Nguyen Manh Cuong

Scopus Publications

Chemical Composition, Antimicrobial, and in Silico Molecular Docking Analysis of β-Asarone-Free Essential Oils from Diploid Acorus calamus L. in Mongolia
Javzmaa Namshir, Selenge Munkhtsetseg, Nomuun Tsevegsuren, Nyamsuren Erdenetsogt, Oyunbileg Yungree, Purevdorj Erdenetsogt, Bolor Tsolmon, Solongo Amgalan, Vu Thanh Loc, Tran Thu Huong, Nguyen Xuan Ha, Dinh Thi Thu Thuy, Ngo Kim Chi, Truong Ngoc Hung, Do Huu Nghi, Chu Quang Truyen, Nguyen Manh Cuong
Chemistry Africa, 2026
The Inclusion of Dietary and Medicinal Mushrooms into Translational Oncology: Pros and Cons at the Molecular Level
Yulia Kirdeeva, Elizaveta Fefilova, Natalia Karpova, Sergey Parfenyev, Alexandra Daks, Alexander Nazarov, Oleg Semenov, Nguyen Thi Van Anh, Vu Thanh Loc, Nguyen Manh Cuong, Oleg Shuvalov
International Journal of Molecular Sciences, 2026
Mushrooms are valued for their nutritional qualities and have been used in traditional medicine since the Neolithic era. They exhibit various bioactivities, including antioxidant, hypocholesterolemic, immunomodulatory, and anticancer effects. The anticancer effects arise via direct action on tumor cells and indirect modulation of the immune system; the latter is the predominant mechanism. Numerous studies indicate that various mushroom species are potent immunostimulants because their cell wall polysaccharides and proteoglycans are recognized by intestinal immune cells. This enhances antitumor immunity through multiple molecular pathways. However, their direct effects on cancer cells are of questionable physiological relevance due to bioavailability constraints. Nevertheless, we hypothesize that the accumulation of non-absorbed polysaccharides in the gastrointestinal tract positions mushrooms as dual-action agents with the potential to treat colorectal cancer by providing indirect immunomodulation and direct local tumor suppression. Conversely, the direct anticancer effects of mushrooms are generally attributed to bioactive secondary metabolites that influence essential cellular processes, including signaling pathways, cell cycle regulation, apoptosis, autophagy, cellular migration, invasion, and cancer stem cell characteristics. Beyond these anticancer effects, clinical evidence suggests that certain mushroom-derived substances can improve survival outcomes for cancer patients and provide supportive care benefits in oncology, thereby improving quality of life. Specifically, mushrooms may mitigate the side effects of chemotherapy and radiotherapy, bolster immune function often suppressed by cancer treatments, and enhance overall well-being. In this review, we discuss the therapeutic benefits of dietary and medicinal mushrooms in cancer care, as well as unresolved challenges and future research directions.
Anti-inflammatory components of the essential oil from the leaves of Citrus × aurantium L. based on network pharmacology study
Tran Thu Huong, Vu Thanh Loc, Nguyen Xuan Ha, Vu Thi Ha, Pham Ngoc Khanh, Dinh Thi Thu Thuy, Tran Duc Binh, Tran The Bach, Nguyen Thi Phuong Trang, Tran Quoc Toan, Nguyen Manh Cuong
Vietnam Journal of Chemistry, 2025
The scientific name of the species “Quýt hoi,” a specialty of Pu Luong Commune, Thanh Hoa, Vietnam, was determined to be Citrus × aurantium L. by morphological and molecular methods. The essential oil of Citrus × aurantium L. leaves possesses a characteristic composition of monoterpene hydrocarbons (56.2%), oxygenated monoterpenes (14.3%), as well as a distinctively high content of aromatic compounds (24.8%). The five main constituents of the oil are γ ‐terpinene (24.7%), thymol methyl ether (14.7%), linalool (12.3%), β ‐pinene (12.2%), and thymol (5.2%). Network pharmacology and molecular docking analyses revealed that ( E )‐ β ‐caryophyllene and bicyclogermacrene were active components interacting with AKT1, GAPDH, and TNF‐ α inflammatory pathway proteins. These findings encourage more research on the Citrus × aurantium L. leaves for the treatment of inflammatory‐related diseases.
Sesuvioside A from Gomphrena celosioides possesses the Dual Anti-gout Actions Via Anti-xanthine Oxidase and Anti-inflammatory Activities
Quang Ngô Văn, Thuy Thanh Thi Thu, Luong Dang Vu, Cuong Trinh Tat, Ha Nguyen Xuan, Cuong Nguyen Manh, Phuong Nguyen Thi Mai
Journal of the Mexican Chemical Society, 2025
Gomphrena celosioides Mart. has been widely used for the treatment of gout in Vietnam. A bio-guided isolation of xanthine oxidase inhibitors revealed that sesuvioside A, the main constituent in the butanol fraction of the aerial parts of G. celosioides, is a potential anti-gout compound. The anti-gout activity of sesuvioside A, a main constituent isolated from the butanol fraction for the first time was further extensively investigated using in vitro biological assays, including inhibition of xanthine oxidase (XO) activity, nitric oxide (NO), intracellular reactive oxygen species (iROS), pro-inflammatory cytokines productions. The obtained results indicated that sesuvioside A exhibited inhibitory activity against XO and NO production with the IC50 values of 31.6 µM and 18.3 µM, respectively. At concentration of 40.0 µM, the compound significantly reduced iROS level and the production of the pro-inflammatory cytokines TNF-α, IL-6, and IL-8 in the lipopolysaccharide-induced macrophages. A molecular docking study revealed that sesuvioside A strongly binds to the targets XO and p-38 MAPK with the estimated energy of -10.55 kcal/mol and -9.78 kcal/mol, respectively. In conclusion, sesuvioside A from the aerial parts of G. celosioides is a new dual anti-gout agent by expressing its inhibitory effects on XO activity and inflammatory targets. The traditional use of G. celosioides as a remedy for gout was supported by the findings in this study. Resumen. La Gomphrena celosioides Mart. Es muy usada en Vietnam para el tratamiento de la gota (hiperurisemia). A través de un proceso de aislamiento bio-dirigido de inhibidores de la xantina oxidasa (XO), se identificó que el sesuviósido A, el constituyente principal de la fracción butanólica de las partes aéreas de G. celosioides, es un compuesto que mostró actividad farmacológica y es candidato para el desarrollo de medicamentos contra la hiperurisemia. La actividad del sesuviósido A —aislado por primera vez como principal componente de dicha fracción— fue investigada extensamente mediante ensayos biológicos in vitro, incluyendo la inhibición de la actividad de la XO, la producción de óxido nítrico (NO), especies reactivas de oxígeno intracelulares (iROS) y citoquinas proinflamatorias. Los resultados obtenidos indicaron que el sesuviósido A presentó actividad inhibitoria sobre la XO y la producción de NO, con valores de IC₅₀ de 31,6 µM y 18,3 µM, respectivamente. A una concentración de 40,0 µM, el compuesto redujo significativamente los niveles de iROS y la producción de las citoquinas proinflamatorias TNF-α, IL-6 e IL-8 en macrófagos inducidos por lipopolisacáridos. Un estudio de acoplamiento molecular reveló que el sesuviósido A se une fuertemente a los blancos moleculares XO y p38 MAPK, con energías estimadas de -10,55 kcal/mol y -9,78 kcal/mol, respectivamente. En conclusión, el sesuviósido A, aislado de las partes aéreas de G. celosioides, representa un nuevo agente anti-gota dual, al ejercer efectos inhibitorios tanto sobre la actividad de la XO como sobre blancos inflamatorios. Los hallazgos de este estudio respaldan el uso tradicional de G. celosioides como remedio para la gota.
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline N-oxides from the aerial parts of Leptopyrum fumarioides as potential COX-2 inhibitors: in vitro and in silico studies
Tserendorj Solongo, Tran Thu Huong, Erdenetsogt Purevdorj, Amgalan Solongo, Battsagaan Bayasgalan, Vu Thanh Loc, Nguyen Xuan Ha, Vu Thi Ha, Nguyen Phi Hung, Do Thi Thao, Nguyen Thi Nga, Hai Pham- The, Pauline Stark, Nguyen Manh Cuong
Journal of Natural Medicines, 2025
Therapeutic effects of Chrysanthemum zawadzkii and its active compound eupatilin in rheumatoid arthritis: in silico and in vitro validation
Vu Thanh Loc, Tsolmon Bolor, Erdenetsogt Purevdorj, Amgalan Solongo, Nguyen Xuan Ha, Tran Thu Huong, Pham Ngoc Khanh, Do Thi Thao, Hai Pham-The, Nguyen Manh Cuong
Natural Product Research, 2025
The 50% ethanol extract of the aerial parts of Chrysanthemum zawadzkii (CZ extract) was evaluated for its inhibitory effects on the production of NO, TNF-α, and XO, and seven isolated flavonoids were tested for COX-2 inhibitory activity. The ethanol extract of C. zawadzkii exhibited a strong inhibitory effect on NO and XO overproduction, with IC50 values of 6.91 µg/mL and 83.48 µg/mL, respectively. Eupatilin (3) significantly suppressed COX-2 expression at a concentration of 100 µM (p < 0.05). Molecular docking analysis and ADMET predictions revealed that eupatilin forms hydrogen bonds and π-σ interactions, which significantly contribute to its binding affinity with residues in the enzyme's active site. Additionally, it exhibits low oral toxicity and good bioavailability in humans. These findings demonstrate the potential of CZ extract and its active compound, eupatilin, as naturally occurring agents with anti-heumatoid arthritis activities, capable of potently inhibiting COX-2 signalling in vitro.
Chemical compositions and antioxidant activities of the essential oil from aerial parts of Caryopteris mongolica Bunge grown in Mongolia
Otgonbayar Bayanjargal, Mishig Dumaa, Bandi Sarantsetseg, Sodnomtseren Purevsuren, Erdenetsogt Nyamsuren, Amgalan Solongo, Vu Thanh Loc, Nguyen Xuan Ha, Tran Thu Huong, Dinh Thi Thu Thuy, Nguyen Manh Cuong
Journal of Essential Oil Bearing Plants, 2025
The chemical composition of the essential oil from the aerial parts of Caryopteris mongolica Bunge, collected during the flowering period in the mountainous region of Songinokhairhan District, Mongolia, was determined following hydrodistillation and analysis by Gas Chromatography-Mass Spectrometry (GC-MS). A total of 65 compounds were identified, accounting for 95.46% of the total essential oil. The essential oil primarily consisted of monoterpene hydrocarbons (32%), diterpene hydrocarbons (10%), sesquiterpene hydrocarbons (15%), and a high content of oxygenated terpenes (over 36%). The major compounds, identified based on GC-FID peak area, were limonene (22.49%), trans-ferruginol (8.48%), phytol (8.41%), D-cadinene (4.44%), abietatriene (4.23%), caryophyllene oxide (3.84%), and β-pinene (3.26%). The antioxidant activity of the essential oil was evaluated for the first time using various test systems, including 1,1-diphenyl- 2-picrylhydrazyl (DPPH), 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+), and the ferric reducing antioxidant power (FRAP) assays. The essential oil from C. mongolica exhibited moderate antioxidant activity, with IC50 values of 12.73 μg/mL (DPPH), 19.68 μg/mL (ABTS+), and FRAP value of 600.12 μmol/L at 25 μg/mL. Molecular docking analysis revealed that the diterpene compounds abietatriene, isopimara-8,15-diene, trans-ferruginol, as well as the sesquiterpene α-calacorene, interact with Keap1, a key protein in the antioxidant pathway. These compounds bind to key amino acids Tyr334, Tyr572 and Phe577, suggesting their potential to inhibit the Keap1-Nrf2 interaction and activate the Nrf2-mediated antioxidant pathway. These findings highlight the promising antioxidant properties of the essential oil from aerial parts of C. mongolica Bunge, warranting further experimental validation.
MDM2 up-regulates the energy metabolism in NSCLC in a p53-independent manner
Elizaveta Fefilova, Yulia Kirdeeva, Sergey Parfenyev, Alexandra Daks, Olga Fedorova, Margarita Sorokina, Nguyen Xuan Ha, Tran Thu Huong, Vu Thanh Loc, Pham The Hai, Nguyen Manh Cuong, Nickolai Barlev, Oleg Shuvalov
Biochemical and Biophysical Research Communications, 2025
In vitro and in silico inhibitory activity of angiotensin-converting enzyme 2 (ACE-2) and anti-inflammatory effects of natural componds from Rheum officinale roots
Nguyen Manh Cuong, Pham Ngoc Khanh, Tran Thu Huong, Nguyen Xuan Ha, Hoang Thi Ngoc Anh, Vu Thanh Loc, Do Huu Nghi, Do Thi Thao, Trinh Thi Thu Ha, Nguyen Phi Hung, Vu Thi Ha, Ludger A. Wessjohann
Vietnam Journal of Science and Technology, 2024
Rhubarb roots (Rheum officinale), a common medicinal plant in folk remedies, and their chemical compositions were investigated for their inhibitory activity of angiotensin-converting enzyme II and anti-inflammatory effects by inhibiting NO production and IL-6 expression. Four natural compounds, including two anthraquinones, chrysophanol (2) and emodin (3), and two stilbenes, rhapontigenin (1) and trans-piceatannol (4), were isolated from the roots of Rhubarb. The results showed that rhapontigenin (1) exhibited an inhibitory effect on the ACE-2 enzyme with an IC50 value of 132 mM. In an in silico study, rhapotigenin (1) had a binding energy value of -9.32 kcal/mol, lower than MLN-4760, on ACE-2. Both rhapontigenin (1) and emodin (3) exhibited inhibitory activity on NO production in primary cultures of macrophages RAW264.7, with IC50 values ranging from 5.65 to 32.3 µg/mL. This is the first study of the anti-ACE-2 and anti-inflammatory activity of Rhubarb root extract and its constituents.
Acetylcholinesterase inhibitory activities of some flavonoids from the root bark of Pinus krempfii Lecomte: in vitro and in silico study
Nguyen Manh Cuong, Pham Ngoc Khanh, Le Thi Hong Nhung, Nguyen Xuan Ha, Tran Thu Huong, Katarina Bauerova, Young Ho Kim, Do Dinh Tung, Trinh Thi Thuy, Nguyen Thi Hoang Anh
Journal of Biomolecular Structure and Dynamics, 2024
From the root bark of Pinus krempfii Lecomte, four flavonoids were isolated and evaluated for their inhibitory activities against AChE and BChE enzymes in vitro and in silico. Tectochrysin (1) was found to inhibit AChE with an IC50 value of 33.69 ± 2.80 μM. The docking study results also showed agreement with the in vitro test results. All four compounds also showed the best binding affinity for the AChE enzyme, characterised by binding energy (ΔG) values as low as -8.1 to -9.3 kcal/mol, in which, the compound tectochrysin had the best binding affinity for the AChE protein with a ΔG value of -9.329 kcal/mol. Tectochrysin (1) was also bound to the amino acid Phe295 of AChE with a bond length of 2.8 Å, similar to the control dihydrotanshinone-I. Galangin (2) also showed its in vitro inhibitory activity against BChE with an IC50 value of 82.21 ± 2.70 μM. In silico, it also had the best binding energy value of -9.072 kcal/mol with BChE and formed hydrogen bonds with the His438 (2.85 Å) residues of BChE like the positive control (tacrine). The steered molecular dynamics (SMD) simulation results of these two complexes revealed a mechanistic insight that the protein-ligand complexes showed stable trajectories throughout the 20 and 150 ns simulations. Moreover, the drug likeliness suggested that both flavonoids (1 and 2) were expected to be drug-like and have an LD50 toxicity level of 5. This study has contributed new results for drug discovery and the development of substances with neuroprotective effects, especially for the treatment of Alzheimer's disease.Communicated by Ramaswamy H. Sarma.
In Vitro and in Silico Study of New Biscoumarin Glycosides from Paramignya trimera against Angiotensin-Converting Enzyme 2 (ACE-2) for Preventing SARS-CoV-2 Infection
Nguyen Xuan Ha, Tran Thu Huong, Pham Ngoc Khanh, Nguyen Phi Hung, Vu Thanh Loc, Vu Thi Ha, Dang Thu Quynh, Do Huu Nghi, Pham The Hai, Christopher J. Scarlett, Ludger A. Wessjohann, Nguyen Manh Cuong
Chemical and Pharmaceutical Bulletin, 2024
Synthesis and antimicrobial activity of new glucosamine derivatives
Lê Đức Anh, Ninh Duc Bao, Le Viet Duc, Luu Van Chinh, Nguyễn Mạnh Cường, et al.
Vietnam Journal of Chemistry, 2023
Studies on hepatoprotective effects of Vietnamese medicinal plants
Phạm Ngọc Khánh, Katarína Bauerová, Nguyễn Mạnh Cường
Vietnam Journal of Science and Technology, 2023
In silico and ADMET study of Morinda longissima phytochemicals against TNF-α for treatment of inflammation-mediated diseases
Nguyen Xuan Ha, Thi Ngoc Anh Hoang, Phạm Ngọc Khánh, Vu Thi Ha, Nguyen Viet Ha, et al.
Vietnam Journal of Chemistry, 2023
Anti-Alzheimer's Activity of Polyphenolic Stilbene-Rich Acetone Fraction of the Oil-Removed Seeds of Passiflora edulis: in Vivo and in Silico Studies
Nadjet Mostefa, Noureddine Djebli, Pham Ngoc Khanh, Nguyen Xuan Ha, Hoang Thi Ngoc Anh, Vu Thi Ha, Tran Thu Huong, Dang Viet Anh, Nguyen Manh Cuong
Chemistry and Biodiversity, 2023
Synthesis and cytotoxic activity of some novel 2’-hydroxychalcones containing murrayafoline A
Le Duc Anh, Luu Van Chinh, Truong Ngoc Hung, Nguyen Manh Cuong, Pham Hong Ngoc
Vietnam Journal of Science and Technology, 2023
Taxonomic revision of Bergera J.Koenig ex L. (Rutaceae) based on the molecular phylogeny and morphology
Feng-Juan Mou, Xiu Hu, Bui Thu Ha, Nguyen Manh Cuong
European Journal of Taxonomy, 2023
IoT solutions for fighting antimicrobial resistance
Dang Ngoc Tung, Nguyen Cuong, Nguyen Thi Thu Hoai
Internet of Things in Biomedical Sciences Challenges and Applications, 2023
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators
Nguyen Manh Cuong, Ninh The Son, Ngu Truong Nhan, Yoshiyasu Fukuyama, Amer Ahmed, Simona Saponara, Alfonso Trezza, Beatrice Gianibbi, Ginevra Vigni, Ottavia Spiga, Fabio Fusi
Molecules, 2022
Trace detection of ciprofloxacin antibiotic using surface-enhanced Raman scattering coupled with silver nanostars
Vu Thi Thu, Nguyen Manh Cuong, Dao Tran Cao, Luu Tien Hung, Luong Truc-Quynh Ngan
Optik, 2022
BIOCONVERSION OF LIGNOCELLULOSIC MATERIALS BY FUNGAL "ENZYME COCKTAIL" WITH THE CONTRIBUTION OF A GLYCOSIDE HYDROLASE FROM XYLARIA POLYMORPHA TO RELEASE CARBOHYDRATES AND BIOMETHANOL
Thuoc Van Doan, Pham Thi Huong, Tran Huu Phong
Vietnam Journal of Science and Technology, 2021
Bergera unifolia (Rutaceae), A New Species from Guangxi (China) Based on Morphological and Molecular Data
Chong-Ling Deng, Chuan-Wu Chen, Xiao-Xiao Wu, Nguyen Manh Cuong, Feng-Juan Mou
Annales Botanici Fennici, 2021
Direct detection of melamine in liquid milk and infant formula using surface-enhanced Raman scattering combined with silver nanodendrites
Nguyen Manh Cuong, Dao Tran Cao, Vu Thi Thu, Luong Truc-Quynh Ngan
Optik, 2021
Chemical Composition of Essential Oils from the Leaves, Stems and Roots of Aristolochia petelotii O.C. Schmidt Growing in Vietnam
Nguyen Quoc Binh, Nguyen Thanh Tung, Nguyen Phuong Hanh, Luu Hong Truong, Nguyen Hieu Cuong, Kieu Thi Hoai, Nguyen Viet Than, Ain Raal
Journal of Essential Oil Bearing Plants, 2021
Soluble epoxide hydrolase inhibitors from Docynia indica (Wall.) Decne.
Le Xuan Duy, Vinh Le Ba, Dan Gao, Vu Dinh Hoang, Tran Quoc Toan, Seo Young Yang, Dao Duy Quang, Young Ho Kim, Nguyen Manh Cuong
Natural Product Research, 2021
Cytotoxic constituents from Isotrema tadungense
Luu Hong Truong, Nguyen Hieu Cuong, Tran Huu Dang, Nguyen Thi My Hanh, Vien Le Thi, Hanh Tran Thi Hong, Tran Hong Quang, Hai Dang Nguyen, Cuong Nguyen Xuan, Nam Nguyen Hoai, Chau Van Minh
Journal of Asian Natural Products Research, 2021
Sulphated flavones and pregnane-type steroids from Helicteres viscida
Luu Hong Truong, Nguyen Hieu Cuong, Tran Huu Dang, Trinh Thi My Dung, Pham Thi Cham, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen Hai Dang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh
Natural Product Research, 2021
Design, synthesis, structure, in vitro cytotoxic activity evaluation and docking studies on target enzyme GSK-3β of new indirubin-3ʹ-oxime derivatives
Nguyen Trong Dan, Hoang Duc Quang, Vuong Van Truong, Do Huu Nghi, Nguyen Manh Cuong, To Dao Cuong, Tran Quoc Toan, Long Giang Bach, Nguyen Huu Thuan Anh, Nguyen Thi Mai, Ngo Thi Lan, Luu Van Chinh, Pham Minh Quan
Scientific Reports, 2020
Vasorelaxing Activity of R -(-)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: Involvement of Smooth Muscle Ca V 12 Channels
Nguyen Manh Cuong, Ninh The Son, Ngu Truong Nhan, Pham Ngoc Khanh, Tran Thu Huong, Nguyen Thi Thu Tram, Giampietro Sgaragli, Amer Ahmed, Alfonso Trezza, Ottavia Spiga, Fabio Fusi
Planta Medica, 2020
Serine protease inhibitors and activators from Dalbergia tonkinensis species
Ninh The Son, Midori Suenaga, Yoiichi Matsunaga, Luu Van Chinh, Miwa Kubo, Kenichi Harada, Nguyen Manh Cuong, Yoshiyasu Fukuyama
Journal of Natural Medicines, 2020
INITIAL STUDY ON SARS-COV-2 MAIN PROTEASE INHIBITION MECHANISM OF SOME POTENTIAL DRUGS USING MOLECULAR DOCKING SIMULATION
Vietnam Journal of Science and Technology, 2020
CHEMICAL COMPOSITIONS OF PASSIFLORA EDULIS SEED OIL CULTIVATED IN VIET NAM
To Dao Cuong, Doan Lan Phuong, Nguyen Van Tuyen Anh, Pham Ngoc Khanh, Tran Thu Huong, Nguyen Manh Cuong
Vietnam Journal of Science and Technology, 2019
Chemical Constituents of the Heartwood of Dalbergia tonkinensis
Ninh The Son, Yoshiyasu Fukuyama, Nguyen Manh Cuong
Chemistry of Natural Compounds, 2019
Chemical constituents of the Vietnamese plants Dalbergia tonkinensis Prain and Cratoxylum formosum (Jack) Dyer in Hook and their DPPH radical scavenging activities
Ninh The Son, Mari Kamiji, Tran Thu Huong, Miwa Kubo, Nguyen Manh Cuong, Yoshiyasu Fukuyama
Medicinal Chemistry Research, 2019
TERPENOIDS FROM THE LEAVES AND STEMS OF DYSOXYLUM TPONGENSE
Pham Ngoc Khanh, Bui Huu Tai, Tran Thu Huong, To Dao Cuong, Young Ho Kim, Nguyen Manh Cuong
Vietnam Journal of Science and Technology, 2019
Identification of soluble epoxide hydrolase inhibitors from the seeds of passiflora edulis cultivated in Vietnam
To Dao Cuong, Hoang Thi Ngoc Anh, Tran Thu Huong, Pham Ngoc Khanh, Vu Thi Ha, Tran Manh Hung, Young Ho Kim, Nguyen Manh Cuong
Natural Product Sciences, 2019
New Constituents from the Roots and Stems of Paramignya trimera
Tran Thu Huong, Vu Thi Ha, To Dao Cuong, Ninh The Son, Tran Quoc Toan, Hoang Thi Ngoc Anh, Nguyen Thi Thu Tram, Sun Hee Woo, Young Ho Kim, Nguyen Manh Cuong
Natural Product Communications, 2019
In silico screening of anthraquinones from Prismatomeris memecyloides as novel phosphodiesterase type-5 inhibitors (PDE-5Is)
Pham Ngoc Khanh, Tran Thu Huong, Ottavia Spiga, Alfonso Trezza, Ninh The Son, To Dao Cuong, Vu Thi Ha, Nguyen Manh Cuong
Revista Internacional De Andrologia, 2018
Antimicrobial activity of the constituents of dalbergia tonkinensis and structural-bioactive highlights
Ninh The Son, Masataka Oda, Naoki Hayashi, Daiki Yamaguchi, Yu Kawagishi, Fumi Takahashi, Kenichi Harada, Nguyen Manh Cuong, Yoshiyasu Fukuyama
Natural Product Communications, 2018
New records of potent in-vitro antidiabetic properties of dalbergia tonkinensis heartwood and the bioactivity-guided isolation of active compounds
Van Nguyen, San-Lang Wang, Ngu Nhan, Thi Nguyen, Nguyen Nguyen, Do Nghi, Nguyen Cuong
Molecules, 2018
Daltonkins A and B, Two New Carboxyethylflavanones from the Heartwood of Dalbergia tonkinensis
Nguyen Manh Cuong, Ngu Truong Nhan, Ninh The Son, Do Huu Nghi, To Dao Cuong
Bulletin of the Korean Chemical Society, 2017
Two new carboxyethylflavanones from the heartwood of Dalbergia tonkinensis and their antimicrobial activities
Ninh The Son, Kenichi Harada, Nguyen Manh Cuong, Yoshiyasu Fukuyama
Natural Product Communications, 2017
Synthesis and in vitro cytotoxic evaluation of novel murrayafoline a derived β-amino alcohols
Luu Van Chinh, Le Duc Anh, Nguyen Thi Nga, Nguyen Thi Ha Ly, Vu Thi Ha, Tran Quoc Toan, Nguyen Manh Cuong, Tran Khac Vu
Letters in Organic Chemistry, 2017
The hepatoprotective activity of a new derivative kaempferol glycoside from the leaves of Vietnamese Phyllanthus acidus (L.) Skeels
Nguyen Cong Thuy Tram, Ninh The Son, Nguyen Thi Nga, Vu Thi Thu Phuong, Nguyen Thi Cuc, Do Thi Phuong, Gilles Truan, Nguyen Manh Cuong, Do Thi Thao
Medicinal Chemistry Research, 2017
Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa
Hong-Jie Zhang, Emily Rumschlag-Booms, Yi-Fu Guan, Dong-Ying Wang, Kang-Lun Liu, Wan-Fei Li, Van H. Nguyen, Nguyen M. Cuong, Djaja D. Soejarto, Harry H. S. Fong, Lijun Rong
Journal of Natural Products, 2017
Inhibitory effects of novel diarylheptanoids and other constituents of the rhizomes of Curcuma singularis on the catalytic activity of soluble epoxide hydrolase
Nguyen Manh Cuong, Doan Thi Van, Ninh The Son, To Dao Cuong, Pham Ngoc Khanh, Nguyen Quoc Binh, Tran Thi Viet Thanh, Ji Sun Lee, Ah Reum Jo, Young Ho Kim
Bulletin of the Korean Chemical Society, 2017
Inhibitory components from Glycosmis stenocarpa on pepper mild mottle virus
Jang Hoon Kim, Ju-Yeon Yoon, Sun Jung Kwon, In Sook Cho, Nguyen Manh Cuong, Seung-Kook Choi, Young Ho Kim, Gug Seoun Choi
Journal of Microbiology and Biotechnology, 2016
Enhancement of contraction and L-type Ca 2+ current by murrayafoline-A via protein kinase C in rat ventricular myocytes
Bojjibabu Chidipi, Min-Jeong Son, Joon-Chul Kim, Jeong Hyun Lee, Tran Quoc Toan, Nguyen Manh Cuong, Byung Ho Lee, Sun-Hee Woo
European Journal of Pharmacology, 2016
Inhibition of soluble epoxide hydrolase activity by compounds isolated from the aerial parts of Glycosmis stenocarpa
Jang Hoon Kim, Abubaker M. A. Morgan, Bui Huu Tai, Doan Thi Van, Nguyen Manh Cuong, Young Ho Kim
Journal of Enzyme Inhibition and Medicinal Chemistry, 2016
Alkylphloroglucinol derivatives and triterpenoids with soluble epoxide hydrolase inhibitory activity from Callistemon citrinus
Pham Ngoc Khanh, Ho Viet Duc, Tran Thu Huong, Ninh The Son, Vu Thi Ha, Doan Thi Van, Bui Huu Tai, Ji Eun Kim, Ah Reum Jo, Young Ho Kim, Nguyen Manh Cuong
Fitoterapia, 2016
Morinlongosides A-C, two new naphthalene glycoside and a new iridoid glycoside from the roots of Morinda longissima
Nguyen Manh Cuong, Tran Thu Huong, Ninh The Son, To Dao Cuong, Doan Thi Van, Pham Ngoc Khanh, Vu Thi Ha, Nguyen Cong Thuy Tram, Pham Quoc Long, Young Ho Kim
Chemical and Pharmaceutical Bulletin, 2016
Functional, electrophysiological and molecular docking analysis of the modulation of Cav1.2 channels in rat vascular myocytes by murrayafoline A
S Saponara, M Durante, O Spiga, P Mugnai, G Sgaragli, TT Huong, PN Khanh, NT Son, NM Cuong, F Fusi
British Journal of Pharmacology, 2016
Paratrimerins A and B, two new dimeric monoterpene-linked coumarin glycosides from the roots and stems of paramignya trimera
Nguyen Manh Cuong, Tran Thu Huong, Pham Ngoc Khanh, Nguyen Van Tai, Vu Thi Ha, Ninh The Son, Bui Huu Tai, Young Ho Kim
Chemical and Pharmaceutical Bulletin, 2015
Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor-stimulated vascular smooth muscle cells
Joo-Hui Han, Yohan Kim, Sang-Hyuk Jung, Jung-Jin Lee, Hyun-Soo Park, Gyu-Yong Song, Nguyen Manh Cuong, Young Ho Kim, Chang-Seon Myung
Korean Journal of Physiology and Pharmacology, 2015
Chemical constituents of Miliusa balansae leaves and inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells
Nguyen Phuong Thao, Bui Thi Thuy Luyen, Bui Huu Tai, Nguyen Manh Cuong, Youn Chul Kim, Chau Van Minh, Young Ho Kim
Bioorganic and Medicinal Chemistry Letters, 2015
Sensitization of cardiac Ca2+ release sites by protein kinase C signaling: evidence from action of murrayafoline A
Joon-Chul Kim, Jun Wang, Min-Jung Son, Nguyen Manh Cuong, Sun-Hee Woo
Pflugers Archiv European Journal of Physiology, 2015
In vitro vasoactivity of zerumbone from Zingiber zerumbet
Fabio Fusi, Miriam Durante, Giampietro Sgaragli, Pham Khanh, Ninh Son, Tran Huong, Van Huong, Nguyen Cuong
Planta Medica, 2015
Antiplatelet action of indirubin-3'-monoxime through suppression of glycoprotein VI-mediated signal transduction: A possible role for ERK signaling in platelets
Jung-Jin Lee, Joo-Hui Han, Sang-Hyuk Jung, Sang-Gil Lee, In-Su Kim, Nguyen Manh Cuong, Tran Thu Huong, Pham Ngoc Khanh, Young Ho Kim, Yeo-Pyo Yun, Jin Yeul Ma, Chang-Seon Myung
Vascular Pharmacology, 2014
A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity
Bui Thi Thuy Luyen, Bui Huu Tai, Nguyen Phuong Thao, Seo Young Yang, Nguyen Manh Cuong, Young In Kwon, Hae Dong Jang, Young Ho Kim
Bioorganic and Medicinal Chemistry Letters, 2014
Vascular L-type Ca2+ channel blocking activity of sulfur-containing indole alkaloids from Glycosmis petelotii
Nguyen Manh Cuong, Pham Ngoc Khanh, Pham Thu Huyen, Ho Viet Duc, Tran Thu Huong, Vu Thi Ha, Miriam Durante, Giampietro Sgaragli, Fabio Fusi
Journal of Natural Products, 2014
Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses
Nguyen Thi Hong Van, Trinh Anh Vien, Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Pham Quoc Long, Luu Tuan Anh, Nguyen Manh Cuong, Jae-Hyoung Song, Hyun-Jeong Ko, Nanyoung Kim, Seon Ju Park, Seung Hyun Kim
Natural Product Communications, 2014
Vasorelaxing activity of two coumarins from Murraya paniculata Leaves
Nguyen Manh Cuong, Pham Ngoc Khanh, Ho Viet Duc, Tran Thu Huong, Bui Huu Tai, Nguyen Quoc Binh, Miriam Durante, Fabio Fusi
Biological and Pharmaceutical Bulletin, 2014
Alterations of contractions and L-type Ca2+currents by murrayafoline-A in rat ventricular myocytes
Min-Jeong Son, Bojjibabu Chidipi, Joon-Chul Kim, Tran Thu Huong, Bui Huu Tai, Young Ho Kim, Joung Real Ahn, Nguyen Manh Cuong, Sun-Hee Woo
European Journal of Pharmacology, 2014
Cytotoxic compounds from Brucea mollis
Mai Hung Thanh Tung
Scientia Pharmaceutica, 2013
Synthesis of novel derivatives of murrayafoline a and their inhibitory effect on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells
Tran Thi Thu Thuy, Nguyen Manh Cuong, Tran Quoc Toan, Ngo Ngoc Thang, Bui Huu Tai, Nguyen Xuan Nhiem, Hye-Jin Hong, Sohyun Kim, Stephanie Legoupy, Young Sang Koh, Young Ho Kim
Archives of Pharmacal Research, 2013
2-Aryl- and 2-amido-benzothiazoles as multifunctional vasodilators on rat artery preparations
Fabio Fusi, Miriam Durante, Giampietro Sgaragli, Nguyen Manh Cuong, Phan Thi Phuong Dung, Nguyen Hai Nam
European Journal of Pharmacology, 2013
Oleanane-triterpenoids from Panax stipuleanatus inhibit NF-κB
Chun Liang, Yan Ding, Seok Bean Song, Jeong Ah Kim, Manh Cuong Nguyen, Jin Yeul Ma, Young Ho Kim
Journal of Ginseng Research, 2013
Mechanism of osthole inhibition of vascular Cav1.2 current
Fabio Fusi, Giampietro Sgaragli, Le Minh Ha, Nguyen Manh Cuong, Simona Saponara
European Journal of Pharmacology, 2012
Antioxidative and anti-inflammatory effect of quercetin and its glycosides isolated from mampat (Cratoxylum formosum)
So-Jin Choi, Bui Huu Tai, Nguyen Manh Cuong, Young-Ho Kim, Hae-Dong Jang
Food Science and Biotechnology, 2012
Oleanolic triterpene saponins from the roots of Panax bipinnatifidus
Nguyen Huu Tung, Tran Hong Quang, Nguyen Thi Thanh Ngan, Chau Van Minh, Bui Kim Anh, Pham Quoc Long, Nguyen Manh Cuong, Young Ho Kim
Chemical and Pharmaceutical Bulletin, 2011
An evaluation of the RNase H inhibitory effects of Vietnamese medicinal plant extracts and natural compounds
Bui Huu Tai, Nguyen Duy Nhut, Nguyen Xuan Nhiem, Tran Hong Quang, Nguyen Thi Thanh Ngan, Bui Thi Thuy Luyen, Tran Thu Huong, Jennifer Wilson, John A. Beutler, Ninh Khac Ban, Nguyen Manh Cuong, Young Ho Kim
Pharmaceutical Biology, 2011
A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis
Bui Huu Tai, Nguyen Xuan Nhiem, Tran Hong Quang, Nguyen Thi Thanh Ngan, Nguyen Huu Tung, Yohan Kim, Jung-Jin Lee, Chang-Seon Myung, Nguyen Manh Cuong, Young Ho Kim
Bioorganic and Medicinal Chemistry Letters, 2011
Chrysosplenol C increases contraction in rat ventricular myocytes
Min-Jeong Son, Hyun Kyung Kim, Do Thi Thu Huong, Young Ho Kim, Tran Van Sung, Nguyen Manh Cuong, Sun-Hee Woo
Journal of Cardiovascular Pharmacology, 2011
Buddlejasaponins from the flowers of buddleja officinalis
Bui Huu Tai, Nguyen Manh Cuong, Nguyen Xuan Nhiem, Nguyen Huu Tung, Tran Hong Quang, Young Ho Kim
Chemistry of Natural Compounds, 2011
Synthesis and anti-osteoporosis potential of two new indirubin-3'-oxime derivatives
Nguyen Manh Cuong
Journal of the Korean Society for Applied Biological Chemistry, 2010
New pyrano-pyrone from goniothalamus tamirensis enhances the proliferation and differentiation of osteoblastic MC3T3-E1 cells
Bui Huu Tai, Vu Thi Huyen, Tran Thu Huong, Nguyen Xuan Nhiem, Eun-Mi Choi, Jeong Ah Kim, Pham Quoc Long, Nguyen Manh Cuong, Young Ho Kim
Chemical and Pharmaceutical Bulletin, 2010
Studies on the acetylation and NMR reassignment of indirubin derivatives
Nguyen Manh Cuong, Bui Huu Tai, Dang Hoang Hoan
Natural Product Research, 2010
Inhibitory Effects of Indirubin Derivatives on the Growth of HL-60 Leukemia Cells
Nguyen Manh Cuong, Bui Huu Tai, Dang Hoang Hoan, Tran Thu Huong, Young Ho Kim, Jae-Hee Hyun, Hee-Kyoung Kang
Natural Product Communications, 2010
Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins
Hyuk Choi, Jungsug Gwak, Munju Cho, Min-Jung Ryu, Jee-Hyun Lee, Sang Kyum Kim, Young Ho Kim, Gye Won Lee, Mi-Young Yun, Nguyen Manh Cuong, Jae-Gook Shin, Gyu-Yong Song, Sangtaek Oh
Biochemical and Biophysical Research Communications, 2010
Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis
Bui Huu Tai, Bong Yong Jung, Nguyen Manh Cuong, Pham Thuy Linh, Nguyen Huu Tung, Nguyen Xuan Nhiem, Tran Thu Huong, Ngo Thi Anh, Jeong Ah Kim, Sang Kyum Kim, Young Ho Kim
Biological and Pharmaceutical Bulletin, 2009
Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells
Bui Huu Tai, Nguyen Manh Cuong, Tran Thu Huong, Eun-Mi Choi, Jeong-Ah Kim, Young Ho Kim
Journal of Asian Natural Products Research, 2009
First synthesis of dimethyl-1H-isochromeno[3,4-b]carbazoles
Nguyen Manh Cuong, Heike Wilhelm, Andrea Porzel, Ludger Wessjohann
Natural Product Communications, 2009
1-O-Substituted derivatives of murrayafoline A and their antifungal properties
N.M. Cuong, H. Wilhelm, A. Porzel, N. Arnold, L. Wessjohann
Natural Product Research, 2008
1-O-Substituted derivatives of murrayafoline A and their antifungal properties
Nguyen Manh Cuong, Heike Wilhelm, Andrea Porzel, Norbert Arnold, Ludger Wessjohann
Natural Product Research, 2008
A new dimeric carbazole alkaloid from Glycosmis stenocarpa roots
Nguyen Manh Cuong, Tran Quang Hung, Tran Van Sung, Walter Chacles Taylor
Chemical and Pharmaceutical Bulletin, 2004
A new ent-kaurane diterpenoid from Croton tonkinensis leaves
Pham Thi Hong Minh, Pham Hoang Ngoc, Walter C. Taylor, Nguyen Manh Cuong
Fitoterapia, 2004
Cytotoxic activity of Vietnamese herbal medicines against A549 cells
Korean Journal of Pharmacognosy, 2002
A new cyclobutane lignan from Cinnamomum balansae
Nguyen Manh Cuong, Walter C. Taylor, Tran Van Sung
Natural Product Letters, 2001
Glypetelotine, a sulphur-containing indole alkaloid from Glycosmis petelotii
Nguyen Manh Cuong, Walter C. Taylor, Tran Van Sung
Phytochemistry, 1999
Flavanoids from Carya tonkinensis
Pharmazie, 1996

Nguyen Manh Cuong

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