Natural Products
Mass Spectrometry
Nuclear Magnet Resonance
116
Scopus Publications
2145
Scholar Citations
28
Scholar h-index
63
Scholar i10-index
Scopus Publications
Exploring Anatomical and Chemical Markers to Characterize and Differentiate Among Bidens Species Carolina Sabedotti, Isabella da Silveira, Izabel Pietczak Migacz, Luiza Stolz Cruz, Ana Carolina Terso Ventura, et al. Revista Brasileira De Farmacognosia, 2026 Bidens pilosa L., Bidens alba (L.) DC., and Bidens subalternans DC., Asteraceae, are often misidentified because of their morphological similarities. The present study provides a comparative analysis of the morpho-anatomical characteristics, histochemical, and chemical fingerprints obtained by liquid chromatography mass spectrometry for these three species. Light microscopy, field emission scanning electron microscopy, and energy-dispersive X-ray spectroscopy were used to characterize diagnostic structures. Histochemical assays and LC-MS were applied to obtain chemical information from leaf, stem, and root extracts, and multivariate chemometrics including principal component analysis were used to classify the datasets. The morpho-anatomical and histochemical analysis allowed the identification and differentiation of the three species; also, the LC-MS analysis revealed that the main compounds in Bidens extracts are phenolics, and using chemometrics methods was possible to discriminate by species and plant parts. Together, these complementary approaches provide a robust basis for distinguishing closely related Bidens species and support more reliable pharmacognostic identification. Graphical Abstract
Metabolomics-Driven Identification of Resistance Biomarkers in Dwarf Cashew (Anacardium occidentale L.) under Black Mold Stress João G. da Cruz, Jhonyson A. C. Guedes, Gisele S. da Silva, Lorena M. A. e Silva, Paulo R. V. Ribeiro, et al. Journal of the Brazilian Chemical Society, 2026 This study employed an integrated untargeted metabolomics approach to identify resistanceassociated biomarkers in dwarf cashew (Anacardium occidentale L.) genotypes under black mold stress-a severe foliar disease caused by Pilgeriella anacardii Arx & Müller. Metabolomic profiling was performed using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MSE) and nuclear magnetic resonance (NMR) spectroscopy. This methodology enabled a comprehensive analysis of four dwarf cashew genotypes with varying resistance to P. anacardii: ‘CCP 76’ and ‘BRS 189’ were susceptible, ‘BRS 226’ was intermediate, and ‘BRS 265’ was resistant. Orthogonal partial least squares discriminant analysis (OPLS-DA) revealed clear metabolic segregation between resistant, susceptible, and intermediate genotypes, with high predictive power (R2 Y ≥ 0.98; Q2 ≥ 0.95). Resistant clones (BRS 265 and BRS 226) showed pronounced metabolic reprogramming, marked by increased accumulation of flavonoid glycosides (quercetin-3-D-glucoside, isoquercetin), flavan-3-ols ((+)-catechin, gallocatechin), galloylated glucose derivatives (penta- and tetra-O-galloyl-glucosides), and biflavonoids (amentoflavone, agathisflavone). These compounds function as antioxidants, membrane disruptors, metal chelators, enzyme inhibitors, and immune response modulators. Pathway enrichment analysis highlighted the activation of flavonoid and flavonol biosynthesis as central to resistance. Elevated sucrose levels in resistant genotypes suggest a role in energy supply and systemic signaling. Altogether, this metabolomic fingerprint supports a complex biochemical defense strategy and offers robust biomarkers for marker-assisted selection.
Green Coconut Biorefinery: RSM and ANN–GA Optimization of Coconut Water Microfiltration with IntegratedTechno-Economic Analysis José Diogo da Rocha Viana, Moacir Jean Rodrigues, Arthur Claudio Rodrigues de Souza, Raimundo Marcelino da Silva Neto, Paulo Riceli Vasconcelos Ribeiro, et al. Foods, 2026 The coconut water market continues to expand, but industrial supply is constrained by the high perishability of fresh coconut water and the need for stabilization routes that preserve quality. This study optimized crossflow microfiltration of coconut water using a silicon carbide (SiC) ceramic membrane, high permeability, chemical/thermal robustness, and cleanability, and assessed the techno-economic feasibility of a green coconut biorefinery producing microfiltered coconut water and coconut pulp. Pressure and temperature were modeled and optimized using a face-centered design (FCD) and artificial neural networks coupled with a genetic algorithm (ANN–GA), considering permeate flux and fouling index (p < 0.05). Both approaches converged to the same operating point, and experimental validation at 75 kPa and 30 °C achieved 605.32 ± 15.34 L h−1 m−2 and 82.79 ± 1.35% at VRR = 1. Sample-level fit statistics favored ANN (higher R2 and lower sample-level errors), whereas condition-wise grouped cross-validation (leave-one-condition-out) indicated higher predictivity and lower RMSECV for the quadratic FCD/RSM models across experimental conditions, highlighting response-dependent generalization within the investigated domain. Fouling analysis indicated concentration polarization as the main resistance contribution and a flux-decline behavior best described by the intermediate blocking mechanism. A SuperPro Designer® simulation over a 20-year project life indicated economic feasibility under baseline assumptions (Internal rate of return—IRR = 23.80%, Net present value—NPV = US$733,761, payback = 2.96 years), with profitability remaining attractive under ±10% selling-price variation. Overall, the process optimization and modeling outcomes align with the economic case, reinforcing the potential of this biorefinery concept for industrial deployment.
Phytochemical Composition and Evaluation of Acute Toxicity, Antioxidant, and Antibacterial Activities of Spondias mombin L. and Myracrodruon urundeuva Allemão Ethanolic Extracts Against Vibrio parahaemolyticus Luiz G. A. Santos‐Filho, Renata B. Reis, Ana Sheila Q. Souza, Kirley M. Canuto, Paulo Riceli V. Ribeiro, et al. Chemistry and Biodiversity, 2025 Plant‐derived natural products are emerging as promising sources of bioactive compounds against parasites and microorganisms. This study investigated the phytochemical composition, antibacterial and antioxidant activities, and acute toxicity of ethanolic extracts from Spondias mombin L. and Myracrodruon urundeuva Allemão. Extracts were analyzed by ultra‐performance liquid chromatography coupled with mass spectrometry (UPLC–MS). Antibacterial activity was tested against Vibrio parahaemolyticus strains, whereas antioxidant activity was assessed using the DPPH assay. Acute toxicity was evaluated with Artemia salina nauplii. The M. urundeuva extract contained hydrolyzable tannins, gallic acid derivatives, anacardic acids, and agathisflavone, along with phenolic acids and dimeric chalcones, including urundeuvine B, in the stem bark. Only procyanidins were detected in S. mombin extracts. Both extracts exhibited moderate antibacterial activity and promising antioxidant potential, relevant for neutralizing oxidative bacterial defenses through scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), thereby supporting cellular redox homeostasis. The M. urundeuva extract showed the lowest minimum inhibitory concentration (MIC, 0.625–1.25 mg/mL) and, together with S. mombin, demonstrated bactericidal activity surpassing ampicillin. Low acute toxicity was observed for both extracts (LC50 > 1000 µg/mL), reinforcing their potential safety. These findings suggest that these plant extracts are promising natural alternatives for controlling V. parahaemolyticus in aquaculture systems.
Searching for Hypoglycemic Compounds from Brazilian Medicinal Plants Through UPLC-HRMS and Molecular Docking Elisabeth Mariano Batista, Gabriela Araújo Freire, Caio Bruno Rodrigues Martins, Raimundo Rigoberto Barbosa Xavier Filho, Gisele Silvestre da Silva, et al. Plants, 2025 Type 2 diabetes mellitus remains a major global health challenge, and natural hypoglycemic compounds are of increasing interest. Aqueous extracts from five Brazilian medicinal plants (Lippia origanoides Kunth, Amburana cearensis (Allemão) A.C. Smith, Justicia pectoralis Jacq., Libidibia ferrea (Mart. ex Tul.) L.P. Queiroz, and Spondias mombin L.) were evaluated for α-glucosidase and intestinal disaccharidase inhibition; next, they were chemically profiled by UPLC-HRMS. Extracts of L. origanoides, A. cearensis, and J. pectoralis exhibited the strongest activities, attributed to flavonoids, iridoid and cinnamic acid derivatives, phenolic acids, and saponins. Molecular docking identified hyperoside, eudesmic acid and isoquercitrin as their main α-glucosidase inhibitors, respectively. In vitro testing confirmed that isoquercitrin effectively inhibited α-glucosidase (IC50 = 0.09 mg mL−1), showing stronger activity than acarbose. ADME simulations indicated low gastrointestinal absorption but favorable intestinal enzyme-targeted properties, consistent with their pharmacological profiles. Acute toxicity in zebrafish showed low toxicity for L. origanoides and A. cearensis and moderate levels for J. pectoralis, supporting their overall safety. These findings highlight these species as promising sources of bioactive compounds for developing safe, plant-based antidiabetic agents.
Antioxidant films from mango kernel components Pedro E.F. Melo, Ana Priscila M. Silva, Francisco P. Marques, Paulo R.V. Ribeiro, Men de sá M. Souza Filho, et al. Food Hydrocolloids, 2019
Exploring Anatomical and Chemical Markers to Characterize and Differentiate Among Bidens Species C Sabedotti, I da Silveira, IP Migacz, LS Cruz, ACT Ventura, PV Farago, ... Revista Brasileira de Farmacognosia 36 (1), 47 , 2026 2026
Efficient and sustainable recovery of bioactive compounds from cashew nut testa shell ( Anacardium occidentale L.) using pressurized liquid extraction J da Silva, AFV da Silva, K Cesca, PRV Ribeiro, ES de Brito, SRS Ferreira Analytical and Bioanalytical Chemistry 418 (6), 1627-1644 , 2026 2026 Citations: 3
Evaluation of Ceramic and Polymeric Membranes for Crossflow Microfiltration of Coconut Water: Filtration Performance and Composition of the Clarified Coconut Water JD da Rocha Viana, E de Godoy Alves Filho, LMA e Silva, PRV Ribeiro, ... Journal of Food Engineering, 113027 , 2026 2026 Citations: 1
Green Coconut Biorefinery: RSM and ANN–GA Optimization of Coconut Water Microfiltration with IntegratedTechno-Economic Analysis JDR Viana, MJ Rodrigues, ACR Souza, RM Silva Neto, PRV Ribeiro, ... Foods 15 (4), 623 , 2026 2026
Metabolomics-Driven Identification of Resistance Biomarkers in Dwarf Cashew ( Anacardium occidentale L.) under Black Mold Stress JG Cruz, JAC Guedes, GS Silva, LMA Silva, PRV Ribeiro, MVV Martins, ... Journal of the Brazilian Chemical Society 37, e-20250178 , 2026 2026
Volatile and phenolic compounds associated with melon resistance to Liriomyza sativae JF Vasconcelos, WVA Saraiva, L De Lima Farias, PRV Ribeiro, ... Arthropod-Plant Interactions 19 (6), 100 , 2025 2025
Use of Fava d'Anta extract in maize cultivation under saline stress KR Saraiva, TVA Viana, CF Lacerda, GG Sousa, MA Bezerra, KM Canuto, ... Revista Ambiente & Água 20, e3081 , 2025 2025
Searching for Hypoglycemic Compounds from Brazilian Medicinal Plants Through UPLC-HRMS and Molecular Docking EM Batista, GA Freire, CBR Martins, RRB Xavier Filho, GS Silva, ... Plants 14 (22), 3517 , 2025 2025 Citations: 1
Phytochemical Composition and Evaluation of Acute Toxicity, Antioxidant, and Antibacterial Activities of Spondias mombin L. and Myracrodruon urundeuva Allemão Ethanolic … LGA Santos‐Filho, RB Reis, ASQ Souza, KM Canuto, PRV Ribeiro, ... Chemistry & Biodiversity 22 (11), e00534 , 2025 2025 Citations: 1
Chemical characterization and in vitro evaluation of the antifungal activity of Caryocar coriaceum Wittm. extracts against Candida spp. and their potential mechanisms of action MJCB Silveira, VP de Farias Cabral, DS Rodrigues, LEA Moreira, ... Microbial Pathogenesis, 108031 , 2025 2025 Citations: 1
LC‐MS Analysis and Antimicrobial Activity of Different Extracts of Spondias purpurea L MEP da Silva, JNP Carneiro, CVB Oliveira, ATL dos Santos, RP da Cruz, ... ChemistrySelect 10 (34), e03127 , 2025 2025 Citations: 2
UPLC-PDA-ESI-QDA characterization and evaluation of the antioxidant and anxiolytic activities of the ethanolic extract of Sarcomphalus joazeiro (Mart.) Hauenschild leaves NKG de Carvalho, MP da Silva, DOD Leite, GJT Salazar, ... Pharmacological Research-Natural Products 7, 100223 , 2025 2025 Citations: 3
Simultaneous optimization of microwave- and ultrasound-assisted extractions of bioactive compounds from cashew nut testa shell ( Anacardium occidentale L.) J da Silva, L Benvenutti, PRV Ribeiro, ES de Brito, SRS Ferreira Biomass Conversion and Biorefinery 15 (9), 14017-14035 , 2025 2025 Citations: 6
Sustainable Extraction of Bioactive Compounds from Annona muricata L. Leaves by Deep Eutectic Solvents (DESs) LF Oton, PRV Ribeiro, ES de Brito, RS de Santiago-Aguiar ACS omega 10 (16), 16909-16920 , 2025 2025 Citations: 7
Chemical Composition and Antidiabetic Potential of a Phenolic-Rich Extract from Cashew Fiber RRBX Filho, PRV Ribeiro, LMA Silva, LL Pereira, GA Freire, CBR Martins, ... ACS Food Science & Technology 5 (4), 1687-1698 , 2025 2025 Citations: 4
Oxidative stability and affective/descriptive sensory properties of cashew nut ( Anacardium occidentale L.) oil during accelerated storage conditions AR Leal, GF de Oliveira, EKM da Silva, AJC Araújo, IMS Araújo, ... Journal of Food Science 90 (4), e70176 , 2025 2025 Citations: 2
Analysis of germination and vigor of cashew seeds for germplasm conservation by NMR and uPLC-qTOF-MS/MS based metabolomics EG Alves Filho, JRA de Queirós, OH Bonilla, HCR Magalhães, ... Food Research International 204, 115918 , 2025 2025
An Eco-Friendly High-Pressure Biorefinery Approach for the Recovery of Valuable Compounds from Cashew Nut Testa Shell ( Anacardium occidentale L. ) J da Silva, TMS Torres, PRV Ribeiro, ES de Brito, SRS Ferreira Food and Bioprocess Technology 18 (2), 1997-2016 , 2025 2025 Citations: 6
Study of the Chemical Diversity in Spondias tuberosa Leaves During the Phenological Evolution Stages: Metabolomic and Chemometric Approaches Associated … FWM Nascimento, TA Gondim, PRV Ribeiro, MAC Lima, VR Oliveira, ... Journal of the Brazilian Chemical Society 36 (5), e-20240219 , 2025 2025 Citations: 1
Uso do extrato da Fava d’Anta no cultivo do milho sob estresse salino KR Saraiva, TVA Viana, CF Lacerda, GG Sousa, MA Bezerra, KM Canuto, ... Revista Ambiente & Água 20, e3081 , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Chemical profiling of guarana seeds (Paullinia cupana) from different geographical origins using UPLC-QTOF-MS combined with chemometrics GS da Silva, KM Canuto, PRV Ribeiro, ES de Brito, MM Nascimento, ... Food Research International 102, 700-709 , 2017 2017 Citations: 127
Ultrasound-assisted and pressurized liquid extraction of phenolic compounds from Phyllanthus amarus and its composition evaluation by UPLC-QTOF AD Sousa, AIV Maia, THS Rodrigues, KM Canuto, PRV Ribeiro, ... Industrial Crops and Products 79, 91-103 , 2016 2016 Citations: 113
Antioxidant films from mango kernel components PEF Melo, APM Silva, FP Marques, PRV Ribeiro, ES Brito, JR Lima, ... Food Hydrocolloids 95, 487-495 , 2019 2019 Citations: 97
Green coffee seed residue: A sustainable source of antioxidant compounds A Castro, FB Oda, MGJ Almeida-Cincotto, MG Davanço, ... Food Chemistry 246, 48-57 , 2018 2018 Citations: 97
Stabilizing effect of montmorillonite on acerola juice anthocyanins HL Ribeiro, AV de Oliveira, ES de Brito, PRV Ribeiro, HMC Azeredo Food chemistry 245, 966-973 , 2018 2018 Citations: 67
Phytochemical profile of Anacardium occidentale L.(cashew tree) and the cytotoxic and toxicological evaluation of its bark and leaf extracts AR Costa, JR de Lima Silva, TJS de Oliveira, TG da Silva, PS Pereira, ... South African Journal of Botany 135, 355-364 , 2020 2020 Citations: 53
UPLC–qTOF-MS/MS-based phenolic profile and their biosynthetic enzyme activity used to discriminate between cashew apple (Anacardium occidentale L.) maturation stages AG Cunha, ES Brito, CFH Moura, PRV Ribeiro, MRA Miranda Journal of Chromatography B 1051, 24-32 , 2017 2017 Citations: 51
Chemical composition of thermally processed coconut water evaluated by GC–MS, UPLC-HRMS, and NMR AG Cunha, EG Alves Filho, LMA Silva, PRV Ribeiro, THS Rodrigues, ... Food Chemistry 324, 126874 , 2020 2020 Citations: 48
Gastroprotective and anti-inflammatory activities integrated to chemical composition of Myracrodruon urundeuva Allemão-A conservationist proposal for the species WRA Galvão, R Braz Filho, KM Canuto, PRV Ribeiro, AR Campos, ... Journal of ethnopharmacology 222, 177-189 , 2018 2018 Citations: 48
Sequential extraction of flavonoids and pectin from yellow passion fruit rind using pressurized solvent or ultrasound CG de Souza, THS Rodrigues, LMA e Silva, PRV Ribeiro, ES de Brito Journal of the Science of Food and Agriculture 98 (4), 1362-1368 , 2018 2018 Citations: 46
Analysis by UPLC-MS-QTOF and antifungal activity of guava (Psidium guajava L.) CF Bezerra, JE Rocha, MK do Nascimento Silva, TS de Freitas, ... Food and chemical toxicology 119, 122-132 , 2018 2018 Citations: 45
Impact of bioaccessibility and bioavailability of phenolic compounds in biological systems upon the antioxidant activity of the ethanolic extract of Triplaris gardneriana seeds JJL Neto, TS de Almeida, JL de Medeiros, LR Vieira, TB Moreira, ... Biomedicine & Pharmacotherapy 88, 999-1007 , 2017 2017 Citations: 45
Chemical profiling of secondary metabolites from Himatanthus drasticus (Mart.) Plumel latex with inhibitory action against the enzymes α-amylase and α-glucosidase: In vitro and … FS Morais, KM Canuto, PRV Ribeiro, AB Silva, ODL Pessoa, CDT Freitas, ... Journal of ethnopharmacology 253, 112644 , 2020 2020 Citations: 42
UPLC-MS-ESI-QTOF characterization and evaluation of the antibacterial and modulatory antibiotic activity of Ziziphus joazeiro Mart. aqueous extracts JC Andrade, ARP Silva, ATL Santos, MA Freitas, JNP Carneiro, ... South African Journal of Botany 123, 105-112 , 2019 2019 Citations: 42
Drying kinetics and effect of air-drying temperature on chemical composition of Phyllanthus amarus and Phyllanthus niruri AD Sousa, PRV Ribeiro, KM Canuto, GJ Zocolo, RCA Pereira, ... Drying technology 36 (5), 609-616 , 2018 2018 Citations: 38
Chemotaxonomic evaluation of different species from the Myrtaceae family by UPLC-qToF/MS-MS coupled to supervised classification based on genus LS Santos, EG Alves Filho, PRV Ribeiro, GJ Zocolo, SM Silva, ... Biochemical Systematics and Ecology 90, 104028 , 2020 2020 Citations: 37
Effect of pulsed light on postharvest disease control-related metabolomic variation in melon ( Cucumis melo ) artificially inoculated with Fusarium pallidoroseum FO Filho, EO Silva, MMA Lopes, PRV Ribeiro, AH Oster, JAC Guedes, ... PLoS One 15 (4), e0220097 , 2020 2020 Citations: 35
Garlic passion fruit (Passiflora tenuifila Killip): Assessment of eventual acute toxicity, anxiolytic, sedative, and anticonvulsant effects using in vivo assays DKR Holanda, NJ Wurlitzer, AP Dionisio, AR Campos, RA Moreira, ... Food Research International 128, 108813 , 2020 2020 Citations: 32
Ultrasound-assisted extraction of anthocyanins from grape pomace using acidified water: Assessing total monomeric anthocyanin and specific anthocyanin contents BLA Decker, E de Godoy Alves Filho, LMA e Silva, PRV Ribeiro, ... Food Research International 194, 114910 , 2024 2024 Citations: 31
Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes LGS Souza, MCS Almeida, TLG Lemos, PRV Ribeiro, ES de Brito, ... Bioorganic & Medicinal Chemistry Letters 26 (2), 435-439 , 2016 2016 Citations: 31
