Combined Melorheostosis and Osteopoikilosis: Uncommon Presentation with Sciatic Nerve Neuropathy: A Case Report Ismail Tawfeek Badr, Mohamed Kamal Mesregah, Sanjiv Rampal, Mahmoud Mohamed Moawad, Bahaa Zakarya Hasan Jbjs Case Connector, 2026 Case: A 27-year-old man presented with an 8-year history of chronic right gluteal and posterior thigh pain, worsened by sitting and unresponsive to conservative treatment. Imaging revealed widespread melorheostosis and osteopoikilosis of the right lower extremity, with 2 gluteal soft tissue masses compressing the sciatic nerve. The masses were excised using a dual surgical approach, achieving successful sciatic nerve decompression. Postoperatively, the patient regained normal sitting and sleeping tolerance, with complete pain relief maintained over a 15-month follow-up. Conclusion: Melorheostosis, a rare sclerosing bone disorder sometimes associated with osteopoikilosis, may require surgery when large lesions cause nerve compression.
Autogenous structural bone graft reconstruction of ≥ 10-mm-deep uncontained medial proximal tibial defects in primary total knee arthroplasty Ahmed Abdel-Monem Dewidar, Mohamed Kamal Mesregah, Mustafa Mohamed Mesriga, Ahmed Mohamed El-Behiry Journal of Orthopaedics and Traumatology, 2024 Background Management of uncontained medial proximal tibial defects during primary total knee arthroplasty (TKA) can be challenging, especially for defects ≥ 10 mm in depth. This study sought to assess the outcomes of autogenous structural bone grafts to address these defects. Materials and methods In this prospective study, patients with uncontained medial proximal tibial defects ≥ 10 mm in depth undergoing TKA were managed by autogenous structural bone grafts fixed by screws and were followed up for at least 36 months. Patients were followed-up clinically with Knee Society Score (KSS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Additionally, radiological follow-up was done to assess bone graft union and implant stability. Results The study included 48 patients with a mean age of 69.2 ± 4.5 years. The mean body mass index (BMI) was 31.4 ± 3.7 kg/m2. The mean defect depth was 17 ± 3.6 mm. With a mean follow-up period of 52.2 ± 12.3 months, the median KSS improved significantly from 30 preoperatively to 89, P < 0.001. The median WOMAC score reduced significantly from 85 preoperatively to 30.5, P < 0.001. The mean ROM increased significantly from 73 ± 12.4 preoperatively to 124 ± 8.4 degrees, P < 0.001. The mean graft union time was 4.9 ± 1 months. No significant complications were reported. Conclusions Autogenous bone graft reconstruction is a safe and effective method of addressing uncontained medial proximal tibial defects in primary TKA. Level of evidence Level IV.
Radiographic Risk Factors for Adjacent Segment Disease Following Anterior Cervical Discectomy and Fusion (ACDF): A Systematic Review and Meta-Analysis Mohamed Kamal Mesregah, Melissa Baker, Camilla Yoon, Hans-Joerg Meisel, Patrick Hsieh, et al. Global Spine Journal, 2024 Study Design Systematic review and meta-analysis. Objectives To assess the radiographic risk factors for adjacent segment disease (ASD) following anterior cervical discectomy and fusion (ACDF) for degenerative cervical spine pathologies. Methods PubMed, Embase and the Cochrane Library databases were searched up to December 2023. The primary inclusion criteria were degenerative spinal conditions treated with ACDF, comparing radiological parameters in patients with and without postoperative ASD. The radiographic parameters included intervertebral disc height, cervical sagittal alignment, sagittal segmental alignment, range of motion, segmental height, T1 slope, sagittal vertical axis (SVA), thoracic inlet angle (TIA), and plate to disc distance (PPD). Risk of bias was assessed for all studies. The Cochrane Review Manager was utilized to perform the meta-analysis. Results From 7044 articles, 13 retrospective studies were included in the final analysis. Three studies had “not serious” bias and the other 10 studies had serious or very serious bias. The total number of patients in the included studies was 1799 patients. Five studies included single-level ACDF, 2 studies included multi-level ACDF, and 6 studies included single or multi-level ACDF. On meta-analysis, the significant risk factors associated with ASD development were reduced postoperative cervical lordosis (mean difference [MD] = 3.35°, P = .002), reduced last-follow-up cervical lordosis (MD = −3.02°, P = .0003), increased preoperative to postoperative cervical sagittal alignment change (MD = −3.68°, P = .03), and the presence of developmental cervical canal stenosis (Odds ratio [OR] = 4.17, P < .001). Conclusions Decreased postoperative cervical lordosis, greater change in cervical sagittal alignment and developmental cervical canal stenosis were associated with an increased risk of ASD following ACDF.
Subaxial cervical fractures Ki-Eun Chang, Brandon Yoshida, Mohamed Kamal Mesregah, Zorica Buser, Jeffrey C. Wang Orthopaedics and Trauma Current Concepts and Best Practices, 2024
Clinical effectiveness of interlaminar epidural injections of local anesthetic with or without steroids for managing chronic neck pain: A systematic review and meta-analysis Pain Physician, 2020
Combined Melorheostosis and Osteopoikilosis: Uncommon Presentation with Sciatic Nerve Neuropathy: A Case Report IT Badr, MK Mesregah, S Rampal, MM Moawad, BZ Hasan JBJS Case Connector 16 (1), e25 , 2026 2026
Comments on" Successful results obtained in the treatment of adolescent forearm fractures with locked intramedullary nailing"—The need for a large multi-center study to … MK Mesregah Chinese Journal of Traumatology 28 (06), 515-515 , 2025 2025
Surgical treatment of monostotic fibrous dysplasia of the proximal femur in children and adolescents: Observational European Paediatric Orthopaedic Society multicenter study TP Van Geloven, PB De Witte, MK Laitinen, DA Campanacci, K Döring, ... Journal of children's orthopaedics 19 (5), 367-376 , 2025 2025
Outcomes of arthroscopic rotator cuff repair via single-row anchor technique versus transosseous anchorless technique: A randomized controlled trial MM Mesriga, MK Mesregah, AAM Dewidar, HE Saad, AM Ebied Journal of Clinical Orthopaedics and Trauma 64, 102951 , 2025 2025 Citations: 3
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P73. Impact of Baseline Denosumab and Teriparatide Treatments in Osteoporotic Patients with Lumbar Spondylolisthesis Undergoing Posterior Decompression and Fusion Surgery of … N Van Halm-Lutterodt, K Ansari, NR Storlie, M Jiang, MKM Mesregah, ... The Spine Journal 24 (9), S98 , 2024 2024
P43. Impact of radiographic parameters on adjacent segment disease after anterior cervical discectomy and fusion: a systematic review and meta-analysis M Baker, MKM Mesregah, JC Wang, ST Yoon, Z Buser The Spine Journal 24 (9), S83-S84 , 2024 2024
Radiographic risk factors for adjacent segment disease following anterior cervical discectomy and fusion (ACDF): a systematic review and meta-analysis MK Mesregah, M Baker, C Yoon, HJ Meisel, P Hsieh, JC Wang, ST Yoon, ... Global Spine Journal 14 (7), 2183-2200 , 2024 2024 Citations: 12
Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050 Y Jin, C Guo, M Abbasian, M Abbasifard, JH Abbott, A Abdullahi, A Abedi, ... Med 5 (8), 943-962. e6 , 2024 2024 Citations: 57
Global, regional, and national burden of gout, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 M Cross, KL Ong, GT Culbreth, JD Steinmetz, E Cousin, H Lenox, ... The Lancet Rheumatology 6 (8), e507-e517 , 2024 2024 Citations: 295
The impact of enhanced recovery after surgery (ERAS) on opioid consumption and postoperative pain levels in elective spine surgery E Stanton, Z Buser, MK Mesregah, K Hu, TA Pickering, B Schafer, R Hah, ... Clinical Neurology and Neurosurgery 242, 108350 , 2024 2024 Citations: 10
Subaxial cervical fractures KE Chang, B Yoshida, MK Mesregah, Z Buser, JC Wang Orthopaedics and Trauma: Current Concepts and Best Practices, 671-678 , 2024 2024 Citations: 1
Autogenous structural bone graft reconstruction of≥ 10-mm-deep uncontained medial proximal tibial defects in primary total knee arthroplasty AAM Dewidar, MK Mesregah, MM Mesriga, AM El-Behiry Journal of Orthopaedics and Traumatology 25 (1), 22 , 2024 2024 Citations: 9
Global, regional, and national burden of neck pain, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 AM Wu, M Cross, JM Elliott, GT Culbreth, LM Haile, JD Steinmetz, ... The Lancet Rheumatology 6 (3), e142-e155 , 2024 2024 Citations: 363
Analysis of Complications in Multilevel Anterior Cervical Discectomy and Fusion Using Osteobiologics Other than Bone Morphogenetic Protein: A Systematic Review JP Cabrera, N Agarwal, MK Mesregah, R Rodrigues-Pinto, Y Wu, ... Global Spine Journal 14 (2_suppl), 86-93 , 2024 2024 Citations: 1
Complications with demineralized bone matrix, hydroxyapatite and beta-tricalcium phosphate in single and two-level anterior cervical discectomy and fusion surgery JP Cabrera, S Muthu, MK Mesregah, R Rodrigues-Pinto, N Agarwal, ... Global spine journal 14 (2_suppl), 78-85 , 2024 2024 Citations: 3
As simple as it sounds? The treatment of simple bone cysts in the proximal femur in children and adolescents: Retrospective multicenter EPOS study of 74 patients TPG van Geloven, L van der Heijden, MK Laitinen, DA Campanacci, ... Journal of children's orthopaedics 18 (1), 85-95 , 2024 2024 Citations: 13
Cannabis use disorder and complications after anterior cervical diskectomy and fusion N Van Halm-Lutterodt, JA Albright, NR Storlie, MK Mesregah, K Ansari, ... World Neurosurgery 181, e1001-e1011 , 2024 2024 Citations: 7
Global, regional, and national burden of other musculoskeletal disorders, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 TK Gill, MM Mittinty, LM March, JD Steinmetz, GT Culbreth, M Cross, ... The Lancet Rheumatology 5 (11), e670-e682 , 2023 2023 Citations: 445
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Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis … Global Burden of Disease 2019 Cancer Collaboration, JM Kocarnik, ... JAMA oncology 8 (3), 420-444 , 2022 2022 Citations: 2329
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Automated MRI-based deep learning model for detection of Alzheimer’s disease process W Feng, NV Halm-Lutterodt, H Tang, A Mecum, MK Mesregah, Y Ma, H Li, ... International Journal of Neural Systems 30 (06), 2050032 , 2020 2020 Citations: 202
Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990–2019: results from the Global Burden of Disease Study 2019 JR Ledesma, J Ma, A Vongpradith, ER Maddison, A Novotney, MH Biehl, ... The Lancet Infectious Diseases 22 (2), 222-241 , 2022 2022 Citations: 178
Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 … AE Micah, IE Cogswell, B Cunningham, S Ezoe, AC Harle, ER Maddison, ... The lancet 398 (10308), 1317-1343 , 2021 2021 Citations: 149
Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019 AE Peden, P Cullen, KL Francis, H Moeller, MM Peden, P Ye, M Tian, ... The Lancet public health 7 (8), e657-e669 , 2022 2022 Citations: 79
Demographic, clinical, and operative risk factors associated with postoperative adjacent segment disease in patients undergoing lumbar spine fusions: a systematic review and … MK Mesregah, B Yoshida, N Lashkari, A Abedi, HJ Meisel, A Diwan, ... The Spine Journal 22 (6), 1038-1069 , 2022 2022 Citations: 64
Functional and oncological outcome after treatment of chondroblastoma with intralesional curettage WA Ebeid, BZ Hasan, IT Badr, MK Mesregah Journal of Pediatric Orthopaedics 39 (4), e312-e317 , 2019 2019 Citations: 58
Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050 Y Jin, C Guo, M Abbasian, M Abbasifard, JH Abbott, A Abdullahi, A Abedi, ... Med 5 (8), 943-962. e6 , 2024 2024 Citations: 57
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