Munther Abduljaleel MUHAMMAD-ALI
@uobasrah.edu.iq
Ecology / College of Science
University of Basrah
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Environmental Science, Pharmaceutical Science, Pollution
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Hawraa Kadhim Abdul-hussein and Munther Abduljaleel Muhammad-Ali
ANSF Publications
Synthetic dyes are widely used in textiles, paper, plastic, and other industries, which are toxic and harmful to the environment and humans. Adsorption is an efficient method to control wastewater. Cellulose is an abundant, renewable, and eco-friendly polymer produced by plants and trees. This study examined the possibility of using extracted free cellulose from corrugated cardboard (CC), cellulose composite with AgNPs of Myrtus communis L. extract (CAgM) and cellulose composite with AgNPs of banana peel extract (CAgB) for the removal of the cationic dyes, Safranine-T (ST), from aqueous solutions. The scope of this research included the characterization of sorbents using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscope (SEM), Energy Dispersive X-ray Spectroscopy (EDX), X-Ray Diffraction (XRD), Gas Chromatography–Mass Spectrometry (GC-MS), Ultraviolet–Visible Spectroscopy, determination of time contact, adsorbent mass, pH and temperature effect on the effectiveness of dye sorption using 50 mL of solution. The use of waste paper materials as sorbents was found not to pose any severe risk of aquatic environment contamination. Safranine-T (ST) sorption intensities were the highest at pH 8 and pH 10. The waste paper sorbents proved particularly effective in removing cationic dyes, like in the case of CC and CAgM, which had a sorption capacity that reached 89.16% and 84.22 %, respectively, and 84.04% towards CAgM. An adsorption isotherm study showed that the best equation used to describe the adsorption system is the Freundlich equation, with excellent correlation R2 > 0.9707.
Zainab Abdulhussein, Munther Muhammad-Ali, and Ekhlas Jasim
University of Benin
Plant extracts are important in the treatment of many bacterial infections, including henna extracts. Pharmacognosy have become an alternative to traditional medications because of a synergistic effect in combating bacterial infections and no multiple side effects. This investigation examined the antibacterial efficacy of Lawsonia inermis acetone extract against bacteria isolated from urinary tract infections (UTIs) and wounds, including Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumonia, and Escherichia coli. To isolate the pathogenic bacteria (P. aeruginosa, S. aureus, K. pneumonia, and E. coli), clinical pathogenic samples were obtained. Acetone extract of Lawsonia inermis leaves was produced using Soxhlet extraction and the solution of solid extract was investigated by the cork borer technique which gave an inhibitory zone of 18 to 22 mm against the four species of bacteria. 16 phytocompounds (1a–1p) were identified in the extract using gas chromatography-mass spectrophotometry (GC–MS) peak area percentage (10.66-1.72%). The analysis of phytochemicals using molecular docking simulations of their antibacterial potential revealed binding affinities of – 4.38 to – 7.83 kcal/mol, – 4.67 to – 7.47 kcal/mol, – 5.06 to – 9.07 and – 4.41 to – 7.30 kcal/mol against the dihydropteroate synthase and gyrase B 24kDa proteins of E. coli, and TyrRS and gyrase B proteins of S. aureus, respectively. The extract phytochemicals were subjected to physicochemical parameters evaluation: ADMET predictions. Pharmacokinetic prediction indicates fewer adverse effects. The extract has potential antimicrobial activity, with higher levels of clinical safety based on ADMET predictions.
Munther Abduljaleel Muhammad Ali, Ekhlas Qanber Jasim, and Abeer Issa Mohammed
Manuscript Technomedia LLP
Aim: The objective of this study is synthesis of 1,2,4-triazole derivatives, evaluation there in vitro antimicrobial activity and showing the molecular docking. Materials and Methods: Two series of 5-alkylthio-3-aryl-4-phenyl-1,2,4-triazoles were successfully synthesized. The 1,2,4-triazole thiol was produced via cyclization reaction using the hydrazide compounds (2-hydroxybenzohydrazide and 5-bromofuran-2-carbohydrazide), which were then employed as nucleophilic species to attract various kinds of alkyl halides to synthesis the final compounds. All produced compounds underwent spectroscopic characterization and tested their antibacterial and antifungal activities. With synthetic ligands, molecular docking studies were conducted against the proteins 1AJ0, 1JIJ, and 4ZA5 to identify the crucial interactions underlying antimicrobial activity. Results: UV-visible, FTIR, 1H-NMR and CHNS analysis were confirmed the chemical structures and purity. Initial antibacterial screening results showed that several produced compounds 1e , 1f , 2e , and 2f have good inhibitory effects, whilst some compounds 2e demonstrated high antifungal activity when compared to the control drug fluconazole. Two active substances, 1e and 2e , showed a moderate level of toxicity, with LD 50 values of 3.5 and 2.3 g/kg, respectively. The strongest compounds, 1e , 1f , 2e , and 2f , demonstrated high binding energy antibacterial and antifungal activity, which were supported by docking analysis. Conclusion: Triazole derivatives were synthesized by multi-reaction steps with high yields. Some synthesized triazole derivatives showed promising antibacterial and antifungal activities as compared with parent compounds and standard drugs. The results of antimicrobial activities of compounds were enhanced by good affinity of molecular docking of these compounds with the active site of proteins as compared with standard drugs amoxicillin and fluconazole.
Hawraa Kadhim Abdul-Hussein and Munther Abduljaleel Muhammad-Ali
IOP Publishing
Abstract Many industries, including textiles, paper, and plastics, use synthetic dyes, which are toxic and harmful to both people and the environment. Adsorption is an efficient wastewater management method. Plants and trees produce cellulose, which is a plentiful, renewable, and ecologically safe polymer. In this study, the effectiveness of corrugated cardboard (CC) in eliminating cationic dyes, such as safranine-T (ST) and Crystal Violet (CV), from aqueous solutions was examined. The scope of this study encompasses the characterization of sorbents (FTIR, SEM, EDX, XRD, GC-MS, and UV-Visible Spectrum) and assessment of the impact of pH on dye sorption efficiency. There is no significant risk of aquatic environmental contamination when waste paper products are used as sorbents. The adsorption intensities of crystal violet (CV) and safranine-T (ST) peaked at pH 8. As demonstrated by cellulose by freezing dry (CF) and cellulose by chemical method (CAg), which had sorption capacities of 91.16% and 82.21% for safranine-T (ST) dye and 93.40% and 88.78% for Crystal Violet (CV) dye, respectively, the waste paper sorbents were very successful in eliminating cationic dyes.
Sajjad F. Alasadi, Munther Abduljaleel Muhammad-Ali, and Suhad A. Taha
IOP Publishing
Abstract Removing heavy metals from water is of great benefit because these elements pose great risks to human health. Over the past decades, many traditional methods have been used to remove these pollutants from water, such as: ultrafiltration, reverse osmosis, ion exchange, solvent extraction and chemical precipitation. However, these methods have disadvantages such as high costs. In this study, aqueous and ethanolic extracts of rosemary (Salvia Rosmarinus) were introduced to remove heavy elements from polluted river water as new environmental sustainability. Five heavy metals were monitored and tested their concentrations in river water by Inductively Coupled Plasma Spectroscopy (ICP). The results showed that the alcoholic and aqueous extract of rosemary proved to be highly effective in removing the element (Fe) by 100%, and it was also able to remove the element (B) by 92%, while the removal rate of (As) and (Mn) was 100%, while it was able to reduce (Sr) by 29%. The best removal rates were recorded at a pH of 8, with a removal time of 30 minutes, and an extract concentration of 0.2 g/L of polluted water. Rosemary extract has proven its effectiveness in removing heavy elements and is considered a promising future alternative in the field of water treatment.
Alasadi et al.
Egyptian Knowledge Bank
Malak Khalaf Daish, Munther Abduljaleel Muhammad-Ali, and Widad M. Tahet Al-Asadi
IOP Publishing
Abstract Salinity is one of the major biological stressors that has an impact on the growth and development of plants. Because of AgNPs distinct physical and chemical characteristics as well as their huge surface area in relation to their size. Green synthesized of AgNPs was used to reduce the salt stress aquatic plant Ceratophyllum demersum. AgNPs were biosynthesized by Capparis spinosa L. extract and characterized using UV-Vis, FT-IR, XRD, SEM and TEM techniques which gave spherical shape of crystal size 44.33 nm. Three concentrations of AgNPs were prepared (0.05, 0.1 and 0.15 g) and used to study the salt stress. The effect on the properties of the aquatic environment was carried out at four weeks for salt pressure. As a result, the study showed that these particles improved the properties of the aquatic environment by reducing the amount of dissolved salt ions. In addition, the growth rate of the C. demersum plant increased, the amount of chlorophyll and the total organic carbon content increased and the proline content decreased So, we conclude from this study that AgNPs is a useful, ecofriendly and interesting application for use in environmental treatments, especially in water treatment.
Huda Saleh Abood, Ekhlas Qanber Jasim, and Munther Abduljaleel Muhammad-Ali
ARTS Publishing
In this work, four hydrazone Schiff base derivatives N-(2,4-Dinitro-phenyl)-N’-(1H-pyrrol-2-ylmethylene)-hydrazine (1a), N-Benzo [1,3] dioxol-5-ylmethylene-N’-(2,4-dinitro-phenyl)-hydrazine (1b), (E)-5-((2-(2,4-dinitrophenyl)hydrazono)methyl)-2-hydroxybenzoic acid (1c) and (E)-1-(2,4-dinitrophenyl)-2-(2-methoxybenzylidene)hydrazine (1d) were synthesized by reaction of four aldehydes namely pyrrole-2-carboxaldehyde, piperonal, 5-formylsalicylic acid, and o-vanillin with 2,4-dinitrophenyl hydrazine to produce the final compounds 1a, 1b, 1c, and 1d, respectively. These four compounds were investigated as corrosion inhibitors in aqueous mild acidic static solution. FTIR, HNMR, and elemental analysis were used to elucidate the chemical structure of the synthesized inhibitors. Using potential dynamic polarization measurements, these inhibitors’ efficiency in preventing C-steel corrosion in 1.00 M HCl was studied. The results of the experiments revealed that 1×10−3 M is the ideal concentration for 1a, 1b, 1c, and 1d, and that the corresponding inhibition efficiencies for these subunits were 80.70%, 91.30%, 91.34, and 88.80%, respectively. The best corrosion inhibitors were compounds 1b and 1c. Furthermore, studies suggested that these substances are mixed-type inhibitors and that the efficiency of the inhibition is strongly correlated with their quantity. Quantum paraments included Dipole moment, energy band gap (ΔE), value of energy of lowermost unoccupied molecular orbital (ELUMO), and energy of high most occupied molecular orbital (EHOMO) using Molecular Operating Environment MOE, Gaussian, and HyperChem software packages were determined which demonstrated strong agreement between algorithmic and practical findings.
Ekhlas Qanber Jasim
ARTS Publishing
Mesalazine, often referred to as mesalamine or 5-aminosalicylic acid (5-ASA), and its derivatives are some of the first medications to be approved for treating digestive tract inflammations, including ulcerative colitis and mild to moderate Crohn’s disease. Sulfasalazine, discovered in 1938 for therapeutic use, was the first mesalazine derivative. High yields of four different mesalazine derivatives were synthesized, including two Schiff bases and two azo compounds. The present study involved the synthesis of Schiff bases through the reaction of mesalazine with pyrrole-2-carbaldehyde or indole-2-carbaldehyde, resulting in the formation of 5-(((1H-pyrrol-2-yl)methylene)amino)-2-hydroxybenzoic acid (1) or 5-(((1H-indol-2-yl)methylene)amino)-2hydroxybenzoic acid (2), respectively. The synthesis of azo compounds involved the coupling of mesalazine with sulfamethoxazole or pyridoxine, resulting in the formation of 5-amino-2-hydroxy-3-((4-(N-(5-methylisoxazol-3-yl)sulfamoyl)phenyl)diazenyl)benzoic acid (3) or 2-hydroxy-5-((5-hydroxy-3,4-bis(hydroxymethyl)-6-methylpyridin-2-yl)diazenyl)benzoic acid (4), respectively. The identification of the synthesized compounds was carried out using IR and 1H-NMR spectroscopy. Antibacterial assessment of the synthetic compounds was performed in vitro against gram-negative bacteria (such as Escherichia coli and Pseudomonas aeruginosa) and gram-positive bacteria (Staphylococcus aureus). The antibacterial activity studies demonstrated that against Escherichia coli and Staphylococcus aureus, the Schiff base compounds are more active than azo compounds. Compound 1 showed the highest activity, resulting in a 23 mm inhibition zone against E. coli at 1000 ug/ml. In contrast, the antibacterial activity of compound 2 was observed to be 25 mm against S. aureus at the same highest concentration.
Dhay J. Edan, Munther Abduljaleel Muhammad-Ali, and Raghad Shubbar Jaafar
IOP Publishing
Abstract The current study aimed to use biological treatment using plant extracts; extracted from some locally available plants: Lawsonia inermis (Henna), and Myrtus communis (Yass), against pathogenic bacteria isolated from heavy water in hospitals that do not have treatment plants. The two studied plants were extracted using two different solvents (water and alcohol). Diagnosis of these extracted using Gas chromatography (GC-MS) showed that the alcoholic extraction led to a higher percentage of effective phenolic compounds than the aqueous extract. Sewage water was used to isolate bacteria and according to the morphological, and biochemical, confirmed by using the vitke II instrument; six types of pathogenic bacteria were identified (Staphylococcus lentus, Staphylococcus xylosus Sphingomonas paucimobilis, Escherichia coli, klebsiella oxytoca, Serratia ficaria). The two Alcoholic plant extracted showed excellent antibacterial activity against all pathogenic bacteria than the water extracted as revealed by the diameter of the inhibition zone.
Amani Abd Al-Ridha Al-Abdullah, Ekhlas Qanber Jasim, and Munther Abduljaleel Muhammad-Ali
IOP Publishing
Abstract The objective of the current study was to analyze the chemical compositions and antibacterial properties of Laurus nobilis. The bacterial strain was isolated from urine sample of female patients have urinary tract infection in Al-Basrah Teaching Hospital. Two solvents (hot and cold aqueous and ethanol) were used to extract the dried leaves of L. nobilis. While there were differences in the inhibition zones that solvent extracts demonstrated against bacterial pathogens, all of them significantly inhibited pathogens. The diameters of the inhibition zones on Staphylococcus aureus where the alcoholic extract was in the range of 17-29 mm, 22-28 mm for hot water and 12-14 mm for cold aqueous extract. The diameters of the inhibition zones on Klebsiella pneumoniae for alcoholic extract were 18-20 mm, 19-21.5 mm for hot aqueous extract and 12-17 mm for cold water extract. The GC-MS analysis demonstrated the presence of different phytochemical compounds in the extract of Laurus nobilis. A total of 60 compounds were identified, for ethanolic extract, tris (2-methylenecyclopropyl)methanol, (3aS,6aR,9aR,9bS)-3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one and (3aS,6aR,9aR,9bS)-6-methyl-3,9-dimethylene-3a,4,6a,7,8,9,9a,9b-octahydroazuleno[4,5-b]furan-2(3H)-one were the major compounds with percentage values 9.64%, 8.86% and 7.43%, respectively. For hot water extract, the major three compounds were 5-(hydroxymethyl)furan-2-carbaldehyde 11.64%, 2-methyl-5-nitro-2H-1,2,3-triazol-4-amine 8.39% and tris(2-methylenecyclopropyl)methanol 6.81%. Whereas, for cold water extract, the major compounds were n-Hexadecanoic acid 26.05%, Bis(2-ethylhexyl) phthalate 22.94% and Octadecanoic acid 8.25%. Molecular docking showed that these nine major compounds had an excellent binding affinity -4.25 to -8.56 kcal/mol against S. aureus using protein 1JIJ. The binding affinity of these compounds against K. pneumoniae (protein 6PIB) were in the range - 4.03 to -8.22 kcal/mol.
munther Muhammad-Ali, Abeer Mohammad, Basim Hameed, and Dhurgham Shaheed
Polish Pharmaceutical Society
Husam Hamza Salman, Munther Abduljaleel Mohammed Ali, and Eman Tariq Ali
African Journals Online (AJOL)
Purpose: To synthesize and screen some new nitrone compounds derived from terephthaldehyde for their anticancer potential.
 Methods: Six new compounds (H, p-Me,p-Br, p-Cl, o-Cl and m-Me) were synthesized via a condensation reaction between terephthaldehyde and a variety of aryl hydroxylamine compounds derived from nitrobenzene and its derivatives. The chemical structures of these compounds were identified using elemental CHN analysis and were elucidated using Fourier Transform infra-red (FT-IR), 1H-nuclear magnetic resonance (1H NMR), mass spectrometry (MS), and elemental analysis. The anticancer effects of the compounds were screened in vitro with respect to their cytotoxicity on MCF7 human cancer cells line. The IC50 values were obtained by MTT assay and their effects on apoptosis of MCF-7 cells were assessed using Acridine orange-ethidium bromide AO/EtBr staining method under a fluorescence microscope.
 Results: Only four compounds (2b, 2d, 2e, and 2f) inhibited more than 50 % of the growth of MCF-7 cells. The strongest anti-proliferation effect against MCF-7 cells was exhibited by 2f (m-Me), producing more apoptosis which increased membrane disruption and consistency of lysosome vacuoles; it also exhibited higher cytotoxic effects on human cancer cell lines (IC50 < 7.5) than the other synthesized compounds.
 Conclusion: The new nitrone compounds (2b, 2d, 2e, and 2f) synthesized from terephthaldehyde exhibit some anticancer properties, and so are potential anticancer agents.
 Keywords: Terephthaldehyde, Nitrone, Cytotoxicity, Anticancer, MCF-7 cells
Mustafa M. AL-Hakiem, Rita S. Elias, and Munther A. Mohammed-Ali
GP Innovations Pvt. Ltd.
New series of Schiff base compounds obtained from sulfa drugs have been synthesized by the reaction of sulfonamide compounds (sulfadiazine, sulfapyridine, sulfamethazine, or sulfamerazine) with corresponding aromatic aldehydes (3-pyridinecarboxaldehyde or 4-pyridinecarboxaldehyde). The synthesized compounds were characterized by FT-IR, ESI-Mass, and 1H-NMR spectroscopy to confirm the chemical structures of synthesized compounds. The purity of all synthesized compounds were verified using pre-coated TLC (MERCK) plates using dichloromethane: methanol (9:1) solvent system. The chromatographic plates were viewed under ultraviolet(UV) light at 254 nm The sulfonamide Schiff base compounds were tested for antibacterial evaluation against two pathogenic Gram-positive bacteria (Staphylococcus aureus, Streptococcus spp.) and two pathogenic Gram-negative bacteria (Escherichia coli and Klebsiella pneumonia). The antibacterial activity of synthesized compounds was evaluated by assessing the inhibitory concentration by measuring their inhibition zone versus certain kinds of standard antibiotics with concentrations (500, 750, and 1000) μg /ml. Most synthesized compounds at high concentration were moderately active against all tested bacteria ,compound SH7 showed best antibacterial activity for both (Gram-positive and Gram-negative) bacteria while SH8 compound exhibited moderate antibacterial activity against Gram-positive bacteria and weak activity (<10 mm) against Gram-negative bacteria and all synthesized compounds were less antibacterial activity for all tested bacterial strains than standard drugs.
Ekhlas Qanber Jasim, M.A. Munther Abduljaleel, and Rajaa Hussein Fayadh
Asian Journal of Chemistry
five 1,3,4-thiadiazole compounds were synthesized. The prepared compounds were identified by CHNS analysis, FT-IR and 1 H NMR spectroscopy. The corrosion rates in the presence of thiadiazole as a steel corrosion inhibitor in the cooling water system which taken from South Fertilizer Company, Basra, Iraq were measured by the weight loss method and potentiodynamic polarization measurements. The weight loss method was studied in different times (1-5 h) and in 303 to 333 K temperature range. Results obtained revealed that thiadiazole compounds performed as a corrosion inhibitor for mild steel in this medium and its efficiency attains to 86.55 % at 5 × 10 -3 M at 303 K and by potentiodynamic polarization measurements its efficiency attains to 85.35 % in the same conditions. The apparent activation energies, enthalpies and entropies of the dissolution process and the free energies were determined and discussed.