Melis Rahime Yildirim

@kuttam.ku.edu.tr

Cellular and Molecular Medicine
Koç University Translational Medicine Center

Melis Rahime Yildirim


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https://researchid.co/melisyildirim

RESEARCH, TEACHING, or OTHER INTERESTS

Biotechnology, Molecular Medicine, Cancer Research, Drug Discovery
2

Scopus Publications

6

Scholar Citations

2

Scholar h-index

Scopus Publications

  • A Perspective on the Characterization of Early Neural Progenitor Cell-Derived Extracellular Vesicles for Targeted Delivery to Neuroblastoma Cells
    Oğuz Kaan Kırbaş, Batuhan Turhan Bozkurt, Melis Rahime Yıldırım, Pakize Neslihan Taşlı, Hüseyin Abdik, Fikrettin Şahin, Ezgi Avşar Abdik
    Neurochemical Research, 2024
    As an element of the cellular signaling systems, extracellular vesicles (EVs) exhibit many desirable traits for usage as targeted delivery vehicles. When administered, EVs cause little to no toxic or immune response, stay in circulation for longer periods compared to synthetic carriers, preferentially accumulate in tissues that are the same or similar to their cell-of-origin and can pass through the blood-brain barrier. Combined, these traits make neural EVs a particularly promising tool for delivering drugs to the brain. This study aims to combine tissue and EVs engineering to prepare neural differentiated cells derived EVs that exhibit neural properties, to develop an effective, tissue-homing drug and gene delivery platform for the brain. Early neural differentiated cell-derived EVs were produced with neural characteristics from neural differentiated human neonatal dermal fibroblasts. The EVs carried key neural proteins such as Nestin, Sox2 and Doublecortin. The cellular uptake of early neural differentiated cell-derived EVs was higher compared to non-neural EVs during in vitro uptake assays on neuroblastoma cells. Moreover, eND-EVs were significantly decreased the viability of neuroblastoma cells. In conclusion, this study revealed that early neural differentiated cell-derived EVs have potential as a promising drug carrier for the treatment of various neural disorders. Graphical Abstract
  • The emerging role of breast cancer derived extracellular vesicles-mediated intercellular communication in ovarian cancer progression and metastasis
    Melis Rahime Yıldırım, Oğuz Kaan Kırbaş, Hüseyin Abdik, Fikrettin Şahin, Ezgi Avşar Abdik
    Medical Oncology, 2024

RECENT SCHOLAR PUBLICATIONS

  • A Perspective on the Characterization of Early Neural Progenitor Cell-Derived Extracellular Vesicles for Targeted Delivery to Neuroblastoma Cells
    OK Kırbaş, BT Bozkurt, MR Yıldırım, PN Taşlı, H Abdik, F Şahin, ...
    Neurochemical Research 49 (9), 2364-2378 , 2024
    2024.0
    Citations: 4
  • The emerging role of breast cancer derived extracellular vesicles-mediated intercellular communication in ovarian cancer progression and metastasis
    MR Yıldırım, OK Kırbaş, H Abdik, F Şahin, E Avşar Abdik
    Medical Oncology 41 (1), 30 , 2023
    2023.0
    Citations: 2
  • CURRENT APPROACHES IN SCIENCE OF LIFE
    B AYDIN, APH ABDİK, APDM ÜYÜKLÜ, APDS ÇAM, TADDA MUTLU, ...

MOST CITED SCHOLAR PUBLICATIONS

  • A Perspective on the Characterization of Early Neural Progenitor Cell-Derived Extracellular Vesicles for Targeted Delivery to Neuroblastoma Cells
    OK Kırbaş, BT Bozkurt, MR Yıldırım, PN Taşlı, H Abdik, F Şahin, ...
    Neurochemical Research 49 (9), 2364-2378 , 2024
    2024.0
    Citations: 4
  • The emerging role of breast cancer derived extracellular vesicles-mediated intercellular communication in ovarian cancer progression and metastasis
    MR Yıldırım, OK Kırbaş, H Abdik, F Şahin, E Avşar Abdik
    Medical Oncology 41 (1), 30 , 2023
    2023.0
    Citations: 2
  • CURRENT APPROACHES IN SCIENCE OF LIFE
    B AYDIN, APH ABDİK, APDM ÜYÜKLÜ, APDS ÇAM, TADDA MUTLU, ...