"Open-minded researcher working on phytochemicals' anti-cancer, antidiarrheal, and antimalarial effect"
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Scopus Publications
Scopus Publications
Knowledge and prevention practices regarding cytomegalovirus among pregnant women in Gondar city a multicenter cross-sectional study Habtamu Semagne Ayele, Alemante Tafese Beyna, Assefa Belay Asrie, Tafere Mulaw Belete, Abaynesh Fentahun Bekalu, Abebech Tewabe Gelaye, Gebresilassie Tadesse, Gizachew Kassahun Bizuneh, Demis Getachew, Assefa Kebad Mengesha Scientific Reports, 2026 Cytomegalovirus (CMV), a herpesvirus, poses a significant teratogenic risk during pregnancy, particularly in low- and middle-income countries such as Ethiopia. As no effective vaccine currently exists, pregnant women should adopt preventive measures and develop a good understanding of the various aspects of CMV infection to reduce the rate of seroconversion. Due to the scarcity of data in Ethiopia, this study aimed to assess the knowledge and prevention practices of pregnant women regarding CMV in Gondar city, Northwest Ethiopia. A facility-based cross-sectional study was conducted among pregnant women aged 18 years and above in six randomly selected health settings from August 1st to October 30th, 2024. Using a single population proportion formula, the sample size was determined to be 616, and study participants were enrolled through stratified random sampling. Data were then collected via face-to-face interviews using a pretested questionnaire adapted from previously published studies. The collected data were entered and analyzed using SPSS version 26. To assess knowledge and preventive practices regarding CMV, both binary and multivariable logistic regression analyses were performed, with p-values < 0.25 and < 0.05 considered as the criteria for inclusion in multivariate analysis and statistical significance, respectively. Additionally, adjusted odds ratios (AOR) with 95% confidence intervals were computed to express the strength of association between independent and dependent variables. Of the 616 study subjects, 575 responded, resulting in a response rate of 93.34%. The study showed that 26.6% and 34% of pregnant women demonstrated good knowledge and prevention practices for CMV. Based on the multivariable analysis, it was found that pregnant women aged 38 and above (AOR = 1.775, CI = 1.196-3.198, p = 0.016), having higher educational attainment (AOR = 2.244, 95% CI = 1.177-4.280, p = 0.002) and being diagnosed with CMV (AOR = 1.848, 95% CI: 1.026-3.687, p = 0.018) were independently associated with good knowledge. Similarly, married individuals had 1.197 times higher odds of having good prevention practices (AOR = 1.197, 95% CI = 1.025-2.713, p = 0.02). Additionally, pregnant women in their third trimester of pregnancy had 1.259 times higher odds of having good prevention practices (AOR = 1.259, 95% CI = 1.010-3.879, p = 0.039). In general, the level of knowledge and preventative practices regarding CMV infection was low among the studied population. To address the low levels of knowledge and prevention practices regarding CMV infection, several contributing factors were identified to guide interventional activities. This finding should prompt policymakers and health care providers to collaborate and provide health initiatives. It is also essential that pregnant women are actively engaged in health education and encouraged to stay informed about this teratogenic virus to improve these outcomes.
Pattern of use and awareness of side-effects of non-steroidal anti-inflammatory drugs among general public in Gondar city, North west Ethiopia Habtamu Semagne Ayele, Alemante Tafese Beyna, Assefa Belay Asrie, Tafere Mulaw Belete, Addisu Afrassa Tegegne, Demis Getachew, Tekletsadik Tekleslassie Alemayehu, Gizachew Kassahun Bizuneh, Samuel Teferi Chanie, Assefa Kebad Mengesha Scientific Reports, 2026 BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for managing pain, fever, and inflammation. Though over 30 million people use NSAIDs worldwide, a widespread unawareness of their side effects persists, resulting in irrational use and increased global hospital admissions. Currently, no studies have been conducted in Ethiopia concerning the patterns of NSAIDs use or awareness of their side effects. Therefore, this study aims to assess NSAIDs patterns of use and the public's awareness of associated side effects. METHOD: A community-based cross-sectional study was conducted in Gondar City, Northwest Ethiopia, from March to May 2025. A systematic random sampling technique was used to enroll 771 participants. Data were collected using a pretested structured questionnaire and analyzed with SPSS Version 26 employing binary and multivariable logistic regression. RESULT: In this study, 91.24% response rate was achieved and revealed an NSAIDs use prevalence rate of 74.6%, while 52.3% study subjects were aware of NSAIDs side effects. Meanwhile, factors significantly associated with NSAIDs use included age ≥ 49 years (AOR = 1.28, CI = 1.013-2.952, p = 0.001); being retired (AOR = 1.505, CI = 1.011-3.87, p = 0.014); an ex-smoker (AOR = 1.874, CI = 1.021-2.982, p = 0.01) and having gastrointestinal disease (AOR = 2.435, CI = 1.329-3.871, p = 0.012) or heart disease (AOR = 1.576, CI = 1.278-2.686, p = 0.01). Awareness of NSAIDs side effects was also significantly associated with the following factors: being female (AOR = 1.960, CI = 1.402-2.889, p = 0.006); being a student (AOR = 1.801, CI = 1.076-3.014, p = 0.025); and comorbidities such as musculoskeletal disease (AOR = 1.785, CI = 1.092-2.883, p = 0.03). CONCLUSION: The perceived prevalence of NSAID use, coupled with notable gaps in awareness highlights the critical need for targeted public health education. This should be achieved through collaborative efforts with relevant bodies and healthcare professionals, especially pharmacists, to promote safer and more informed NSAID use.
Impacts of Herbal Medicine Use on Lipid Profiles in Type 2 Diabetic Patients in Northwest Ethiopia: A Comparative Cross-Sectional Study Assefa Belay Asrie, Tafere Mulaw Belete, Tezera Jemere Aragaw, Melshew Fenta Misker, Alemante Tafese Beyna, Habtamu Semagne Ayele, Kidist Goshime Tekle, Yonas Zewdu Milikit, Ephrem Adane Andargie, Hiwot Tesfaselassie Afework, Yenatfanta Gezu Lenjiso, Gebrehiwot Lema Legese Biomed Research International, 2026 Background Blood lipid abnormalities are common among Type 2 diabetes mellitus (T2DM) patients, and achieving better glycemic control may help improve their lipid profiles. Concomitant use of herbal medicines with conventional antidiabetic medications is a common practice among T2DM patients in Ethiopia. This study was conducted to evaluate the impacts of herbal medicine use on lipid profiles among T2DM patients. Method This is a cross‐sectional study and was conducted from May 01 to July 30, 2024. A sample of 416 participants was approached for the study. The sample size was calculated using a single population proportion formula. A systematic random sampling method was used to select the participants. The data were collected through interviewer‐administered questionnaire and patient medical record reviews. Patients were randomly selected, and their corresponding medical records, retrieved from the archive based on follow‐up schedules of the patients, were accessed and reviewed using a data collection tool adapted from previous studies. Lipid parameters, including total cholesterol (TC), triglycerides (TG), low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C) levels, as well as TC/LDL‐C, TG/LDL‐C, and LDL‐C/HDL‐C ratios and atherogenic index of plasma (AIP), were compared between herbal medicine users and nonusers using the Mann–Whitney U Test and linear regression analysis. Results Of the participants approached, 381 (91.6%) were included in the study. Among the participants included in the study, 141 (37.0%) reported having used herbal medicine since they were diagnosed with diabetes, and almost all were active users at the time of the study. The median TC, TG, and LDL‐C levels and TC/HDL‐C, TG/HDL‐C, and LDL‐C/HDL‐C ratios and AIP of herbal medicine users were significantly lower than those of nonusers ( p < 0.01), whereas the median HDL‐C was significantly higher ( p < 0.05). Moreover, linear regression analyses indicated that the TC, TG, and LDL‐C levels were decreased by 6.84 mg/dL ( β = −6.84, p < 0.05), 8.69 mg/dL ( β = −8.69, p < 0.01), and 6.75 mg/dL ( β = −6.75, p < 0.05), respectively, whereas HDL‐C values increased by 1.59 ( β = 1.59, p < 0.05) in herbal drug users as compared with nonusers. Similarly, compared with nonusers, TC/HDL‐C, TG/HDL‐C, and LDL‐C/HDL‐C ratios in herbal medicine users were reduced by 0.32 ( β = −0.32, p < 0.01), 0.34 ( β = −0.34, p < 0.01), and 0.23 ( β = −0.23, p < 0.05), respectively, whereas AIP decreased by 0.041. Conclusion In conclusion, the use of herbal medicines was associated with significant reductions in TC, TG, and LDL‐C levels, as well as in the TC/HDL‐C, TG/HDL‐C, and LDL‐C/HDL‐C ratios and AIP, whereas also associated with a significant increase in HDL‐C levels. The results imply that herbal remedies may have beneficial effects in optimizing serum lipid levels in T2DM patients and could ultimately help reduce associated cardiovascular risks. However, because this study was cross‐sectional and carried out at a single site, we recommend conducting more rigorous, multicenter observational and trial studies to generate more comprehensive and conclusive results.
Impact of health literacy and medication adherence on achieving blood pressure goals among hypertensive patients at the University of Gondar Comprehensive Specialized Referral Hospital, Northwest Ethiopia Alemante Tafese Beyna, Assefa Kebad Mengesha, Habtamu Semagne Ayele, Firomsen Mamuye Dajane, Abreham Honelgn Mule, Assefa Belay Asrie, Tafere Mulaw Belete, Demis Getachew, Tekletsadik Tekleslassie Alemayehu, Gebresilassie Tadesse, Gebremariam Wulie Geremew, Liknaw Workie Limenh, Gizachew Kassahun Bizuneh Plos One, 2026 Background This study assessed hypertensive health literacy and its association with achieving blood pressure goals at the University of Gondar Comprehensive Specialized Hospital, Ethiopia. Method A cross-sectional study was conducted with 393 hypertensive patients from September 1 to October 30, 2024, selected through simple random sampling. Data were analyzed using t-tests, one-way ANOVA, and logistic regression, with p < 0.05 considered significant. Result Among the 393 participants, only 40.2% of participant achieved their blood pressure goal. Only 15% and 30.8% had high hypertensive health literacy and adherence levels, respectively. Participants living in an urban area (AOR = 5.1, 95% CI: 2.74–9.17, p < 0.001), with higher education (AOR = 2.7, 95% CI: 1.15–6.75, p < 0.023), living with hypertension for more than 10 years (AOR = 3.4, 95% CI: 1.54–7.58, p < 0.002), using three or more antihypertensive drugs (AOR = 0.3, 95% CI: 0.13–0.95, p < 0.041), adhering to treatment (AOR = 2.7, 95% CI: 1.34–5.55, p < 0.005), and having high hypertension health literacy (AOR = 3.8, 95% CI: 1.36–10.90, p < 0.011) were more likely to achieve blood pressure goal. Variables like residence (p < 0.001), marital status (p < 0.004), educational status (p < 0.013), occupation (p < 0.013), number of antihypertensive medications (p < 0.001), and presence of complication (p < 0.002) showed a significantly mean difference in hypertension health literacy score. There is a significant association between hypertensive health literacy and medication adherence with a p-value of < 0.001. Conclusion Most participants did not achieve their target blood pressure goals. Hypertensive health literacy and medication adherence were significantly associated with blood pressure goals. To improve these outcomes, health policies should focus on creating community-based educational programs that empower patients with a better understanding of their condition and the importance of following their treatment plans. Additionally, increasing access to healthcare resources and support can provide the guidance patients need to manage their hypertension effectively. By strengthening these initiatives, we can help more individuals take control of their health and achieve better blood pressure management.
Assessment of glycemic control, health-related quality of life, and associated factors in type 2 diabetic patients attending a comprehensive specialized hospital in Northwest Ethiopia Assefa Belay Asrie, Tafere Mulaw Belete, Melshew Fenta Misker, Alemante Tafese Beyna, Habtamu Semagne Ayele, Kidist Goshime Tekle, Yonas Zewdu Milikit, Ephrem Adane Andargie, Hiwot Tesfaselassie Afework, Yenatfanta Gezu Lenjiso, Gebrehiwot Lema Legese Plos One, 2025 Background Poor glycemic control in type 2 diabetes mellitus (T2DM) leads to serious complications that negatively impact health-related quality of life (HRQoL). This study aimed to assess glycemic control, HRQoL, and their associated factors in T2DM patients. Method This is a cross-sectional study and was conducted from May 1 to July 30, 2024. Systematic random sampling technique was used to recruit the study participants. The average fasting blood glucose (FBG) levels of three consecutive tests during follow-up visits were extracted from patient medical records while the data pertaining HRQoL were collected through interview using EQ-5D five-level (EQ-5D-5L) questionnaire and EQ visual analog scale (EQ VAS). EQ-5D-5L utility scores were determined using disutility values established for Ethiopian context. The FBG level was used to categorize patients by glycemic status (controlled or uncontrolled). Binary logistic regression analysis was performed to outline factors associated with glycemic control. Mann–Whitney U and Kruskal–Wallis tests were used to compare the median utility and VAS scores between subgroups. Furthermore, Tobit regression analysis was performed to determine factors associated with HRQoL. Results Nearly half (48.7%) of the patients were with uncontrolled glycemic levels (out of the target 4.4−72 mmol/L). In the multivariate logistic regression analysis, age, disease duration, comorbid conditions, diabetes complications, adherence to antidiabetic medications, and herbal medicine use were associated with glycemic control. Pain/discomfort, performing usual activities, and anxiety/depression were HRQoL dimensions in which the majority of participants reported problems; 85.8%, 76.2%, and 74.6% of participants, respectively, reported having problems in the dimensions. The overall median (interquartile range) EQ-5D-5L utility score was 0.86 (0.76–0.93) while EQ VAS score was 75.0 (65.0–80.0). The Tobit regression analysis showed that older age, diabetes duration, comorbid conditions, diabetic complications, and herbal medicine use were significantly negatively associated with HRQoL scores. On the other hand, engagement in physical exercise, controlled glycemic level, and adherence to antidiabetic treatments were found to be positively associated. Conclusion In conclusion, nearly half of the patients were with uncontrolled glycemic level. The majority of participants reported problems in pain/discomfort, usual activities, and anxiety/depression dimensions of HRQoL. Several factors were correlated with both glycemic control and HRQoL. Adherence to antidiabetic medications was positively associated with both glycemic control and HRQoL. In contrast, older age, longer duration of diabetes, presence of comorbidities, diabetic complications, and use of herbal medicine were all negatively associated with both outcomes. On the other hand, adherence to dietary recommendations was positively associated only with glycemic control, while engagement in physical exercise was positively associated only with HRQoL. Moreover, glycemic control was associated with improved HRQoL. The findings underscore the importance of interventions targeting modifiable factors, such as dietary modifications, physical activity, and adherence support, to improve overall glycemic control and HRQoL.
Diuretic effects of hydromethanolic extract of Rumex nepalensis Spreng. leaves and its solvent fractions in mice Fasika Argaw Tafesse, Tafere Mulaw Belete, Assefa Belay Asrie Phytomedicine Plus, 2025 The leaves of Rumex nepalensis Spreng. have been traditionally utilized for treating urinary retention and as a diuretic, but scientific validation is limited. This study aimed to evaluate the diuretic activity of R. nepalensis leaf extracts using standardized experimental models. The leaves of the plant were dried under shade, crushed to a coarse powder, and subjected to cold maceration with 80% methanol and concentrated. A portion of the crude extract was taken and fractionated using solvents of increasing polarity: n-hexane, ethyl acetate, and water. The mice were divided into different groups, including negative control groups (received 2% tween 80 or distilled water), positive control groups (given 10 mg/kg of furosemide), and experimental groups receiving the 80% methanol extract or its solvent fractions at doses of 100, 200, and 400 mg/kg orally. Then urine volume was measured at 1 st , 2 nd , 3 rd , 4 th , and 5 th hours post-dosing of the treatments. Meanwhile, a urine sample was taken from each animal for electrolyte analysis and pH measurement. The mean values of the treatment groups were finally compared against those of the negative controls. The results showed that the 80% methanol extract, ethyl acetate fraction, and aqueous fraction at doses of 200 and 400 mg/kg produced significant diuretic effects, marked by substantial increases in urine volume compared to the negative control (p < 0.001). The fractions also demonstrated significant natriuresis and kaliuresis effect at these doses (p < 0.001), further confirming their diuretic efficacy. Additionally, the highest doses of the crude extract (p ˂ 0.01), ethyl acetate fraction (p < 0.001), and aqueous fraction (p < 0.001) significantly increased the pH of the urine. This investigation demonstrated the diuretic effect of the hydromethanolic extract of R. nepalensis leaves and its ethyl acetate and aqueous fractions. The observed diuretic effect is possibly attributable to the presence of different secondary metabolites. However, this work lacks chemical characterization of the extract and the fractions using advanced analytical techniques and mechanistic studies. These limitations may be addressed by other studies in the future. Despite these limitations, the current study has offered a scientific verification for the traditional therapeutic application of R. nepalensis leaves and this may serve as a foundation for future research on the chemical composition and pharmacological properties of the plant.
Review on the Ethnopharmacological Use of Medicinal Plants and Their Anticancer Activity from Preclinical to Clinical Trial Tafere Mulaw Belete, Alemante Tafese Beyna Natural Product Communications, 2025 Traditional medicine has played a key role in cancer treatment, particularly in developing countries where herbal remedies are extensively utilized. Ethnopharmacological knowledge has highlighted several medicinal plants traditionally used to treat cancers. However, only a fraction of these plants have undergone scientific evaluation to validate their anticancer potential. This review summarizes the ethnopharmacological use, preclinical studies, and clinical trial data of plant-derived compounds with anticancer properties. Preclinical investigations have demonstrated substantial cytotoxic activities of plant extracts and isolated fractions against various human cancer cell lines. For instance, extracts from Acokanthera schimperi, Clematis simensis, Euphorbia schimperiana, Kalanchoe petitiana , and Plumbago zeylanicum demonstrated potent activities across various cancer types, with IC50 values ranging between 0.086 and 6.37 μg/mL. Building on these preclinical findings, several plant-derived compounds have progressed to clinical trials. Curcumin from Curcuma longa is undergoing Phase II trial for advanced pancreatic cancer. Tea polyphenols and *indole-3-carbinol/3,3-diindolylmethane have shown efficacy in Phase II trials for multiple myeloma and breast cancer, respectively. Besides, epigallocatechin, lycopene, resveratrol (Polygonum, sulforaphane ( Brassica oleracea ), roscovitine/seliciclib, thymoquinone, piperine, Berberine and genistein are under Phase I–III trials. This review integrates ethnopharmacological knowledge, preclinical data, and clinical evidence, showing the key role of medicinal plants in anticancer drug discovery. While significant progress has been made, further studies are required to isolate, characterize, and elucidate the mechanisms of action of bioactive compounds. Bridging traditional medicine with contemporary research offers promising avenues for the development of novel chemotherapeutic and chemopreventive agents, advancing the fight against cancer.
Assessment of healthcare workers knowledge and attitudes towards Mpox infection at University of Gondar Comprehensive Specialized Referral Hospital, Ethiopia Alemante Tafese Beyna, Ermias Teklehaimanot Yefter, Assefa Belay Asrie, Habtamu Semagne Ayele, Tafere Mulaw Belete, Wondim Ayenew, Gashaw Sisay Chanie, Liknaw Workie Limenh, Melese Legesse Mitku, Mihret Melese, Gizachew Kassahun Bizuneh, Assefa Kebad Mengesha Frontiers in Public Health, 2025 BackgroundHealthcare workers are on the frontlines of fighting health risks, especially during epidemics. Despite their critical role, their knowledge and attitudes toward Mpox have not been previously evaluated at the University of Gondar Comprehensive Specialized Hospital, Ethiopia. This study aimed to assess the knowledge and attitudes of healthcare workers regarding Mpox at this hospital.MethodThis cross-sectional study assessing 382 HCWs. It was conducted on August 1–30, 2024. Data was collected using a self-administered questionnaire. A simple random sampling technique was used. Bivariate and multivariate binary logistic regression analysis was used. p &lt; 0.05 was considered as Significant.ResultAlmost half of the participants (48.40%) showed good knowledge, and 49.20% displayed a positive attitude toward Mpox. Age ≥ 50 Years old (AOR = 4.1, 95% CI 1.33–12.07), Physicians (AOR = 3.2, 95% CI 1.57–6.50), pharmacists (AOR = 3.5, 95% CI 1.55–8.06), having a B.Sc. Degree (AOR = 3.2, 95% CI 1.58–6.84), having M.Sc. (AOR = 3.3, 95% CI 1.60–6.84), work experience of 5–10 years (AOR = 3.2, 95% CI 1.78–5.95), HCWs who get information primarily from training (AOR = 2.7, 95% CI 1.08–6.70), and HCWs attending training including Mpox (AOR = 1.9, 95% CI 1.16–3.19) were more likely to having good knowledge than their counter. HCWs those having a M.Sc. degree (AOR = 2.1, 95% CI 1.11–4.20), physician (AOR = 2.1, 95% CI 1.10–4.16), pharmacist (AOR = 2.6, 95% CI 1.21–5.76), HCWs having work experience of 5–10 (AOR = 2.5, 95% CI 1.44–4.38), and HCWs attending training including Mpox (AOR = 1.9, 95% CI 1.18–3.07) were more likely to have positive attitude than their counter.ConclusionThis study revealed nearly half of the participants had a limited knowledge and negative attitudes. To addressing this gap it is essential to support training, integrate education, and improve resource accessibility.
The prevalence of depression and anxiety among cardiovascular patients at University of Gondar specialized hospital using beck's depression inventory II and beck anxiety inventory: A cross-sectional study Tihitina Sisay, Missaye Mulate, Tewodrose Hailu, Tafere Mulaw Belete Heliyon, 2024 Psychosocial issues are leading factor as well as consequences of cardiovascular disease. Identifying factors associated with depression facilitate service quality improvement for inpatients. This study assessed the prevalence and identified associated factors with depression and anxiety among patients with cardio vascular disease. Method: An institution-based cross-sectional study was conducted with a convenience sample of 370 stable adult patients from June 1 to July 30, 2020 among cardiovascular disease patients at the University of Gondar Specialized Hospital Ethiopia. Data were collected by using structured questionnaires. Data analyses were conducted using SPSS version 21. The statistical significance declared at p-value <0.05. Result: In this study, among 370 Cardiovascular diseases patients, 228 (61.6 %) suffer from anxiety, and 53.51 % (198) suffer with depression. There was a significant mean difference in the level of depression and anxiety between male and female Cardiovascular diseases patients. The females' scores of depression (mean = 28, p < 0.01) and anxiety (mean = 25.3, p < 0.01) were more than that of males 'scores of depression (mean = 15.1, p < 0.01) and anxiety (mean = 12.3, p < 0.01). Cardiovascular diseases patients aged greater than 60 years have the highest rate of prevalence of depression in all age group. Being in the age category of greater than 60 years was 1.16 (0.57-2.32) times more likely to have depression than the age category of 18-24 years. Depression and anxiety were significantly associated with being woman, widowed, being single, unable to read and write, and possess mental disorders history.
Patient satisfaction with antiretroviral therapy service provided by pharmacists in Dembia district health institutions, Northwest Ethiopia Tafere Mulaw Belete, Solomon Asmamaw Tadesse, Kidist Atnafu, Minilik Kelemu, Assefa Belay Asrie AIDS Research and Therapy, 2023 Background The patients’ perception of the health service is a vital tool for measuring health service quality. Besides, Patient satisfaction is an essential feature in assessing the quality of health services. Health institution leaders are considering quantifiable patient satisfaction data as a means to evaluate the health care service. Method An institution-based cross-sectional study was employed from 21/8/2022 to 21/9/2022 among 308 patients attending ART pharmacy services in three health institutions of Dembia distinct. Data were collected by using a questionnaire and reviewing medical charts. Results were calculated and presented in the form of texts, tables, and graphs. Variables with a p-value of 0.05 were considered significant determinants of patient satisfaction. Result A total of 308 HIV patients were recruited with a response rate of 100%. The overall prevalence of satisfaction among respondents was 231(75%). Being unable to read and write [1.21(AOR = 1.07–4.31)] and patient age greater than 48 years 1.9(0.73–2.59) were significantly associated with the level of patient satisfaction. Among the participants 66.9% were satisfied with clear and organized service, and 76% were satisfied with the convenience of a private counseling room. Conclusion The general patient satisfaction at the antiretroviral therapy clinic did not achieve the national target of 85% satisfaction with significant differences among health centers. Being educated to a higher level, absence of signs and directions to ART clinics, and not having the opportunity to ask questions were the factors influencing patient satisfaction with ART service.
1. Belete TM. Recent Updates on the Development of Deuterium- Containing Drugs for the treatment of Cancer. 2022 October; 16: 3465-3472.
2. Belete TM. Recent Progress in the Development of Novel Mycobacterium Cell Wall Inhibitor to Combat Drug-Resistant Tuberculosis. Microbiology Insights. 2022 May;15:11786361221099878.
3. Belete TM. Review on the immune response, safety and efficacy of emergency use authorization granted covid-19 vaccines. The open 16.
4. Belete TM. The Current Status of Gene Therapy for the Treatment of Cancer. Biologics: Targets & Therapy. 2021; 15:67.
5. Belete TM. Review on Up-to-Date Status of Candidate Vaccines for Covid-19 Disease. Infection and Drug
6. Belete TM. A review on Promising vaccine development progress for COVID-19 disease. Vacunas. 2020 Jun 13.
7. Belete TM. An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease. Clinical pharmacology: advances and applications. 2020; 12:203.
8. Desta GT, Adela Alemu M, Tsegaw A, Belete TM, Adugna BY. Antidiarrheal Effect of 80% Methanol Extract and Fractions of Clerodendrum myricoides (Hochst.) Vatke (Lamiaceae) Leaf in Swiss Albino Mice. Evidence-Based Complementary and Alternative Medicine. 2021 Oct 19; 2021.
9. Belete TM. Recent Progress in the Development of New Antimalarial Drugs with Novel Targets. Drug Design, Development and Therapy. 2020; 14:3875.
10. Belete TM. A recent achievement in the disc
