME and Protox-II servers, followed by molecular docking studies with AutoDock Vina. Six compounds exhibited stronger binding affinities against DPP-IV compared to Evogliptin (-7.1 kcal/mol), five outperforming Bosentan (- 7.5 kcal/mol) against ETB, and six better than Bezafibrate (-7.5 kcal/mol) against PPAR-α. Postdocking analysis identified Isoginkgetin for both DPP-IV and ETB receptors, while Kaempferol for PPAR-α. MD simulation studies of Isoginkgetin-DPP-IV, Isoginkgetin-ETB, and Kaempferol- PPAR-α resulted in the ETB-Isoginkgetin complex with the most favourable binding stability, rapid equilibration, and consistent hydrogen bonding. Network pharmacology analysis further highlighted Isoginkgetin's ability to modulate key proteins (CYP19A1, ESR2, GSK3B, XDH, PTGS2) associated with crucial CVD-related pathways. Conclusion: The findings highlight the multi-target therapeutic potential of Isoginkgetin in mitigating the initiation and progression of atherosclerosis.
(1Z,4Z)-dimethyln'1,N'4-BIS(2,4-dinitrophenyl)terephtha lohydrazonate: A Novel Schiff Base with its Co(II) and Cd(II) Complexes, Structural Investigations to Biological Potential Pinky ., Anita Rani, Pooja Dhiman, Mehmat Varol, Hardeep Singh Tuli, Priyanka Siwach, Manoj Kumar Anti Infective Agents, 2026 Aims: The purpose of this study was to develop and evaluate novel antimicrobial Schiff base and their transition metal complexes. Background: Antibiotics that were often used to treat microorganisms are no longer effec-tive against them because of developed resistance. It is believed that newly developed Schiff bases and their transition metal complexes could function well as antimicrobial agents and have considerable pharmacological efficacy. Methods: In this report new Schiff base ligand was synthesized by taking the 1:1 stoichio-metric ratio of 2, 4-dinitrophenyl hydrazine and dimethyl tetraphthalate, with ethanol serv-ing as the solvent subsequently its Co(II) and Cd(II) Complexes were created by reacting the synthesized Schiff base ligand with the corresponding metal salts in the form of chlo-rides. Results: All of the target compounds' structures were evaluated using sophisticated analyt-ical techniques, such as elemental analysis, FT-IR, 1H and 13C NMR, and LCMS. In order to determine each compound's biological potential as an antimicrobial agent, its effective-ness was also assessed. The results of the molecular docking studies were found to be com-patible with biological potential. At concentrations of 100–250 ppm, the zones of inhibition were discovered to be between 9–20 mm for ligands and 10-23 mm for complexes. The outcome showed that, in comparison to the Schiff base ligand, metal complexes have supe-rior biological activity. Conclusion: The current study provided a unique method for creating novel and physiolog-ically active Schiff bases and their transition metal complexes. The findings demonstrate that the compounds produced are a promising antimicrobial mediator against contemporary human illnesses. Additionally, it may pave the way for further research on drug-resistant microbes with potential biological applications.
Production of selected secondary metabolites in callus and shoot cultures of Ficus religiosa L. - A valuable medicinal plant Research Journal of Biotechnology, 2014
Influence of casein hydrolysate on in vitro rooting of F. religiosa Micro- Shoots and survival rate during transplantation Annals of Biology, 2014
Optimization of ISSR marker to evaluate genetic diversity in plantago ovata germplasm Annals of Agri Bio Research, 2011
Effect of season, explants, growth regulators and sugar level on induction and long term maintenance of callus cultures of Ficus religiosa L. African Journal of Biotechnology, 2011
STS marker based tracking of slow rusting Lr34 gene in Indian wheat genotypes Indian Journal of Biotechnology, 2009
Photoluminescence and electrical conductivity of silicon containing multilayer structures of diamond like carbon Journal of Optoelectronics and Advanced Materials, 2009
Fatty acid composition of some promising genotypes of garlic (Allium sativum L.) Annals of Biology, 2006
A Prospective Randomized Comparative Study to Evaluate Efficacy, Tolerability, and Cost-effectiveness of Transdermal Diclofenac and Ketoprofen Patches for Postoperative … B Chethan, S Priyanka, HS Suraj Journal of Postgraduate Medicine, Education and Research 60 (2), 55-61 , 2026 2026 Citations: 1
Implementation of a Feedforward-Compensated PI PWM Controller for EV Auxiliary Power Supply using TI C28379D microcontroller J Subbaiah, R Sriranjani, S Priyanka 2026 Innovations in Machine, Engineering, and Digital Conference (IMED), 1-5 , 2026 2026
Enhanced EKF-Based Sensorless Closed-Loop Speed Estimation for BLDC Motor Drive S Priyanka, S Jayalalitha, R Sriranjani 2026 International Conference on Electric Power and Renewable Energy (EPREC … , 2026 2026
(1Z, 4Z)-dimethyln'1, N'4-BIS (2, 4-dinitrophenyl) terephtha lohydrazonate: A Novel Schiff Base with its Co (II) and Cd (II) Complexes, Structural Investigations to Biological … Pinky, A Rani, P Dhiman, M Varol, HS Tuli, P Siwach, M Kumar Anti-Infective Agents 24 (1), E22113525366387 , 2026 2026
Sensorless Speed Estimation of BLDC Motor Using Modified Extended Kalman Filter S Priyanka, R Sriranjani, S Jayalalitha 2025 IEEE Silchar Subsection Conference (SILCON), 1-6 , 2025 2025 Citations: 1
Novel Drug Molecules for Atherosclerosis from Ginkgo biloba, an Endangered Himalayan Herb, Via Pharmacoinformatics Approaches. S Chahal, A Debnath, P Ridhal, RK Singh, A Mishra, P Siwach Current Pharmaceutical Biotechnology , 2025 2025
Effect of 8-week practice of Bramari Pranayama on stress levels and cognitive functions in young adults. MN Kala, S Priyanka, G Suchitra, J Shirisha, RS Chouhan 2025
Assessment of Road Surface Conditions Using Machine Learning R Anand, S Priyanka, PG Goud Journal of Transportation Engineering and Its Applications ISSN: 3107-4499 … , 2025 2025 Citations: 1
Antihypertensive potential of diosgenin: A comparative pharmacoinformatics study S Chahal, A Debnath, R Kumari, P Ridhal, RK Sahoo, BK Biswal, ... Computers in Biology and Medicine 196, 110911 , 2025 2025 Citations: 2
Virtual Hall-Effect sensor for BLDC motor drive with velocity controller S Priyanka, R Sriranjani, S Jayalalitha, M Sujeeth, BK Kumar 2025 IEEE 5th International Conference in Power Engineering Applications … , 2025 2025 Citations: 2
Electives implementation in competency-based medical education: Perspective of final year medical undergraduate students in a tertiary care hospital S Priyanka, K Vasundara, R Shubha, B Chethan, R Kumar Indian Journal of Physiology and Pharmacology 69 (2), 180-185 , 2025 2025 Citations: 1
Docking simulations: assessing flavonoids from Terminalia arjuna as TNF-α modulators for mitigating inflammation. S Chahal, N Saini, P Ridhal, R Kumari, P Siwach 2025
Sesbania grandiflora activated carbon as a high-efficiency stable and reusable adsorbent for sustainable fluoride removal D Sivakumar, MP Selvan, J Nouri, MJ Jabin, S Priyanka, G Madhubala Global Journal of Environmental Science and Management 11 (2), 653-676 , 2025 2025 Citations: 5
ANTIMICROBIAL ACTIVITIES OF POLYPHENOLS & ALKALOIDS IN INDIAN MEDICINAL PLANTS S Kumar, S Priyanka, NB Admuthe, T Mishra, MDR Sawant, M Velammal Cuestiones de Fisioterapia 54 (4), 1064-1075 , 2025 2025 Citations: 1
ASSESSMENT OF ANTIBIOTIC PRESCRIBING PATTERN USING WHO ACCESS, WATCH, AND RESERVE CLASSIFICATION (AWARE) AT A TERTIARY CARE CENTRE OF NORTHERN INDIA: A CROSS-SECTIONAL STUDY S KUMAR, P SIWACH, K MEHTA, A MATHUR JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH , 2025 2025
THE IMPACT OF HEAVY VEHICLE CHARACTERISTICS ON THE PERFORMANCE AND RESPONSE OF THE PAVEMENT RP Kumar, BS Reddy, RM Perumal, VP Raju, CH Kalyani, S Priyanka, ... Proceedings on Engineering 7 (1), 49-58 , 2025 2025
Role of Gut Hormones in the Control of Digestive Physiology: Emerging Insights and Clinical Relevance S Priyanka 2025
Biotechnological advances in agriculture, healthcare, environment and industry P Siwach, SK Gahlawat, RK Salar, JS Duhan, PK Sadh CRC Press , 2024 2024
Terminalia arjuna for Treatment of Cardiovascular Diseases: From Traditional Usage to High-Throughput Drug Discovery S Chahal, I Singh, H Jain, A Rani, AR Gill, A Mishra, P Siwach Biotechnological Advances in Agriculture, Healthcare, Environment and … , 2024 2024
Molecular Epidemiology of Cotton Leaf Curl Virus Disease: Recent Developments toward Sustainable Fiber Production I Singh, H Jain, PK Sadh, S Chahal, SK Sain, SS Sohrab, P Siwach Biotechnological Advances in Agriculture, Healthcare, Environment and … , 2024 2024
MOST CITED SCHOLAR PUBLICATIONS
Allelic Diversity Among Basmati and Non-Basmati Long-grain Indica Rice Varieties using Microsatellite Markers P Siwach, S Jain, N Saini, VK Chowdhury, RK Jain Journal of Plant Biochemistry and Biotechnology 13 (1), 25-32 , 2004 2004 Citations: 127
Folk medicine used in gynecological and other related problems by rural population of Haryana JP Yadav, S Kumar, P Siwach Indian Journal of Traditional Knowledge 5 (3), 323-326 , 2006 2006 Citations: 118
Enhanced shoot multiplication in Ficus religiosa L. in the presence of adenine sulphate, glutamine and phloroglucinol P Siwach, AR Gill Physiology and Molecular Biology of Plants 17 (3), 271-280 , 2011 2011 Citations: 95
Physiological traits associated with heat tolerance in bread wheat ( Triticum aestivum L.) GC Pandey, HM Mamrutha, R Tiwari, S Sareen, S Bhatia, P Siwach, ... Physiology and Molecular Biology of Plants 21 (1), 93-99 , 2015 2015 Citations: 63
Micropropagation of Ficus religiosa L. via leaf explants and comparative evaluation of acetylcholinesterase inhibitory activity in the micropropagated and … P Siwach, AR Gill 3 Biotech 4 (5), 477-491 , 2014 2014 Citations: 47
Biotechnology: prospects and applications RK Salar, SK Gahlawat, P Siwach, JS Duhan Springer , 2013 2013 Citations: 46
Understanding heat-shock proteins’ abundance and pivotal function under multiple abiotic stresses P Kumar, D Paul, S Jhajhriya, R Kumar, S Dutta, P Siwach, S Das Journal of Plant Biochemistry and Biotechnology 33 (4), 492-513 , 2024 2024 Citations: 44
Phytochemical evaluation and HPTLC fingerprint profile of Cassia fistula L Seasotiya, P Siwach, A Malik, S Bai, P Bharti, S Dalal International journal of advances in Pharmacy, biology and chemistry 3 (3 … , 2014 2014 Citations: 42
Effect of season, explants, growth regulators and sugar level on induction and long term maintenance of callus cultures of Ficus religiosa L. P Siwach, AR Gill, K Kumari African Journal of Biotechnology 10 (24), 4879 , 2011 2011 Citations: 40
Distant monitoring and controlling of solar driven irrigation system through IoT M Mahalakshmi, S Priyanka, SP Rajaram, R Rajapriya 2018 National power Engineering conference (NPEC), 1-5 , 2018 2018 Citations: 37
Biodiversity conservation of Himalayan medicinal plants in India: A retrospective analysis for a better vision M Siwach, P Siwach, P Solanki, AR Gill Int J Biodivers Conserv 5 (9), 529-540 , 2013 2013 Citations: 35
STS marker based tracking of slow rusting Lr34 gene in Indian wheat genotypes TR Priyamvada, MS Saharan, R Chatrath, P Siwach, B Mishra Ind. J. Biotechnol 8, 207-213 , 2009 2009 Citations: 35
SHPI: Smart healthcare system for patients in ICU using IoT BS Egala, S Priyanka, AK Pradhan 2019 IEEE International Conference on Advanced Networks and … , 2019 2019 Citations: 33
Plant biotechnology: recent advancements and developments SK Gahlawat, RK Salar, P Siwach, JS Duhan, S Kumar, P Kaur Springer Singapore , 2017 2017 Citations: 32
A novel method SEProm for prokaryotic promoter prediction based on DNA structure and energetics A Mishra, S Dhanda, P Siwach, S Aggarwal, B Jayaram Bioinformatics 36 (8), 2375-2384 , 2020 2020 Citations: 30
Advances in animal biotechnology and its applications SK Gahlawat, JS Duhan, RK Salar, P Siwach, S Kumar, P Kaur Springer , 2018 2018 Citations: 29
Free radical scavenging activity, phenolic contents and phytochemical analysis of seeds of Trigonella foenum graecum L Seasotiya, P Siwach, S Bai, A Malik, P Bharti, S Dalal Asian Pac J Health Sci 1, 219-226 , 2014 2014 Citations: 27
Effects of adenine sulphate, glutamine and casein hydrolysate on in vitro shoot multiplication and rooting of Kinnow mandarin ( Citrus reticulata Blanco) P Siwach, S Chanana, AR Gill, P Dhanda, J Rani, K Sharma, H Rani, ... African Journal of Biotechnology 11 (92), 15852-15862 , 2012 2012 Citations: 27
The influence of plant growth regulators, explant nature and sucrose concentration on in vitro callus growth of Thevetia peruviana Schum P Siwach, K Grover, AR Gill Asian Journal of Biotechnology 3 (3), 280-292 , 2011 2011 Citations: 25
The effect of Hyperglycemia on some biochemical parameters in diabetes mellitus G Gitanjali, G Sudeep, G Neerja, A Deepak, S Priyanka J Clin Diag Res 4, 3181-6 , 2010 2010 Citations: 25