Munther Abduljaleel MUHAMMAD-ALI
@uobasrah.edu.iq
Ecology / College of Science
University of Basrah
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Environmental Science, Pharmaceutical Science, Pollution
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Huda Saleh Abood, Ekhlas Qanber Jasim, and Munther Abduljaleel Muhammad-Ali
ARTS Publishing
In this work, four hydrazone Schiff base derivatives N-(2,4-Dinitro-phenyl)-N’-(1H-pyrrol-2-ylmethylene)-hydrazine (1a), N-Benzo [1,3] dioxol-5-ylmethylene-N’-(2,4-dinitro-phenyl)-hydrazine (1b), (E)-5-((2-(2,4-dinitrophenyl)hydrazono)methyl)-2-hydroxybenzoic acid (1c) and (E)-1-(2,4-dinitrophenyl)-2-(2-methoxybenzylidene)hydrazine (1d) were synthesized by reaction of four aldehydes namely pyrrole-2-carboxaldehyde, piperonal, 5-formylsalicylic acid, and o-vanillin with 2,4-dinitrophenyl hydrazine to produce the final compounds 1a, 1b, 1c, and 1d, respectively. These four compounds were investigated as corrosion inhibitors in aqueous mild acidic static solution. FTIR, HNMR, and elemental analysis were used to elucidate the chemical structure of the synthesized inhibitors. Using potential dynamic polarization measurements, these inhibitors’ efficiency in preventing C-steel corrosion in 1.00 M HCl was studied. The results of the experiments revealed that 1×10−3 M is the ideal concentration for 1a, 1b, 1c, and 1d, and that the corresponding inhibition efficiencies for these subunits were 80.70%, 91.30%, 91.34, and 88.80%, respectively. The best corrosion inhibitors were compounds 1b and 1c. Furthermore, studies suggested that these substances are mixed-type inhibitors and that the efficiency of the inhibition is strongly correlated with their quantity. Quantum paraments included Dipole moment, energy band gap (ΔE), value of energy of lowermost unoccupied molecular orbital (ELUMO), and energy of high most occupied molecular orbital (EHOMO) using Molecular Operating Environment MOE, Gaussian, and HyperChem software packages were determined which demonstrated strong agreement between algorithmic and practical findings.
Ekhlas Qanber Jasim
ARTS Publishing
Mesalazine, often referred to as mesalamine or 5-aminosalicylic acid (5-ASA), and its derivatives are some of the first medications to be approved for treating digestive tract inflammations, including ulcerative colitis and mild to moderate Crohn’s disease. Sulfasalazine, discovered in 1938 for therapeutic use, was the first mesalazine derivative. High yields of four different mesalazine derivatives were synthesized, including two Schiff bases and two azo compounds. The present study involved the synthesis of Schiff bases through the reaction of mesalazine with pyrrole-2-carbaldehyde or indole-2-carbaldehyde, resulting in the formation of 5-(((1H-pyrrol-2-yl)methylene)amino)-2-hydroxybenzoic acid (1) or 5-(((1H-indol-2-yl)methylene)amino)-2hydroxybenzoic acid (2), respectively. The synthesis of azo compounds involved the coupling of mesalazine with sulfamethoxazole or pyridoxine, resulting in the formation of 5-amino-2-hydroxy-3-((4-(N-(5-methylisoxazol-3-yl)sulfamoyl)phenyl)diazenyl)benzoic acid (3) or 2-hydroxy-5-((5-hydroxy-3,4-bis(hydroxymethyl)-6-methylpyridin-2-yl)diazenyl)benzoic acid (4), respectively. The identification of the synthesized compounds was carried out using IR and 1H-NMR spectroscopy. Antibacterial assessment of the synthetic compounds was performed in vitro against gram-negative bacteria (such as Escherichia coli and Pseudomonas aeruginosa) and gram-positive bacteria (Staphylococcus aureus). The antibacterial activity studies demonstrated that against Escherichia coli and Staphylococcus aureus, the Schiff base compounds are more active than azo compounds. Compound 1 showed the highest activity, resulting in a 23 mm inhibition zone against E. coli at 1000 ug/ml. In contrast, the antibacterial activity of compound 2 was observed to be 25 mm against S. aureus at the same highest concentration.
Amani Abd Al-Ridha Al-Abdullah, Ekhlas Qanber Jasim, and Munther Abduljaleel Muhammad-Ali
IOP Publishing
Abstract The objective of the current study was to analyze the chemical compositions and antibacterial properties of Laurus nobilis. The bacterial strain was isolated from urine sample of female patients have urinary tract infection in Al-Basrah Teaching Hospital. Two solvents (hot and cold aqueous and ethanol) were used to extract the dried leaves of L. nobilis. While there were differences in the inhibition zones that solvent extracts demonstrated against bacterial pathogens, all of them significantly inhibited pathogens. The diameters of the inhibition zones on Staphylococcus aureus where the alcoholic extract was in the range of 17-29 mm, 22-28 mm for hot water and 12-14 mm for cold aqueous extract. The diameters of the inhibition zones on Klebsiella pneumoniae for alcoholic extract were 18-20 mm, 19-21.5 mm for hot aqueous extract and 12-17 mm for cold water extract. The GC-MS analysis demonstrated the presence of different phytochemical compounds in the extract of Laurus nobilis. A total of 60 compounds were identified, for ethanolic extract, tris (2-methylenecyclopropyl)methanol, (3aS,6aR,9aR,9bS)-3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one and (3aS,6aR,9aR,9bS)-6-methyl-3,9-dimethylene-3a,4,6a,7,8,9,9a,9b-octahydroazuleno[4,5-b]furan-2(3H)-one were the major compounds with percentage values 9.64%, 8.86% and 7.43%, respectively. For hot water extract, the major three compounds were 5-(hydroxymethyl)furan-2-carbaldehyde 11.64%, 2-methyl-5-nitro-2H-1,2,3-triazol-4-amine 8.39% and tris(2-methylenecyclopropyl)methanol 6.81%. Whereas, for cold water extract, the major compounds were n-Hexadecanoic acid 26.05%, Bis(2-ethylhexyl) phthalate 22.94% and Octadecanoic acid 8.25%. Molecular docking showed that these nine major compounds had an excellent binding affinity -4.25 to -8.56 kcal/mol against S. aureus using protein 1JIJ. The binding affinity of these compounds against K. pneumoniae (protein 6PIB) were in the range - 4.03 to -8.22 kcal/mol.
Dhay J. Edan, Munther Abduljaleel Muhammad-Ali, and Raghad Shubbar Jaafar
IOP Publishing
Abstract The current study aimed to use biological treatment using plant extracts; extracted from some locally available plants: Lawsonia inermis (Henna), and Myrtus communis (Yass), against pathogenic bacteria isolated from heavy water in hospitals that do not have treatment plants. The two studied plants were extracted using two different solvents (water and alcohol). Diagnosis of these extracted using Gas chromatography (GC-MS) showed that the alcoholic extraction led to a higher percentage of effective phenolic compounds than the aqueous extract. Sewage water was used to isolate bacteria and according to the morphological, and biochemical, confirmed by using the vitke II instrument; six types of pathogenic bacteria were identified (Staphylococcus lentus, Staphylococcus xylosus Sphingomonas paucimobilis, Escherichia coli, klebsiella oxytoca, Serratia ficaria). The two Alcoholic plant extracted showed excellent antibacterial activity against all pathogenic bacteria than the water extracted as revealed by the diameter of the inhibition zone.
munther Muhammad-Ali, Abeer Mohammad, Basim Hameed, and Dhurgham Shaheed
Polish Pharmaceutical Society
Husam Hamza Salman, Munther Abduljaleel Mohammed Ali, and Eman Tariq Ali
African Journals Online (AJOL)
Purpose: To synthesize and screen some new nitrone compounds derived from terephthaldehyde for their anticancer potential.
 Methods: Six new compounds (H, p-Me,p-Br, p-Cl, o-Cl and m-Me) were synthesized via a condensation reaction between terephthaldehyde and a variety of aryl hydroxylamine compounds derived from nitrobenzene and its derivatives. The chemical structures of these compounds were identified using elemental CHN analysis and were elucidated using Fourier Transform infra-red (FT-IR), 1H-nuclear magnetic resonance (1H NMR), mass spectrometry (MS), and elemental analysis. The anticancer effects of the compounds were screened in vitro with respect to their cytotoxicity on MCF7 human cancer cells line. The IC50 values were obtained by MTT assay and their effects on apoptosis of MCF-7 cells were assessed using Acridine orange-ethidium bromide AO/EtBr staining method under a fluorescence microscope.
 Results: Only four compounds (2b, 2d, 2e, and 2f) inhibited more than 50 % of the growth of MCF-7 cells. The strongest anti-proliferation effect against MCF-7 cells was exhibited by 2f (m-Me), producing more apoptosis which increased membrane disruption and consistency of lysosome vacuoles; it also exhibited higher cytotoxic effects on human cancer cell lines (IC50 < 7.5) than the other synthesized compounds.
 Conclusion: The new nitrone compounds (2b, 2d, 2e, and 2f) synthesized from terephthaldehyde exhibit some anticancer properties, and so are potential anticancer agents.
 Keywords: Terephthaldehyde, Nitrone, Cytotoxicity, Anticancer, MCF-7 cells
Mustafa M. AL-Hakiem, Rita S. Elias, and Munther A. Mohammed-Ali
GP Innovations Pvt. Ltd.
New series of Schiff base compounds obtained from sulfa drugs have been synthesized by the reaction of sulfonamide compounds (sulfadiazine, sulfapyridine, sulfamethazine, or sulfamerazine) with corresponding aromatic aldehydes (3-pyridinecarboxaldehyde or 4-pyridinecarboxaldehyde). The synthesized compounds were characterized by FT-IR, ESI-Mass, and 1H-NMR spectroscopy to confirm the chemical structures of synthesized compounds. The purity of all synthesized compounds were verified using pre-coated TLC (MERCK) plates using dichloromethane: methanol (9:1) solvent system. The chromatographic plates were viewed under ultraviolet(UV) light at 254 nm The sulfonamide Schiff base compounds were tested for antibacterial evaluation against two pathogenic Gram-positive bacteria (Staphylococcus aureus, Streptococcus spp.) and two pathogenic Gram-negative bacteria (Escherichia coli and Klebsiella pneumonia). The antibacterial activity of synthesized compounds was evaluated by assessing the inhibitory concentration by measuring their inhibition zone versus certain kinds of standard antibiotics with concentrations (500, 750, and 1000) μg /ml. Most synthesized compounds at high concentration were moderately active against all tested bacteria ,compound SH7 showed best antibacterial activity for both (Gram-positive and Gram-negative) bacteria while SH8 compound exhibited moderate antibacterial activity against Gram-positive bacteria and weak activity (<10 mm) against Gram-negative bacteria and all synthesized compounds were less antibacterial activity for all tested bacterial strains than standard drugs.
Ekhlas Qanber Jasim, M.A. Munther Abduljaleel, and Rajaa Hussein Fayadh
Asian Journal of Chemistry
five 1,3,4-thiadiazole compounds were synthesized. The prepared compounds were identified by CHNS analysis, FT-IR and 1 H NMR spectroscopy. The corrosion rates in the presence of thiadiazole as a steel corrosion inhibitor in the cooling water system which taken from South Fertilizer Company, Basra, Iraq were measured by the weight loss method and potentiodynamic polarization measurements. The weight loss method was studied in different times (1-5 h) and in 303 to 333 K temperature range. Results obtained revealed that thiadiazole compounds performed as a corrosion inhibitor for mild steel in this medium and its efficiency attains to 86.55 % at 5 × 10 -3 M at 303 K and by potentiodynamic polarization measurements its efficiency attains to 85.35 % in the same conditions. The apparent activation energies, enthalpies and entropies of the dissolution process and the free energies were determined and discussed.