I am a Pharm D graduate (March 2025) from Jawaharlal Nehru Technological University, India, and an currently PhD scholar in Public Health at Manipal Academy of Higher Education. My research spans diabetes management, cardio-metabolic health, precision medicine, and computational drug discovery, with a focus on integrating clinical research and public health strategies to improve patient outcomes.
I have held roles as a Research Mentor and Article Editor, Clinical Research Coordinator and Public Health Intern (ICMR-NIE), contributing to projects in diabetes epidemiology, drug development, and health systems research. I have authored and co-authored peer-reviewed articles and book chapters published in Current Problems in Cardiology, Primary Care Diabetes, and the Journal of Basic and Clinical Physiology and Pharmacology. My contributions have been recognized with several awards, including the INSPIRE Award (Andhra Pradesh Government),and First Prize for Patient Information Leaflet (Int
EDUCATION
Pharm D , (
RESEARCH, TEACHING, or OTHER INTERESTS
Endocrinology, Diabetes and Metabolism, Public Health, Environmental and Occupational Health
Early aggressive treatment with DMARDs vs. step-up therapy in rheumatoid arthritis: a traditional review of joint damage and functional outcomes Amruth Akhil Alluri, Aditya Rajesh Pawar, Shrishti Prakash Khetan, Rohan Singhal, Shruti Suresh Suvarna, Mehal Ravindra Adsure, Swathi N.L. Journal of Basic and Clinical Physiology and Pharmacology, 2026 Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive joint inflammation and structural damage. Two primary treatment strategies – step-up therapy and early aggressive DMARD therapy have been widely debated in clinical practice. The step-up approach begins with NSAIDs or corticosteroids, progressing to DMARDs based on disease severity, whereas early aggressive therapy prioritizes immediate DMARD initiation to prevent irreversible joint damage. This comprehensive review evaluates the effectiveness of these strategies by analyzing randomized controlled trials (RCTs), meta-analyses, and cohort studies assessing treatment outcomes, remission rates, and radiographic progression. A literature search was conducted across PubMed, Scopus, and Web of Science, including studies published between 2010 and 2024. Key clinical trials, including TICORA, COBRA, BeSt, and CAMERA, were critically analyzed to assess the comparative benefits and limitations of both treatment approaches. Evidence suggests that early aggressive therapy is associated with higher remission rates, reduced radiographic progression, and improved long-term physical function, whereas the step-up approach often leads to delayed disease control and cumulative joint damage. However, concerns related to treatment adherence, cost-effectiveness, and safety profiles necessitate further investigation. Future research should focus on biomarker-driven personalized treatment strategies, optimizing drug sequencing, and long-term comparative effectiveness studies to refine RA management.
Efficacy of Metabolic and Bariatric Surgery Compared with GLP-1 Receptor Agonist Treatment in Preventing Mortality and Major Adverse Cardiac Events Among Individuals with Obesity and Type 2 Diabetes: A Systematic Review and Meta-analysis Joshua Chadwick, Chandru Sivamani, Suchitra Lakshmi, Vishali Baskaran, Swathi N.L., Lavanya Ayyasamy, Ganeshkumar Parasuraman, Bhavani Shankara Bagepally Obesity Surgery, 2026 Obesity and type 2 diabetes mellitus (T2DM) significantly increase cardiovascular morbidity and mortality worldwide. Metabolic and bariatric surgery (MBS) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are effective interventions for T2DM and obesity, but comparative evidence on their long-term impact on major adverse cardiovascular events (MACE) and all-cause mortality is lacking. This systematic review and meta-analysis evaluated the efficacy of MBS versus GLP-1 RAs therapy in reducing these outcomes. The review was registered in PROSPERO beforehand and carried out following the PRISMA framework. A comprehensive literature search identified randomized controlled trials (RCTs) and observational studies comparing MBS with GLP-1 RAs regimens in adults with obesity and T2DM. The primary outcomes were all-cause mortality and MACE. We used the Cochrane Risk of Bias 2.0 (ROB 2) tool and Newcastle-Ottawa Scale (NOS) to assess the quality of the study. Meta-analytic techniques were used to synthesize effect estimates. Pooled analysis of eligible studies suggested that MBS offered greater reductions in both MACE and all-cause mortality than GLP-1 RAs therapy. The relative risk reduction for MACE was approximately 52% in favor of MBS. Despite notable heterogeneity, sensitivity analyses confirmed result robustness. The overall certainty of evidence was moderate, reflecting variations in populations, interventions, and study designs. MBS offers significantly greater cardiovascular protection than GLP-1 RAs therapy in individual with obesity and T2DM, reducing MACE and all-cause mortality. GLP-1 RAs remains an important option, particularly for patients contraindicated for surgery or preferring pharmacotherapy. Further long-term comparative and cost effectiveness studies are needed to inform the clinical decisions.
The role of the urinary microbiome in diabetes-associated UTIs: Current understanding and future directions Meenakshi Reddy Yathindra, Rithvika Badugu, Shaurya Kumar Singh, Sowthrisha Paluri, Hrudai Poudala, Naraginti Leninbabu Swathi Journal of Basic and Clinical Physiology and Pharmacology, 2026 This review explores the interplay between type 2 diabetes mellitus (T2DM) and urinary microbiome dysbiosis, focusing on its role in urinary tract infections (UTIs). Once considered sterile, the urinary tract hosts a diverse microbiota that supports mucosal immunity and pathogen resistance. In T2DM, chronic hyperglycemia and glycosuria disrupt microbial balance, impair immune responses, and increase UTI susceptibility. Glycosuria promotes pathogenic colonization, biofilm formation, and microbial shifts, with studies reporting a threefold rise in Escherichia coli and a 56 % reduction in Lactobacillus spp. in diabetic women with recurrent UTIs. Diabetic urine shows reduced diversity, higher abundance of Klebsiella , Pseudomonas , and Enterococcus , and elevated IL-8. Microbiota-targeted interventions, including probiotics ( Lactobacillus crispatus , Lactobacillus rhamnosus GR-1), prebiotics (astaxanthin), and phytotherapeutics (cranberry), demonstrate potential via lactic acid, hydrogen peroxide production, competitive exclusion, and NF-κB modulation. A 12-month RCT showed significant UTI recurrence reduction with probiotics. Advances in 16 S rRNA sequencing and metagenomics reveal microbial signatures associated with diabetic UTIs, though methodological heterogeneity limits comparability. A review of 1,200 publications (2000–2024) highlights the need for longitudinal studies and precision microbiota therapeutics to translate findings into clinical practice.
Berries: bioactive components and their effect on human health N.L. Swathi, Ketan Sarvakar, Mandeep Singh Sibian, Vivek Kumar Garg, Shree Rath, Esraa M. AlEdani, Akachukwu Marytheresa Onwuka Berries and Nutrition A Holistic Approach to Health, 2026
Leveraging AI and ITRS in Drug Discovery for Inflammatory and Cardiovascular Diseases N. L. Swathi, Allenki Vineesh, Abhilash Dinesh Sadhankar, Muhammad Muzzamil, Akhil Arun, M. Karpakavalli, Dipanjan Maity, Ancelin Wilfy, J. Anto Musy Bosco, Gaurav Singh Pilkhwal Revolutionizing Pharmaceuticals with AI Driven Drug Discovery Design and Development, 2026 Artificial Intelligence (AI) and Intelligent Translational Research Systems (ITRS) are reshaping drug discovery for inflammatory and cardiovascular diseases by enabling rapid, data-driven identification of novel therapeutic targets and optimization of drug development pipelines. These technologies integrate genomics, proteomics, and clinical data to accelerate translational insights and support personalized treatment strategies. AI models aid in virtual screening, biomarker identification, and adaptive clinical trial designs, reducing time and cost. ITRS further bridge preclinical and clinical domains, enhancing reproducibility and translational relevance. Despite their promise, challenges persist, including algorithmic bias, data privacy concerns, and the need for transparent validation processes. Ethical oversight is essential to ensure fairness and patient safety. Regulatory frameworks must adapt to the evolving digital landscape, emphasizing interoperability, accountability, and real-world applicability.
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1): A novel therapeutic target in diabetes mellitus Receptor Targeted Therapies in Diabetes Mellitus from Pathophysiology to Innovative Treatments, 2025
Incretin-based therapies: Advancements, challenges, and future directions in type 2 diabetes management Amruth A. Alluri, Yashaswi Guntupalli, Shruti Suresh Suvarna, Yuliya Prystupa, Shrishti Prakash Khetan, Bharath Vejandla, Naraginti Lenin Babu Swathi Journal of Basic and Clinical Physiology and Pharmacology, 2025 Incretin-based medicines have considerably impacted the treatment of type 2 diabetes mellitus (T2DM), providing considerable advantages in glycemic regulation, weight control, and cardiovascular results. This narrative review examines progress in incretin medicines, encompassing glucagon-like peptide-1 (GLP-1) receptor agonists, dual-receptor, and triple-receptor agonists, while emphasizing their therapeutic advantages, obstacles, and prospective developments. The examined articles were sourced from databases including PubMed and Google Scholar, concentrating on publications predominantly from 2010 to 2024. Selective foundational papers released before this timeline were incorporated to furnish critical historical context about incretin processes and their discovery. Incretin-based medicines, despite their therapeutic efficacy, encounter hurdles including elevated treatment costs, patient compliance difficulties, and variability in response attributable to genetic and physiological variables. Moreover, there are still deficiencies in comprehending the long-term cardiovascular safety and cancer risks linked to these medicines. Emerging dual- and triple-receptor agonists demonstrate potential in overcoming the shortcomings of conventional GLP-1 receptor agonists, providing enhanced metabolic results and broader uses in intricate disease profiles. Future research must concentrate on economic obstacles, streamlined regimens, customized medicine, the integration of artificial intelligence, patient stratification, as well as the safety and efficacy of incretin-based medicines for holistic management of T2DM.
Impact of Covid 19 on Skin Microbiome Shaik Firoz, S. Kavitha, G. Swapna, Maleehah Faatimah, Md. Ayesha Sultana, N. L. Swathi, Esraa M. AlEdani Updates in Clinical Dermatology, 2025
Breast cancer stem cells targeted strategies N. L. Swathi, Ishwar Basavan, Evaristus Chinonso Odoh, Shadrach Chinecherem Eze, Jawahar Chowdary Sushma Swaraj, Nandini Sharma Spatially Variable Genes in Cancer Development Progression and Treatment Response, 2024
Healthcare Information Systems Management N. L. Swathi, S. Kavitha, M. Karpakavalli Improving Healthcare Quality and Patient Engagement Management and Technology Insights, 2024
Artificial intelligence and its integration with regenerative medicine approach Tungki Pratama Umar, Dessy Agustini, Abdelrahman M. Makram, Muhammad Muzzamil, Bella Stevanny, Randa Elsheikh, N. L. Swathi, Tulika Garg, Aulia Ananditia Putri, Nityanand Jain Integrating Digital Health Strategies for Effective Administration, 2023
RECENT SCHOLAR PUBLICATIONS
Early aggressive treatment with DMARDs vs. step-up therapy in rheumatoid arthritis: a traditional review of joint damage and functional outcomes A Akhil Alluri, A Rajesh Pawar, S Prakash Khetan, R Singhal, ... Journal of Basic and Clinical Physiology and Pharmacology 37 (2), 71-93 , 2026 2026
GLP-1 RAs vs. SGLT2is: Divergent Pathways of Cardiovascular Inflammation Control in Obesity-Associated Diabetes AH Samuel, AHS Kshatri, RN Babu, HS Patel, SH Viswanathan, ... Annales d'Endocrinologie, 102494 , 2026 2026 Citations: 1
Efficacy of Metabolic and Bariatric Surgery Compared with GLP-1 Receptor Agonist Treatment in Preventing Mortality and Major Adverse Cardiac Events Among Individuals with … J Chadwick, C Sivamani, S Lakshmi, V Baskaran, S NL, L Ayyasamy, ... Obesity Surgery, 1-12 , 2026 2026
The role of the urinary microbiome in diabetes-associated UTIs: current understanding and future directions MR Yathindra, R Badugu, SK Singh, S Paluri, H Poudala, NL Swathi Journal of Basic and Clinical Physiology and Pharmacology 37 (1), 9-24 , 2026 2026
Exosomes and Other Extracellular Vesicles in Regenerative Medicines SS Vasudevan, TY Kandrikar, NL Swathi, MB Shabbir, N Vora, A Shabbir, ... Clinical Potential of Exosomes, 551-602 , 2026 2026
Berries: bioactive components and their effect on human health NL Swathi, K Sarvakar, MS Sibian, VK Garg, S Rath, EM AlEdani, ... Berries and Nutrition, 139-160 , 2026 2026 Citations: 1
Leveraging AI and ITRS in Drug Discovery for Inflammatory and Cardiovascular Diseases NL Swathi, A Vineesh, AD Sadhankar, M Muzzamil, A Arun, ... Revolutionizing Pharmaceuticals With AI-Driven Drug Discovery, Design, and … , 2026 2026
Early aggressive treatment with DMARDs vs. step-up therapy in rheumatoid arthritis: a traditional review of joint damage and functional outcomes. A Alluri, R Pawar, R Adsure Journal of Basic and Clinical Physiology and Pharmacology , 2025 2025
Terpenoids modulation of the IFI16-AIM2 interaction for enhanced immune response in lung squamous cell carcinoma and AIM2-dysregulated diseases A Ali, A Alamri, W Ullah, T Waseem, SL Ali, T Al Arian, NL Swathi In Silico Pharmacology 13 (3), 1-29 , 2025 2025 Citations: 5
Application of Artificial Intelligence in Connection with Gut Microbiota to Detect Neurological Disorders NL Swathi, KR Siddique, H Babul, PK Singh, D Kumar Biotics and the Gut–Brain Axis in Neurological Disorders, 334-349 , 2025 2025
Parkinson’s Disease and Gut Microbiota S NL, TP Umar, WI Abo-Elenien, S Bhagat, AS Al Sakini, SN Rai Microbiota Profiling for Precision Medicine: Biomarker-Targeted Drug … , 2025 2025
Parkinson's Disease and Gut Microbiota NL Swathi, TP Umar, WI Abo-Elenien, S Bhagat, AS Al Sakini, SN Rai Microbiota Profiling for Precision Medicine: Biomarker-Targeted Drug … , 2025 2025
MON-804 Cracks in the Foundation: Temporal and Geographic Trends in Bone Disorder Mortality in the US MZ Jan Kakakhel, S Cheema, R Haider, R Noor, S NL, SM Irshad, A Ullah, ... Journal of the Endocrine Society 9 (Supplement_1), bvaf149. 546 , 2025 2025
SUN-608 Diabetes and Chronic Kidney Disease: A Two-Decade Analysis of Mortality Trends and Demographic Disparities MZ Jan Kakakhel, S Cheema, R Haider, F Saleem, A Ullah, M Shah, ... Journal of the Endocrine Society 9 (Supplement_1), bvaf149. 1257 , 2025 2025 Citations: 2
The Role of Artificial Intelligence in Psoriasis NL Swathi, S Muhammad, M Muzzamil, A Arun, H Athul, EM AlEdani Applications of Artificial Intelligence in Common Dermatological Diseases, 19-38 , 2025 2025
Beyond Borders: Global Perspectives on Stem Cell Therapeutics NL Swathi, P Mallari, M Dabhi, S Shrivastava Stem Cell Therapeutics, 705-738 , 2025 2025
The Effect of COVID-19 and Its Vaccination on Lichen Planus Exacerbation M Faatimah, NL Swathi, R Madishetty, M Ayesha Sultana, CC Reddy, ... COVID-19 Vaccination and Dermatological Diseases, 33-44 , 2025 2025
Impact of Covid 19 on Skin Microbiome S Firoz, S Kavitha, G Swapna, M Faatimah, M Ayesha Sultana, NL Swathi, ... COVID-19 Vaccination and Dermatological Diseases, 97-109 , 2025 2025
The Role of Teledermatology in the COVID-19 Pandemic NL Swathi, EM AlEdani COVID-19 Vaccination and Dermatological Diseases, 89-96 , 2025 2025
COVID-19 Vaccination and Dermatological Diseases EM AlEdani, H Maibach Springer Nature Switzerland , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Currently trending and futuristic biological modalities in the management of different types of diabetes: A comprehensive review A ALi, U Manzoor, SL Ali, MD Marsool, PK Parida, AD Marsool, NL Swathi J Popul Ther Clin Pharmacol 30 (18), 2948-70 , 2023 2023 Citations: 16
Incretin-based therapies: advancements, challenges, and future directions in type 2 diabetes management AA Alluri, Y Guntupalli, SS Suvarna, Y Prystupa, SP Khetan, B Vejandla, ... Journal of Basic and Clinical Physiology and Pharmacology 36 (2-3), 95-111 , 2025 2025 Citations: 11
Intermittent fasting versus continuous caloric restriction for glycemic control and weight loss in type 2 diabetes: A traditional review HA Lakhani, D Biswas, M Kuruvila, MS Chava, K Raj, JT Varghese, ... Primary Care Diabetes 19 (3), 203-213 , 2025 2025 Citations: 8
Epigenetic mechanisms in the transfer of metabolic disorders: a comprehensive review NL Swathi, Z Shakhatreh, A Tahir, J Singh, S Sulaiman, H Athul, ... Cureus 17 (3) , 2025 2025 Citations: 7
Causes and Management of Nutritional Deficiency Disorders A Nayak, S Misra IGI Global , 2024 2024 Citations: 6
Terpenoids modulation of the IFI16-AIM2 interaction for enhanced immune response in lung squamous cell carcinoma and AIM2-dysregulated diseases A Ali, A Alamri, W Ullah, T Waseem, SL Ali, T Al Arian, NL Swathi In Silico Pharmacology 13 (3), 1-29 , 2025 2025 Citations: 5
Immunological insights into nutritional deficiency disorders A Hajar, NL Swathi, A Ali Causes and Management of Nutritional Deficiency Disorders, 61-84 , 2024 2024 Citations: 5
Mindfulness training for cardiovascular health in type 2 diabetes: A critical review A Gandhi, R Rajkumar, SN Dakka, J Sania, F Khurram, J Cabrera Current Problems in Cardiology 49 (12), 102833 , 2024 2024 Citations: 4
Artificial Intelligence and Its Integration with Regenerative Medicine Approach Integrating Digital Health Strategies for Effective Administration 3, 32 -57 , 2023 2023 Citations: 4
Healthcare Information Systems Management NL Swathi, S Kavitha, M Karpakavalli Improving Healthcare Quality and Patient Engagement: Management and … , 2025 2025 Citations: 3
SUN-608 Diabetes and Chronic Kidney Disease: A Two-Decade Analysis of Mortality Trends and Demographic Disparities MZ Jan Kakakhel, S Cheema, R Haider, F Saleem, A Ullah, M Shah, ... Journal of the Endocrine Society 9 (Supplement_1), bvaf149. 1257 , 2025 2025 Citations: 2
Precision medicine and epigenetics: personalized diabetes care NL Swathi, I Basavan, M Muzzamil, A Venkatesan, GS Rama, A Arun Biomedical Research Developments for Improved Healthcare, 288-309 , 2024 2024 Citations: 2
Advanced Technologies in Clinical Research and Drug Development NL Swathi, A Kumar The Ethical Frontier of AI and Data Analysis, 1-17 , 2024 2024 Citations: 2
GLP-1 RAs vs. SGLT2is: Divergent Pathways of Cardiovascular Inflammation Control in Obesity-Associated Diabetes AH Samuel, AHS Kshatri, RN Babu, HS Patel, SH Viswanathan, ... Annales d'Endocrinologie, 102494 , 2026 2026 Citations: 1
Berries: bioactive components and their effect on human health NL Swathi, K Sarvakar, MS Sibian, VK Garg, S Rath, EM AlEdani, ... Berries and Nutrition, 139-160 , 2026 2026 Citations: 1
Evaluating the Impact of Individualized Interventions on Diabetes Distress and Glycemic Outcomes: A Shift From Glycated Hemoglobin (HbA1c) to Random Blood Sugar (RBS) in a … NL Swathi, M Devadarshini, AP Mohammed, D Jothieswari, M Umar, ... Cureus 17 (3) , 2025 2025 Citations: 1
Breast Cancer Stem Cells Targeted Strategies NL Swathi, I Basavan, EC Odoh, SC Eze, JCS Swaraj, N Sharma Spatially Variable Genes in Cancer: Development, Progression, and Treatment … , 2025 2025 Citations: 1
Medicinal and Nutritional Importance of Punica granatum in Human Health NL Swathi, V Vishnoi, KS Priya, AM Onwuka Medicinal Plants and their Bioactive Compounds in Human Health: Volume 1 … , 2024 2024 Citations: 1
Fetal and Neonatal Outcomes in Booked vs. UnBooked Deliveries: A Systematic Review and Meta-analysis of the Global Literature J Mansoor, U Hafeez, NU Khan, A Ali, R Zubair, NL Swathi, A Nadeem, ... 2024 Citations: 1
Early aggressive treatment with DMARDs vs. step-up therapy in rheumatoid arthritis: a traditional review of joint damage and functional outcomes A Akhil Alluri, A Rajesh Pawar, S Prakash Khetan, R Singhal, ... Journal of Basic and Clinical Physiology and Pharmacology 37 (2), 71-93 , 2026 2026