Nuray Esra Aksakal

@akademik.halic.edu.tr

Halic University( Nutrition and Dietetics Department,English)
Assistant Professor

Nuray Esra Aksakal


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https://researchid.co/nesraksakal

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Inorganic Chemistry, Organic Chemistry, General Chemistry
8

Scopus Publications

115

Scholar Citations

5

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Naringenin-Loaded PEG Polymers with Varying Molecular Weights: Preparation and Evaluation of Singlet Oxygen Quenching Activity
    Nuray Esra Aksakal, Zeynep Munteha Sahin, Elif Yıldız Gül, Ceyda Okudu
    Chemistryselect, 2025
    This study presents a facile, cost‐effective strategy to develop functional polymers by non‐covalently loading naringenin‐a bioactive yet poorly water‐soluble flavonoid‐into PEGs with different molecular weights. Unlike conventional encapsulation methods with complex chemical steps, this strategy is rapid, purification‐free, and potentially scalable. The effect of PEG chain length (550, 2k, 5k Da) on naringenin's solubility, interactions, and stability was systematically assessed by UV‐Vis and gravimetric methods. Thermogravimetric analysis further revealed enhanced thermal stability upon naringenin loading, with T max values increasing by 10–15 °C across all PEG matrices. The photochemical behavior of the naringenin‐loaded PEG systems was investigated through singlet oxygen quenching using DPBF degradation, revealing that all formulations exhibited distinct quenching activity, with PEG‐2k achieving the highest efficiency (40.0%), which was nearly identical to that of free naringenin (41.3%). This behavior is likely related to the optimal hydrophilic‐flexible balance of PEG‐2k, which may promote better interaction and stabilization of naringenin. While most studies focus on simple antioxidant carriers or synthetic quenchers, this work demonstrates the feasibility of incorporating natural flavonoids into polymers while maintaining comparable photoreactivity to free naringenin, even at lower loading levels. Moreover, all formulations used a low naringenin‐to‐polymer mass ratio (1:5), suggesting that minimal naringenin can still achieve strong quenching. Overall, this strategy demonstrates the potential for solubilization, photostabilization, and functional retention of flavonoids, suggesting a scalable and cost‐effective design for future biomedical and advanced polymer applications.
  • Revealing the photochemical pathways of BODIPY-ruthenium(II) Polypyridyl complexes: Synthesis, characterization, and Photooxidation behavior
    Saleh Sameer S. Sattar, Nuray Esra Aksakal, Elif Yıldız Gül, Buse Köse, Esra Tanrıverdi Eçik
    Polyhedron, 2025
  • A fully conjugated imidazole-fused perylene phenantroline ruthenium(II) complex in photocatalytic oxidation
    Nuray Esra Aksakal, Fatma Aksakal, Elif Yıldız Gül, Esra Tanrıverdi Eçik, Fatma Yuksel
    Inorganica Chimica Acta, 2024
  • InCl3-Catalyzed One-Pot Synthesis of Pyrrolo/Indolo- and Benzooxazepino-Fused Quinoxalines
    Nuray Esra Aksakal, Metin Zora
    ACS Omega, 2024
    In this paper, we describe an efficient InCl3-catalyzed two-component reaction of 1-(2-aminophenyl)pyrroles/indoles and 2-propargyloxybenzaldehydes for the direct synthesis of 12bH-benzo[6,7]1,4-oxazepino[4,5-a]pyrrolo/indolo[2,1-c]quinoxalines. This high atom- and step-economical one-pot process generates three new C/N–C bonds in a single synthetic operation, resulting in the formation of new six- and seven-membered heterocyclic rings. The easy availability of the starting materials, the use of the relatively inexpensive indium catalyst, and the good substrate scope are the salient features of this strategy. The proposed mechanistic pathway involves imine formation, two consecutive cyclizations via electrophilic aromatic substitution and nucleophilic addition reactions, and the H shift step.
  • Crystal Structures of Two Perylenediimides: A Study of Bay-Substitution
    Nuray Esra Aksakal, Yurii Chumakov, Fatma Yuksel
    Journal of Chemical Crystallography, 2019
    The crystal structures of N,N′-bis(2,6-diisopropylphenyl)-3,4,9,10-perylenetetracarboxylic diimide (PDI-1) and 1,6,7,12-tetrakis(4-tert-butylphenoxy)-N,N′-bis(2,6-diisopropylphenyl)-3,4,9,10-perylenetetracarboxylic diimide (PDI-2) are reported for the first time. The π-conjugated perylene skeleton of PDI-1 is nearly planar while the tetra tert-butylphenoxy substitution on bay positions give rise to highly twisted perylene skeleton in PDI-2. Density functional theory and the Boltzmann transport equation has been applied to calculate the semiclassical thermoelectric transport properties of crystalline PDI-1 and PDI-2 as a function of solid-state packing, and the effect of bay-substitution have been investigated.
  • Novel ruthenium(ii) and iridium(iii) BODIPY dyes: Insights into their application in photodynamic therapy: In vitro
    Nuray Esra Aksakal, Esra Tanrıverdi Eçik, Hasan Hüseyin Kazan, Gönül Yenilmez Çiftçi, Fatma Yuksel
    Photochemical and Photobiological Sciences, 2019
    Organic–metal complexes are promising molecules for use in photodynamic therapy (PDT). The aim of this study was to investigate in vitro effects of novel Ru(II) and Ir(III) BODIPY complexes for PDT. These hybrid organic–metal molecules ( Ru-BD and Ir-BD ) have been synthesized via reactions of a BODIPY precursor ( BD ) with a phenanthroline unit bearing Ru(II) ( 3 ) and novel Ir(III) ( 4 ) compounds. The crystal structures of the new distyryl BODIPY ( BD ) and Ru(II) complex ( 3 ) are also reported. The photophysical and singlet oxygen generation properties of Ru-BD and Ir-BD were investigated in comparison with unsubstituted BODIPY ( BD ). Moreover, Ru-BD and Ir-BD have been biologically evaluated in vitro in chronic myeloid leukemia and cervical cancer cell lines in terms of photodynamic therapy efficacy in the presence of BD control. These complexes were not toxic in the dark but red light was needed to induce cell death. These data support the fact that Ru-BD could be accepted as a valuable photosensitizer-drug for further PDT treatment.
  • Structural and Optical Properties of New Naphthalene and Perylene Imide Imidazoles
    Nuray Esra Aksakal, Meltem Bayar, Hakan Dumrul, Devrim Atilla, Yurii Chumakov, Fatma Yuksel
    Polycyclic Aromatic Compounds, 2019
    New unsymmetrically substituted naphthalene and perylene imide imidazoles, N-(2-ethylhexyl)-naphthalene-3,4-(4,5-dicyano-1,2-benzimidazole)-9,10-dicarboxyimide and N-(1-heptyloctyl)-perilene-3,4-(4,5-dicyano-1,2-benzimid-azole)-9,10-dicarboxyimide, were synthesized via condensation reactions of diaminophthalonitrile and aromatic monoimide monoanhydride derivatives. Their structural analyses have been conducted by using general spectroscopic methods including FT-IR, 1H- and 13C-NMR, mass and elemental analysis. The molecular structure of naphthalene derivative was also determined by single crystal x-ray diffraction. Electronic absorption and emission properties were investigated on comparison. For studied compounds, both DFT and TDDFT calculations were carried out with the 6-311G(d,p) basis set, taking into account solvation effects by means of polarizable continuum model as implemented in the Gaussian 09 package.
  • A novel photosensitizer based on a ruthenium(ii) phenanthroline bis(perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy
    Nuray Esra Aksakal, Hasan Hüseyin Kazan, Esra Tanrıverdi Eçik, Fatma Yuksel
    New Journal of Chemistry, 2018
    In this study, a novel photosensitizer having two perylenediimide units and a phenanthroline ruthenium(ii) coordination moiety (Ru-BP)has been developed for photodynamic therapy (PDT) of cancer cells.

RECENT SCHOLAR PUBLICATIONS

  • Naringenin‐Loaded PEG Polymers with Varying Molecular Weights: Preparation and Evaluation of Singlet Oxygen Quenching Activity
    NE Aksakal, ZM Sahin, EY Gül, C Okudu
    ChemistrySelect 10 (42), e04081 , 2025
    2025.0
  • Revealing the photochemical pathways of BODIPY-ruthenium (II) Polypyridyl complexes: Synthesis, characterization, and Photooxidation behavior
    SSS Sattar, NE Aksakal, EY Gül, B Köse, ET Eçik
    Polyhedron, 117675 , 2025
    2025.0
  • Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies
    D Beyazgül, NE Aksakal
    Anatolian Clinic the Journal of Medical Sciences 29 (3), 372-386 , 2024
    2024.0
    Citations: 1
  • InCl 3 -Catalyzed One-Pot Synthesis of Pyrrolo/Indolo- and Benzooxazepino-Fused Quinoxalines
    NE Aksakal, M Zora
    ACS omega 9 (30), 33251-33260 , 2024
    2024.0
    Citations: 9
  • A fully conjugated imidazole-fused perylene phenantroline ruthenium (II) complex in photocatalytic oxidation
    NE Aksakal, F Aksakal, EY Gül, ET Eçik, F Yuksel
    Inorganica Chimica Acta 562, 121882 , 2024
    2024.0
    Citations: 3
  • Structural and optical properties of new naphthalene and perylene imide imidazoles
    NE Aksakal, M Bayar, H Dumrul, D Atilla, Y Chumakov, F Yuksel
    Polycyclic Aromatic Compounds 39 (4), 363-373 , 2019
    2019.0
    Citations: 9
  • Novel ruthenium(II) and iridium(III) BODIPY dyes: insights into their application in photodynamic therapy in vitro
    NE Aksakal, ET Eçik, HH Kazan, GY Çiftçi, F Yuksel
    Photochemical & Photobiological Sciences 18 (8), 2012-2022 , 2019
    2019.0
    Citations: 38
  • Crystal Structures of Two Perylenediimides: A Study of Bay-Substitution
    NE Aksakal, Y Chumakov, F Yuksel
    Journal of Chemical Crystallography 49 (2), 72-79 , 2019
    2019.0
    Citations: 14
  • A novel photosensitizer based on a ruthenium (ii) phenanthroline bis (perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy
    NE Aksakal, HH Kazan, ET Eçik, F Yuksel
    New Journal of Chemistry 42 (21), 17538-17545 , 2018
    2018.0
    Citations: 41
  • Revealing the Photochemical Pathways of Bodipy-Ruthenium (Ii) Polypyridyl Complexes: Synthesis, Characterization, and Photooxidation Behavior
    E Tanrıverdi Eçik, SS Sattar, NE Aksakal, E Yıldız Gül, B Köse
    Characterization, and Photooxidation Behavior , 0

MOST CITED SCHOLAR PUBLICATIONS

  • A novel photosensitizer based on a ruthenium (ii) phenanthroline bis (perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy
    NE Aksakal, HH Kazan, ET Eçik, F Yuksel
    New Journal of Chemistry 42 (21), 17538-17545 , 2018
    2018.0
    Citations: 41
  • Novel ruthenium(II) and iridium(III) BODIPY dyes: insights into their application in photodynamic therapy in vitro
    NE Aksakal, ET Eçik, HH Kazan, GY Çiftçi, F Yuksel
    Photochemical & Photobiological Sciences 18 (8), 2012-2022 , 2019
    2019.0
    Citations: 38
  • Crystal Structures of Two Perylenediimides: A Study of Bay-Substitution
    NE Aksakal, Y Chumakov, F Yuksel
    Journal of Chemical Crystallography 49 (2), 72-79 , 2019
    2019.0
    Citations: 14
  • InCl 3 -Catalyzed One-Pot Synthesis of Pyrrolo/Indolo- and Benzooxazepino-Fused Quinoxalines
    NE Aksakal, M Zora
    ACS omega 9 (30), 33251-33260 , 2024
    2024.0
    Citations: 9
  • Structural and optical properties of new naphthalene and perylene imide imidazoles
    NE Aksakal, M Bayar, H Dumrul, D Atilla, Y Chumakov, F Yuksel
    Polycyclic Aromatic Compounds 39 (4), 363-373 , 2019
    2019.0
    Citations: 9
  • A fully conjugated imidazole-fused perylene phenantroline ruthenium (II) complex in photocatalytic oxidation
    NE Aksakal, F Aksakal, EY Gül, ET Eçik, F Yuksel
    Inorganica Chimica Acta 562, 121882 , 2024
    2024.0
    Citations: 3
  • Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies
    D Beyazgül, NE Aksakal
    Anatolian Clinic the Journal of Medical Sciences 29 (3), 372-386 , 2024
    2024.0
    Citations: 1
  • Naringenin‐Loaded PEG Polymers with Varying Molecular Weights: Preparation and Evaluation of Singlet Oxygen Quenching Activity
    NE Aksakal, ZM Sahin, EY Gül, C Okudu
    ChemistrySelect 10 (42), e04081 , 2025
    2025.0
  • Revealing the photochemical pathways of BODIPY-ruthenium (II) Polypyridyl complexes: Synthesis, characterization, and Photooxidation behavior
    SSS Sattar, NE Aksakal, EY Gül, B Köse, ET Eçik
    Polyhedron, 117675 , 2025
    2025.0
  • Revealing the Photochemical Pathways of Bodipy-Ruthenium (Ii) Polypyridyl Complexes: Synthesis, Characterization, and Photooxidation Behavior
    E Tanrıverdi Eçik, SS Sattar, NE Aksakal, E Yıldız Gül, B Köse
    Characterization, and Photooxidation Behavior , 0