Drug Discovery, Molecular Biology, Spectroscopy, Radiology, Nuclear Medicine and imaging
2
Scopus Publications
Scopus Publications
Species-specific acid-base characterization of carnosine and homocarnosine using nuclear magnetic resonance Arash Mirzahosseini, Mirsadra Molaei, Károly Mazák, Tamás Pálla, István Köteles, Nikolett Varró, István Mándity, Béla Noszál Chemical Physics Letters, 2022 A C T Carnosine and homocarnosine have long been known to be important constituents of the human metabolome, performing pH-and redox homeostasis-related roles. These are the most important imidazole-containing 'small' chemical entities in biological media. In this work these dipeptides were studied by 1 H NMR-pH titration under near-physiological conditions. The resulting acid-base properties are quantified in terms of 6 macroscopic and 24 microscopic protonation constants, which show good agreement with previous results. A deeper knowledge in the physicochemical properties of the studied dipeptides may give further insight into the molecular level interpretation of their biosynthesis pathways, and biochemical reactions.
A rare case of COVID-19 vaccine-induced myopericarditis in a young adult Arman Sharbatdaran, Yasmeen Chahal, Mirsadra Molaei, Dishang Bhavsar Radiology Case Reports, 2022 Although extremely rare, the COVID-19 mRNA vaccine can induce myopericarditis without left ventricular dysfunction, and there have been rare reports of such incidents. However, these prior cases either did not have pericardial effusion without reduced left ventricular ejection fraction or had a more typical presentation of vaccine-induced myopericarditis such as shortness of breath or tactile temperature. We present a rare case of a 25-year-old man who developed myopericarditis following administration of the second dose of COVID-19 mRNA Vaccine. As vaccination plays a significant role in the fight against the COVID-19 pandemic, it is essential to highlight the physical manifestations of the vaccine's potential adverse effects and risk factors to increase the general population's awareness regarding the importance of emergent medical care.
