Michchenko Ekaterina

@muctr.ru

Department of Nanomaterials and Nanotechnology
Mendeleev University of Chemical Technology of Russia

Michchenko Ekaterina


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https://researchid.co/mishchenkoek

RESEARCH, TEACHING, or OTHER INTERESTS

Colloid and Surface Chemistry, Drug Guides
8

Scopus Publications

Scopus Publications

  • Nanoemulsions and Solid Lipid Nanoparticles with Encapsulated Doxorubicin and Thymoquinone
    E. V. Mishchenko, A. M. Gileva, E. A. Markvicheva, M. Yu. Koroleva
    Colloid Journal, 2023
    Abstract— Nanoemulsions (NEs) and solid lipid nanoparticles (SLNs) are promising drug delivery systems. In this work, paraffin oil NEs and stearic acid SLNs stabilized with Tween 60 and Span 60 have been studied. NEs with an average droplet diameter of ~50 nm and suspensions of SLNs with an average size of ~30 nm are stable to aggregation for more than 90 days. The rates of penetration of lipid particles into cancer cells (C6 and MCF-7) depend on their sizes. After incubation for 1 h, lipid nanoparticles ~50 nm in size penetrate into cells, are distributed in their internal space, and concentrate in the nuclei. The cytotoxicity of doxorubicin- or thymoquinone-loaded NEs and SLNs against MCF-7 and HTC 116 cell lines is higher than the cytotoxicity of the individual substances. Wherein, unloaded NEs and SLNs show low cytotoxicity. The obtained results demonstrate that paraffin oil NEs and stearic acid SLNs are promising to be used as carriers of both lipophilic and amphiphilic drugs, including doxorubicin and thymoquinone. The accumulation of lipid nanoparticles with sizes smaller than 100 nm in cell nuclei is an advantage of such systems for the delivery of anticancer drugs, because this leads to DNA replication suppression followed by cell apoptosis.
  • Development and Study of a Carbon–Mineral Catalyst Based on Natural Clay and Tire Crumb for the Oxidative Decomposition of Nonionic Surfactants with Hydrogen Peroxide in Wastewater
    M. M. Fidchenko, M. B. Alekhina, A. N. Beznosyuk, A. D. Varnavskaya, E. V. Mishchenko
    Kinetics and Catalysis, 2023
    Abstract Samples of a carbon–mineral catalyst based on natural clay and tire crumb for the oxidative decomposition of nonionic surfactants (NSes) with hydrogen peroxide in wastewater have been developed and studied. The iron content in the samples has been varied in a range of 2.3–3.9 wt %. The effect of the pyrolysis temperature varied for the samples in a range of 350–800°C on changes in their textural characteristics, the number and type of acid sites on the surface, and the ζ-potential (zeta potential) of colloidal systems based on the synthesized samples has been studied. Using model solutions under steady-state and dynamic conditions, the effect of the pyrolysis temperature used for the samples on their catalytic properties in the oxidative decomposition of H2O2 and the neonol AF 9-10 NS with hydrogen peroxide has been studied. The best result in the oxidation of neonol AF 9-10 with hydrogen peroxide has been obtained in the presence of a carbon–mineral catalyst sample calcined at 650°C.
  • Bioavailability of nanoenulsions modified with curcumin and cerium dioxide nanoparticles
    A.D. Shirokikh, V.A. Anikina, E.A. Zamyatina, E.V. Mishchenko, M.Y. Koroleva, V.K. Ivanov, N.R. Popova
    Nanosystems Physics Chemistry Mathematics, 2023
    In this work, the physicochemical properties and biological activity of nanoemulsions prepared from paraffin oil and stabilized by nonionic surfactants as carriers of curcumin and cerium dioxide nanoparticles were studied. An analysis of the results showed that curcumin was incorporated into the oil droplets while cerium dioxide nanoparticles were adsorbed on the surface of oil droplets. The nanoemulsion droplet size did not exceed 100 nm. The absence of toxicity to mouse embryonic fibroblasts in vitro and after a single intraperitoneal injection to mice in vivo makes the nanoemulsions promising drug carriers for advanced biomedical applications.
  • Microemulsions and nanoemulsions modified with cationic surfactants for improving the solubility and therapeutic efficacy of loaded drug indomethacin
    Alla B Mirgorodskaya, Marina Yu Koroleva, Rushana A Kushnazarova, Ekaterina V Mishchenko, Konstantin A Petrov, Oxana A Lenina, Alexandra B Vyshtakalyuk, Alexandra D Voloshina, Lucia Ya Zakharova
    Nanotechnology, 2022
    In this work, a noncovalent strategy was successfully used to modify colloidal stability and in vitro and in vivo efficacy of two amphiphilic formulations of the anti-inflammatory drug indomethacin. Namely, nanoemulsions and microemulsions based on oleic acid and nonionic surfactants have been produced and compared. The influence of cationic surfactants cetyltrimethylammonium bromide and its carbamate bearing analogue on the size characteristics, stability and ability to provide prolonged action of loaded drug indomethacin has been evaluated. Adding the positively charged molecules in the surface layer of nanoemulsions and microemulsions has shown the stability increase along with maintaining the size characteristics and homogeneity in time. Moreover, the carbamate modified analogue demonstrated beneficial behavior. Indomethacin loaded in microemulsions and nanoemulsions showed prolonged-release (10%–15% release for 5 h) compared to a free drug (complete release for 5 h). The rate of release of indomethacin from nanoemulsions was slightly higher than from microemulsions and insignificantly decreased with an increase in the concentration of the cationic surfactant. For carbamate surfactant nanocarrier loaded with fluorescence probe Nile Red, the ability to penetrate into the cell was supported by flow cytometry study and visualized by fluorescence microscopy. In vitro tests on anti-inflammatory activity of the systems demonstrated that the blood cell membrane stabilization increased in the case of modified microemulsion. The anti-inflammatory activity of the encapsulated drug was tested in rats using a carrageenan-induced edema model. Nanoemulsions without cationic surfactants appeared more efficient compared to microemulsions. Indomethacin emulsion formulations with carbamate surfactant added showed slower carrageenan-induced edema progression compared to unmodified compositions. Meanwhile, the edema completely disappeared upon treatment with emulsion loaded indomethacin after 4 h in the case of microemulsions versus 5 h in the case of nanoemulsions.
  • Solid lipid nanoparticles and nanoemulsions with solid shell: Physical and thermal stability
    M. Koroleva, I. Portnaya, E. Mischenko, I. Abutbul-Ionita, L. Kolik-Shmuel, D. Danino
    Journal of Colloid and Interface Science, 2022
  • Nanoemulsions and Nanocapsules with Oleic Acid
    E. V. Mishchenko, E. E. Timofeeva, A. S. Artamonov, I. B. Portnaya, M. Yu. Koroleva
    Colloid Journal, 2022
    Nanoemulsions are promising disperse systems that can be used as carriers of hydrophobic drugs and biologically active compounds. In this work, nanoemulsions, which contain oleic acid as a dispersed phase and are stabilized with mixtures of nonionic surfactants, Tween 80/Span 80 and Tween 60/Span 60, have been studied. Nanoemulsions stabilized with Tween 80 and Span 80 are unstable. Dispersed phase droplets of such systems undergo intense flocculation and coalescence. Nanoemulsions stabilized with Tween 60 and Span 60 have appeared to be much more stable. The average particle diameter of the dispersed phase remains almost unchanged for a long time at 25°C, as well as in two cycles of heating to 60°C and subsequent cooling to 5°C. Microcalorimetry has been employed to determine the temperatures of phase transitions in such nanoemulsions. The obtained thermograms have two peaks due to melting of oleic acid and a mixed adsorption layer consisting of Tween 60 and Span 60 molecules. Since a solid shell is formed on the surface of oleic acid droplets, such systems can be considered to be nanocapsules.
  • Economic and fast electro-flotation extraction of heavy metals from wastewater
    Imran Ali, Kon’kova Tatiana, Than Zaw Htay, Hein Thu Aung, Mishenko Ekaterina, Mohammad Nahid Siddiqui, Abdulraheem S. A. Almalki, A. Alhadhrami, Abdullah alsubaie, Ahmed M. Hameed, Ahmed Alharbi
    Environmental Technology United Kingdom, 2022
    Fast electroflotation extraction of heavy metals from wastewater is described. The results of experimental investigations of the extraction of iron, aluminium and chromium hydroxides from aqueous solutions in the presence of surfactants of various natures and ions of calcium by electroflotation are presented. It was found that the presence of Ca2+ in the solution at a concentration of 0.5 g/L reduced the degree of electroflotation extraction of Al(OH)3, Fe(OH)3, Cr(OH)3 regardless of the nature of the electrolyte. The addition of surfactants in the system in the presence of Ca2+ increased the amount of extraction of the dispersed phase. The greatest effect is achieved with the help of anionic surfactant sodium dodecyl sulphate, while the degree of extraction reached 98%. The high efficiency of the process of electroflotation extraction of the dispersed phase was due to the hydrophobization of the particle surface owing to the adsorption of surfactants on the surface of hydroxides. The recent method is useful to treat wastewater contaminated with aluminium, iron and chromium metal ions. The reason is that this method is very fast working within 20 min; Moreover, pH 7.0 working made this method ideal for utilisation in natural water treatment economically. GRAPHICAL ABSTRACT
  • Mechanism of Inversion of Montmorillonite Sorption Properties by Cationic Surfactant
    T. V. Kon’kova, A. P. Rysev, E. V. Mishchenko
    Inorganic Materials Applied Research, 2020
    Organo-mineral derivatives of montmorillonite modified by salts of quaternary ammonium compounds are promising adsorbents for wastewater purification from heavy metal anions, as well as anionic dyes and pesticides. The understanding of the mechanism of anion adsorption by the example of montmorillonite modified by didecyldimethylammonium chloride cationic surfactant is expanded. The high rate of chromium anion adsorption, the appearance of adsorption capacity only during charge exchange of the surface, and the pH dependence of adsorption, including for pH-independent nitrate anions, indicate that a significant contribution to adsorption of anions is made by silanol and aluminol groups on the edge surface of the aluminosilicate layers of the mineral. The redistribution of access to various types of adsorption centers of the surface for adsorptive is the mechanism of inversion of the adsorption properties for montmorillonite. The inner negatively charged surface is screened by the double layer of the surfactant molecules that block the interlayer space. The surfactant molecules are not hydrated, which impedes delamination of the mineral in aqueous medium.