PRATAP KUMAR PATRA

@cutm.ac.in

Associate Professor, Pharmaceutical Chemistry
School of pharmacy and life sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha

PRATAP KUMAR PATRA


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https://researchid.co/patra1981
Dr. Pratap obtained his B.
Pharma from College of Pharmaceutical Sciences, Berhampur under
Biju Pattanaik University of Technology, Rourkela, Odisha in 2005
and M. Pharm in Pharmaceutical Chemistry from College of
Pharmaceutical Sciences, Berhampur under Biju Pattanaik
University of Technology, Rourkela, Odisha in 2008. He was
awarded Ph.D from Berhampur University, Berhampur, Odisha in 2016. He has more than 15
years of teaching experience. His main area of interest in research includes Phytochemistry,
Analytical chemistry and formulation and evaluation of Herbal formulations. He has published
40 research articles (Google Scholar Citation-60, h-index- 5, i10 index-2) in various international
and national journals as well as prepresented more than 35 papers in various international and
national conferences. Presently he is guiding 2 number of Ph.D research scholars under him in
CUTM and Lovely Professional University. To his credit he has 4 patents in his name.

EDUCATION

M. Pharm, Ph>D

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacy, Analytical Chemistry, Organic Chemistry, Pharmaceutical Science
13

Scopus Publications

127

Scholar Citations

6

Scholar h-index

5

Scholar i10-index

Scopus Publications

  • Synaptic aging and neurodegeneration: the role of synaptic vesicle dynamics and neurotransmitter imbalance
    Pranay Wal, Abhijit Dutta, Talha Jawaid, Mujeeb Ur Rahman, Gowri Krishnaperumal, S. Renuka Jyothi, Irwanjot Kaur, Shaker Al-Hasnaawei, Aashna Sinha, Laxmidhar Maharana, Sourav Debnath, Pratap Kumar Patra, Hanish Singh Jayasingh Chellammal, Lalit Kumar Tyagi, Smitha Kumari, Amin Gasmi
    Biogerontology, 2026
  • Innovative Drug Delivery Strategies for Enhanced Treatment of Antimicrobial Resistance
    Pranay Wal, Ankita Wal, Ajay Kumar, Hanish Singh Jayasingh Chellammal, Pratap Kumar Patra, Manish R. Bhise, Dileep Kumar, Sanjana Gupta, Amin Gasmi
    Current Drug Delivery, 2026
    Introduction: Antimicrobial resistance (AMR) presents a major global health threat, driven by the overuse and misuse of antibiotics. Traditional drug delivery systems face significant limitations in effectively addressing this issue, including poor targeting, low bioavailability, and the development of resistance. Nanoparticle-based drug delivery systems (NDDS) have emerged as a novel approach to overcome these limitations and combat resistant bacteria by improving drug delivery and targeting. This review aims to evaluate the mechanisms of AMR and the effectiveness of nanoparticle- based drug delivery systems in combating resistant bacteria. Methods: The methodology employed in this review involved a systematic search of peer-reviewed literature in databases such as PubMed, Google Scholar, Scopus, and Web of Science. The search strategy focused on identifying relevant articles using keywords and phrases such as "nanoparticle drug delivery systems," "antimicrobial resistance," "nanomedicine," "liposomes," "nanoemulsions," and "polymeric nanoparticles." The review included studies evaluating the mechanisms of antimicrobial resistance, the applications of NDDS, and their implications and advancements in combating AMR. Results: Nanoscale drug delivery vehicles and antibacterial nanoparticles have demonstrated significant potential as effective treatments for infections. Nanoparticles, with their small and controllable size, offer unique properties such as enhanced reactivity, a functionalizable structure, and a high surface area-to-volume ratio. NDDS, including liposomes, nanoemulsions, solid lipid nanoparticles, polymeric nanoparticles, and metal nanoparticles, have gained attention due to their ability to enhance drug bioavailability and targeting effectiveness. Conclusion: Nanoparticles present a promising strategy to combat AMR. Their capacity to bypass traditional resistance mechanisms and improve drug delivery underscores their potential in the development of effective antimicrobial therapies. Further research is essential to optimize nanoparticle formulations for clinical translation, ensuring their safety and efficacy in treating resistant bacterial infections. This review highlights the importance of integrating nanotechnology into antimicrobial strategies to address the growing challenge of AMR.
  • Molecular mechanisms of signaling transduction pathways of drug target molecules with recent advancements and future perspectives for successful therapy: a comprehensive and exploratory review
    Sujana Kamepalli, Sambamoorthy Unnam, Satyabrata Bhanja, Krishna Reddy Yeduru, Pratap Kumar Patra, Nasreen Sulthana, Roja Pathakota, Renukadevi Thota, Arun Kumar Sanapala
    Beni Suef University Journal of Basic and Applied Sciences, 2025
    Background With an emphasis on current developments and potential future perspectives in therapeutic applications, this comprehensive review delves into the molecular mechanisms of signaling transduction pathways associated with pharmacological target molecules. Since these pathways are essential to the cellular response to pharmacological drugs, understanding them is necessary for developing effective treatments. The notion of cellular signaling and the range of signaling pathways that control important cellular functions are first explained in this chapter. It highlights the intricate interactions between the essential elements of signaling pathways, such as effectors, ligands, receptors, and intercellular messengers. Main body It explores the activation and subsequent signaling events of several receptors, including intracellular nuclear, t-kinase, GPCR (G-protein-coupled receptors), and ionic receptors. We reviewed innovative methods that have sped up the discovery of new drug targets and clarified intricate signaling networks, like X-ray crystallography, advanced Cryo-EM (Cryo-Electron Microscopy), high-throughput screening, allosteric modulations, Artificial intelligence, and machine learning. This review attempts to explain the clear pathway of drug target molecules for novel, focused treatments that improve patient outcomes and further the field of drug development by combining existing knowledge and suggesting future research avenues. Conclusion Prospects for the future highlight the value of interdisciplinary teams in addressing these issues, encouraging advancements in combination therapies and tailored delivery systems that can get around current drawbacks in traditional therapy. In a rapidly changing biomedical landscape, this review seeks to shed light on pathways toward more effective, customized therapies that address the underlying molecular mechanisms of disease. Ultimately, it hopes to improve patient care and therapeutic outcomes by synthesizing current knowledge and suggesting strategic research directions. Graphical abstract
  • Exploring application & recent advances of response surface methodology driven approach in drug design and nanotechnology
    Bikash Ranjan Jena, Aradhana Panigrahi, Surya Kanta Swain, Himansu Bhusan Samal, Pratap Kumar Patra
    Indian Journal of Microbiology Research, 2025
    Exploring application & recent advances of response surface methodology driven approach in drug design and nanotechnology - IJMR- Print ISSN No: - 2394-546X Online ISSN No:- 2394-5478 Article DOI No:- 10.18231/j.ijmr.2025.022, Indian Journal of Microbiology Research-Indian J Microbiol Res
  • Recent Advancement in Drug Targeting Therapies in the Treatment of Pancreatic Cancer
    Ranjit K. Harwansh, Junainah Abd Hamid, Pranay Wal, Rohitas Deshmukh, Pratap Kumar Patra, Amin Gasmi
    Current Pharmaceutical Design, 2025
    Objective of the Study: This review aims to critically analyze the scope for targeting drugs towards the treatment of improving outcomes in PDAC, focusing on DNA repair inhibitors, antiangiogenic therapy, inhibitors of the KRAS pathway, anti-stromal, and nanoparticle-based therapy. Materials and Methods: A critical review of preclinical and clinical studies was conducted to summarize the therapeutic interventions that target specific mutations in PDAC, components of the tumor microenvironment, and drug delivery systems, especially nanotechnology, to enhance targeting and efficacy. Results: Inhibitors and nanotechnology-based targeted therapies have reported promise in preclinical models: drug delivery is enhanced with the loss of PDAC resistance mechanisms. Formulations and combinations targeting KRAS as well as other pathways point toward improved drug delivery over 'orthodox' treatment approaches. Conclusion: This review concludes that although improvement in therapies for PDAC has incrementally been proven in recent literature, however, more research is expected to enhance these approaches so that they can be applied appropriately at the clinical stage. In future studies, it is expected to optimize treatment combinations, address mechanisms of resistance, and improve the delivery of drugs.
  • Development of Oral Insulin Delivery System in Diabetes - New Insights and Approaches - A Systematic Review
    Zulfa Nooreen, Anup Patil, Harshita Sachan, K. Gowri, Ashish Kumar Kyada, Pratap Kumar Patra, Deepak Nathiya
    Recent Advances in Drug Delivery and Formulation, 2025
    Introduction: Diabetes is a condition linked to inadequate synthesis or operation of insulin, a peptide hormone produced by the β cells in the pancreatic islets. Subcutaneous administration remains the most popular mode of administration. With the SC route, non-compliance by patients is common. In an attempt to lower the barrier to oral insulin administration, a number of produced. The present review is to gather information from current researchers on oral insulin delivery in order to make it more bioavailable as an injection that is not painful and does not harm to skin as well. Method: The content is taken from Scifinder, PubMed, Google Scholar, Research Gate, Science Direct, Springer Nature, Bentham Science, PLOS One, MEDLINE, and the NCBI database, etc. Results: Insulin delivery is a major concern nowadays. Due to various drawbacks of subcutaneous injection, academia and industrial researchers are working on oral insulin delivery. Numerous novel formulation of oral delivery of insulin is compiled, like nanoparticles, microspheres, liposomes, hydrogel, and niosomes, focused on the effectiveness of dose-dependent therapy that delivers oral insulin that is equivalent to subcutaneous insulin. Discussion: In contrast to the conventional method, novel delivery approaches may improve oral insulin administration. The role of polymers plays an important role in the delivery of insulin through novel approaches. Conclusions: In this review, we summarize pathophysiology, types, and routes of oral insulin administration, and treatment methods related to oral delivery. Furthermore, we discuss all above mentioned delivery approaches in detail.
  • Real-life vaccination opportunities for the treatment of various women’s diseases
    Nanomedicine Advancements and Intersectional Perspectives for Women S Health, 2025
  • Quantification of Alectinib in spiked rabbit plasma using liquid chromatography-electro spray ionization-tandem mass spectrophotometry: An application to pharmacokinetic study
    H. K. Sundeep Kumar, Suman Acharyya, Prasenjit Mondal, Pratap Kumar Patra, Satyabrata Sahu
    Current Chemistry Letters, 2023
    The current technique was developed to estimate the amount of alectinib present in spiked rabbit plasma using liquid chromatographic mass spectrometry. The liquid-liquid extraction method was used, and chromatographic separation was carried out on a C18 (4.6mm id x 50mm) analytical column with a mobile phase consisting of acetonitrile and water with 0.1% formic acid at a volume ratio of 75:25. Alectinib's product m/z +483.2 (parent) 396.1 (product) and the internal standard m/z +447.5 (parent) 380.3 (product) were both obtained using positive ion mode. The calibration curve was linear from 0.5 to 600 ng/ml. The percentage extraction recovery (98.15% → 98.86%), demonstrated excellent matrix and analyte selectivity (% interference = 0), and satisfactory stability study results in all types (% nominal 94.94% → 99.63%). The intra and interday accuracy with % nominal 97 → 98.8%, precision % CV ≤ 2% in all quality control levels. The rabbit model's pharmacokinetic parameters were examined, and alectinib's area under the curve (AUC 0—∞) was 4269 ± 8.13 hr.ng/ml. The half-life of elimination (t1/2) is 8.52 ± 6.66 hours. The currently established approach was used in rabbit blood samples for pharmacokinetic investigations of commercial formulations since it was thought to be a novel, verified bioanalytical method based on experimental results.
  • Synthesis and antibacterial activity screening of some novel pyrazole derivatives
    International Journal of Pharmacy and Pharmaceutical Sciences, 2014
  • Antioxidant study of different extracts of Scoparia dulcis
    International Journal of Pharmacy and Pharmaceutical Sciences, 2014
  • Formulation and in vitro studies of Carvedilol microspheres with its characterization
    International Journal of Pharmacy and Pharmaceutical Sciences, 2014
  • Synthesis and evaluation of anti-microbial activity of some substituted novel Azetidinone derivatives
    Rasayan Journal of Chemistry, 2013
  • Solubility and dissolution improvement of Aceclofenac using B- Cyclodextrin
    International Journal of Drug Development and Research, 2012

RECENT SCHOLAR PUBLICATIONS

  • Synaptic aging and neurodegeneration: the role of synaptic vesicle dynamics and neurotransmitter imbalance
    P Wal, A Dutta, T Jawaid, MU Rahman, G Krishnaperumal, ...
    Biogerontology 27 (2), 55 , 2026
    2026
  • The future of personalized fertility treatment with nanomedicine
    S Acharyya, S Sahu, PK Patra, R Pradhan, R Dolui, HKS Kumar
    Nanotechnology in the Treatment of Infertility, 345-365 , 2026
    2026
  • Real-life vaccination opportunities for the treatment of various women’s diseases
    S Sahu, S Acharyya, PK Patra, R Pradhan, SK Sahu, J Debata, ...
    Nanomedicine Advancements and Intersectional Perspectives for Women's Health … , 2026
    2026
  • Curcuma Longa Phytocompounds: An in Silico Analysis Aimed at Targeting the EGFR Protein as a Potential Anti-cancer Agent
    HP Mishra, TK Suvvari, S Grover, C Mohapatra, PK Patra
    Apollo Medicine 22 (5), 361-365 , 2025
    2025
    Citations: 1
  • Molecular mechanisms of signaling transduction pathways of drug target molecules with recent advancements and future perspectives for successful therapy: a comprehensive and …
    RTAKS Sujana Kamepalli, Sambamoorthy Unnam, Satyabrata Bhanja, Krishna Reddy ...
    Beni-Suef University Journal of Basic and Applied Sciences 14 , 2025
    2025
    Citations: 1
  • Metformin's anticancer odyssey: Revealing multifaceted mechanisms across diverse neoplastic terrains- a critical review
    RU Rashmi Saxena Pal, Talha Jawaid, M.A. Rahman, Rakesh Verma, Pratap Kumar ...
    Biochimie 233, 109-121 , 2025
    2025
    Citations: 14
  • Recent Advancement in Drug Targeting Therapies in the Treatment of Pancreatic Cancer
    PKPAG Ranjit K Harwansh, Junainah Abd Hamid, Pranay Wal, Rohitas Deshmukh*
    Current Pharmaceutical Design , 2025
    2025
    Citations: 1
  • Exploring application & recent advances of response surface methodology driven approach in drug design and nanotechnology
    A Panigrahi, BR Jena, SK Swain, HB Samal, PK Patra
    2025
  • Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance
    AG Tapan Behl, Ashishkumar Kyada, R Roopashree, Deepak Nathiya, Renu Arya, M ...
    Ageing Research Reviews 102 , 2024
    2024
    Citations: 24
  • SPECTROSCOPIC ANALYSIS OF FRACTIONS OF TABERNAEMONTANA DIVARICATA (LINN) R.Br LEAF
    BKS Taqiuddin, Rajan Kumar, Partap Kumar Patra, Sukriti Vishwas, Rakesh ...
    African Journal of Biological Science 6 (12), 4625-4645 , 2024
    2024
  • Exploring the Therapeutic Potential of Imidazothiadiazole Derivatives: A Comprehensive Review with Structures
    MST Dr Pankaj Agrawal, Dr. Pratap Kumar Patra, Dr Sachin M Mahajan, Neha ...
    African Journal of Biological Sciences 6 (12), 3613-3627 , 2024
    2024
  • A new analytical method development and validation for the estimation of bedaquiline by reverse-phase high-performance liquid chromatography
    PK Patra, A Basak, R Islam, B Sarkar, C Mondal
    2024
  • A Novel RP-HPLC Method Development and Validation of Anti-Malarial Drugs Atovaquone and Proguanil Hydrochloride in Bulk Drug and Marketed Pharmaceutical Dosage Form
    RS Pratap Kumar Patra
    International Journal of Pharma Research and Health Sciences, 2022; 10(1 … , 2022
    2022
  • Study of Antioxidant Properties from Different Extracts of Scoparia dulcis (Sweet broom weed)
    PK Patra, J Debata, ES Reddy, HB Samal
    Technological Innovation in Pharmaceutical Research Vol. 5, 16-23 , 2021
    2021
  • A Novel Ultra Performance Liquid Chromatographic Method for the Estimation of Lercanidipine in Bulk and Tablet Dosage Form
    USKPPKP Satyabrata Sahu
    Journal of Pharmaceutical Research International 33 (59(A)), 768-776 , 2021
    2021
    Citations: 1
  • Development and Validation of Novel Ultra Performance Liquid Chromatography Technique for the Simultaneous Determination of Metformin and Repaglinide in Bulk and Formulation
    SAPKP H. K. Sundeep Kumar
    Journal of Pharmaceutical Research International 33 (33A), 115-124 , 2021
    2021
  • RP-HPLC Method for the Simultaneous Estimation of Benazepril and Hydrochlorothiazide in Pure form and Marketed Pharmaceutical Dosage
    CMR PRATAP KUMAR PATRA
    High Technology Letters 7 (11), 309-329 , 2021
    2021
  • SIMULTANEOUS ESTIMATION FOR THE DEVELOPMENT AND VALIDATION OF LERCANIDIPINE AND ATENOLOL IN BULK FORM AND PHARMACEUTICAL FORMULATION BY RP-HPLC METHOD
    DPKP GUDIGOPURAM DEEPTHI
    International Journal of Research 8 (4), 3146-3165 , 2019
    2019
  • DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE QUANTITATIVE ESTIMATION FOR TRIAMTERENE AND HYDROCHLOROTHIAZIDE IN API AND TABLET DOSAGE FORM
    DPKP SAMREEN BEGUM
    International Journal of Research 8 (4), 3210-3231 , 2019
    2019
  • A NEW RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF EMPAGLIFLOZIN IN API AND TABLET DOSAGE FORM
    JDPK Patra
    Asian Journal of Research in Chemistry and Pharmaceutical Sciences 7 (2 … , 2019
    2019

MOST CITED SCHOLAR PUBLICATIONS

  • Solubility and dissolution improvement of aceclofenac using β-Cyclodextrin
    HB Samal, J Debata, NN Kumar, S Sneha, PK Patra
    Int. J. Drug Dev. Res 4, 326-333 , 2012
    2012
    Citations: 35
  • Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance
    AG Tapan Behl, Ashishkumar Kyada, R Roopashree, Deepak Nathiya, Renu Arya, M ...
    Ageing Research Reviews 102 , 2024
    2024
    Citations: 24
  • Antioxidant study of different extracts of Scoparia dulcis
    PK Patra, J Debata, ES Reddy, HB Samal
    International journal of pharmacy and pharmaceutical sciences 6 (1), 600-603 , 2014
    2014
    Citations: 16
  • Metformin's anticancer odyssey: Revealing multifaceted mechanisms across diverse neoplastic terrains- a critical review
    RU Rashmi Saxena Pal, Talha Jawaid, M.A. Rahman, Rakesh Verma, Pratap Kumar ...
    Biochimie 233, 109-121 , 2025
    2025
    Citations: 14
  • Formulation and in vitro studies of carvedilol microspheres with its characterization
    KV Reddy, PK Patra, K Divakar, BV Reddy
    International Journal of Pharmacy and Pharmaceutical Sciences 6 (4), 329-332 , 2014
    2014
    Citations: 10
  • Synthesys and screening of analgesic activity of some novel pyrazole
    PK Patra, CN Patra, S Pattnaik
    International Journal of Pharmaceutical Sciences And Research 5 (5), 1874 , 2014
    2014
    Citations: 6
  • Synthesis and antibacterial activity screening of some novel pyrazole derivatives
    PK Patra, CN Patra, S Pattnaik
    Int. J. Pharm. Pharm. Sci 6, 801-805 , 2014
    2014
    Citations: 6
  • Antifungal and Anthelmintic Activity of Some Novel Pyrazole Derivative
    PK Patra, CN Patra, S Pattnaik
    Asian Journal of Research in Chemistry 7 (1), 7 , 2014
    2014
    Citations: 4
  • Evaluation of anti-diarrhoeal activity of ethanolic leaf extract of Scoparia dulcis linn on wister albino rats
    A Dey, G Panigrahi, L Deb, K Nongalleima, P Patra
    Indian Journal of Research in Pharmacy and Biotechnology 1 (1), 78 , 2013
    2013
    Citations: 3
  • PHYTOCHEMICAL INVESTIGATION AND HEPATOPROTECTIVE EFFECT OF &ITSCOPARIA DULCIS&IT AGAINST CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN RATS
    PK Patra, SK Shete, S Dange
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH 9 (3), 1086-1092 , 2018
    2018
    Citations: 2
  • Anthelmintic Activity of Cleome hassleriana Seed Extracts
    J Debata, HB Samal, PK Patra
    Int J Pharm Pharm Sci 5 (4), 574-576 , 2013
    2013
    Citations: 2
  • Curcuma Longa Phytocompounds: An in Silico Analysis Aimed at Targeting the EGFR Protein as a Potential Anti-cancer Agent
    HP Mishra, TK Suvvari, S Grover, C Mohapatra, PK Patra
    Apollo Medicine 22 (5), 361-365 , 2025
    2025
    Citations: 1
  • Molecular mechanisms of signaling transduction pathways of drug target molecules with recent advancements and future perspectives for successful therapy: a comprehensive and …
    RTAKS Sujana Kamepalli, Sambamoorthy Unnam, Satyabrata Bhanja, Krishna Reddy ...
    Beni-Suef University Journal of Basic and Applied Sciences 14 , 2025
    2025
    Citations: 1
  • Recent Advancement in Drug Targeting Therapies in the Treatment of Pancreatic Cancer
    PKPAG Ranjit K Harwansh, Junainah Abd Hamid, Pranay Wal, Rohitas Deshmukh*
    Current Pharmaceutical Design , 2025
    2025
    Citations: 1
  • A Novel Ultra Performance Liquid Chromatographic Method for the Estimation of Lercanidipine in Bulk and Tablet Dosage Form
    USKPPKP Satyabrata Sahu
    Journal of Pharmaceutical Research International 33 (59(A)), 768-776 , 2021
    2021
    Citations: 1
  • RP-HPLC method development and validation of Regorafenib in pure form and pharmaceutical dosage form
    J Debata, PK Patra, P Suresh
    Asian Journal of Research in Chemistry 11 (4), 763-767 , 2018
    2018
    Citations: 1
  • Synaptic aging and neurodegeneration: the role of synaptic vesicle dynamics and neurotransmitter imbalance
    P Wal, A Dutta, T Jawaid, MU Rahman, G Krishnaperumal, ...
    Biogerontology 27 (2), 55 , 2026
    2026
  • The future of personalized fertility treatment with nanomedicine
    S Acharyya, S Sahu, PK Patra, R Pradhan, R Dolui, HKS Kumar
    Nanotechnology in the Treatment of Infertility, 345-365 , 2026
    2026
  • Real-life vaccination opportunities for the treatment of various women’s diseases
    S Sahu, S Acharyya, PK Patra, R Pradhan, SK Sahu, J Debata, ...
    Nanomedicine Advancements and Intersectional Perspectives for Women's Health … , 2026
    2026
  • Exploring application & recent advances of response surface methodology driven approach in drug design and nanotechnology
    A Panigrahi, BR Jena, SK Swain, HB Samal, PK Patra
    2025