Substituted quinolinones. Part 22. In vitro antimicrobial evaluation of some 4-hydroxy-1-methyl-3-pyrazolinylquinolin-2(1H)-ones as useful antibiotic intermediates Mohamed Abass, Elham S. Othman Research on Chemical Intermediates, 2015 Thirty derivatives of 3-pyrazolylquinolinone, in three different types; enaminones 1a–j, enones 2a–j, and hydrazonones 3a–j, have been investigated for their in vitro antimicrobial activity. The tested compounds have been screened against four chosen microorganisms, two bacteria strains (Staphylococcus aureus, as Gram-positive bacterium, and Escherichia coli, as Gram-negative bacterium), and two fungi strains (Aspergillus flavus and Candida albicans). Disc plate and serial dilutions techniques were used to evaluate and determine the antimicrobial activity and minimum inhibition concentration of the tested compounds. The results revealed that the enaminone derivatives 1a–j have desirable antimicrobial activity against both bacteria and fungi groups, and they are promising useful antibiotic intermediates.
Substituted quinolinones. 18. 3-Acetyl-4-methylthioquinolin-2(1H)-one as useful synthon intermediate for synthesis of some new quinolinones Mohamed M. Hassan, Elham S. Othman, Mohamed Abass Research on Chemical Intermediates, 2013 3-Acetyl-4-methylthioquinolin-2(1H)-one (3) has been prepared and its reactivity towards treatment with different reagents, dilute sulfuric acid, aqueous sodium hydroxide, and hydrogen peroxide, is described. The reactions of compound 3 with benzylamine, benzaldehyde, DMF-DMA, Vilsmeier-Haack reagent, 2-chloro-3-formyl-pyridopyrimidone and malononitrile have been carried out under convenient conditions. Compound 3 underwent heterocyclization reactions with some binucleophiles, hydrazine, hydroxylamine, urea, thiourea, semicarbazide, and thiosemicarbazide, furnishing some known five, six, and seven heterocyclic annellated quinolines. All the new compounds have been characterized using different spectral and analytical tools.
Substituted quinolinones, part 11: Efficient synthesis of different 3-(4-arylidene and hetarylidene-5-oxopyrazolin-3-yl) quinolin-2-ones Mohamed Abass, Elham S. Othman, Akram Hassan Synthetic Communications, 2007 Several 3‐(4‐arylidene and hetarylidene‐5‐oxopyrazolin‐3‐yl)quinolin‐2‐ones 6–26 were synthesized in an efficient methodology utilizing both pyrazolinylquinolinone 2 and its chromenylmethylene derivative 10. Compound 2 was derivatized by Knoevenagel condensation with different carbonyl compounds. Nucleophilic ring opening–ring closure (RORC) of the compound 10 furnished the desired 4‐methylenepyarzolinone bearing novel five‐, six‐, and seven‐membered heterocycles, in good yields.
Synthesis and cyclization reactions with quinolinyl keto esters I. Chemical reactivity of quinolinyl β-keto ester and quinolinyl α,β- unsaturated ketones Chemical Papers, 2005
Some nucleophilic cyclization reactions with 3-[4-(benzo[1,3]dioxolylmethylene)pyrazolyl]quinolone Acta Chimica Slovenica, 2003
Chemistry of substituted quinolinones. III. Synthesis and reactions of some novel 3-pyrazolyl-2-quinolinones Mohamed Abass, Elham S. Othman Synthetic Communications, 2001 The preparation of 4-hydroxy-1-methyl-3-(5-oxo-4,5-dihydro-1H-3-pyrazolyl)-1,2-dihydro-2-quinolinone (3) and its hydrazono-, aminomethylidene- and arylidene derivatives has been achieved. The synthesis of fused heterocyclic polynuclear systems containing quinolinone moiety is also described.
New quinolones and naphthyridinones bearing heterocyclic rings Chemical Papers, 1999
Synthesis of new 3-acryloyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline derivatives and their behaviour towards some nucleophiles Chemical Papers, 1997
