Advancements in Macrocyclic Supramolecular Assemblies of Hyaluronic Acid: Enhancing Biocompatibility and Targeted Therapeutics Kuppusamy Sathishkumar, Murali Santhoshkumar, D Shanmugapriya, Nallusamy Duraisamy, Mohammed Mujahid Alam, Abdullah G. Al‐Sehemi, Punniyakotti Parthipan Chemistryselect, 2026 Hyaluronic acid (HA), a naturally occurring glycosaminoglycan, has emerged as a versatile biomaterial for biomedical applications owing to its biocompatibility, biodegradability, and intrinsic affinity for CD44 and related receptors. Recent advances in supramolecular chemistry have enabled the construction of macrocyclic HA assemblies incorporating cyclodextrins, cucurbiturils, calixarenes, and pillararenes, creating dynamic, injectable, and stimuli‐responsive platforms for therapeutic delivery and tissue regeneration. This review provides a macromolecule‐centric, translationally oriented synthesis of HA macrocycle systems, critically comparing construction strategies (HA molecular weight, grafting chemistry, solvent conditions), drug inclusion capacity across hydrophobic, hydrophilic, and biological payloads, and rheological design rules governing injectability, bioprinting fidelity, and tissue‐specific performance. We integrate structure assembly function relationships with emerging clinical use‐cases in oncology, ocular therapy, wound healing, cartilage/bone repair, and gene delivery. Importantly, we identify key translational bottlenecks scalability, batch reproducibility, long‐term safety of macrocycles, and regulatory classification and propose design principles and manufacturing considerations to bridge laboratory innovation with clinical deployment. Looking forward, multi‐host architectures, hybrid crosslinking strategies, and integration with 3D bioprinting and immunoengineering are highlighted as enabling directions for next‐generation HA supramolecular therapeutics. This review aims to guide rational design of clinically viable HA macrocyclic assemblies for precision biomaterials and regenerative medicine.
Biogenic-Assisted Synthesis of Cu–Zn–Co Ternary Oxides Nanocomposite: Investigation on Their Bioactivity and Electrochemical Behavior Sheikdawood Parveen, Baskar Anbumani, Manickam Karthigai Priya, Punniyakotti Parthipan, Gnanasekaran Lalitha, et al. Chemistryselect, 2026 ABSTRACT Nanoparticles are the materials of the future after their well garnished development, especially, in the field of biomedical and energy sectors because of its qualitative priority of people. By spotting these aspects, we determine to synthesize a mixed metal oxide appended nanocomposite (NAC) from Cu, Zn and Co. We eradicate the utilization of chemicals by plant‐assisted synthetic approach. In this method we employs the aqueous extract from Myristica fragrans (nutmeg) mace as a reducing, capping and stabilizing agent to synthesize the mixed metal oxide‐based nanocomposite composed of Cu, Zn, and Co. FT‐IR, UV–Visible, PXRD, scanning electron microscopy (SEM), EDS, and transmission electron microscopy (TEM) techniques supports the formation of desired NAC in both morphologically and chemically. The antioxidant activity of the NAC was assessed against the DPPH • , ABTS •+ , NO • , ferric reducing antioxidant power (FRAP), and O 2− free radicals. Further, the electrochemical properties of CV, GCD and EIS are measured in 6 M NaOH. At a 1 Ag −1 current density, the composite exhibit greater capacitance (402.04 C g −1 ), after 2000 cycles the NAC electrode shows excellent 95% of capacity retention.
Persistence of Polycyclic Aromatic Hydrocarbons and Microplastics: A Serious Alarm to Human Health and Ecosystems Lakshminarayanan Sivakumar, Rajaram Rajamohan, Amuthalinkam T. Asaithambi, Punniyakotti Elumalai, Arunagiri Santhosh Kumar, Jinjie Cui, Xueke Gao, Punniyakotti Parthipan, Woong Kim, Muthusamy Govarthanan Chemical Record, 2026 Polycyclic aromatic hydrocarbons (PAHs) and microplastics (MPs) are among the most persistent organic pollutants in the environment, posing significant ecological and human health risks. These compounds exhibit the ability to migrate across air, water, and the soil environment, undergoing transformation processes that contribute to their environmental persistence. MPs have a strong tendency to attract PAHs due to their high surface area and their hydrophobic properties, and act as a platform for accumulating a wide variety of environmental contaminants on their surfaces. The PAHs and MPs have been detected across various ecosystems, including air, water, and soil. These pollutants are also present in living organisms, such as plants, animals, and even in the human body. Experimental studies indicate that chronic exposure to these pollutants is correlated with severe health effects and disrupts critical ecological functions. The United States environmental protection agency (U.S. EPA) has classified 16 specific PAH compounds as environmental hazards, recognizing their carcinogenic potential. This review focuses on the source, adsorption characteristics, and transport dynamics at the interface of PAHs and MPs pollutants. Understanding this interaction is vital for assessing the bioavailability of these combined contaminants to aquatic organisms, as it significantly influences their toxicity profiles and overall environmental consequences. In addition, the review explores how climate‐related factors affect the fate, transport, and transformation of these contaminants in both terrestrial and aquatic environments. It also assesses the contributions of PAHs and MPs to climate change and global warming, providing insights into their broader ecological and environmental implications.
Derris Indica Leaves Extract as a Green Inhibitor for the Corrosion of Aluminium in Alkaline Medium Electro-Materials Research Laboratory, Centre for Nanoscience, Technology, Pondicherry University, Puducherry-605014, India., Neha K Nambiar, Department of Chemistry, CHRIST (Deemed to be University), Bengaluru-560029, India., D. Brindha, PG & Research Dept. of Chemistry, Periyar EVR College, Trichy – 620023, India., Parthipan Punniyakotti, Electro-Materials Research Laboratory, Centre for Nanoscience, Technology, Pondicherry University, Puducherry-605014, India., B.R. Venkatraman, PG & Research Dept. of Chemistry, Periyar EVR College, Trichy – 620023, India., Subramania Angaiah, Electro-Materials Research Laboratory, Centre for Nanoscience, Technology, Pondicherry University, Puducherry-605014, India. Engineered Science, 2022
Progress and opportunities in metal-rich cobalt sulfides-based nanostructures for high-performance supercapacitors P Elumalai, R Govindan, X Gao, P Parthipan, J Theerthagiri, J Luo, J Cui, ... Journal of Energy Storage 164, 122008 , 2026 2026
Seaweed-Derived Polysaccharide Hydrogels for Diabetic Wound Healing: Strategies, Mechanisms and Therapeutic Applications K Sathishkumar, ND Patel, M Santhoshkumar, C Ponnusamy, SKP Velu, ... Carbohydrate Polymers, 125381 , 2026 2026
Advancements in Macrocyclic Supramolecular Assemblies of Hyaluronic Acid: Enhancing Biocompatibility and Targeted Therapeutics K Sathishkumar, M Santhoshkumar, D Shanmugapriya, N Duraisamy, ... ChemistrySelect 11 (15), e06857 , 2026 2026
Biogenic synthesis of Ag–CeO2 bimetallic nanocomposite from Eucalyptus globulus and their potential application in microbial influenced corrosion protection of mild steel K Vignesh, A Satheeshkumar, P Parthipan, P Selvarajan, Z Fang, ... Inorganic Chemistry Communications 186, 116314 , 2026 2026
Chitosan nanocomposite films with metal nanoparticles: Synthesis, antimicrobial mechanisms and applications in sustainable packaging P Parthipan, M Santhoshkumar, D Shanmugapriya, N Duraisamy, ... Carbohydrate Polymers 377, 124868 , 2026 2026 Citations: 3
Algal Biorefineries for a Circular Bioeconomy: Integrating Nanobiomaterial Synthesis, Multi-Product Valorization and Sustainable Manufacturing P Parthipan, M Santhoshkumar, D Shanmugapriya, N Duraisamy, ... Waste and Biomass Valorization, 1-18 , 2026 2026
Crude bioactive metabolites of Streptomyces maritimus DT as biogenic corrosion inhibitor for microbiologically influenced corrosion in cooling water systems D Thirumurugan, M Prabaharan, R Vijayakumar, AA Prakash, J Selvin, ... Journal of Environmental Chemical Engineering, 122406 , 2026 2026
Biogenic‐Assisted Synthesis of Cu–Zn–Co Ternary Oxides Nanocomposite: Investigation on Their Bioactivity and Electrochemical Behavior S Parveen, B Anbumani, MK Priya, P Parthipan, G Lalitha, A Manikandan, ... ChemistrySelect 11 (8), e05666 , 2026 2026
Persistence of Polycyclic Aromatic Hydrocarbons and Microplastics: A Serious Alarm to Human Health and Ecosystems L Sivakumar, R Rajamohan, AT Asaithambi, P Elumalai, AS Kumar, J Cui, ... The Chemical Record, e202500206 , 2026 2026
Synthesis and Characterization of Copper, Zinc, and Nickel Oxides‐Based Nanocomposite by Using Clitoria ternatea Flower Extract for Antioxidant Studies and … S Parveen, K Suganthi, P Parthipan, M Rajasekar, T Panneerselvam, ... ChemistrySelect 10 (45), e03871 , 2025 2025
Oil mineral aggregates engineered from bio-synthesized calcite nanoparticles for improved crude oil biodegradation S Ramesh, AK Prasad, P Parthipan, V Karthick, N Prasanth Bhatt Biodegradation 36 (6), 122 , 2025 2025
Characterization of Halophilic Bacteria Vreelandella piezotolerant DM1 on Biodegradation of Polyaromatic Hydrocarbons and its Pathway R Duraimurugan, K Vignesh, C Sahasra, P Parthipan, J Narenkumar, ... Water, Air, & Soil Pollution 236 (12), 807 , 2025 2025 Citations: 2
Mitigation of sulphate-reducing bacterial consortium induced corrosion on API 5LX carbon steel using bioactive compounds from Capsicum annuum fruit derivatives AS Kumar, P Dhandapani, L Sivakumar, J Narenkumar, P Elumalai, ... Journal of Environmental Chemical Engineering, 120483 , 2025 2025
Emerging sensor technologies for detecting pollutants in ecosystems X Gao, L Wang, P Elumalai, S Lakshminarayanan, X Zhu, L Wang, ... Coordination Chemistry Reviews 542, 216849 , 2025 2025 Citations: 14
Cell Wall Disintegration in Microalgae: Implications for Efficient Fucoxanthin Extraction SK Venkatachalam, M Fareed, N Duraisamy, K Lavanya, P Digala, ... Waste and Biomass Valorization, 1-16 , 2025 2025 Citations: 1
Impact of the COVID-19 pandemic on diagnosis and disease stage in HPV-positive oropharyngeal cancer: insights and future directions J Narenkumar, P Parthipan Oral Oncology 168, 107541 , 2025 2025
Evaluating the risk-modifying effects of HSV-1 and HSV-2 on head and neck cancer in relation to tobacco, alcohol, and HPV-16 S Abilaji, P Parthipan Oral Oncology 168, 107516 , 2025 2025 Citations: 1
Impact Assessment and Evaluation of Micro (nano) plastics Exposure in the Human Health System: A Review P Parthipan, V Sathish, A Rajasekar, AS Vickram, S Thanigaivel, ... Advanced Sustainable Systems 9 (9), e00143 , 2025 2025 Citations: 2
Formulations of chitosan/TiO2/ZnO ternary nanocomposites-based alkyd nanopaint for marine anti-biofouling application L Sivakumar, SK Arunagiri, D Perumal, M Thiyagarajan, P Bhatt, ... International Biodeterioration & Biodegradation 204, 106136 , 2025 2025 Citations: 1
Assessment of a hollow cylindrical Ti-TiO2/IrO2/RuO2 mesh electrode for effective treatment of hospital wastewater using a portable electrochemical reactor P Dhandapani, M kumar Pichandi, A Rajasekar, P Parthipan, ... Journal of the Indian Chemical Society, 101985 , 2025 2025 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
Biosurfactant and Degradative Enzymes Mediated Crude Oil Degradation by Bacterium Bacillus subtilis A1 P Parthipan, E Preetham, LL Machuca, PKSM Rahman, K Murugan, ... Frontiers in microbiology 8, 193 , 2017 2017 Citations: 363
Neem extract as a green inhibitor for microbiologically influenced corrosion of carbon steel API 5LX in a hypersaline environments P Parthipan, J Narenkumar, P Elumalai, PS Preethi, AUR Nanthini, ... Journal of Molecular Liquids 240, 121-127 , 2017 2017 Citations: 162
Allium sativum (garlic extract) as a green corrosion inhibitor with biocidal properties for the control of MIC in carbon steel and stainless steel in oilfield environments P Parthipan, P Elumalai, J Narenkumar, LL Machuca, K Murugan, ... International Biodeterioration & Biodegradation 132, 66-73 , 2018 2018 Citations: 138
Enhanced biodegradation of hydrophobic organic pollutants by the bacterial consortium: Impact of enzymes and biosurfactants P Elumalai, P Parthipan, M Huang, B Muthukumar, L Cheng, ... Environmental Pollution 289, 117956 , 2021 2021 Citations: 129
Anti-bacterial and anti-biofilm properties of green synthesized copper nanoparticles from Cardiospermum halicacabum leaf extract P Punniyakotti, P Panneerselvam, D Perumal, R Aruliah, S Angaiah Bioprocess and Biosystems Engineering 43 (9), 1649-1657 , 2020 2020 Citations: 109
Environmental fate and ecotoxicological behaviour of pesticides and insecticides in non-target environments: Nanotechnology-based mitigation strategies P Punniyakotti, S Vinayagam, R Rajamohan, SD Priya, M Moovendhan, ... Journal of Environmental Chemical Engineering 12 (5), 113349 , 2024 2024 Citations: 102
Bio-electrokinetic remediation of crude oil contaminated soil enhanced by bacterial biosurfactant AA Prakash, NS Prabhu, A Rajasekar, P Parthipan, MS AlSalhi, ... Journal of Hazardous Materials 405, 124061 , 2021 2021 Citations: 100
Glycolipid biosurfactant as an eco-friendly microbial inhibitor for the corrosion of carbon steel in vulnerable corrosive bacterial strains P Parthipan, D Sabarinathan, S Angaiah, A Rajasekar Journal of Molecular Liquids 261, 473-479 , 2018 2018 Citations: 94
Agrochemical pollution: A serious threat to environmental health P Elumalai, X Gao, P Parthipan, J Luo, J Cui Current opinion in environmental science & health 43, 100597 , 2025 2025 Citations: 90
Biologically reduced graphene oxide as a green and easily available photocatalyst for degradation of organic dyes P Parthipan, L Cheng, A Rajasekar, M Govarthanan, A Subramania Environmental Research 196, 110983 , 2021 2021 Citations: 88
Biosurfactant and enzyme mediated crude oil degradation by Pseudomonas stutzeri NA3 and Acinetobacter baumannii MN3 P Parthipan, P Elumalai, K Sathishkumar, D Sabarinathan, K Murugan, ... 3 Biotech 7 (5), 278 , 2017 2017 Citations: 81
Impact of biosurfactant and iron nanoparticles on biodegradation of polyaromatic hydrocarbons (PAHs) P Parthipan, L Cheng, P Dhandapani, P Elumalai, M Huang, A Rajasekar Environmental Pollution 306, 119384 , 2022 2022 Citations: 75
Ginger extract as green biocide to control microbial corrosion of mild steel J Narenkumar, P Parthipan, A Usha Raja Nanthini, G Benelli, K Murugan, ... 3 Biotech 7 (2), 133 , 2017 2017 Citations: 73
Bioengineered silver nanoparticles as potent anti-corrosive inhibitor for mild steel in cooling towers J Narenkumar, P Parthipan, J Madhavan, K Murugan, SB Marpu, ... Environmental Science and Pollution Research 25 (6), 5412-5420 , 2018 2018 Citations: 70
Characterization of hydrocarbon degrading bacteria isolated from Indian crude oil reservoir and their influence on biocorrosion of carbon steel API 5LX P Parthipan, P Elumalai, YP Ting, PKSM Rahman, A Rajasekar International Biodeterioration & Biodegradation 129, 67-80 , 2018 2018 Citations: 69
Green synthesis of biomass derived carbon dots via microwave-assisted method for selective detection of Fe3+ ions in an aqueous medium HS George, H Selvaraj, A Ilangovan, K Chandrasekaran, VR Kannan, ... Inorganic Chemistry Communications 157, 111348 , 2023 2023 Citations: 58
Characterization of bacterial community in oil-contaminated soil and its biodegradation efficiency of high molecular weight (> C40) hydrocarbon B Muthukumar, P Parthipan, MS AlSalhi, NS Prabhu, TN Rao, ... Chemosphere 289, 133168 , 2022 2022 Citations: 58
Eco-friendly synthesis of reduced graphene oxide as sustainable photocatalyst for removal of hazardous organic dyes P Parthipan, MA Al-Dosary, AA Al-Ghamdi, A Subramania Journal of King Saud University-Science 33 (4), 101438 , 2021 2021 Citations: 56
Evaluation of Syzygium aromaticum aqueous extract as an eco-friendly inhibitor for microbiologically influenced corrosion of carbon steel in oil reservoir environment P Parthipan, MS AlSalhi, S Devanesan, A Rajasekar Bioprocess and Biosystems Engineering 44 (7), 1441-1452 , 2021 2021 Citations: 54
Role of thermophilic bacteria ( Bacillus and Geobacillus ) on crude oil degradation and biocorrosion in oil reservoir environment P Elumalai, P Parthipan, J Narenkumar, B Anandakumar, J Madhavan, ... 3 Biotech 9 (3), 79 , 2019 2019 Citations: 54